Psychosis
Articles tagged with Psychosis
Cannabis and tobacco co-use increases psychosis chances in high-risk cohorts: Study
The boy on the balcony who never came outside
Dr. Dilek Colak's journey began with a childhood observation of a boy with mental illness, which inspired her to pursue a career in neuroscience. Her current work focuses on understanding autism and schizophrenia through the study of human brain organoids.
Bullying and adverse social climate take measurable toll on mental health of gender-diverse youth
Research found that gender-diverse teens reported higher rates of psychological stress and psychotic-like experiences, which can lead to depression, anxiety, and other serious mental health disorders. Bullying and unsupportive legislation drove these findings.
A poorly “cleaned” brain increases the risk of psychosis
Early alterations in the brain's clearance system may contribute to psychosis vulnerability. A study found that individuals with 22q11.2 deletion syndrome, a genetic condition, had impaired glymphatic system function from childhood, which may promote psychosis onset.
A comprehensive review charts how psychiatry could finally diagnose what it actually treats
Emerging research across conceptual frameworks, biomarker science, digital phenotyping, and artificial intelligence synthesizes a translational pathway toward a more biologically grounded and clinically useful approach to psychiatric diagnosis. The current system falls short due to standardized clinical language and lack of biological ...
Genetic risk for mental illness is far less disorder-specific than clinicians have assumed, massive Swedish study reveals
A massive Swedish study of over 2 million individuals reveals that genetic risk for mental illness is far less disorder-specific than clinicians have assumed. Schizophrenia shows the highest genetic specificity, while drug use disorder has a much lower specificity, scattering its genetic risk across multiple conditions.
Dysregulation of the immune system differentiates depression and psychosis in young adulthood
A study found distinct inflammatory biomarkers and brain signatures for early-stage depression and psychosis, differing even in the earliest stages. These findings support customized therapies and may reduce risk of severe progression.
Key alterations in the cerebral cortex of people with psychosis
The study reveals that psychosis does not follow a single trajectory but is influenced by individual differences and treatment. It shows that cortical volume reduction, particularly in regions with high serotonin and dopamine receptor density, is a hallmark of the disease.
Psychosis rates increasing in more recent generations
A large study of over 12 million people in Ontario found that psychosis rates are increasing in more recent generations, with higher rates among younger individuals. The study suggests that factors such as substance use, socioeconomic stress, and negative childhood experiences may contribute to these rising trends.
Psychosis patients ‘living in metaphor’ -- new study radically shifts ideas about delusions
New study finds psychosis delusions emerge from emotional experiences, bodily reactions, and linguistic fabric. Participants described intense emotional embodiment and disembodiment, with some experiencing positive feelings of awe and love.
Schizophrenia-linked genetic variant renders key brain receptor completely unresponsive to both natural and therapeutic compounds
Researchers at Flinders University discover a genetic mutation that silences a brain receptor, rendering it unresponsive to both natural trace amines and clinical drug candidates. The C182F variant eliminates receptor signaling and reduces cell surface expression, with profound implications for emerging psychiatric treatments.
Researchers from NUS Medicine and the Institute of Mental Health detect early brain changes linked to future psychosis development
The study used advanced neuroimaging methods to identify early, network-level changes in over 3,000 individuals at varying levels of risk for psychosis. Individuals at high clinical risk exhibited early disruptions in brain network organisation despite mild clinical symptoms.
Artificial intelligence can improve psychiatric diagnosis
Large language models can help improve psychological questionnaires by avoiding redundant items and making diagnosis more efficient. The study found that LLMs recognize common symptom associations and can be used to develop precise and efficient questionnaires.
International Consortium of Women’s Mental Health Experts present scientific evidence to support classification of postpartum psychosis as a distinct disease
International Consortium of Women's Mental Health Experts recommend classifying postpartum psychosis as a distinct category within standardized medical coding systems. This classification is crucial for improving patient outcomes and saving lives, particularly due to the risks associated with the condition to both patients and infants.
Brain scan as a BMI oracle for people with mental disorders
Researchers developed a machine learning model that uses MRI scans to predict which patients with mental illnesses will gain weight after diagnosis, and which ones won't. The BMIgap tool has the potential to prevent future weight gain and reduce the risk of metabolic diseases.
