Articles tagged with Bacteriophages
Researchers discovered that phages cooperate to rapidly infect bacteria, overcoming destruction by CRISPR. The cooperation allows the first phage to sacrifice itself and produce anti-CRISPR compounds to neutralize some CRISPs, helping subsequent phages. This new model proposes a tipping point between numbers and speed of CRISPR and ant...
A new delivery technique using dry, porous microparticles coated with phages successfully treated pneumonia in infected mice and reduced bacterial levels in cystic fibrosis models. The technique improves the distribution of phages in the lungs and could one day be used to deliver a dry-powder phage via an inhaler.
A new platform enables quick discovery of molecules that recognize specific strains of bacteria, overcoming challenges in developing targeted antibiotics. The approach uses phage display with chemically enhanced peptides, resulting in potent and selective probes against two antibiotic-resistant bacterial pathogens.
Researchers use droplet-sized miniecosystems to simultaneously test antibody binding affinity and cell function, reducing the drug discovery process. The new method enables scientists to select functional antibodies directly with phage display.
Research reveals that lytic bacteriophages contribute to PD by reducing neurotransmitter-producing bacteria, and may be a diagnostic and treatment target.
A clinical study confirms the safety and tolerability of using bacteriophages to eliminate disease-causing bacteria in the gut, promoting beneficial bacteria growth. The treatment shows no apparent side effects and improves inflammatory markers and gut bacterial diversity.
Scientists at the University of Copenhagen have successfully targeted and killed E. coli using a cocktail of viruses, preserving the surrounding community of commensal bacteria in a simulated small intestinal microbiome. This breakthrough could lead to a new treatment method for food-borne illnesses without the use of antibiotics.
Researchers from Ohio State University have discovered that viral infections can affect nutrient turnover, health, and disease in bacteria commonly found in the environment. The study highlights the importance of understanding these interactions to improve environmental preservation and human health, potentially leading to new ways to ...
Research examines subgingival virome in periodontal health and disease, finding lower virus levels in healthy controls compared to diseased subjects. The dominant viruses were members of the Herpes Simplex family, with gram-negative phages predominating in diseases.
Researchers have found four bacteriophages effective in eliminating Yersinia enterocolitica from food and kitchenware. The study's results suggest phage treatment could become a routine method in food production to prevent foodborne infections.
Researchers have developed a novel technology platform to genetically modify phage genomes systematically, providing additional functionality. The new phage workbench allows for the creation of custom bacteriophages with various functions, overcoming constraints associated with naturally occurring phages.
Researchers found 457 novel phage sequences in bacterial genomes from the female urinary microbiome, suggesting a common set of phages that reside in the bladder. The study also indicates that phage may contribute to urinary health and offers potential alternative treatment for urinary tract infections.
Researchers are exploring phages as a solution to combat antibiotic resistance. Studies suggest that phages can alter microbial balances and have been proposed for use in faecal microbiota transplantations. Despite challenges, phage therapy may offer a promising alternative to traditional antibiotics.
A team of Norwegian researchers has developed a tool to monitor bacterial strains in cheese cultures, enabling prompt detection and countermeasures to maintain quality. The tool uses next-generation sequencing to analyze the epsD gene, which is involved in resisting phage and producing exopolysaccharide.
Scientists have developed an antibacterial coating that embeds viruses to destroy bacteria, with the coated films retaining their effectiveness for up to three months. The coating, made from a combination of pullulan and trehalose, has shown promise in preventing bacterial contamination of food.
Researchers at Rice University and the University of Science and Technology of China have developed a combination of antibacterial phages and magnetic nanoparticle clusters that infect and destroy bacteria protected by biofilms in water treatment systems. The innovative material, which uses bacteriophages combined with nanoparticles, c...
Scientists used bacteriophages to treat a patient with a deadly, antibiotic-resistant bacteria. The patient recovered well after the treatment, which could be an alternative to failing antibiotics for treating multidrug-resistant infections.
Researchers discover bacteriophages that can effectively reduce bacterial levels and improve health in mice infected with antibiotic-resistant 'superbugs.' The study's findings suggest phages could be a promising alternative to antibiotics, with potential benefits including fewer side effects and the ability to evolve against resistance.
Researchers at ETH Zurich found that inflammation triggers the transfer of phage genes to Salmonella bacteria, increasing their pathogenicity. Vaccination can prevent this process, alleviating the risk of phage release.
Scientists at the University of Liverpool have shown that phage therapy can kill drug-resistant strains of Pseudomonas aeruginosa, a common cause of chronic lung infections in Cystic Fibrosis patients. The study suggests that phage therapy could be a valuable addition to treatment options for these hard-to-treat infections.
