Researchers found that four-month treatment is as effective as six months in non-severe TB cases, allowing for savings on screening and training healthcare workers. The study's results led to a change in the World Health Organisation's global guidelines, recommending a shorter treatment course for children with non-severe TB.
SourceUniversity College London·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateMar 9, 2022
A recent study found a high prevalence of HIV, tuberculosis, and malaria in the Gambela region of Ethiopia, highlighting the need for targeted health services. The research suggests that addressing these diseases at a local level could be more effective than a nationwide response.
SourceCurtin University·JournalBMJ Global Health·DateFeb 25, 2022
A study led by A*STAR's Genome Institute of Singapore has identified the gene KCNJ15 as a key player in helping the immune system fight tuberculosis. The research found that TB patients have altered acetylation levels at thousands of DNA regions, which helps to reduce the ability of bacteria to reproduce inside cells.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalNature Microbiology·DateFeb 16, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found that starting combined antiretroviral therapy against simian immunodeficiency virus two weeks after infection significantly reduced chronic immune activation, SIV replication, and latent TB reactivation. This study contributes to the growing evidence on the complex interaction between HIV and tuberculosis.
SourceTexas Biomedical Research Institute·JournalJournal of Clinical Investigation·DateFeb 15, 2022
Researchers identified 40 peptide pairs with potential cross-reactivity between BCG vaccination and SARS-CoV-2, offering a new strategy to complement existing COVID-19 vaccines. These peptides can induce T cell responses and INF-γ production, providing long-lasting immunity against viral infections.
SourceUniversity of Houston·JournalFrontiers in Immunology·DateJan 13, 2022
Researchers at Weill Cornell Medicine discovered that deleting the EtfD Mtb enzyme renders Mycobacterium tuberculosis unable to sustain an infection in mice. The enzyme plays a critical role in fatty acid breakdown, making it an attractive target for TB treatment.
SourceWeill Cornell Medicine·JournalNature Communications·DateDec 21, 2021
Researchers identified 'pre-resistance' signs in bacteria, predicting future resistance to antibiotics. This discovery allows doctors to select the best treatments for bacterial infections and paves the way for personalized genomic therapy.
SourceUniversity College London·JournalNature Communications·TypeObservational study·DateDec 15, 2021
Researchers at La Jolla Institute for Immunology identified Th1* cells as a key marker in the body's immune signature following BCG vaccination. The study found that these cells respond well to the vaccine and can help fight the Mycobacterium tuberculosis bacterium that causes TB.
SourceLa Jolla Institute for Immunology·JournalEBioMedicine·TypeExperimental study·DateDec 13, 2021
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers analyzed TB and COVID-19 patients in California, finding shared sociodemographic characteristics and medical risk factors. The study highlights the importance of addressing these factors to improve health outcomes for both conditions.
SourceJAMA Network·JournalJAMA Network Open·DateDec 3, 2021
Researchers at the University of Alabama at Birmingham discovered the mechanism of secretion and trafficking of Mycobacterium tuberculosis' toxin TNT, which kills over 1 million people annually. The ESX-4 type VII secretion system plays a crucial role in transporting TNT across cell membranes.
SourceUniversity of Alabama at Birmingham·JournalNature Communications·TypeExperimental study·DateNov 24, 2021
A study led by New York University researchers found that the FDA-approved hepatitis C treatment telaprevir can increase bacterial sensitivity to antibiotics and reduce antibiotic resistance. The antiviral blocks the function of essential proteins in bacteria, revealing an opportunity to repurpose the drug to use alongside antibiotics.
SourceNew York University·JournalCell Chemical Biology·TypeExperimental study·DateNov 23, 2021
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Infants who contract cytomegalovirus (CMV) before age 12 months are at a significantly higher risk of developing TB later in their childhood. The study found that babies infected with CMV were more than three times more likely to develop TB after age 1 than children who had not become infected with CMV.
SourceBoston University School of Medicine·JournalThe Lancet Global Health·TypeObservational study·DateNov 17, 2021
Researchers at Trinity College Dublin have discovered that lactate can influence cells in the lung environment to support immune defenses against infection while limiting collateral damage. Lactate may hold therapeutic potential as a host-directed therapy for diseases like TB and COVID-19, which cause destruction of pulmonary tissue.
SourceTrinity College Dublin·JournalFrontiers in Immunology·DateOct 7, 2021
A study published in The Lancet Global Health found that nearly one-fifth of young people with tuberculosis (10-24 years old) in Brazil experienced adverse treatment outcomes. Factors associated with these outcomes included poverty, HIV, homelessness, and drug use, highlighting the need for greater attention to this age group in tuberc...
