Articles tagged with Skin Cancer
UCSF researchers found that Erα plays a crucial role in overcoming innate anti-cancer mechanisms and developing resistance to treatment. Inhibiting Erα RNA-binding activity restored tamoxifen's potency against breast cancer tumors, making the cells more sensitive to stress and apoptosis.
Researchers at Penn Medicine and The Wistar Institute will explore new treatments for skin cancer using the grant, including projects on exosomal PD-L1 and autophagy inhibition. The team aims to improve patient outcomes and develop more effective immunotherapy strategies.
A phase II clinical trial of remetinostat gel found a 69.7% response rate to the topical treatment, with complete responses observed across multiple BCC subtypes, and a durable response in nodular BCCs.
Two new molecules have been found to prevent skin aging after being exposed to ultraviolet light, generating minute amounts of hydrogen sulfide to correct energy production and usage in skin cells. This could pave the way for a new way to protect deeper layers of skin using these compounds.
Researchers developed an AI algorithm to assess metastatic potential in skin cancers, predicting disease characteristics that can guide treatments. The tool distinguished subtle features in images that are invisible to the human eye, offering new insights into cancer prognoses.
Researchers at Moffitt Cancer Center identify beta-HPV as potential biomarker for predicting squamous cell carcinoma development in older adults. The presence of beta-HPV in skin swabs was significantly associated with an increased risk of developing squamous cell carcinomas, particularly in areas of UV skin damage.
The NTU team created flexible UV light sensors that are 25 times more responsive and 330 times more sensitive than existing sensors. These sensors can be used in wearable devices to monitor personal UV exposure and reduce the risk of skin cancer.
A £8 million project led by the University of Warwick aims to develop new technology combining probes that detect cancer tumours through the skin with high-precision robotic surgery. The Terabotics project has the potential to lead to real-time diagnosis and more comprehensive removal of tumours with reduced need for follow-up surgery.
A research team from City University of Hong Kong has designed a simple electromechanical device that can detect skin disorders such as psoriasis by measuring tissue stiffness. The device provides real-time evaluations of deep tissue stiffness, allowing for accurate targeting of lesions and monitoring of skin health status.
A team of University of Alberta researchers has discovered a way to use 3-D bioprinting technology to create functional cartilage in just four weeks, which can be used to restore nasal features in skin cancer patients. This method reduces the risk of complications and provides a more precise solution for reconstructive surgery.
Researchers at Ohio State University suggest that an oral drug currently used to treat neuromuscular diseases could help prevent a common form of skin cancer caused by UVB radiation. The study found that the neurotransmitter dopamine can stop the development and progression of certain UVB-induced precancerous squamous skin cancers.
Researchers found that fat grafting procedures can reduce pain and improve skin health in patients with radiation-induced skin injury, leading to better outcomes and improved quality of life. However, more research is needed to confirm the benefits and address potential risks.
Researchers at Massachusetts General Hospital discovered that activating nuclear IL-33 in chronic inflammation promotes abnormal cell growth and division, leading to cancer. Inhibiting IL-33's expression may help prevent cancers associated with inflammation.
Researchers at Yale University have developed an injection treatment for skin cancer that uses polymer-based nanoparticles carrying chemotherapy agents. The treatment's bioadhesive properties allow it to kill cancer cells and stimulate the immune system, potentially eliminating the need for surgery.
A new study reveals that people with a genetically weakened skin barrier are more susceptible to faster uptake of common chemicals, increasing the risk of skin diseases and cancer. Researchers screened 500 participants in Sweden, finding twice as high doses of pesticides in those with the mutation.
Scientists have developed a new method for analyzing the structure of skin using T-rays, which can help diagnose and treat conditions like eczema and psoriasis. The technique measures the refractive index of skin to determine hydration levels, providing valuable information on skin thickness and properties.
Researchers used bioengineered models of patient-specific skin to study how inherited DNA defects cause skin damage and deadly squamous cell carcinoma in children with Fanconi anemia. The study identified key biological connections important to skin formation and function, leading to accelerated blistering and disease progression.
A new report from UCSF links climate change to a significant increase in global cancer rates, particularly lung, skin, and gastrointestinal cancers. The study highlights the need for urgent action to mitigate climate change and reduce air pollution to prevent cancer cases and deaths.
Researchers found that moles stop growing due to normal cell-to-cell communication, not stress from cancer genes. This discovery could lead to new treatments for preventing skin cancer by exploiting existing mechanisms controlling cell growth.
Researchers found a slight increase in risk of ovarian cancer and some types of breast cancer among women who used permanent hair dyes. Natural hair color was also associated with an increased risk of certain cancers, while the use of darker hair dye colors may be linked to higher concentrations of ingredients.
