Articles tagged with Swine Flu
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A community cohort study in Hong Kong found more children than adults were infected with H1N1, but children were less likely to progress to severe disease. Serology studies like this one can help estimate rates of severe disease per infection for revised pandemic preparedness plans.
Researchers evaluated Public Health Grid technology during the 2009 H1N1 pandemic to enhance epidemiologists' and disease-control agencies' abilities. The grid approach allowed for quick data acquisition, secure modeling of disease spread, and effective intervention deployment.
Researchers used computational techniques to analyze 5,000 strains of influenza A viruses and identified six strains with particularly close genetic relationships to the H1N1 pandemic virus. These 'bottleneck' viruses were found to be the culprits behind the emergence of the pandemic strain.
The article highlights the factors influencing vaccine production, access, and uptake, including technologies used to manufacture vaccines, national regulations, and cold chain requirements. The authors emphasize the need for improved surge capacity within the vaccine industry to meet global demand during pandemics.
Research suggests that the swine flu outbreak of winter 2009-2010 was more widespread than previously realized, with almost half of Scottish adults carrying antibodies to the virus. The study found that people from deprived areas were twice as likely to contract the virus.
Scientists analyzed over 650 influenza viruses from Hong Kong pigs, tracing the emergence of subtypes that can infect humans. The study highlights the potential for gene-swapping between viruses and recommends continued surveillance to understand how this process might lead to new variants with human flu epidemic risks.
A long-term study reveals that increased transport of live pigs has driven an increase in the diversity of swine influenza viruses found in Hong Kong over the past three decades. The study suggests that this rising diversity may lead to a higher likelihood of swine-to-human transmission, although the risk remains unquantified.
A study published in PLOS Medicine found that closing schools and implementing social distancing measures significantly reduced H1N1 flu transmission rates in Mexico by 29-37%. The study analyzed data from the Mexican Institute for Social Security and showed a decline in hospitalization rates from 70% to 10% during this period.
Researchers studied pandemic influenza H1N1 morbidity and mortality in 32 Mexican states, finding age distribution and risk of severe disease varied by age group. The study supports the effectiveness of early mitigation efforts like mandatory school closures.
Researchers at Women & Infants Hospital of Rhode Island found that pregnant women infected with H1N1 influenza during the 2009 pandemic were more likely to give birth to lower-weight babies. The studies also tracked outcomes and determined the importance of timely antiviral treatment in pregnancy.
A study found low vaccine acceptance rates among parents of black and Hispanic children, with only 36% indicating they would immunize against H1N1. Parents' confidence in vaccines and their preventive abilities were key factors influencing vaccination decisions.
A new study from the Norwegian Institute of Public Health found significant differences in mortality rates between urban and isolated rural communities during the 1918 Spanish flu pandemic. Mortality rates were much higher in isolated communities, with up to 90-100% of adults over 30 years dying from the virus.
Researchers at MIT have identified a single mutation in the H1N1 genetic makeup that would allow it to be much more easily transmitted between people. The finding should give the World Health Organization something to watch out for, as new strains of the virus may emerge with greater ability to infect humans.
Researchers from Imperial College London found that children are about three times more likely to transmit flu to those of the same gender. The study also showed that sitting next to an infected person does not significantly increase a child's risk of catching flu. This comprehensive analysis will help make more accurate models for pre...
A study published in Clinical Infectious Diseases suggests that convalescent plasma therapy may reduce the death rate in patients severely ill with 2009 H1N1 influenza. The treatment showed a 20% mortality rate compared to 55% in non-treated patients, and reduced viral load at a higher rate.
A new study in BioEssays reveals that the H1N1 pandemic challenged the conventional ideal of antigenic shift, where a virus emerges from an existing subtype. The research suggests that pandemics can result from a shift within lineages of existing subtypes, not just the introduction of a new strain.
Researchers identified broadly protective antibodies against a variety of flu strains in patients infected with the 2009 H1N1 pandemic strain, suggesting a pan-influenza vaccine may be feasible. The antibodies could guide efforts to design a vaccine providing long-lasting protection against a wide spectrum of flu viruses.
Researchers found that people infected with 2009 H1N1 and recovered produced antibodies protective against a variety of flu strains. The study suggests incorporating these defenses into a vaccine could provide broad protection against all influenza strains.
Research analyzing California hospital data found extreme obesity significantly increased risk of death from 2009 H1N1. Half of hospitalized patients over 20 were obese, with nearly three-fold increased odds of death compared to non-obese counterparts.
