About The Study: In this randomized clinical trial, genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) did not improve control of depression symptoms at 3 months compared with usual care but was associated with higher depression remission rates at 6 months. These findings suggest a possible longer-term clinical benefit and indicate that future studies should focus on the durability and long-term impact of genotype-guided prescribing in the management of depressive symptoms.
Corresponding Author: To contact the corresponding author, Josh F. Peterson, MD, MPH, email josh.peterson@vumc.org .
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(doi:10.1001/jamanetworkopen.2026.10609)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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