Articles tagged with Rheumatism
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A study found that using SGLT2i drugs in patients with gout and type 2 diabetes can lead to lower rates of starting urate-lowering therapy, NSAIDs, and diuretics. This could streamline care and reduce medication burden for these patients.
The European Alliance of Associations for Rheumatology (EULAR) has introduced three overarching principles and 11 points to consider for assessing disease activity in AOSD. The guidelines emphasize the importance of adopting a valid, reliable, and easily transferable definition of disease activity, which includes fever, skin rash, arth...
The European Alliance of Associations for Rheumatology has developed a new disease activity score (EAPSDAS) to assess clinical manifestations in antiphospholipid syndrome (APS). The score evaluates thrombotic, obstetric, microvascular, and non-thrombotic symptoms, providing insights into disease activity and treatment response.
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
A new review provides simplified criteria for defining gout remission and proposes integrated management strategies for sustained disease control. The authors highlight the importance of individualized urate-lowering therapy and proactive flare prevention, using imaging to show patients visual proof of crystal dissolution.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
Researchers developed a points-based classification model using eight variables to assess joint pain, genetic mutations, and iron loading. The criteria show promise in diagnosing haemochromatosis arthropathy with high specificity and sensitivity, paving the way for new treatment options.
The European Alliance of Associations for Rheumatology (EULAR) is hosting the EULAR 2026 Congress in London, featuring a scientific program with new clinical data and updated treatment guidelines. The congress will also provide exclusive media opportunities, including a press conference and one-on-one interviews with expert panelists.
EULAR has established new points to consider and consensus definitions for managing difficult-to-treat psoriatic arthritis, aiming to improve treatment options and care for patients. The guidelines focus on identifying the biology behind treatment non-response and promote personalized treatment approaches.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
A recent study from Karolinska Institutet reveals how a gene associated with several rheumatic diseases affects cell movement. The researchers discovered that the DIORA1 gene regulates cell movement by interacting with MRCK kinases, which are important for the cell's skeleton and ability to move.
Researchers analyzed immune cell transcriptomes to understand JIA's pathogenesis. Monocytes, monocyte-derived dendritic cells, and platelets are increased in JIA patients, while B-cell responses differ between sJIA and non-sJIA subtypes.
The European Alliance of Associations for Rheumatology (EULAR) journal Annals of the Rheumatic Diseases (ARD) has achieved a notable increase in its impact factor to 20.6, surpassing 58 other titles in rheumatology and reaffirming its status as the leading journal for original research in both basic and clinical fields. This recognitio...
Recent studies suggest that early biologics in severe psoriatic arthritis may not significantly benefit patients compared to standard step-up care with methotrexate. However, a study found that intensive therapy with early biologics or combination csDMARDs can rapidly control disease activity and maintain better outcomes at 1 year.
The recombinant zoster vaccine was found to be well-tolerated in patients with inflammatory rheumatic musculoskeletal diseases, with only a few reports of flare and serious AEs. The majority of patients tolerated the vaccine without significant adverse events.
Research discovers mitochondrial respiration impairment accelerates skeletal ageing by altering cell metabolism and reducing regenerative abilities. The study highlights the role of mitochondria in skeletal health and potential therapeutic avenues.
Pusan National University researchers have identified genes that are overexpressed in peri-implantitis, a condition similar to periodontitis but with higher recurrence rates. The study's findings may help diagnose and treat the disease with targeted therapies.
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
A scoping review found associations between myositis disease activity and gluten exposure in patients with inflammatory myopathies and celiac disease. The study suggests that gluten may act as an exogenous antigen driving myositis in genetically predisposed patients.
A retrospective cohort study found associations between COVID-19 and the long-term risk of various autoimmune and autoinflammatory connective tissue disorders. Long-term monitoring and care are crucial to mitigate these risks, taking into account demographic factors, disease severity, and vaccination status.
Researchers at Umeå University have identified unique inflammatory protein profiles in the blood of individuals with severe periodontitis, which is associated with lower levels of EGF and OLR-1 proteins. The study provides a promising lead for developing biomarkers and treatments for the disease.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
A Charité study found that taking proton pump inhibitors (PPIs) simultaneously with cortisone preparations is associated with a higher risk of osteoporosis in patients with inflammatory rheumatic conditions. The study analyzed the bone health of over 1,500 patients and found that PPI use led to significantly lower bone density.