A head-to-head trial found that the adjuvanted split-virus vaccine achieved a more rapid and stronger immune response than the whole-virus vaccine. In young adults, a single dose of the adjuvanted vaccine induced early seroprotection within one week, suggesting potential for reduced dosing frequency.
A study published in PLoS ONE found that iota-carrageenan directly binds to influenza viruses, blocking attachment and spread. In animal experiments, it demonstrated equivalent efficacy to Tamiflu, offering a potential alternative for treating H1N1 influenza.
A single dose of the 2009 H1N1 influenza vaccine was found to be safe and induced a strong immune response in individuals with asthma. Participants over 60 with severe asthma required a higher dose for adequate protection.
A new computer model projects flu season severity by analyzing genetic and serological data, explaining over 90% of variation in severity. The study provides insights for informed decision-making in planning for influenza, including vaccine selection.
Recent studies reveal a rise in dual-resistance among certain influenza viruses, their increased transmission, and the limited availability of alternative treatment options. This poses significant public health concerns.
Researchers found that a massive, uncontrolled activation of the complement system led to severe lung damage and death in young adults. The study's findings suggest that this over-reaction is responsible for making healthy young and middle-aged adults seriously ill during pandemic flu, explaining why they are disproportionately affected.
The study found that while the second wave was substantially larger, with 4.8 times more hospital admissions and 53% of deaths, fewer patients had severe outcomes due to public health interventions. The percentage of severe outcomes decreased in the second wave compared to the first.
A study found that states with higher past seasonal influenza vaccination coverage or use of other preventive health services showed higher H1N1 vaccine rates. States with lower adult vaccination coverage had longer disease circulation periods, suggesting households may not need vaccinations if someone already has the flu.
Studies found that more than one-fourth of children hospitalized with 2009 H1N1 required intensive care or died. Children with underlying illnesses and infants born prematurely were at greater risk of severe complications. The virus spread rapidly worldwide, particularly in children and young adults.
A study found 70 pediatric deaths related to pandemic influenza A H1N1 in England over a 9-month period. Children from Bangladeshi and Pakistani communities had significantly higher mortality rates compared to white British children.
A study analyzing H1N1 antibody levels suggests a third wave is unlikely in 2010. Adults aged 50-79 years are at a higher risk of severe outcomes if infected.
The H1N1 pandemic showed the need for faster vaccine production and clear communication to address risks to vulnerable populations. The delay in vaccine manufacturing and unclear messages hindered efforts, resulting in significant years of life lost among younger age groups.
Researchers have created a novel anaerobic digestion reactor that can generate electricity comparable to 25 wind turbines. Additionally, scientists have isolated a bacterium capable of decontaminating groundwater contaminated with chlorinated alkanes.
The conference focuses on managing global health security during mass gatherings, such as the Hajj pilgrimage. It covers various areas including communicable disease alert and response systems, water and sanitation management, and bioterrorism management.
The 2009 H1N1 pandemic response was a mixed bag, with some key successes like swift international coordination and robust public health measures. However, there were also areas for improvement, such as limited preparedness at national levels and slower vaccine development.
Experts speculate on future of H1N1 pandemic virus, predicting low mortality rates due to existing immunity in the population. The degree of immunity and potential changes to the virus will impact the upcoming influenza season.
Scientists estimate that at least 183 million Americans have immunity to the 2009 pandemic H1N1 virus due to exposure or vaccination. They predict the virus will persist in a form causing relatively few deaths, but caution against complacency and urge influenza vaccination for all ages.
The Models of Infectious Disease Agent Study (MIDAS) researchers used computational modeling to predict the potential outcomes of different interventions for the H1N1 flu strain. The study found that vaccinating school-aged children substantially reduced overall disease spread and prevented up to 100 million additional cases.
A recent study found that the 2009 pandemic influenza A (H1N1) caused a higher rate of neurological complications in children than the seasonal flu. The most common complications observed were seizures and encephalopathy.
A study analyzed data from influenza cases in Wisconsin and found that children with 2009 H1N1 infections were not at higher risk for hospital admission or pneumonia compared to seasonal H1N1 or H3N2 infections. Adults also showed similar risks of serious outcomes, indicating lower severity of symptoms.
Researchers have developed a new method for visualizing individual virus particles, enabling a more detailed understanding of these minute pathogens. The technique, known as surface plasmon resonance microscopy, allows for the detection and measurement of viral mass, with a detection limit rivaling conventional methods by three to four...