A Rice University study models the dynamic evolution of the microbial immune system, revealing a three-region phase diagram where phages thrive or are driven to extinction. The study explains confusing CRISPR experimental results by highlighting the importance of encounter rates and mutation parameters.
Researchers at Texas A&M AgriLife Research have found that viruses make decisions about their actions in host bacteria, similar to human decision-making. The study's findings could lead to the development of more effective phage therapy for treating bacterial diseases.
A team of scientists from Tufts University has developed a virus cocktail that prevents cholera infection in animal models. The treatment, which uses bacteriophages to target the cholera bacteria, was found to be effective in eliminating the bacteria and reducing symptoms in over half of treated animals.
Researchers developed a new analytical procedure using bioconjugates to identify bacterial species in minutes, reducing waiting time and increasing measurement accuracy. The technique uses a flow cytometer and is easy to adapt and inexpensive.
Scientists have identified two bacteriophages, dubbed superspreaders, that promote the transfer of antibiotic resistance genes in bacterial communities. These phages, SUSP1 and SUSP2, can efficiently release plasmid DNA intact upon phage lysis, which may drive bacterial evolution in natural environments.
Researchers discovered that phages can invade bacteria by transferring attachment molecules via membrane vesicles, facilitating horizontal gene transfer and expansion of the phage host range. This mechanism enables phages to deliver DNA into new species, promoting attachment to non-host species and potentially transmitting antibiotic r...
A study published in PNAS details a mathematical model of the timing of phage-induced cell death, revealing high precision and counterintuitive insights into regulatory mechanisms. The research has implications for medicine and broader applications in chemical kinetics, ecological modeling, and statistical physics.
Researchers at the University of Pittsburgh are using cross-assembly phage (crAssphage) as an indicator of fecal contamination in water, which can help prevent disease outbreaks and improve public safety. The study aims to establish a correlation between crAssphage presence and pathogens in irrigation water.
Phage therapy, which uses viruses to kill bacteria, has shown no adverse effects in clinical trials and holds promise for treating antibiotic-resistant infections. Researchers plan to use phages against E. coli in the gut or MRSA on the skin, with a goal of establishing a central repository for phages.
Researchers found a phage carrying animal-like DNA related to the black widow spider toxin gene, which also shares DNA with animal genomes. This discovery may provide insights into genetic engineering Wolbachia to fight diseases.
The University of Copenhagen is receiving $1 million to research manipulating intestinal flora for obesity prevention. The project, PhageGut, aims to use lytic phages to shape the composition of the intestinal flora and prevent obesity.
Researchers at the University of Nevada, Reno have successfully reduced salmonella bacteria in ground poultry, pork, and beef by up to 90% using bacteriophages. The study's findings offer promising results for improving food safety in the meat industry.
Silva-Valenzuela will work in the laboratory of Andrew Camilli to determine which types of bacteriophages can effectively eliminate the cholera bacteria in water. The team aims to develop a novel approach to prevent cholera outbreaks.
EPFL scientists have described the atomic-level mechanism of bacteriophage infection using state-of-the-art tools. The breakthrough reveals how the baseplate coordinates attachment and contraction of the viral tail, shedding light on a complex process that has major implications for medicine and research.
A new study found that nonpathogenic viruses can be transferred during fecal transplants, but these viruses appear to be harmless to humans. The researchers analyzed fecal transplants from a single donor to three children with chronic ulcerative colitis and found mostly temperate bacteriophages were transmitted.
A new study published in PLOS Biology reveals a vast diversity of RNA viruses that infect bacteria, with over 122 new types identified. This discovery opens up new avenues for understanding the ecological dynamics between bacteriophages and bacteria, and potentially developing new strategies to combat antibiotic-resistant infections.
Researchers have identified 122 new types of RNA bacteriophages in diverse ecological niches, providing an opportunity to define their contributions to ecology and explore them as novel tools. The study suggests that RNA bacteriophages likely play a much larger role in shaping the bacterial makeup of worldwide habitats than previously ...
Scientists are exploring the potential of bacteriophages, which target specific bacteria, to prevent and treat intestinal illnesses like Salmonella, Campylobacter, and E. coli in children. The research aims to develop a new approach for treating food poisoning in developing countries.
Researchers at San Diego State University discovered that bacteriophages employ subdiffusive motion to find and kill bacteria in mucosal surfaces. This novel hunting strategy is more effective when bacterial concentrations are high, making it a unique approach among predators on Earth.
