Articles tagged with Skin Cancer
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Researchers have identified eight new loci that increase a person's risk for squamous cell skin cancer, bringing the total to 22. The study confirmed previously known risk loci while adding new genomic locations, providing insight into genetic associations and molecular pathways involved in skin cancer development.
Researchers identified Merkel cell polyomavirus in 7 out of 18 patients with Merkel cell carcinoma, a rare skin cancer. The study suggests that most MCC cases in India are likely caused by UV-linked damages, while some may be virus-positive, offering new targets for therapy and diagnosis.
Researchers found elevated risks of skin cancer, gastrointestinal and blood side effects, as well as liver test abnormalities and cirrhosis in participants taking low-dose methotrexate. The study provides a detailed side-effect profile that may inform more informed prescribing practices.
Two studies found that individuals with non-heterosexual orientations and non-cisgender identities have a higher lifetime prevalence of skin cancer. The research highlights significant disparities in skin cancer rates among LGBTQ+ populations in the US, underscoring the need for targeted prevention efforts.
Rates of skin cancer were higher among gay and bisexual men compared to heterosexual men. However, bisexual women had a lower rate of skin cancer than heterosexual women. The study's findings highlight the importance of addressing skin cancer risk in sexual minority populations.
A study published in the British Journal of Dermatology found that higher mercury levels in the blood are associated with an increased prevalence of non-melanoma skin cancer. Participants with high total or methyl mercury levels had nearly double or 1.7 times greater odds of non-melanoma skin cancer, respectively.
The University of Arizona Cancer Center is developing new strategies to prevent squamous cell carcinoma, the second most-common form of non-melanoma skin cancer. The $6.9m grant will assess the importance of a novel immune protein and test topical drugs to inhibit its action.
Researchers found a new long non-coding RNA, PRECSIT, that regulates the growth and invasion of squamous cell carcinoma in skin. PRECSIT's expression is linked to the tumor suppressor gene p53, promoting cancer progression via STAT3 signaling.
A new treatment approach for cutaneous T-cell lymphoma, a rare blood disease, has been proposed by University of Alberta researcher Robert Gniadecki. He found that cancer cells originate from the blood, not the skin, and suggests treating malignant clones in the blood rather than waiting until they reach the skin.
A skin cream used to treat warts and skin cancer has been found to prevent infection from viral diseases like Zika and dengue when applied after a mosquito bite. The cream works by activating the skin's immune response, preventing the virus from spreading throughout the body.
Researchers at NYU Langone Health have discovered a new role for circular RNA in regulating the spread of melanoma cancers. The study found that CDR1as blocks the aggressive growth of cancer cells, while its loss promotes it. Higher levels of CDR1as were linked to increased survival rates among patients with melanoma.
A recent study published in the Journal of Telemedicine and Telecare found that a telehealth program increased primary care physicians' accurate diagnosis of skin conditions by nearly 84% for adult cases and 72% for pediatric cases. The program provided expert recommendations through videoconferencing sessions with dermatologists, redu...
High-dose-rate brachytherapy offers excellent cure rates and cosmetic outcomes for elderly patients with common skin cancers, including squamous cell carcinoma and basal cell carcinoma. The treatment delivers a precise dose of radiation directly to the tumor while sparing healthy tissue nearby.
Researchers from VIB-UGent Center for Inflammation Research found that HMGB1 controls the actions of neutrophils, a specific type of immune cells, in skin wounds and that this is crucial for cancer initiation. Targeting this pathway could be beneficial in diabetic wound care and in patients suffering from skin blistering diseases.
Yale researchers have discovered hyperhotspots in the human genome that are up to 170-times more sensitive to ultraviolet radiation, potentially leading to a new way of predicting skin cancer risk. By analyzing these hyperhotspots, doctors could gain a better understanding of a patient's exposure history and skin cancer risk.
Complementary therapies used to treat breast cancer skin lesions may delay wound healing and interfere with systemic treatments. Herbal products like green chiretta and feverfew have been shown to negatively impact blood clotting, exacerbating scarring and dressing effectiveness.
Researchers found that newly cancerous pigment stem cells migrate up and out of hair follicles to establish melanomas in nearby surface skin before spreading deeper. This discovery sheds new light on the biology of melanoma and suggests potential new ideas for treatment.
Researchers found that commensal papillomaviruses on human skin can induce immunity protecting against squamous cell carcinoma. The presence of these viruses in patients with suppressed immune systems was shown to reduce the risk of skin cancer, suggesting a novel method for prevention using a vaccine to boost the immune system.
