Articles tagged with Psychiatric Disorders
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Dr. Ronald C. Kessler's decades-long research transformed international understanding of psychiatric disorders and suicide prevention. His work exposes the global scope of mental health challenges and highlights key factors in prevention.
Researchers found that psilocybin reduced novelty-seeking in control mice, but heightened it in anorexia model mice. Inflammation levels were also altered, contradicting expectations based on human studies. The study's findings have implications for understanding anorexia nervosa and the potential therapeutic effects of psychedelics.
A rare genetic mutation has been discovered that can explain why some people do not respond to newer schizophrenia treatments. The mutation, known as C182F, removes a structural bond in the TAAR1 receptor, blocking its binding site and rendering drugs ineffective.
The latest APA Journal issues explore the intersection of neuroplasticity and substance use, as well as emerging trends in outpatient psychotherapy. The American Psychiatric Association's flagship journals offer insightful research on mental health topics.
A large study of over 12 million people in Ontario found that psychosis rates are increasing in more recent generations, with higher rates among younger individuals. The study suggests that factors such as substance use, socioeconomic stress, and negative childhood experiences may contribute to these rising trends.
A UH psychologist's study finds that anxiety sensitivity and pain-related anxiety are linked to mental health problems and clinically significant alcohol use among survivors of traumatic sexual assault. The investigation highlights the importance of addressing both types of anxiety in reducing the risk of lifelong challenges.
The study reveals that the paraventricular thalamic nucleus (PVT) is the central pathological substrate of bipolar disorder, with notable alterations in cell number and gene expression. This discovery highlights the PVT as a potential diagnostic and therapeutic target for improving patient outcomes.
Dissociation is a complex survival mechanism in response to overwhelming trauma, affecting memory, identity, and perception. Research confirms its prevalence among individuals who have experienced trauma, and effective dissociation-specific treatment options are needed.
A groundbreaking study found that social and academic difficulties emerge years before clinical symptoms of psychosis appear, offering a critical window for early intervention. Early-life struggles are strongly predicted to later negative symptoms and cognitive impairment.
A recent survey study found a significant association between generative AI use and increased depressive symptoms in US adults. The magnitude of the effect varied by age group, suggesting that further research is needed to understand the causal relationship and underlying factors.
A study of over 500 survivors found severe psychological trauma with somatic symptoms persisting decades after the attack. The results highlight the need for culturally sensitive mental health services, compensation, and ongoing care for chemical attack survivors.
Researchers from Kyushu University found that the brain forms new, high-density clusters of synapses on specific segments of dendrites during adolescence, challenging the 'adolescent synaptic pruning' hypothesis. This discovery may offer new hope for understanding the biological basis of schizophrenia and other neurodevelopmental condi...
A study found that a small, implanted vagus nerve stimulation device produced substantial and sustained improvements in depressive symptoms, quality of life, and daily function in patients with treatment-resistant depression. The device showed lasting benefits even after two years, with nearly one-third of participants who didn't respo...
Resonant breathing significantly reduced anxiety and insomnia symptoms and improved heart rate variability in hospitalised psychiatric patients with severe somatic symptoms. The intervention was well-tolerated and required minimal cognitive effort.
A study funded by the National Cancer Institute aims to test a low-cost intervention using future-focused thoughts to help people quit smoking. The project will examine the effectiveness of episodic future thinking in reducing impulsivity and promoting healthier choices.
New study finds psychosis delusions emerge from emotional experiences, bodily reactions, and linguistic fabric. Participants described intense emotional embodiment and disembodiment, with some experiencing positive feelings of awe and love.
A Dartmouth study identifies a novel target for using psilocybin to treat depression and anxiety without hallucinations. The serotonin 1B receptor is found to promote the therapeutic benefits of psilocybin, providing a potential new approach for developing safer and more cost-efficient medications.
Research from Karolinska Institutet found that alpha frequency determines body ownership by modulating temporal integration of bodily signals. Faster frequencies led to higher temporal resolution, while slower frequencies caused broader timing differences.
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
Researchers at Flinders University discover a genetic mutation that silences a brain receptor, rendering it unresponsive to both natural trace amines and clinical drug candidates. The C182F variant eliminates receptor signaling and reduces cell surface expression, with profound implications for emerging psychiatric treatments.
A comprehensive review synthesizes emerging evidence on AMPKα isoforms' dual roles in Alzheimer's disease. The analysis proposes that this complexity may explain why pharmacological approaches have yielded mixed results in treating the disease. Isoform-specific targeting is proposed as a novel therapeutic strategy.