Professor Leith Zakraoui was awarded the 2024 IOF CNS Medal for his dedicated work in advancing musculoskeletal health at both national and international levels. He has been a key figure in strengthening IOF activities in Africa and promoting education and awareness within the region.
A new study published in the Journal of the American Heart Association suggests that treating gum disease after a heart rhythm ablation procedure can lower oral inflammation and reduce the risk of AFib recurrence. Researchers found that an index measuring the severity of gum inflammation was associated with the return of AFib, highligh...
Women with selected rheumatic diseases experience a higher prevalence of childlessness, while risks for pre-eclampsia, low birth weight, and preterm delivery are increased for many conditions. Men with rheumatic conditions also face a higher risk of childlessness, although the impact on fertility varies among different diseases.
This study found that SIRT6 activation improves DNA damage repair efficiency and reduces baseline DNA damage in chondrocytes from older donors. MDL-800 treatment also lowered p16 promoter activity and decreased DNA damage in murine cartilage explants, supporting the concept of SIRT6 as a critical regulator of DNA repair.
A NSF-funded project, MABLE, is developing a digital app using crowdsensing, AI, and robotics to empower individuals with responsive maps and turn-by-turn instructions. The app aims to improve accessibility and navigation for persons with visual or mobility impairments, such as those with low vision and wheelchair users.
The European Alliance of Associations for Rheumatology (EULAR) has developed new recommendations for managing fatigue in people with inflammatory rheumatic and musculoskeletal diseases. The guidelines emphasize the importance of monitoring fatigue and offering management options based on a shared decision between patients and healthcar...
The updated EULAR recommendations for managing SLE emphasize individualized, multidisciplinary care and consider patient education and societal costs. Non-pharmacological interventions and careful drug selection based on disease type and severity are also key to improving long-term outcomes.
A systematic review and meta-analysis of 16 studies involving 875 patients with knee osteoarthritis found significant reductions in patient-reported pain from the third month onwards. Stem cell treatment was most effective when using patient's own fat-derived stem cells, leading to better pain alleviation and recovery of joint function.
A clinical trial found that high levels of anti-Ro/SSA antibodies in pregnant women are associated with an increased risk of fetal atrioventricular block (AVB), a condition that can be fatal. Home-based fetal heart rate monitoring reliably detects conduction abnormalities, potentially reducing the need for serial echocardiograms.
A recent study found that transient inflammatory pain causes persistent mitochondrial and metabolic disturbances in sensory neurons, leading to failure in pain resolution. Targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
Researchers propose a new approach to testing treatments for osteoarthritis by focusing on individuals who sustain knee trauma, such as ACL tears. This approach identifies a high-risk group of patients with early disease, allowing for targeted treatment and prevention strategies.
A systematic review and meta-analysis of 195 clinical trials found that cell therapy can reduce the risk of death from COVID-19 by 60%. The studies, conducted in 30 countries between January 2020 and December 2021, used various types of cells, including mesenchymal stem cells and natural killer cells.
A new study found that around one in five people with compromised immune systems have no COVID-19 antibodies after three or more vaccinations. The MELODY study identified specific groups at higher risk of not producing antibodies, highlighting the need for targeted interventions and booster vaccines.
A systematic review suggests fibromyalgia is associated with a 27% heightened risk of death from all causes, with elevated risks for cancer, accidents, and infections. Regular monitoring of patients' physical and mental health is crucial to minimize these risks.
A new proof-of-concept Randomized Controlled Trial found tofacitinib effective and safe for Polymyalgia Rheumatica treatment, potentially avoiding steroid use. The study's results suggest a promising alternative treatment option for patients with this condition.
A new study has created the world's largest map of normal breast tissue, highlighting 12 major cell types and 58 biological cell states. The atlas also identifies differences based on ethnicity, age, and menopause status, providing a powerful resource for researchers studying breast cancer and other diseases.
A new study found that a higher body mass index (BMI) increases the risk of five different rheumatic diseases, including gout and psoriatic arthritis. Women are more susceptible to these diseases than men, particularly those who have gone through menopause.