Researchers from Technical University of Munich discovered an inactive receptor in cancer cells prevents checkpoint inhibitors from reactivating the immune system. This leads to a weakened immune response against cancer cells.
Stevens researchers create technology to detect skin lesions and determine if they are cancerous or benign using millimeter-wave radiation. The device could reduce unnecessary biopsies by 50% and disrupt the $5.3 billion diagnostic market for skin cancer.
Research by Oregon State University found that stricter arsenic standards have led to a significant decrease in public water system violations, dropping from 1.3% in 2008 to 0.55% in 2017. This translates to nearly 1 million fewer people exposed to out-of-arsenic-compliance water.
A meta-analysis of 58 studies found that brachytherapy and Mohs surgery have better cosmetic outcomes than conventional excision and external beam radiation therapy. These treatments offer effective alternatives to surgery for patients, particularly those who may not be suitable for surgical options.
Athletes who engage in outdoor sports and exercise are at increased risk of skin cancer, with up to eight-fold exposure limit exceeded during summer and autumn months. Sun protection is crucial for these groups, as research shows a higher incidence of malignant skin cancer among active individuals.
Researchers found that UV radiation damages skin by weakening cell bonds, leading to structural degradation and increased tissue fragility. The study suggests using sunscreen to protect not only against skin cancer but also to maintain skin health and prevent infections.
Researchers will investigate how solar UVB radiation triggers skin cancer and develop prevention and treatment strategies, including testing natural products and existing drugs.
Researchers at the University of Pennsylvania have identified LSD1 as a key regulator of skin cell turnover and found that blocking it could be an effective treatment method for non-melanoma skin cancers. The study shows that targeting LSD1 can force skin cells to differentiate, potentially turning tumor cells into healthier cells.
The GW Cancer Center is conducting a randomized, placebo-controlled phase III trial to investigate cemiplimab's safety and effectiveness in preventing recurrence and metastasis in high-risk cutaneous squamous cell carcinoma. The study aims to enroll over 400 participants worldwide.
Researchers from Brown University found that people with high vitamin A intake had a 17% reduced risk of developing squamous cell carcinoma, the second-most-common type of skin cancer. The majority of vitamin A came from diets rich in fruits and vegetables.
Researchers found a significant association between vitamin A intake and reduced risk of cutaneous squamous cell cancer. The study followed nearly 125,000 health professionals for over 26 years.
The effects of skin aging differ among ethnic groups, with varying levels of damage from environmental factors such as sunlight. Key findings show that patients of color experience changes in pigmentation, while those of European descent have thinner skin and wrinkles.
Researchers found that antibiotics can reduce the number of cancer cells and diminish cancer in patients with CTCL, a rare type of lymphoma. The study suggests that aggressive antibiotic treatment may inhibit not only the bacteria but also the cancer cells.
A study published in Journal of Drugs in Dermatology highlights the need for tailored skin cancer prevention programs to reach non-white and younger populations. The research found significant gaps in sun protective knowledge and behavior among these groups, emphasizing the importance of comprehensive community-based solutions.
Scientists create ointment to treat melanoma and Merkel carcinoma by suppressing tumor protein synthesis. The ointment's delivery system overcomes stability issues, allowing it to penetrate damaged skin cells and prevent relapse.
A study by Brigham Young University found that viewing images of skin cancer and UV damage visuals significantly increases people's likelihood to screen themselves for cancer. The study used a variety of methods, including visual stimulation with images of moles being removed, to demonstrate the impact on behavior
Researchers observed micro-perforations in the basement membrane zone, allowing inflammatory cells to access and feed growing cancer cells. This 'window' into the cancer process enables targeting of these weak spots with cancer therapeutics.
Researchers used single-cell RNA sequencing to identify genes expressed by each cell in the aorta, grouping them into separate populations based on gene expression profiles. This allowed for accurate distinction between stem cells and other blood vessel cells, providing key insights into their identity.
A study found that nearly all Pinterest pins for homemade sunscreens positively portrayed their effectiveness but offered insufficient UV radiation protection. The researchers emphasized the importance of using commercially sold and regulated sunscreen products to protect against skin cancer.
Researchers at the University of British Columbia have developed a specialized microscope that can diagnose diseases like skin cancer and perform precise surgery without cutting skin. The technology uses ultrafast infrared lasers to scan tissue quickly and selectively treat diseased structures.
A study by Johns Hopkins Medicine and partners found that a simple performance evaluation letter can reduce unnecessary tissue removal in Mohs micrographic surgery for skin cancer. The intervention led to an improvement in surgical behavior, sustained for one year, with 83% of notified physicians reducing their practice.