Researchers have engineered viruses to target specific bacteria, offering a new approach to combatting human disease. The customizable viruses could be used to treat various infections, including those caused by E. coli, Yersinia, and Klebsiella bacteria.
Researchers at Brigham Young University have successfully used bacteriophage to decontaminate human MRSA bacteria from surfaces and fabrics, showing promise in treating the deadly superbug. The findings offer hope in combating antibiotic-resistant MRSA, which can cause serious disease and death.
Researchers at Texas A&M AgriLife Research have discovered a natural cocktail of four bacteriophages that can prevent and treat Pierce's disease in wine grapes. The phage treatment offers an alternative to pesticides for disease control, with promising results in both greenhouse experiments and field testing.
Researchers found phages in 49 out of 50 chicken samples that can transduce antimicrobial resistance genes to E. coli bacteria, highlighting the need for phage therapy and improved disinfection methods.
Researchers found that nearly half of chicken meat samples contained viruses capable of transferring antibiotic resistance genes. Phages were able to transfer resistance to multiple antibiotics, including extended spectrum betalactam antibiotics.
Researchers identified a bacteriophage from Jerusalem sewage that can infect and eliminate Enterococcus faecalis biofilms, a common cause of persistent root canal infections. This phage therapy approach may offer a new solution for combating antibiotic-resistant bacteria.
Scientists at Brigham Young University have developed a natural treatment using phages to protect baby bees from American Foulbrood, a deadly disease that kills off larvae and leads to hive collapse. The researchers identified five phage candidates for honeybee treatment, providing a potential alternative to antibiotics.
Researchers found that phages can force cholera bacteria to give up their virulence in order to survive, making them less fit to cause infection. This discovery suggests a new strategy for treating or preventing cholera using phage therapy.
Researchers have discovered how viruses called bacteriophages can be engineered to target and destroy a range of bacteria, including antibiotic-resistant C. diff, which causes fatal infections in hospitals. The study provides hope for developing an alternative to antibiotics.
Researchers have developed a way to identify isolated pieces of DNA floating outside the bacterial chromosome, which can play important roles in virulence and antibiotic resistance. Extrachromosomal DNA elements, such as phages and plasmids, were found widespread among medically important strains of Staphylococci.
A team of researchers found that a significant portion of life uses different vocabularies where the same word means different things in different organisms. This challenges the long-held assumption of a universal genetic code, with up to 10% of bacteria possessing codon reassignments.
Researchers at the University of Missouri have developed a new method for anthrax detection that can identify anthrax in just five hours, compared to current tests which take 24-48 hours. The new method uses a bioluminescent reporter phage to detect anthrax bacteria and rule out false positives.
A new alternative approach to traditional introductory laboratory courses significantly increases student retention rates. Research published in mBio found that SEA-PHAGES students continued on to their second year at over 90% higher rates than other groups.
A new study at Caltech describes a mechanism for bacterial biofilms to induce the transformation of marine invertebrates from larvae to adults. Researchers discovered that phage tail-like structures, similar to those used by viruses to inject genetic material into bacteria, play a crucial role in this process.
Researchers have isolated viruses that specifically target the highly infectious hospital superbug C. diff, which can cause severe diarrhoea and dehydration. The discovery could lead to a new treatment for this condition, with the potential to revolutionise the way it is treated in clinics.
Researchers at the University of Arizona have identified a dozen new types of unknown viruses infecting different strains of marine bacteria. These bacteriophages play key roles in global processes such as oxygen and carbon cycling, climate patterns, and nutrient availability.
Researchers found that bacteriophages significantly reduce C. difficile cells and toxin production without harming the gut microbiota, offering a potential new therapeutic agent to combat hospital infections. However, some bacteria may develop resistance due to lysogeny, requiring further development to control C. difficile infections.
Researchers discover gut viruses confer antibiotic resistance to bacteria by transferring genes that help them withstand multiple antibiotics, raising concerns about the emergence of superbugs and the need for a new approach to mitigate development of antibiotic resistance
A new study reveals that certain viruses, known as bacteriophages, can hijack the immune systems of bacteria to overcome their defenses. This discovery has significant implications for phage therapy, which could potentially treat bacterial infections resistant to antibiotics.
Scientists have identified a unique phage that acts as a predator, infecting and harming competing bacterial strains in the human intestine. The discovery could lead to new techniques for controlling bacteria in a natural way, opening up questions about the role of phages in shaping gut communities.
Scientists have isolated and studied 11 viruses that can infect and kill the acne-causing bacterium P. acnes, potentially paving the way for topical therapies. The study found that these phages share a high degree of similarity in their DNA, making it less likely to develop resistance to phage-based antimicrobial therapy.