Neighborhood trust benefits some more than others
A new study from Karolinska Institutet and UCL found that living in a safe neighborhood with high personal trust reduces psychosis risk among Swedish or European origin residents, but increases it for North African or Middle Eastern origin individuals. The researchers emphasize the need for inclusive environments to promote mental heal...
Brain cell discoveries reshape understanding of psychiatric disorders
Groundbreaking research by Dr. Bruce M. Cohen has uncovered critical abnormalities in energy metabolism and cellular connectivity that contribute to psychiatric disorders. The study's findings suggest therapeutic avenues that may be better targeted and more effective than current treatments.
Cannabis use among individuals with psychosis after state-level commercial cannabis legalization
Individuals with psychosis reported a large increase in current cannabis use following legalization, exceeding previous estimates for the general population. This finding highlights the need for policymakers to consider the potential health impacts of cannabis use on individuals with psychosis.
An app to better manage cannabis use
A nationwide app called CHAMPS aims to support safer cannabis consumption among young adults who've experienced a psychotic episode. The pilot study found the app to be well-regarded and can be integrated into real clinical environments.
Racial discrimination may increase psychosis risk
A major review of international evidence found that racial discrimination contributes to the development of psychosis, with people experiencing discrimination being 77% more likely to develop psychotic symptoms. The study highlights the need for public health action to tackle systemic racism and its impact on mental health disparities.
Racial/ethnic discrimination might be a factor in disparities in psychosis risk
A systematic review of 23 primary studies found a positive association between racial/ethnic discrimination and psychosis risk. The largest effect sizes were observed in non-clinical settings, suggesting that experiences of racism may play a role in the development of psychosis.
Largest ever study into cannabis use investigates risk of paranoia and poor mental health in the general population
Research from King's College London and University of Bath found that people who self-medicate with cannabis for physical or mental discomfort are more likely to develop paranoia and anxiety. The study also discovered a link between childhood trauma and increased paranoia scores, which is exacerbated by cannabis use.
Five things to know about cannabis and psychosis
Increased cannabis potency has been linked to a rise in schizophrenia cases. THC content has increased by 5 times since the 2000s, contributing to this correlation.
Mexican neuroscientist identifies glutamate biomarker predicting schizophrenia treatment success
Dr. Camilo de la Fuente-Sandoval has developed a groundbreaking approach to schizophrenia treatment prediction using neuroimaging and comprehensive clinical care. His team's research reveals elevated glutamate levels in the associative striatum that normalize with effective antipsychotic treatment.
Women whose sister experienced postpartum psychosis are more than 10 times as likely to experience it themselves, according to new research
Research found that women whose sister experienced postpartum psychosis are over 10 times more likely to experience it themselves. The study highlights genetic and shared environmental influences and suggests early recognition and prevention are crucial.
Medicaid unwinding disrupted kids’ and young adults’ access to chronic disease medicine
A new study finds that Medicaid unwinding disrupted kids' and young adults' access to chronic disease medication, particularly for those living in states with the largest drops in Medicaid enrollment. The disruptions led to increased use of private insurance or cash for prescriptions, exacerbating health issues.
Research Spotlight: understanding sudden unusual mental or somatic experiences
Researchers identified risk factors for sudden unusual mental or somatic experiences, including past psychedelic use, reality distorting practices, and extensive spiritual practice. These findings can help clinicians diagnose and treat associated suffering, and inform the development of practical guidelines.
A study led by UPF reveals which brain mechanisms allow psychosis to remit
Researchers have identified differences in neural connectivity patterns between patients with recovered and persistent psychosis. These differences enable the development of new intervention strategies for patients with psychosis, according to a study published in Nature Mental Health.
What links cannabis use and psychosis? Researchers point to the brain’s dopamine system
Researchers have found that people with cannabis use disorder have elevated dopamine levels in a brain region associated with psychosis. This could explain why frequent cannabis use increases the risk of hallucinations and delusions. The study's findings may help doctors educate patients about the potential risks of frequent cannabis u...
New study reveals potential biological link between cannabis use and psychosis
Researchers found individuals with cannabis use disorder exhibit increased dopamine levels in the brain, a key factor in psychosis. This study suggests that regular cannabis use is linked to signs of increased dopamine activity.