Dr Germain Honvo, a young investigator, receives the prestigious award for his international contributions to osteoarthritis research and publications on guideline development. He is recognized as a future thought leader in the musculoskeletal field.
The IOF Medal of Achievement is awarded to individuals who significantly advance osteoporosis research and increase awareness of the disease. Professor Jean-Yves Reginster has made major impacts on the field through his original scientific contributions, education, and advocacy.
Bernard Cortet receives ESCEO-IOF Herbert Fleisch Medal for groundbreaking contributions to osteoporosis research, including publications on clinical recommendations and patient outcomes. He is recognized for his leadership roles in French Society of Rheumatology and Osteoporosis Research and Information Group.
Professor Osvaldo Daniel Messina was awarded the 2023 IOF CNS Medal for his significant contributions to osteoporosis prevention. He has expanded IOF's messages and outreach in Argentina and internationally, promoting fracture prevention and healthy mobility.
The IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases is the largest international scientific event devoted to musculoskeletal disorders. The congress presents new clinical advances and research on osteoporosis, osteoarthritis, sarcopenia, frailty, and rare skeletal disorders.
A new study from Lund University estimates that regression to the mean can account for up to 1 point improvement in pain scores among osteoarthritis patients. This natural phenomenon can lead to false positives in clinical trials, masking the true efficacy of treatments.
Rheumatologists are crucial in detecting neurologic Lyme disease due to its broad spectrum of symptoms and signs. Early treatment has a favorable prognosis, but delayed diagnosis can lead to severe symptoms.
Researchers find that patients with destructive nasal lesions may be suffering from cocaine-induced granulomatosis with polyangiitis, a condition often misdiagnosed. Cocaine use can trigger production of antibodies leading to symptoms similar to idiopathic Granulomatosis With Polyangiitis.
The new EULAR points-to-consider support individuals with rheumatic and musculoskeletal diseases (RMDs) by acknowledging the benefits of staying in work, including increased self-worth and financial independence. These principles aim to optimise work-life balance and support physical and mental health.
A large randomized clinical trial demonstrated Octagam 10% as an efficacious and well-tolerated treatment option for adult dermatomyositis patients. The study showed improved outcomes in patients with this rare disease, providing a much-needed treatment alternative.
A collaborative network led by Cincinnati Children's Hospital Medical Center has received an $8 million grant to identify and validate biomarkers for acute rheumatic fever. This will enable the development of a sensitive and specific diagnostic test, crucial for diagnosing rheumatic heart disease, which is caused by a slow but progress...
The Brigham and Women's Hospital will implement and evaluate an integrated service delivery model (PEN-Plus) for severe chronic noncommunicable diseases, such as type 1 diabetes and rheumatic heart disease, in eight low- and lower-middle-income countries. The initiative aims to enable one million of the world's poorest children and you...
The International Osteoporosis Foundation proposes a screening strategy to identify women at high risk of hip fracture, which could lead to a reduction in treatment gaps and improved identification of fractures. The approach combines low-cost assessment with targeted intervention using low-cost generic treatments.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
Dr Nicholas Fuggle, a UK researcher, has been awarded the prestigious ESCEO-IOF Pierre Meunier Young Scientist Award for his significant contributions to research in musculoskeletal ageing. He is recognized for his work on determinants of musculoskeletal ageing and digital healthcare.
The International Osteoporosis Foundation awarded Professor Thierry Thomas the IOF Committee of Scientific Advisors (CSA) Medal of Achievement for his outstanding scientific contributions to osteoporosis. The award recognizes his work on secondary fracture prevention and post-fracture care coordination programs.
Professor Antonio Cherubini has made significant contributions to the field of geriatric medicine and musculoskeletal diseases. He is recognized for his work on aging, bone health, and age-related diseases.
The Virtual WCO-IOF-ESCEO 2022 Congress will feature leading experts on osteoporosis, osteoarthritis, and musculoskeletal diseases, with a focus on new clinical research and advances in prevention and patient care. Prestigious awards will also be presented.
The World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO) 2022 will discuss secondary fracture prevention. Global experts will provide clinical guidance and information on post-fracture care through various sessions.
Researchers aim to determine if knee structure changes predict clinical outcomes in people with osteoarthritis. The study will examine 76,000 X-rays and clinical data from diverse cohorts to establish healthy knee structure ranges.