Professor Dan Stein was a visionary who bridged neuroscience, clinical care, and philosophy to transform psychiatric research in Africa. His integrative approach produced scholarship of extraordinary range, with over 1,600 peer-reviewed publications and a Google Scholar h-index exceeding 220.
Scientists at Salk Institute find protein CCN1, secreted by astrocytes, maintains stable neural circuits in adult brains. The discovery could lead to new therapeutics for brain injury and stroke.
Researchers found that ADHD enables high entrepreneurial alertness and risk-taking, while dyslexia fosters advanced delegation strategies. Bipolar traits correlate with creativity and a willingness to pursue bold ventures. The study advocates for business environments that value neurodiverse strengths, rather than seeking normalcy.
The study found that behavioral health care accounted for $41.8 billion of overall health spending in 2022, with families paying an average of $2.9 billion out-of-pocket. The costs have grown more than twice as fast as other types of medical care, with telehealth visits increasing by 99% per year.
A new study suggests that AI chatbots like ChatGPT can help reduce mental health stigma by making people feel more comfortable seeking support. The research found that believing the tool is effective plays a key role in reducing concerns about external judgment and increasing its perceived effectiveness.
A study published in Biological Psychiatry identifies a distinct immuno-inflammatory biomarker in the brain linked to immune system dysfunction and poorer response to standard treatments. The findings provide potential value for clinical prediction and precision therapies.
A recent study has identified five categories of psychiatric disorders that share similar genetic factors, including compulsive features, internalizing conditions, substance use disorders, neurodevelopmental conditions, and a category combining bipolar disorder and schizophrenia. The research suggests that these shared genetic factors ...
Teenagers who struggle with their bodies are at risk of developing eating disorders and depression in early adulthood, according to a new study. The research, which followed over 2,000 twins, found that body dissatisfaction at age 16 predicted greater symptoms of mental health issues well into the twenties.
Dr. Eric J. Nestler's research has fundamentally reshaped global understanding of addiction and depression by focusing on resilience rather than pathology. His laboratory identified distinct molecular, cellular, and circuit changes in resilient brains that maintain normal behavioral function despite exposure to drugs or stress.
A review of 467 studies confirms that firearm ownership increases suicides, intensifies psychological fragility, and amplifies violence. Safe storage of firearms reduces but does not eliminate the risk, researchers say.
A study of 349 new parents found intrusive thoughts and psychotic-like experiences more prevalent than thought, causing severe distress linked to higher parenting stress and lower satisfaction. The research highlights the need for normalisation, stigma reduction, and targeted support for affected parents.
A new study links rising temperatures to reduced sleep quality and length in US adults, particularly those living on the West Coast. The research estimates that by 2099, people could lose up to 24 hours of sleep each year due to heat, highlighting the potential impact of climate change on sleep health.
Research finds certain psychological disorders are associated with positive attributes like heightened creativity, empathy and resilience. People with mental illnesses may grow and develop unique strengths despite their struggles.
A new study reveals limited data on cognition in individuals with comorbid personality disorder and schizophrenia, leading to unfavourable outcomes. The researchers emphasize the need for further investigation into adapting treatments to support functional recovery.
A new study found that long-term antidepressant use has increased by nearly 20% among young people aged 10-24, raising concerns about potential overprescribing. The study also found no meaningful improvement in efforts to wean patients off antidepressants, highlighting the need for a stronger framework for safely tapering medications.
The December issues of The American Journal of Psychiatry and Psychiatric Services feature updates on substance use disorders, depression, and borderline personality disorder treatment. New research on trauma interventions in schools aims to improve mental health support for students.
Dr. Paul Lucassen's research on adult neurogenesis reveals the link between early life experiences, lifestyle factors, and depression/dementia risk. His work has implications for therapeutic approaches to brain health and disease.
A major meta-analysis found that nitrous oxide can offer fast-acting depressive symptom relief for adults with major depressive disorder and treatment-resistant depression. The study showed significant improvements in mood within 24 hours, but repeated dosing over several weeks was needed to sustain clinical benefit.
Researchers at the University of Plymouth have successfully used transcranial ultrasound stimulation (TUS) to change the function of a deep region of the human brain, specifically the nucleus accumbens. This tiny element is triggered by enjoyable experiences and helps us learn behaviours that lead to rewards.