April issues of APA journals feature research on schizophrenia, borderline personality disorder, medical mistrust, bias, and more
The latest APA journal issues explore treatment and risk factors for schizophrenia, as well as medical mistrust and bias. Research also examines the management of borderline personality disorder, including good psychiatric practice and its effectiveness.
Why does one person develop schizophrenia while another does not? A leading psychiatric geneticist investigates the answer
Dr. Consuelo Walss-Bass shares her groundbreaking research on schizophrenia, emphasizing the importance of considering both genetic predisposition and environmental factors. She also discusses her work with induced pluripotent stem cells to develop personalized psychiatry and reduce stigma around mental health.
Mutation increases enzyme in mouse brains linked to schizophrenia behaviors
Researchers discovered a genetic mutation that increases glycine decarboxylase enzyme, linked to schizophrenia behaviors in mice. The study provides a direct genetic link to psychosis and sheds light on the biochemical pathways involved.
Research spotlight: Mapping lesions that cause psychosis to a human brain circuit and proposed stimulation target
Studies identified 153 cases of psychosis caused by brain lesions, which connected to a common circuit in the hippocampus. The circuit, including the rostromedial prefrontal cortex, is a promising target for transcranial magnetic stimulation therapy, potentially improving symptoms in patients with schizophrenia.
New study reveals hidden manic symptoms in one-fourth of schizophrenia patients
A new study published in Brain Medicine reveals that over 26.7% of schizophrenia patients experience distinct manic symptoms, which can be predicted by the severity of positive symptoms such as hallucinations and delusions.
Researchers explore ketogenic diet’s effects on bipolar disorder among teenagers, young adults
A pilot study will explore whether a ketogenic diet helps stabilize mood symptoms in teens and young adults with bipolar disorder. Preliminary research suggests improvements in mood and executive function among older adults.
UCLA scientist unlocks early warning signs of adolescent psychosis through genetics
Dr. Carrie Bearden's groundbreaking work combines genetic and brain development insights to identify early warning signs of psychosis in adolescents. Her research has exciting implications for personalized medicine and targeted preventive treatments.
Medical researcher explores economic impact of psychedelic therapy implementation
Emory University MD candidate Fayzan Rab's research investigates the economic and public health implications of psychedelic therapy implementation. His work emphasizes making these innovative treatments accessible to traditionally underserved communities.
Antipsychotic medications don't always work the way they're supposed to
A new study by the University of Waterloo found that nearly 68% of Canadian patients who used antipsychotics had more behavioral issues than before medication. Non-drug therapies like music and social interaction have been shown to help manage behavior without antipsychotics.
Cannabis use increases risk of psychosis independently from genetic predisposition
Research from King's College London finds that frequent cannabis use increases psychosis risk, regardless of genetic load for schizophrenia. The study used polygenic risk scores to investigate the relationship between cannabis use and psychosis.
Virtual reality could be gamechanger in police-civilian crisis encounters
A study by Florida Atlantic University found that virtual reality training increased empathy and sympathy towards individuals with mental health conditions in police officers. The training, which simulated realistic scenarios, allowed officers to practice handling complex civilian interactions with greater emotional connection.
Cannabis disrupts brain activity in young adults prone to psychosis: study
A new study found that cannabis use worsens reduced brain connectivity in individuals at high risk of psychosis. This deficit is associated with symptoms like social withdrawal and lack of motivation, which are difficult to treat with current medications.
Childhood attention issues and genetic factors may predict psychosis risk
Researchers at UCLA Health found an association between childhood attention problems and increased psychosis risk, with genetic variants acting as a middleman. The study used data from over 10,000 children to explore the relationship between attention span variability and psychotic-like symptoms.
First study to show high potency cannabis use leaves unique signature on DNA
The study found that frequent users of high-potency cannabis had changes in genes related to mitochondrial and immune function, particularly the CAVIN1 gene. This effect was not explained by tobacco's impact on DNA methylation. The research provides valuable insights into how cannabis use may alter biological processes.
Migration in adolescence may double the risk of psychosis in later life
Research from five European countries suggests that migration in adolescence may increase the risk of psychosis in later life. Migrants from racially minoritized backgrounds face an even higher risk of developing psychotic disorders.