A study published in PLOS ONE found that SPF moisturizer users incompletely cover their eyelid regions during application. The researchers compared sunscreen and moisturizer application and found significantly better coverage with sunscreen. This highlights the importance of using sunscreen for optimal sun protection.
A combination of topical creams reduces precancerous skin lesions and lowers the risk of developing squamous cell carcinoma. The therapy combines 5-fluorouracil with calcipotriol, activating the immune system's T cells to attack tumor cells.
A clinical trial found that immunotherapy treatment significantly reduced the risk of developing squamous cell carcinoma (SCC) in patients with precancerous skin lesions. The study showed a 75% reduction in SCC development on the face and scalp, with only 7% of participants developing SCC compared to 28% in the control group.
Researchers at City of Hope have been awarded $7.5 million to develop new treatments for CTCL, a disfiguring and incurable cancer affecting about 3,000 individuals annually. The grant will support the development of personalized medicine and immunotherapy treatments.
A study of Swedish adults found a U-shaped relationship between kidney function and cancer incidence, with lower eGFR associated with higher cancer risk. The research suggests that individuals with mild to severe chronic kidney disease may be at increased risk for skin (non-melanoma) and urogenital cancers.
Researchers discovered a shared genetic signature among three rare skin diseases, targeting the dermal microenvironment and favoring cancer progression. The study presents new pharmacological targets for treatment, offering a clinical priority to improve patients' lives.
Patients who receive a kidney transplant are at increased risk of skin cancer, with the rate rising after stopping anti-rejection medications, according to a study. The study found that skin cancer rates fell during periods of transplant failure but remained higher than pre-transplant patients on dialysis.
Researchers found that elevated levels of IL-33 and Tregs trigger cancer-promoting chronic inflammation, leading to the development of skin and colon cancer. Blocking this axis can prevent cancer development in mice with chronic dermatitis.
A new study published in The Lancet Infectious Diseases found that having HPV in the hand does not increase the risk of transmitting HPV to a sexual partner. Most HPV detected in the hands likely came from a person's own genital HPV infection.
American University researchers identify Tpl2 gene's role in squamous cell carcinoma, revealing potential therapeutic target for advanced cancers. The study shows that blocking the MET receptor reduces tumors by 60%, offering new hope for treatments.
A new UCLA study overturns the long-held belief that cancer cells are glycolytic, consuming more glucose than normal cells. Instead, researchers found that squamous cell skin cancers can use alternative nutrients like glutamine to fuel their growth.
A team of researchers has discovered a potential method to treat radiation-induced skin fibrosis by manipulating metabolism. They found that metabolic abnormalities are a key factor in the development of this condition, and identified several compounds and cell therapy techniques that may help alleviate its symptoms.
A new study found that cancer patients, particularly those with blood-related cancers, have a significantly higher risk of developing shingles due to the virus reactivating later in life. New shingles vaccines offer great promise as a strategy to prevent shingles and its complications in cancer patients.
Research found that young women who received health and beauty information from friends were more likely to believe indoor tanning made them look and feel better. However, those who got information from news sites understood the immediate risks of indoor tanning.
The new UK skin cancer database reveals over 45,000 cutaneous squamous cell carcinomas (cSCC) occur every year in England, significantly higher than previously estimated. This data enables researchers to evaluate the effectiveness of prevention initiatives and treatment options for this common form of skin cancer.
A research team at Hokkaido University found that lower TRIM29 levels correlate with more mobile and invasive squamous cell carcinoma cells, leading to a worse prognosis. The TRIM-29/keratin interaction plays a crucial role in regulating cell shape and motility.
Researchers used genetic and survey data from over 210,000 participants to identify correlations between known and novel skin cancer risk factors. Combining multiple factors improved predictive accuracy for skin cancer risk, particularly when including a genetic risk score.
The article addresses provoking questions in melanoma immunotherapy, cancer systems biology, and medical oncology. Researchers focus on understanding pigmentation and pigmentary diseases through big data science, collaborative team science, and individualized medicine.
Researchers have discovered that mutant skin cells in humans compete with each other for survival, leading to only the fittest mutants progressing to form cancer. This study reveals that normal human skin is more resilient to cancer than previously thought, and can function normally despite a battle between mutated cells.
A widely used drug has been identified as a contributor to skin cancer development, with researchers calling for enhanced sun protection advice. The study, published in Nature Communications, found a strong association between azathioprine use and a specific mutational signature in cutaneous squamous cell carcinoma.
Researchers identified APOBEC enzymes as major contributors to the development of aggressive skin cancer in patients with Butterfly Syndrome. The discovery reveals a mechanism that instigates tissue damage-driven cancers and provides new therapeutic strategies.