SourceKarolinska Institutet·JournalThe Lancet Global Health·DateSep 14, 2021
Researchers discovered a DNA modification system that coordinates bacterial replication in TB. The DarT/DarG system can be targeted by new antibiotics, offering hope for treating the deadly disease.
SourceUniversity of Surrey·JournalNature·TypeExperimental study·DateSep 8, 2021
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new TB prevention regimen for HIV-positive individuals has shown promising results, with 90.4% completing the three-month course compared to 50.5% of those on a six-month daily treatment. The study suggests that this shorter approach is as safe and effective as the standard treatment.
SourceOhio State University·JournalAnnals of Internal Medicine·TypeRandomized controlled/clinical trial·DateAug 24, 2021
A randomized trial found that a shorter course of rifapentine-isoniazid therapy resulted in significantly higher treatment completion rates compared to a longer daily course. The findings suggest that this regimens can be more effective for preventing tuberculosis disease in individuals with HIV, particularly in high-transmission areas.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateAug 23, 2021
Researchers at Purdue University and Houston Methodist have developed a novel TB vaccine formulation that enhances T cell responses to combat tuberculosis. The new vaccine uses autophagy-mediated antigen presentation, showing promising results in improving immune response.
SourcePurdue University·JournalCell Reports Medicine·DateAug 20, 2021
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Scientists at Rockefeller University have discovered that essential gene targets in TB bacteria can be ranked by their degree of vulnerability to antibiotics. The study found that ideal targets are highly susceptible to inhibition, while invulnerable genes can withstand nearly total inhibition. This research provides new insights into ...
SourceRockefeller University·JournalCell·DateAug 2, 2021
Researchers at the University of Maryland discovered a gene in tuberculosis that inhibits the inflammasome, a signaling system that helps defend against pathogens. The finding may lead to effective gene-based treatments or preventative therapies for tuberculosis.
SourceUniversity of Maryland·JournalPLOS Pathogens·TypeExperimental study·DateJul 29, 2021
Researchers created a 3D view of diseased lung tissue using microCT to reveal that TB granulomas are complex and branched, with unique connections to airways. This has significant implications for treatment, including the potential for aerosolized drug delivery to reduce treatment times.
SourceUniversity of Alabama at Birmingham·JournalAmerican Journal of Respiratory and Critical Care Medicine·TypeExperimental study·DateJul 28, 2021
The UNITE4TB partnership aims to develop new and highly active TB treatment regimens for drug-resistant and -sensitive TB. The consortium will accelerate the clinical evaluation of combinations of existing and novel drugs through advanced trial designs and AI-powered analysis.
The UNITE4TB partnership aims to develop new and highly active TB treatment regimens for drug-resistant and -sensitive TB. The 7-year project will utilize advanced clinical trials networks, adaptive trial designs, and machine learning techniques to accelerate the development of better treatment solutions.
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers have discovered a new approach to treating tuberculosis by boosting the body's immune system and targeting cell death pathways. The study found that using preclinical models, infected cells can be killed by drugs called IAP inhibitors, significantly reducing disease severity.
SourceWalter and Eliza Hall Institute·JournalImmunity·DateJul 12, 2021
A study published at ECCMID 2021 found that individuals with depression and schizophrenia have a higher incidence of TB. The research suggests that mental health may play a causal role in increasing TB risk, particularly through its effect on the immune system.
SourceEuropean Society of Clinical Microbiology and Infectious Diseases·DateJun 30, 2021
Scientists from Hackensack Meridian Center for Discovery and Innovation have uncovered the mechanism of action of a novel anti-tuberculosis drug, triaza-coumarin, which is effective in inhibiting TB disease from within by boosting its on-target activity by two orders of magnitude.
SourceHackensack Meridian Health·JournalProceedings of the National Academy of Sciences·DateJun 29, 2021
The study of Mycobacterium tuberculosis's ESX-5 secretion system reveals a complex molecular machinery that enables the bacterium to infect human cells. The structure of this system provides potential drug targets and new insights into vaccine development.
SourceEuropean Molecular Biology Laboratory·JournalScience Advances·DateJun 25, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A Phase 2 trial showed that combining doxycycline with TB treatment reduces lung cavity size and increases markers of recovery in pulmonary TB patients. This discovery has promise for preventing long-term complications and improving outcomes for those affected by the disease.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalJournal of Clinical Investigation·DateJun 19, 2021
A comprehensive health-screening program in rural northern KwaZulu-Natal, South Africa, has identified a high burden of undiagnosed or poorly controlled non-communicable diseases. The study found that four out of five women over the age of 30 were living with chronic health conditions, highlighting the need for urgent interventions.
