Articles tagged with Skin Cancer
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A phase 2 study found that combining nivolumab and ipilimumab showed a high response rate with durable results for patients with advanced Merkel cell carcinoma. The addition of stereotactic body radiation therapy did not improve efficacy in this dual checkpoint inhibitor therapy.
A new imaging technique called LC-OCT significantly improved the accuracy of basal cell carcinoma (BCC) diagnosis by 12% compared to clinical and dermoscopic examinations. The technique provided detailed 3D images at a cellular level, enabling more accurate differentiation between BCCs and other skin conditions.
Moffitt researchers used computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations. They found that larger subclones are likely due to persistence and older age, not selective sweeps.
Extracellular vesicles and exosomes are membrane-bound vesicles that facilitate intercellular exchange of proteins, lipids, and genetic material. They will be highlighted in upcoming events focusing on mitochondrial quality control, skin ageing, and microbiota.
Researchers found that Merkel cell carcinoma (MCC) Glypican-3 (GPC3) is expressed in nearly 70% of MCC tumors and up to 90% of MCPyV-negative cases. GPC3 expression is associated with worse prognosis, including increased risk of death from MCC. This makes GPC3 a promising target for chimeric antigen receptor T cell therapy.
Researchers at the Centre for Genomic Regulation have identified PDIA6 as a key protein involved in driving melanoma malignancy. The study found that PDIA6 promotes melanoma cell growth by binding to RNA molecules inside tumor cells, making it a promising therapeutic target.
Researchers identified DNA damage-inducible transcript 4 (DDIT4) as a critical factor regulated by histone deacetylase 4 (HDAC4) in skin aging. Overexpression of HDAC4 rescued cells from senescence, while DDIT4 overexpression reversed changes associated with aging.
Researchers from the UCLA Jonsson Comprehensive Cancer Center have identified a method to degrade tumor cell-surface PD-L1 using a small molecule activator of ITCH protein. This approach suppresses relapses of melanoma in animal models by reducing PD-L1 accumulation, allowing T-cells to target tumors more effectively.
A new study found that people over 50 are more likely to use sunscreen if they believe it prevents sunburn, while those who think it takes too much time are less likely. The researchers suggest using reminders from romantic partners or focusing on skin cancer risk as effective messaging strategies.
Researchers developed PASTE, a method to analyze spatial transcriptomics data in three dimensions, enabling biologists to better understand cell environments and identify rare cell types. The technique can integrate information from multiple tissue slices, providing a more complete picture of gene expression within tissues.
Researchers at Stevens Institute of Technology are developing a low-cost handheld device that can accurately diagnose skin cancers in just a few seconds. The device uses millimeter-wave imaging, which reflects differently on cancerous and healthy tissue, allowing for precise detection.
Researchers developed a blood test to detect circulating melanoma cells, which can help diagnose skin cancer and monitor treatment response. The test uses the Melanoma-specific OncoBean platform conjugated with melanoma-specific antibodies.
A new study at the University of Bath found that a key ingredient is missing from all sunscreens, leaving skin vulnerable to damage. The researchers identified iron-trapping extracts that can improve protection against UV rays and oxidative stress, reducing the risk of aging and cancer.
Patients with Merkel cell carcinoma face a high risk of recurrence, with 95% of cases occurring within the first three years. The study found that advanced age, male sex, immunosuppression, and known primary lesions are associated with higher recurrence rates, highlighting the need for targeted surveillance efforts.
Researchers found that Asian American individuals are at higher risk for skin cancer due to genetic predisposition and environmental factors. The study emphasizes the need for targeted screening among this population to prevent skin cancer deaths.
A study reveals how CSDE1 coordinates skin cell senescence, slowing down cellular function without causing death. This leads to the formation of a firewall against cancer, suppressing tumor growth.
Researchers at UCSF developed a new technique using skin grafts with 'privacy glass' to provide a better facial color match for cancer patients. The study found that the technique resulted in a better match than other methods, with an average delta-E calculation of 6.3.
A new study suggests that sun exposure may reduce the risk of multiple sclerosis in children and young adults by up to 52%. Vitamin D levels are also found to be higher in individuals with increased sun exposure, which may play a role in protecting against autoimmune diseases.
A research team has identified a bacterium responsible for producing palmerolide A, a melanoma-fighting compound found in Antarctic sea squirts. The discovery could lead to the development of naturally-derived treatments for skin cancer.
Scientists have identified a cascade of four proteins that activate the cancer-causing protein ∆Np63α. By inhibiting these proteins, cancer stem cells can be controlled, and tumor growth slowed. This breakthrough offers new therapeutic options for squamous cell carcinoma.