Scientists at Case Western Reserve University have discovered how quickly certain pre-cancerous lesions can form on the DNA of our skin when exposed to sunlight, a finding that could lead to more effective prevention methods. The research reveals that these mutations can form in as little as three picoseconds after exposure to UV light.
Researchers from Massachusetts General Hospital studied nearly 94,000 people with atopic dermatitis and found no association between topical immunosuppressants and increased skin cancer risk. The study suggests that patients can safely use these medications to treat their condition without an increased risk of skin cancer.
Researchers at the University of Tsukuba found that epidermal stem cells undergo a change in their complex sugar repertoire with age, which could serve as a biological marker of aging. This 'glycome shift' is characterized by an increase in sialylated complex type N-glycans and a decrease in mannose-type N-glycans.
Researchers have developed a new method for treating skin cancer that uses silica nanoparticles to deliver light-sensitive medication, potentially expanding its use to other types of cancer. This innovative approach could increase the effectiveness of photodynamic therapies by penetrating deeper into tissue.
The GEOMAR research group has successfully discovered a marine alga from the Kiel Fjord that inhibits pathogenic bacteria and kills melanoma-type skin cancer cells with low cytotoxicity. The researchers used bioinformatics methods and machine learning tools to accelerate the discovery process, reducing it from 3-4 years to months.
A recent study by University of Queensland researchers found that AI improved skin cancer diagnostic accuracy when used in collaboration with human clinical checks. The highest diagnostic accuracy was achieved when crowd wisdom and AI predictions were combined, indicating the importance of human-AI collaborations in skin cancer diagnosis.
Researchers have found large clones of skin cells caused by UV exposure can be targeted to reduce skin cancers. This study suggests that stopping these clones may help win the battle against skin cancer.
A face-aging mobile app reduced UV exposure awareness in Brazilian teens, increasing sunscreen use and protective behaviors.
Researchers at Kobe University have demonstrated that 222nm UVC is safe for human skin and eyes, contrary to previous concerns about its carcinogenic effects. The study used xeroderma pigmentosum model mice to test the safety of repeated exposure to 222nm UVC, finding no adverse effects on their eyes or skin.
Researchers at Georgia Institute of Technology have developed a new skin treatment using microscopic STAR particles that can deliver drugs directly to affected areas. The treatment, which involves rubbing the particles on the skin, has shown promising results in inhibiting tumor growth in mice.
Researchers have identified eight new loci that increase a person's risk for squamous cell skin cancer, bringing the total to 22. The study confirmed previously known risk loci while adding new genomic locations, providing insight into genetic associations and molecular pathways involved in skin cancer development.
Researchers identified Merkel cell polyomavirus in 7 out of 18 patients with Merkel cell carcinoma, a rare skin cancer. The study suggests that most MCC cases in India are likely caused by UV-linked damages, while some may be virus-positive, offering new targets for therapy and diagnosis.
Researchers found elevated risks of skin cancer, gastrointestinal and blood side effects, as well as liver test abnormalities and cirrhosis in participants taking low-dose methotrexate. The study provides a detailed side-effect profile that may inform more informed prescribing practices.
Two studies found that individuals with non-heterosexual orientations and non-cisgender identities have a higher lifetime prevalence of skin cancer. The research highlights significant disparities in skin cancer rates among LGBTQ+ populations in the US, underscoring the need for targeted prevention efforts.
Rates of skin cancer were higher among gay and bisexual men compared to heterosexual men. However, bisexual women had a lower rate of skin cancer than heterosexual women. The study's findings highlight the importance of addressing skin cancer risk in sexual minority populations.
A study published in the British Journal of Dermatology found that higher mercury levels in the blood are associated with an increased prevalence of non-melanoma skin cancer. Participants with high total or methyl mercury levels had nearly double or 1.7 times greater odds of non-melanoma skin cancer, respectively.
The University of Arizona Cancer Center is developing new strategies to prevent squamous cell carcinoma, the second most-common form of non-melanoma skin cancer. The $6.9m grant will assess the importance of a novel immune protein and test topical drugs to inhibit its action.
Researchers found a new long non-coding RNA, PRECSIT, that regulates the growth and invasion of squamous cell carcinoma in skin. PRECSIT's expression is linked to the tumor suppressor gene p53, promoting cancer progression via STAT3 signaling.
A new treatment approach for cutaneous T-cell lymphoma, a rare blood disease, has been proposed by University of Alberta researcher Robert Gniadecki. He found that cancer cells originate from the blood, not the skin, and suggests treating malignant clones in the blood rather than waiting until they reach the skin.
A skin cream used to treat warts and skin cancer has been found to prevent infection from viral diseases like Zika and dengue when applied after a mosquito bite. The cream works by activating the skin's immune response, preventing the virus from spreading throughout the body.
