Articles tagged with Bacteriophages
Researchers at NUS and Imperial College London have discovered a new way bacteria share genes, enabling rapid evolution. Lateral cotransduction enables SaPIs to transfer themselves intact with bacterial DNA, making them potent transducing agents.
The Bioaction project leverages bacteria as allies in promoting tissue regeneration, offering a paradigm shift in addressing infections. By developing functional bio-hydrogels, the project aims to accelerate healing and stimulate bone growth, reducing reliance on extended antibiotic therapies.
Researchers find that viruses, like bacteriophages, can eavesdrop on bacterial communication and switch from chill mode to kill mode in response to chemical signals. The study reveals tools that control this strategy and demonstrates its abundance, providing new insights into viral behavior.
Researchers at ETH Zurich have developed a rapid test that detects bladder infections using bacteriophages, which can identify the pathogenic bacteria in under four hours. The test also allows for tailored phage therapy, predicting patient response and increasing treatment effectiveness.
Researchers investigated how gut bacteria respond to repeated antibiotic disruptions, finding that they evolve antibiotic-resistant variants and adapt through slowing of cell growth. The study reveals the complex response of the microbiome to antibiotics, including ecological effects and induction of prophages.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
Researchers at the University of Exeter have captured the structure of a commonly used phage, filamentous phages, which will enable the development of new biotechnology applications. The new insights gained from this research will help improve phage display and other uses in drug discovery.
Researchers from the Institute of Physical Chemistry found that microplastics decrease bacteriophages' infectivity due to leachates and polymer size. The study highlights the impact of microplastics on aquatic ecosystems, affecting both animals and humans.
Researchers have identified a new group of mitochondrial viruses confined to arbuscular mycorrhizal fungi Glomeromycotina, which may represent an ancestral lineage of mitoviruses. These large duamitoviruses possess distinct characteristics and are globally distributed in ecological niches occupied by glomeromycotinian fungi.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
A new study reveals that a Cas protein and a membrane protein work together to enhance anti-viral defense in bacteria. The team found that the membrane protein forms a pore-like structure that disrupts energy production and hinders virus replication, effectively 'pulling the plug' on viral infections.
A new discovery by researchers at the University of Warwick has found a simple material that can prevent bacterial viruses from contaminating laboratories and microbial factories. This breakthrough aims to develop next-generation industrial biotechnologies and remove a bottleneck in fundamental research.
Researchers found an exceptional number of unknown viruses in the faeces of 647 healthy Danish one-year-olds, representing more than 200 families of yet to be described viruses. These viral species likely have a major impact on whether children develop various diseases later on in life.
A study reveals an extremely long tail on a bacteriophage that allows it to infect tough bacteria in hot springs. The 'Rapunzel' virus has a nearly 1-micrometer-long tail and uses a unique 'ball and socket' mechanism for stability.
Scientists have developed a high-throughput genetic screening approach to identify viral proteins that target bacterial cell walls, leading to potential new antibiotics. The method uses a coded library of DNA fragments to investigate unknown genes in environmental samples, sidestepping the need for culturing bacteria.
Researchers explore alternative methods to overcome obstacles in phage therapy, including species specificity, bioavailability, and infectivity loss. Nanotechnology is being used to detect bacteria and facilitate phage delivery, offering a promising diagnostic tool.
Scientists have discovered a new virus that can kill antibiotic-resistant bacteria, including Pseudomonas aeruginosa. The virus, named Fyn8, was found in local creeks near the University of Southern Denmark campus and has been fully sequenced.
A study by Dartmouth College researchers found that bacteria can form protective clusters with rival species, making it harder to kill harmful bacteria. This discovery highlights the importance of studying multispecies biofilm structures and may impact the development of bacteriophages and predatory bacteria as antimicrobial alternatives.
Researchers from UC San Diego and Yale University are exploring the therapeutic potential of
Researchers have gained a better understanding of the structures and functions of Andhra gene products, paving the way for custom phages for therapeutic applications. The high-resolution knowledge of the virus structure is crucial for developing targeted treatments against Staphylococcus epidermidis infections.
Researchers have created a method to edit the genomes of bacteriophages, viruses that infect bacteria, using CRISPR technology. This innovation has the potential to revolutionize the control of microbiomes and treat dangerous drug-resistant infections.
Researchers at the University Hospital Bonn have discovered a new function of CRISPR/Cas9 gene scissors, which produce small signal molecules that bind to proteins, activating an emergency response. This discovery opens up new possibilities for treating diseases using CRISPR technology.