SourceUniversity of Alabama at Birmingham·JournalThe Lancet Global Health·DateJun 18, 2021
A new study validates the Xpert Ultra molecular test as a frontline tool in routine conditions, showing improved sensitivity over its predecessor. The test detects tuberculosis cases with lower bacterial burdens and can identify asymptomatic cases in early stages of the disease.
SourceBarcelona Institute for Global Health (ISGlobal)·JournalEuropean Respiratory Journal·DateJun 17, 2021
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers discovered a stem cell-mediated defense mechanism that reactivates dormant tuberculosis in mice infected with SARS-CoV-2, suggesting potential for new vaccines and avoiding global TB pandemic. This discovery may help develop novel therapeutic approaches against COVID-19 and target antiviral activities.
SourceElsevier·JournalAmerican Journal Of Pathology·DateJun 16, 2021
Researchers have identified seven genes responsible for excessive inflammation and damage to the lungs in tuberculosis. A new drug treatment, doxycycline, has shown promise in reducing lung damage and accelerating recovery in patients with pulmonary TB.
SourceUniversity of Southampton·JournalJournal of Clinical Investigation·DateJun 15, 2021
Researchers have found a new four-month antibiotic regimen using rifapentine to be effective in treating TB, reducing the treatment duration by two months. The study showed that patients with HIV also cleared their TB just as well as those without HIV.
SourceMedical University of South Carolina·JournalNew England Journal of Medicine·DateJun 4, 2021
A recent study on TB outbreak in an Irish prison highlights the need for increased testing and improved care. The study found that 50% of staff may have developed latent TB as a result of occupational exposure, posing a risk of progression to active TB.
SourceTrinity College Dublin·JournalThe International Journal of Tuberculosis and Lung Disease·DateJun 1, 2021
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A multinational study validated a four-month multi-drug therapy regimen as effective as the standard six-month treatment for active tuberculosis, reducing treatment time by a third. The new regimen, which includes rifapentine and moxifloxacin, was safe and well-tolerated.
SourceUniversity of Texas Health Science Center at San Antonio·JournalNew England Journal of Medicine·DateMay 19, 2021
Researchers developed a new basis for comparing tuberculosis treatments using an rRNA synthesis ratio, enabling more intelligent drug design and acceleration of treatments. This tool has crucial implications for combatting the global TB epidemic by providing a durable cure.
SourceUniversity of Colorado Anschutz Medical Campus·JournalNature Communications·DateMay 18, 2021
The new test detects a specific protein (CFP-10) in children's blood samples with high sensitivity and accuracy, identifying TB cases with 100% accuracy. It can detect TB up to 60 weeks before diagnosis, offering early detection and potentially saving lives.
SourceTulane University·JournalBMC Medicine·DateMay 18, 2021
Scientists at the University of Surrey detail how they measure metabolite fluxes in Mycobacterium tuberculosis, crucial for understanding its survival and developing effective treatments. This breakthrough could accelerate progress towards eliminating tuberculosis globally.
SourceUniversity of Surrey·JournalMolecular Systems Biology·DateMay 12, 2021
A groundbreaking study has identified IL-17 cytokine as the primary culprit behind excessive lung inflammation in TB patients. By targeting this pathway, doctors may be able to reduce disease harm and speed up patient recovery.
SourceUniversity College London·JournalScience Translational Medicine·DateMay 10, 2021
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers developed a genetic material-based catalogue to predict antibiotic resistance in MDR-TB, enabling accelerated treatment development. The study found that 99% of predicted drug combinations were effective in traditional microbiological testing.
SourceGerman Center for Infection Research·JournalClinical Infectious Diseases·DateMay 3, 2021
New research reveals fundamental differences in how baby and adult immune cells respond to TB, with a greater ability of adult cells to shift their energy profile after infection. The study highlights the importance of understanding how the immune system uses energy to develop better treatments for vulnerable populations.
SourceTrinity College Dublin·JournalFrontiers in Immunology·DateApr 13, 2021
Researchers identified Mycobacterium tuberculosis' use of rubredoxin B to survive in iron-deficient conditions, helping the bacterium evade the immune system. The study provides new insights into the development of drug resistance and potential targets for therapeutic agents.
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalBioorganic Chemistry·DateApr 8, 2021
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers at the University of Alabama at Birmingham have discovered a novel protein transport system in Mycobacterium tuberculosis, allowing the release of its toxin, tuberculosis necrotizing toxin (TNT), into human macrophages. The study reveals that two small Esx proteins form pores in membranes to facilitate TNT secretion.
SourceUniversity of Alabama at Birmingham·JournalNature Communications·DateApr 8, 2021
The TB burden in Europe is decreasing, with a 19% overall decline from 2015-2019. However, drug resistance remains a major concern, and the COVID-19 pandemic may stall or cause setbacks in the fight against TB. Treatment outcomes are suboptimal, with only 77% of patients successfully completing treatment in 2019.