Researchers at NYU Langone Health have discovered a new role for circular RNA in regulating the spread of melanoma cancers. The study found that CDR1as blocks the aggressive growth of cancer cells, while its loss promotes it. Higher levels of CDR1as were linked to increased survival rates among patients with melanoma.
A recent study published in the Journal of Telemedicine and Telecare found that a telehealth program increased primary care physicians' accurate diagnosis of skin conditions by nearly 84% for adult cases and 72% for pediatric cases. The program provided expert recommendations through videoconferencing sessions with dermatologists, redu...
High-dose-rate brachytherapy offers excellent cure rates and cosmetic outcomes for elderly patients with common skin cancers, including squamous cell carcinoma and basal cell carcinoma. The treatment delivers a precise dose of radiation directly to the tumor while sparing healthy tissue nearby.
Researchers from VIB-UGent Center for Inflammation Research found that HMGB1 controls the actions of neutrophils, a specific type of immune cells, in skin wounds and that this is crucial for cancer initiation. Targeting this pathway could be beneficial in diabetic wound care and in patients suffering from skin blistering diseases.
Yale researchers have discovered hyperhotspots in the human genome that are up to 170-times more sensitive to ultraviolet radiation, potentially leading to a new way of predicting skin cancer risk. By analyzing these hyperhotspots, doctors could gain a better understanding of a patient's exposure history and skin cancer risk.
Complementary therapies used to treat breast cancer skin lesions may delay wound healing and interfere with systemic treatments. Herbal products like green chiretta and feverfew have been shown to negatively impact blood clotting, exacerbating scarring and dressing effectiveness.
Researchers found that newly cancerous pigment stem cells migrate up and out of hair follicles to establish melanomas in nearby surface skin before spreading deeper. This discovery sheds new light on the biology of melanoma and suggests potential new ideas for treatment.
Researchers found that commensal papillomaviruses on human skin can induce immunity protecting against squamous cell carcinoma. The presence of these viruses in patients with suppressed immune systems was shown to reduce the risk of skin cancer, suggesting a novel method for prevention using a vaccine to boost the immune system.
Researchers from Technical University of Munich discovered an inactive receptor in cancer cells prevents checkpoint inhibitors from reactivating the immune system. This leads to a weakened immune response against cancer cells.
Stevens researchers create technology to detect skin lesions and determine if they are cancerous or benign using millimeter-wave radiation. The device could reduce unnecessary biopsies by 50% and disrupt the $5.3 billion diagnostic market for skin cancer.
Research by Oregon State University found that stricter arsenic standards have led to a significant decrease in public water system violations, dropping from 1.3% in 2008 to 0.55% in 2017. This translates to nearly 1 million fewer people exposed to out-of-arsenic-compliance water.
A meta-analysis of 58 studies found that brachytherapy and Mohs surgery have better cosmetic outcomes than conventional excision and external beam radiation therapy. These treatments offer effective alternatives to surgery for patients, particularly those who may not be suitable for surgical options.
Athletes who engage in outdoor sports and exercise are at increased risk of skin cancer, with up to eight-fold exposure limit exceeded during summer and autumn months. Sun protection is crucial for these groups, as research shows a higher incidence of malignant skin cancer among active individuals.
Researchers found that UV radiation damages skin by weakening cell bonds, leading to structural degradation and increased tissue fragility. The study suggests using sunscreen to protect not only against skin cancer but also to maintain skin health and prevent infections.
Researchers at the University of Pennsylvania have identified LSD1 as a key regulator of skin cell turnover and found that blocking it could be an effective treatment method for non-melanoma skin cancers. The study shows that targeting LSD1 can force skin cells to differentiate, potentially turning tumor cells into healthier cells.
Researchers will investigate how solar UVB radiation triggers skin cancer and develop prevention and treatment strategies, including testing natural products and existing drugs.
The GW Cancer Center is conducting a randomized, placebo-controlled phase III trial to investigate cemiplimab's safety and effectiveness in preventing recurrence and metastasis in high-risk cutaneous squamous cell carcinoma. The study aims to enroll over 400 participants worldwide.
Researchers found a significant association between vitamin A intake and reduced risk of cutaneous squamous cell cancer. The study followed nearly 125,000 health professionals for over 26 years.
Researchers from Brown University found that people with high vitamin A intake had a 17% reduced risk of developing squamous cell carcinoma, the second-most-common type of skin cancer. The majority of vitamin A came from diets rich in fruits and vegetables.
The effects of skin aging differ among ethnic groups, with varying levels of damage from environmental factors such as sunlight. Key findings show that patients of color experience changes in pigmentation, while those of European descent have thinner skin and wrinkles.