Duke researchers developed a method to increase the depth of view of optical coherence tomography (OCT), allowing for clear images from beyond a millimeter beneath the skin's surface. The new technique, known as dual-axis OCT, tilts the light source and detector to collect more scattered light from deep tissues.
A new virtual histology technology may reduce the need for invasive skin biopsies, providing a biopsy-free solution for rapid diagnosis of malignant skin tumors. The technology uses deep-learning frameworks to transform images of intact skin into detailed, virtually stained images.
Researchers have developed a new approach to studying prostate cancer, allowing them to track the behavior of individual cancer cells from birth to organ spread. The technique uses whole-organ imaging and artificial intelligence to create a 3D reconstruction of the organ at single-cell resolution.
A Mount Sinai study reveals that young adult cancer patients exhibit distinct genetic hallmarks and immune system responses compared to their older counterparts. These findings suggest personalized treatment approaches for young adults with various types of cancers.
A clinical trial found that giving immunotherapy before targeted therapy improves survival in advanced melanoma patients, with a two-year overall survival rate of 72% compared to 52%. The study suggests that immunotherapy should be the initial approach for treating metastatic melanoma patients, regardless of BRAF mutation status.
The review found that datasets lack images and information about patients with darker skin, which may lead to inaccurate diagnoses. The research highlights the need for better representation of diverse skin tones in training AI models.
A new imaging technique called single-shot photoluminescence lifetime imaging thermometry (SPLIT) measures temperature in 2D, without contact, and in real-time. This technology could improve photothermal therapy and help detect skin cancers.
Researchers found that melanomas detected during routine skin checks were associated with a significantly lower all-cause risk of death, but not melanoma-specific death. The study involved 2,452 patients in Australia and suggests a potential benefit to regular skin cancer screenings.
A new study by the National Center for Atmospheric Research found that the Montreal Protocol will spare Americans from 443 million skin cancer cases and 63 million cataract cases through the end of this century. The treaty phased out ozone-destroying substances, resulting in reduced UV radiation and corresponding health benefits.
Non-melanoma basal and squamous cell skin cancers saw a 30% rise in Ontario over 15 years, mostly among people under age 35. The annual mortality rates increased by almost 5-fold, with males experiencing higher rates than females.
UCSF researchers found that Erα plays a crucial role in overcoming innate anti-cancer mechanisms and developing resistance to treatment. Inhibiting Erα RNA-binding activity restored tamoxifen's potency against breast cancer tumors, making the cells more sensitive to stress and apoptosis.
Researchers at Penn Medicine and The Wistar Institute will explore new treatments for skin cancer using the grant, including projects on exosomal PD-L1 and autophagy inhibition. The team aims to improve patient outcomes and develop more effective immunotherapy strategies.
A phase II clinical trial of remetinostat gel found a 69.7% response rate to the topical treatment, with complete responses observed across multiple BCC subtypes, and a durable response in nodular BCCs.
Two new molecules have been found to prevent skin aging after being exposed to ultraviolet light, generating minute amounts of hydrogen sulfide to correct energy production and usage in skin cells. This could pave the way for a new way to protect deeper layers of skin using these compounds.
Researchers developed an AI algorithm to assess metastatic potential in skin cancers, predicting disease characteristics that can guide treatments. The tool distinguished subtle features in images that are invisible to the human eye, offering new insights into cancer prognoses.
Researchers at Moffitt Cancer Center identify beta-HPV as potential biomarker for predicting squamous cell carcinoma development in older adults. The presence of beta-HPV in skin swabs was significantly associated with an increased risk of developing squamous cell carcinomas, particularly in areas of UV skin damage.
The NTU team created flexible UV light sensors that are 25 times more responsive and 330 times more sensitive than existing sensors. These sensors can be used in wearable devices to monitor personal UV exposure and reduce the risk of skin cancer.
A £8 million project led by the University of Warwick aims to develop new technology combining probes that detect cancer tumours through the skin with high-precision robotic surgery. The Terabotics project has the potential to lead to real-time diagnosis and more comprehensive removal of tumours with reduced need for follow-up surgery.
A research team from City University of Hong Kong has designed a simple electromechanical device that can detect skin disorders such as psoriasis by measuring tissue stiffness. The device provides real-time evaluations of deep tissue stiffness, allowing for accurate targeting of lesions and monitoring of skin health status.
A team of University of Alberta researchers has discovered a way to use 3-D bioprinting technology to create functional cartilage in just four weeks, which can be used to restore nasal features in skin cancer patients. This method reduces the risk of complications and provides a more precise solution for reconstructive surgery.