Researchers at North Carolina State University developed a CRISPR-based system that uses engineered bacteriophages to deliver genetic payloads to specific bacteria, even in complex environments. This technology enables precise single-letter changes to the genome without double-strand DNA breakage.
A study found that vaginally delivered newborns have a higher risk of exposure to pathogenic viruses from the mother's vagina, which can affect their gut health. This challenges the conventional notion that vaginal delivery is safer than cesarean section.
A clinical trial is underway to evaluate the safety and efficacy of bacteriophage therapy in adults with cystic fibrosis who carry Pseudomonas aeruginosa. The trial aims to reduce bacterial load in the lungs using a phage cocktail that targets specific bacteria, providing a potential new treatment for difficult-to-treat infections.
Researchers at the University of Maryland Baltimore County have discovered that some viruses can sense their environment and
A new project will explore the defence mechanisms of bacterial cells to stop the spread of drug-resistant genes. The team, led by Professor Edze Westra, will use a range of methods to understand how bacteria defend against mobile genetic elements (MGEs) that contribute to antimicrobial resistance.
Researchers have developed a systematic strategy for creating phage-resistant E. coli strains, solving a major problem in industrial fermentation. The approach integrates a defense system and mutations to restrict phage life cycle, maintaining bacterial functionality and productivity.
Researchers have designed a phage combination therapy that precisely targets and suppresses gut bacteria associated with inflammatory bowel diseases (IBD). The team identified effective phages against IBD-contributing Kp strains, which attenuated inflammation and tissue damage in mice models.
Researchers discovered that giant viruses, known as bacteriophages, construct a shielded compartment that acts like a nucleus in human cells, protecting their genetic material. The nuclear-like structure allows certain components inside while serving as a defense mechanism against bacterial threats.
Researchers at TUM have developed a cell-free production method for bacteriophages, which can be used to target and combat specific types of antibiotic-resistant bacteria. The new technology has the potential to produce personalized therapeutic phages for clinical trials, addressing multi-resistant germ infections.
Researchers at Texas A&M University's Center for Phage Technology have completed a study on phage therapy, identifying potential applications to fight multidrug-resistant bacterial infections. The study showed promise in treating Acinetobacter baumannii, a deadly pathogen found in hospital settings and the Middle East.
Researchers at Arizona State University have discovered molecular signatures associated with acute and chronic phases of traumatic brain injury (TBI). The study aims to address current limitations in TBI diagnosis and treatment by identifying biomarkers and understanding the blood-brain barrier's role in drug delivery.
Scientists identified that retrons encode toxin proteins kept inactive by a small DNA fragment, unleashing them upon viral attacks. The EMBL team discovered how retrons form antitoxins and found natural switches to trigger growth inhibition complexes.
Giorgi Eliava's contributions to bacteriophage research are commemorated in a peer-reviewed journal. His life and work laid the foundation for phage therapy, which has potential applications in medicine, agriculture, and more. The Eliava Institute of Bacteriophage continues his legacy.
Researchers used bacteriophage therapy to treat 20 complex, antibiotic-resistant lung infections in a clinical trial, resulting in no adverse reactions. More than half of treated patients experienced symptom improvement or reduced bacterial presence. The study's findings advance the promise of phage therapy as an alternative to traditi...
A new study reports on 20 case studies of phage therapy, showing the therapy's success in over half of patients and no adverse effects. The treatment has been shown to be effective against treatment-resistant Mycobacterium infections, with some patients experiencing spectacular outcomes.
Researchers at Aston University have developed a new antibiotic combination that successfully treated a cystic fibrosis patient's deadly lung infection. The combination of imipenem/relebactam with amoxicillin eradicated the infection, enabling the patient to receive a lifesaving lung transplant.
Scientists discovered that bacteria adapt their gene expression to evade bacteriophages in the gut environment, reducing susceptibility to infection. This finding paves the way for improved use of phages in therapeutic purposes.
A new research project led by Professor Edze Westra aims to uncover the mechanisms of molecular communication in viruses, which coordinate their infections and replicate in infected cells. The team will use a combination of theoretical, experimental, and observational approaches to address key questions about viral communication systems.
Researchers at the University of Bologna have developed a new targeted cancer therapy based on a genetically modified phage that selectively eliminates tumour cells. The virus is engineered to transport a drug activated by light to target tumour cells, reducing side effects.