Mental health concerns are a huge part of primary care practice
A study of 350 million primary care visits found that mental health concerns are a significant part of everyday care, affecting 1 in 9 patients. The prevalence of mental health issues was equal to respiratory and cardiovascular complaints, with depression, anxiety, and psychosis being common conditions.
High doses of some prescription stimulants tied to increased psychosis risk
A study by McLean Hospital found that high doses of amphetamine increase the risk of new-onset psychosis or mania in adults. The risk is highest for those taking 30 mg or more of dextroamphetamine, with an 81% attributable risk percentage.
New insights could help prevent psychosis relapses in youth and young adults
Researchers at McGill University have made new findings on the consistency of delusion themes in youth and young adults with psychosis. The study, involving over 600 patients, suggests that delusions often persist even as other symptoms improve, requiring different treatment strategies.
Inflammation during childhood linked to onset of mental health issues in early adulthood – study reveals
A recent study published in JAMA Psychiatry found that children with persistently raised inflammation are at a higher risk of experiencing serious mental health disorders, including psychosis and depression, in early adulthood. The research also discovered that those who experienced inflammation at a young age were more likely to devel...
Groundbreaking study shows promise for early detection and intervention in psychotic disorders such as schizophrenia
Researchers have discovered a link between cognitive impairments and brain network organization in individuals at risk of developing psychotic disorders such as schizophrenia. This finding suggests an opportunity for early diagnosis and intervention, potentially through non-invasive neuromodulation.
An over- or under-synchronized brain may predict psychosis
A UNIGE team studied a cohort of patients with a 22q11.2DS microdeletion and found unique «coupling» between structure and activity of their brain regions, leading to either over- or under-coupling. This specificity paves the way for identifying reliable risk markers.
Bartonella DNA Found in Blood of Patients With Psychosis
A new study has found that patients diagnosed with schizophrenia or another psychotic disorder are three times more likely to have Bartonella DNA in their blood than adults without these disorders. The study suggests a potential role for vector-borne pathogens, such as fleas and ticks, in mental illness.
Children of the 90s study: High-THC cannabis varieties twice as likely to cause psychotic episodes
A new study published in Addiction journal found that high-potency cannabis use between 16 and 18 doubles the risk of psychotic experiences from 19 to 24. Researchers analyzed data from the Children of the 90s study, which tracked over 14,000 individuals from birth to age 24.
Children sleep problems associated with psychosis in young adults
Research from the University of Birmingham found that children who experienced chronic lack of sleep from infancy were more than twice as likely to develop a psychotic disorder in early adulthood. Persistent sleep problems also increased the risk by nearly four times. The study, published in JAMA Psychiatry, suggests that addressing sl...
Study finds biomarkers for psychiatric symptoms in patients with rare genetic condition 22q
A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to 22q11.2 deletion syndrome, a rare genetic condition that can lead to psychosis, ADHD, and other conditions. The study identified two biomarkers, taurine and arachidonic acid, which could predict likelihood of psychosis in patien...
Two key brain systems are central to psychosis, Stanford Medicine-led study finds
Researchers found two key brain systems malfunctioning in people with psychosis, leading to hallucinations and delusions. The study used brain scan data from children, teens, and young adults with psychosis, confirming an existing theory of how breaks with reality occur.
Lonely children more likely to experience psychosis, new study finds
Children who felt lonely for over 6 months before age 12 are at higher risk of experiencing an episode of psychosis. Women were found to be more susceptible to this condition compared to men. The study suggests that addressing social connectedness and emotional well-being from a young age could help prevent psychotic disorders.
Electroconvulsive therapy (ECT) shown to reduce severity of certain mental illnesses
A large naturalistic study found ECT to be effective in reducing illness severity for depression, bipolar depression, schizophrenia, and mania. Common side effects included confusion and cognitive impairment, but rare complications such as prolonged seizures and cardiovascular issues were also reported.
Predicting psychosis before it occurs
A machine-learning tool trained on brain MRI scans of over 2,000 people worldwide can accurately predict psychosis before it occurs. The tool achieved an accuracy rate of 85% in training and 73% in testing, suggesting its potential as a valuable aid for early diagnosis.