A study from the University of Seville found that patients with schizophrenia spectrum disorders show significant reductions in structural similarity between different brain regions, particularly in the temporal, cingulate, and insular lobes. These alterations are associated with cognitive deficits and severe symptoms.
Drinking 3-4 cups of coffee a day may slow the biological ageing of people with severe mental illness by lengthening their telomeres, equivalent to 5 extra biological years. However, no such effects were observed beyond this daily amount.
Researchers discovered that brain enzyme OTULIN regulates tau protein accumulation and has implications for treating neurodegenerative diseases. The study revealed OTULIN's role in controlling gene expression and RNA metabolism, suggesting a potential therapeutic target.
A new genetic study found that people without prior suicidal thoughts or behaviors have fewer psychiatric diagnoses and genetic risk factors for psychiatric conditions compared to those with known suicidality. This suggests that conventional wisdom on how to reduce suicide may need to be rethought.
A new study identifies a brain circuit that can drive repetitive and compulsive behaviors in mice, even when natural rewards are available. The researchers used optogenetics to activate the circuit and induce negative states in mice, leading to prioritization of repetitive behaviors over natural needs.
The article highlights the mismatch between psychedelics and economic drug development principles. Pharmaceutical companies are developing short-acting compounds and neuroplastogens to engineer trips out of the experience altogether. Dr. Sandy Hager's research suggests investors should remain cautious due to weak intellectual property ...
Large language models can help improve psychological questionnaires by avoiding redundant items and making diagnosis more efficient. The study found that LLMs recognize common symptom associations and can be used to develop precise and efficient questionnaires.
A University of Sydney-led study found that 42% of Australian adults experienced traumatic events as children, leading to a 50% higher risk of developing mental health or substance use disorders. Childhood trauma is linked to chronic physical health conditions and can have lifelong consequences.
Researchers aim to identify biological biomarkers that can enable earlier diagnosis and intervention for schizophrenia. Progress in biomarker development is crucial for improving patients' quality of life and reducing the societal burden of the disorder.
A study published in Pediatric Drugs found that children and adolescents with underweight are more likely to discontinue ADHD medication within a year. The researchers also found clear differences in dosage, gender, and age that can affect treatment outcomes.
A recent landmark study identifies adenosine as the critical mediator of rapid antidepressant action, connecting ketamine, ECT, and hypoxia. The discovery raises questions about the potential interference of caffeine with these treatments, highlighting the need for further research on adenosinergic modulation in depression.
A nonsurgical approach has been demonstrated to quiet a specific brain circuit in an animal model by delivering engineered gene therapy only to the targeted region. The method uses low-intensity focused ultrasound to open the blood-brain barrier, allowing precise control over brain activity without impacting off-target areas.
A doctor warns of critical treatment gaps in eating disorders, highlighting the dangers of ignoring physical warning signs and behavioral indicators. Dr. Jennifer Gaudiani advocates for integrated medical and psychological care to address the urgent need for effective treatment.
Higher levels of urban greenness are associated with a 7% reduction in hospital admissions for all cause mental disorders, with stronger associations for substance use disorders and psychotic disorders. The study suggests that greater exposure to greenness increases the protective effect on mental health.
Researchers found somatoform disorders impact 4.6% globally, with 662 years of life lost per 100,000 people due to these conditions. The study highlights the need for increased resource allocation and awareness about these often-diagnosed-incorrectly disorders.
A nationwide study found that involuntary psychiatric patients have a significantly higher risk of suicide, particularly during the first month after discharge. The risk is elevated for several years and is associated with factors such as age, diagnosis, and previous self-harm.
Researchers have developed a new large-scale brain data resource that integrates data from five studies of brain development in children and young adults across three continents. The Reproducible Brain Charts (RBC) project provides a harmonized dataset for tracking changes in brain structure and function, allowing researchers to better...
The latest issues of three American Psychiatric Association journals feature research on schizophrenia, stimulant use disorder, and recovery-oriented approaches for schizophrenia. The publications highlight new treatments and findings on alcohol use disorder, youth mental health, and suicide risk.
Researchers have discovered that stress hormones can silence crucial neuronal genes by interacting with long noncoding RNAs and the polycomb repressive complex 2. This mechanism may provide a new understanding of how stress affects gene expression, particularly in relation to synaptic function and calcium signaling.
The study identified dozens of genetic regions that influence the size and thickness of the corpus callosum and its subregions. The research team created an AI-powered tool that finds and measures the corpus callosum in brain MRI scans automatically, allowing for unprecedented analysis of brain structure at scale and precision.