SourceEuropean Centre for Disease Prevention and Control (ECDC)·DateMar 22, 2021
Researchers found that adding an iron binder to Bedaquiline treatment boosts its ability to combat TB bacteria. The study suggests a promising approach to improving patient outcomes and developing new treatments.
SourceTrinity College Dublin·JournalInternational Journal of Molecular Sciences·DateMar 22, 2021
Researchers at Radboud University Medical Center have found that a higher dose of the anti-tuberculosis drug rifampicin is safe and effective. This could lead to a shorter treatment duration and less resistance, with potential benefits for global tuberculosis treatment.
SourceRadboud University Medical Center·JournalEuropean Respiratory Journal·DateMar 22, 2021
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A new report by Harvard Medical School researchers found that TB diagnoses in the US are often delayed, leading to a higher likelihood of infection transmission and disease progression. The study suggests that increased clinician awareness and education can help minimize these delays.
SourceHarvard Medical School·JournalThe Lancet Infectious Diseases·DateMar 22, 2021
Researchers analyzed ancient human DNA to understand the impact of tuberculosis on European populations. The study found that a specific variant of the TYK2 gene was associated with an increased risk of becoming ill after infection with Mycobacterium tuberculosis.
SourceCell Press·JournalAmerican Journal of Human Genetics·DateMar 4, 2021
Researchers analyzed 70,000 ancient skeletons to find declining rates of transmission for these chronic infectious diseases. The analysis suggests that pathogens may evolve to cause less harm to humans over time, leading to reduced transmission.
A MUSC researcher has been awarded a $9.9 million contract to test TB treatment interventions in areas with severe disease prevalence. The goal is to shorten treatment duration and improve patient adherence, particularly for individuals with latent TB infection.
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers have isolated monoclonal antibodies that effectively target and inhibit the growth of tuberculosis germs in laboratory mice. These biological antibiotics show promise as an alternative to traditional chemical antibiotics, offering a safer and more stable treatment option.
SourceTel-Aviv University·JournalNature Communications·DateFeb 22, 2021
Researchers found a genetic mechanism in Mycobacterium tuberculosis that allows the bacterium to respond to stress rapidly and in manner that is 'history-dependent.' The study suggests this mechanism may be key to understanding tuberculosis latency, a global health problem affecting 2-3 billion people.
A new biomarker has been identified that can determine individual treatment duration for tuberculosis patients, reducing the need for prolonged therapy. The biomarker is based on an RNA signature from 22 genes and was developed using patient cohorts from Germany and Romania.
SourceGerman Center for Infection Research·JournalEuropean Respiratory Journal·DateFeb 19, 2021
Research found fidaxomicin is more effective than existing TB medication at preventing growth of M. tuberculosis, including resistant strains. Fidaxomicin's in vitro activity was compared to rifampicin and showed promise as a potential new treatment for TB.
SourceMicrobiology Society·JournalJournal of Medical Microbiology·DateFeb 17, 2021
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers propose a new TB drug targeting the FtsZ protein, inhibiting cell division and suppressing growth, with potential for long-term effectiveness. The compound has been identified through high-precision molecular simulations, offering a novel solution to the problem of drug resistance in TB.
SourceToyohashi University of Technology (TUT)·JournalAntibiotics·DateJan 18, 2021
Researchers at the University of Sydney have developed a novel method to rapidly synthesize safe vaccines using protein-based immunization. The approach demonstrated strong immune response in mice against tuberculosis and has potential applications for respiratory diseases, including COVID-19.
SourceUniversity of Sydney·JournalProceedings of the National Academy of Sciences·DateJan 18, 2021
Researchers developed a new imaging method to track antibiotic distribution in infected tissues, revealing that some antibiotics only partially penetrate infected cells. This discovery could lead to more targeted treatments and reduced risk of antibiotic resistance.
SourceThe Francis Crick Institute·JournalPLOS Biology·DateJan 5, 2021
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new lung-on-chip model has provided insight into the body's response to early tuberculosis infection. The study revealed that alveolar epithelial cells play a crucial role in controlling bacterial growth by producing surfactant, which reduces surface tension and prevents uncontrolled bacterial growth.
Researchers at San Diego State University have uncovered a crucial clue to the mystery of TB's rapid resistance to antibiotics. They found that the pathogen uses an epigenetic domain to diversify and create multiple subpopulations with varying phenotypes, leading to drug resistance.
Research highlights the need for tuberculosis (TB) screening and ongoing clinical care for people on methotrexate living in areas with high TB prevalence. Methotrexate users taking corticosteroids or immunosuppressants are at increased risk of TB infection.