Researchers discovered that the H1N1 flu virus used a novel amino acid location to adapt to human cells, allowing it to spread efficiently. This finding provides new insight into the biology of flu viruses and reveals a genetic marker for predicting future pandemics.
A new study reveals that coughing and other respiratory symptoms are more accurate indicators of H1N1 infection than fever, which can lead to undetected cases. According to the research, nearly half of individuals with mild H1N1 infections may not display fever, highlighting the need for a more comprehensive screening approach.
Researchers developed a prime-boost vaccine strategy that generated antibodies capable of neutralizing multiple flu strains, including those from different years and subtypes. The vaccine showed significant promise in animal models, with up to 80% survival rate after exposure to high levels of flu virus.
A study by the University of Liverpool found that well over half of hospital admissions and deaths from swine flu occurred in previously healthy people. The research suggests that vaccination may benefit everyone with asthma, regardless of severity of disease.
Over half of UK swine flu hospital admissions and inpatient deaths were from people with no underlying health issues or obvious risk factors. The data support the government's priority vaccination strategy for high-risk groups, but also suggest that everyone with asthma might benefit from vaccination.
A large multicentre study found that early antiviral treatment reduced hospitalization and intensive care admissions among transplant recipients with H1N1. Vaccination and preventive measures may also provide protection for this high-risk population.
Researchers have discovered a monoclonal antibody that is effective against multiple strains of influenza, including Avian H5N1, seasonal H1N1, and the 2009 Swine H1N1 influenza. The antibody targets a conserved region of the viral coat protein, providing broad-spectrum protection against various flu strains.
According to the poll, most employees reported that their company provided hand sanitizer, encouraged sick workers to stay home, and expanded leave policies. Large companies were more likely to take these measures than smaller ones. The survey suggests that businesses will play a vital role in public health during outbreaks.
Researchers found that the 2009 H1N1 influenza vaccine may also protect against the lethal 1918 Spanish influenza virus, alleviating bioterrorism concerns. The study demonstrates cross-protection, showing that people vaccinated against H1N1 may also be protected against 1918.
A 2009 H1N1 pandemic influenza vaccine has been found to protect mice from the 1918 Spanish flu virus. The study's results suggest that people vaccinated against 2009 H1N1 or exposed to the virus may have cross-protective antibodies against the 1918 strain, providing potential protection.
A large study found 68 abnormal brain findings in 953 children, with only six requiring urgent follow-ups. These findings highlight the need for pediatricians to prepare for discussions about incidental discoveries, which can lead to unnecessary tests and fear.
Researchers pinpointed molecular changes that enabled Tamiflu-resistant H1N1 flu viruses to replicate and spread globally. The study revealed two secondary mutations in the neuraminidase gene of resistant strains, allowing them to overcome previous inhibitory effects of Tamiflu.
The article identifies six key public health challenges and data needs to prepare for future pandemics, including measuring age-specific immunity and accurately quantifying severity. Serological surveys and monitoring time-sources are crucial for gathering valuable pandemic data.
A genetic analysis reveals that flu strains in the US don't disappear at the end of winter, but instead migrate to South America and other parts of the world. This knowledge has implications for public health efforts, including antiviral use and vaccination programs.
A recent study in Hong Kong found that fear of the H1N1 virus prompted residents to adopt preventive behaviors such as frequent hand-washing (47% reported washing hands >10 times/day) and wearing face-masks. These behaviors can play a crucial role in controlling pandemic influenza.
A study of 18 patients with H1N1 infection found increased risks of obstetrical complications, including fetal distress and premature delivery. The study suggests that early antiviral treatment may improve maternal outcomes and highlights the need for further research on the impact of H1N1 on pregnant women.
The study found that patients with mild disease responded favourably to oseltamivir treatment, reducing viral clearance and transmission. Containment measures may have delayed large-scale transmission by at least three weeks in Vietnam.
Researchers reconstructed the initial 2009 H1N1 influenza outbreak in Ho Chi Minh City, finding that containment efforts may have delayed establishment of infection but did not prevent community spread. The study also showed that treatment clearance times varied depending on treatment timing and patient characteristics.
A recent study from Stanford University found that DFA testing for H1N1 influenza is unreliable in critically ill patients. The test was more accurate in non-critical cases, with a 26% positive rate in ICU patients compared to an 82% positive rate in non-ICU patients.
A study by the University of Washington found that Google Flu Trends is less accurate in estimating laboratory-confirmed influenza cases compared to CDC surveillance. The analysis revealed a 25% error margin during the 2003-04 flu season, with greatest deviations occurring during periods of high media attention or unexpected activity.