Researchers at Ohio State University suggest that an oral drug currently used to treat neuromuscular diseases could help prevent a common form of skin cancer caused by UVB radiation. The study found that the neurotransmitter dopamine can stop the development and progression of certain UVB-induced precancerous squamous skin cancers.
Researchers found that fat grafting procedures can reduce pain and improve skin health in patients with radiation-induced skin injury, leading to better outcomes and improved quality of life. However, more research is needed to confirm the benefits and address potential risks.
Researchers at Massachusetts General Hospital discovered that activating nuclear IL-33 in chronic inflammation promotes abnormal cell growth and division, leading to cancer. Inhibiting IL-33's expression may help prevent cancers associated with inflammation.
Researchers at Yale University have developed an injection treatment for skin cancer that uses polymer-based nanoparticles carrying chemotherapy agents. The treatment's bioadhesive properties allow it to kill cancer cells and stimulate the immune system, potentially eliminating the need for surgery.
A new study reveals that people with a genetically weakened skin barrier are more susceptible to faster uptake of common chemicals, increasing the risk of skin diseases and cancer. Researchers screened 500 participants in Sweden, finding twice as high doses of pesticides in those with the mutation.
Scientists have developed a new method for analyzing the structure of skin using T-rays, which can help diagnose and treat conditions like eczema and psoriasis. The technique measures the refractive index of skin to determine hydration levels, providing valuable information on skin thickness and properties.
Researchers used bioengineered models of patient-specific skin to study how inherited DNA defects cause skin damage and deadly squamous cell carcinoma in children with Fanconi anemia. The study identified key biological connections important to skin formation and function, leading to accelerated blistering and disease progression.
A new report from UCSF links climate change to a significant increase in global cancer rates, particularly lung, skin, and gastrointestinal cancers. The study highlights the need for urgent action to mitigate climate change and reduce air pollution to prevent cancer cases and deaths.
Researchers found that moles stop growing due to normal cell-to-cell communication, not stress from cancer genes. This discovery could lead to new treatments for preventing skin cancer by exploiting existing mechanisms controlling cell growth.
Researchers found a slight increase in risk of ovarian cancer and some types of breast cancer among women who used permanent hair dyes. Natural hair color was also associated with an increased risk of certain cancers, while the use of darker hair dye colors may be linked to higher concentrations of ingredients.
Scientists at Case Western Reserve University have discovered how quickly certain pre-cancerous lesions can form on the DNA of our skin when exposed to sunlight, a finding that could lead to more effective prevention methods. The research reveals that these mutations can form in as little as three picoseconds after exposure to UV light.
Researchers from Massachusetts General Hospital studied nearly 94,000 people with atopic dermatitis and found no association between topical immunosuppressants and increased skin cancer risk. The study suggests that patients can safely use these medications to treat their condition without an increased risk of skin cancer.
Researchers have developed a new method for treating skin cancer that uses silica nanoparticles to deliver light-sensitive medication, potentially expanding its use to other types of cancer. This innovative approach could increase the effectiveness of photodynamic therapies by penetrating deeper into tissue.
Researchers at the University of Tsukuba found that epidermal stem cells undergo a change in their complex sugar repertoire with age, which could serve as a biological marker of aging. This 'glycome shift' is characterized by an increase in sialylated complex type N-glycans and a decrease in mannose-type N-glycans.
The GEOMAR research group has successfully discovered a marine alga from the Kiel Fjord that inhibits pathogenic bacteria and kills melanoma-type skin cancer cells with low cytotoxicity. The researchers used bioinformatics methods and machine learning tools to accelerate the discovery process, reducing it from 3-4 years to months.
A recent study by University of Queensland researchers found that AI improved skin cancer diagnostic accuracy when used in collaboration with human clinical checks. The highest diagnostic accuracy was achieved when crowd wisdom and AI predictions were combined, indicating the importance of human-AI collaborations in skin cancer diagnosis.
Researchers have found large clones of skin cells caused by UV exposure can be targeted to reduce skin cancers. This study suggests that stopping these clones may help win the battle against skin cancer.
A face-aging mobile app reduced UV exposure awareness in Brazilian teens, increasing sunscreen use and protective behaviors.
Researchers at Kobe University have demonstrated that 222nm UVC is safe for human skin and eyes, contrary to previous concerns about its carcinogenic effects. The study used xeroderma pigmentosum model mice to test the safety of repeated exposure to 222nm UVC, finding no adverse effects on their eyes or skin.
Researchers at Georgia Institute of Technology have developed a new skin treatment using microscopic STAR particles that can deliver drugs directly to affected areas. The treatment, which involves rubbing the particles on the skin, has shown promising results in inhibiting tumor growth in mice.