SMART researchers identified a novel phage lysin, Abp013, with promising antimicrobial ability against Acinetobacter baumannii and Klebsiella pneumoniae. The study demonstrated Abp013's ability to effectively target complex bacterial environments and could advance treatment methods for multidrug-resistant Gram-negative pathogens.
Researchers have created a new type of cholera vaccine consisting of polysaccharides displayed on virus-like particles, generating long-lasting antibody responses in mice. The vaccine shows promise as a next-generation cholera vaccine, potentially replacing current vaccines that last only 2-5 years.
Researchers developed Inducible Directed Evolution (IDE), a new technique for controlling directed evolution in bacteria, allowing up to 30 gene modifications at a time. This approach enables finely tuned changes to bacteria, making it suitable for biopharmaceutical and chemical manufacturing industries.
A new antitoxin mechanism called Panacea has been discovered, neutralizing hundreds of toxins and potentially protecting bacteria against viruses. The study's findings suggest that toxin-antitoxin systems are crucial for phage therapy to treat antibiotic-resistant infections.
A new EU-funded project, MUSIC, will investigate how bacterial defences influence the spread of mobile genetic elements (MGEs) between bacteria. MGEs can change key traits of bacteria, including antibiotic resistance and virulence.
Phages weigh all options and make an informed decision whether to exit the dormant state and attack their bacterial host. The study found that some phage families have developed a complex decision-making strategy, receiving information from neighboring bacteria and controlling communication via arbitrium.
A study published in Annals of the Rheumatic Diseases found that crAss-like phages, a component of the gut virome, are less abundant in individuals with autoimmune diseases. This discovery may lead to the development of targeted therapies to manage autoimmune conditions.
Researchers have discovered a novel mechanism of viral transport by bacterial shuttles traveling along fungal hyphae. This process allows bacteria to benefit from taking viruses on their conquest of new habitats. The study also highlights the potential influence of viruses on nutrient and carbon cycles in soil ecosystems.
New research combines antibiotics and phage therapy to cure infections more effectively and reduce antibiotic use. The study found that bacteriostatic antibiotics trigger CRISPR-Cas adaptive immunity in bacteria, increasing the chances of treatment efficacy.
Researchers discovered a phage that kills Shigella flexneri bacteria and selects for mutant strains with reduced virulence. The phage targets the OmpA receptor on the bacterium, eliminating or reducing its ability to spread in the human intestine.
A team of scientists at KAUST has developed a novel approach for cleaning biofouled membranes in anaerobic bioreactors, combining UV irradiation with bacteriophages to eliminate bacteria. The method improved upon individual treatments and was proven effective over four cleaning cycles.
Researchers discovered that bacteria exchange mobile genetic elements to defend against viruses, enabling rapid evolution of innate immunity and development of resistance. This finding has significant implications for designing phage-based therapies against bacterial infections.
Researchers identified a new family of marine megaphages with genomes over 650 kb in length, which could impact biogeochemical cycling. These 'megaphages', found in the English Channel, are distantly related to human gut phages and represent a new family in the marine environment.
Researchers discovered two defence systems in bacteria that work together to protect against modified DNA bacteriophages. BrxU has the potential to be a biotechnological tool for mapping the human epigenome, which alters in cancer and neurodegenerative diseases.
Researchers at the University of Exeter develop a new method to mimic microenvironments in the human body, overcoming a major obstacle to using phage therapy. The study finds that phage can effectively kill bacteria in these environments without promoting genetic resistance.
Researchers have identified a new prophage-mediated defence system in Salmonella Typhimurium ST313 called BstA, which efficiently suppresses phage attacks. This discovery opens up a new avenue of research and could potentially lead to the development of new biotechnologies.
Scientists have developed a new therapy that combines bacteriophages with antibiotics to treat antibiotic-resistant infections, specifically targeting Mycobacterium abscessus. The treatment, using the bacteriophage 'Muddy', showed significant improvement in survival rates and severity of infections when paired with rifabutin, demonstra...
Researchers at the University of California - San Diego have developed COVID-19 vaccine candidates made from plant viruses and bacteriophages, which can be stored and shipped without refrigeration. These vaccines trigger high production of neutralizing antibodies in mice, offering a potential solution for global distribution efforts.
Researchers have mapped the structure of CRISPR-Cas12j3 from bacteriophages, a discovery that reveals how it works and solves packaging problems for genome editing. The new system has vast potential for precise genome editing with improved efficiencies and alternative targeting mechanisms.