Articles tagged with Human Immunodeficiency Virus
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Researchers at Stanford University School of Medicine have compiled a list of 93 common HIV mutations associated with drug resistance to track the spread of the virus. The updated list is based on data from over 15,000 patients and will be used globally to gauge the effectiveness of HIV medication programs.
Leading scientists issue a challenge to find a way to purge latent HIV infection and eliminate the need for chronic therapy. A drug-free remission goal requires understanding of persistent infection reservoirs and combination approaches.
A new study compares cholesterol treatment in HIV patients and those without HIV, finding that lipid-lowering therapies are effective but not as effective as in non-HIV patients. The study suggests using fibrates with NNRTIs to manage triglyceride levels in HIV patients.
Researchers have successfully infected pig-tailed macaques with a human version of HIV, creating an animal model for studying prevention methods. The new strain, simian-tropic HIV-1 (stHIV-1), can spread almost as quickly as in humans and persists for several months.
Researchers analyzed genetic data from over 2,800 HIV-infected patients to identify 14 'escape mutations' that help the virus survive. These mutations allow the virus to evade the immune system's destruction, making it challenging to develop effective AIDS vaccines.
Dr. Sara Sawyer will use a $120,000 grant to study how HIV and its host cells have evolved together over time. By analyzing the genomes of primates, she aims to identify critical genes and proteins that could lead to new antiviral drug targets.
Research in Cameroon reveals that 88.3% of women are willing to accept HIV testing during labor, leading to a higher rate of detected infections compared to previously estimated rates. The study recommends an opt-out approach for HIV testing during labor to increase the number of mother-infant pairs receiving appropriate treatment.
A new study found that gene therapy can be developed as a potentially effective treatment for HIV, reducing viral load and preserving the immune system. The technique involves delivering genes to cells to prevent viral replication, with promising results in a clinical trial involving 74 HIV-positive adults.
A new study reveals that the majority of US states have laws consistent with or neutral toward the CDC's revised HIV testing guidelines. Despite concerns about opt-out screening, the study finds protections for patient autonomy are not required by state laws in many cases.
The study solved the structure of a biological protein from the vaccinia virus, providing insights into its relationships with other viruses. This discovery is significant as it can help develop new therapies to treat various viruses, offering potential solutions to outbreaks and pandemics.
A UK survey found that only 30% of mental health workers discuss sexual health issues with service users, despite 80% agreeing it's an important part of their role. The study also revealed low levels of awareness about HIV risks among people with schizophrenia, leading to concerns about infection rates and staff safety.
Population immunity to measles was insufficient to interrupt transmission three years after a mass vaccination campaign in Zambia. Repeated mass vaccination campaigns are necessary to achieve high routine vaccine coverage and reduce measles deaths and illness.
A five-year Canadian study led by Dr. Cécile Tremblay aims to develop new strategies to fight AIDS in individuals who naturally control their HIV infection progression. The study will analyze factors predicting favourable outcomes and identify drivers of HIV diversity.
A variant of the protein Nef has been identified as a potential target for HIV treatment, with the goal of suppressing its production to prevent AIDS progression. Researchers believe that a drug affecting Nef could provide protection against the virus and complement existing therapies.
A team of researchers highlights challenges and concerns with unlinked anonymous HIV testing in developing countries. They outline strategies to harmonize high-quality surveillance with international ethical standards, including reviewing justifications, providing confidential voluntary testing, and strengthening local capacity.
A Johns Hopkins study found that HIV-positive kidney transplant recipients can achieve one-year survival rates comparable to those without HIV, provided key risk factors for transplant failure are recognized and controlled. The study's results reflect the impact of newer antiretroviral therapies on reducing HIV-related deaths.
Scientists have identified a critical element in HIV pathogenesis: the translational control of HIV-1 RNA in the cytoplasm. A Sam68 mutant suppresses Nef expression by sequestering nef mRNA, offering a new strategy for developing anti-HIV therapeutics.
A study published in Blood journal reveals that individuals with rare blood type Pk are more resistant to HIV infection, while those without it are more susceptible. This discovery paves the way for new therapeutic approaches to induce HIV resistance and promote further understanding of the pandemic.
Prisons have high-risk environments for HIV transmission due to needle-sharing. Implementing needle/syringe programs (NSPs) and opioid substitution therapy (OST) can reduce risky behavior, overdose deaths, and improve relationships between prisoners and staff. These measures are essential for protecting prisoners' health.
A new study found that circumcision significantly reduced HIV infection risk in heterosexual African American men with known exposure. The study's findings complement previous research on adult male circumcision in Africa.
HIV can infect immune cells in a woman's vaginal tract through the skin, not just through breaks or lesions. The virus penetrates healthy genital skin to reach its targets within four hours.
Researchers have identified broad-spectrum aptamers that can treat many subtypes of HIV-1 by inhibiting reverse transciptase. These synthetic molecules can reduce viral infectivity and block the normal action of RT enzyme.
Scientists at Northwestern University found that HIV can penetrate female genital tissue by moving quickly between skin cells, allowing the virus to reach immune cells. This discovery challenges the long-held assumption that the female genital tract is an efficient barrier to viral penetration.
A new study found that HIV's rate of evolution slows significantly when a patient's CD4+ T-cell count drops, which can happen long before symptoms of AIDS appear. This change allows the immune system to keep up with the virus, potentially making it harder for it to develop resistance to treatment.
A study of 1833 HIV patients found that specific mitochondrial DNA genotypes accelerate AIDS development, while others delay it. This suggests that genetic tests could provide accurate prognoses and guide early treatment initiation.
The American College of Physicians recommends that physicians adopt a routine screening policy for HIV, encouraging patients to get tested regardless of risk factors. Timely identification of undiagnosed cases can help prevent HIV transmission.
Researchers at Penn State have discovered that increasing selenium levels in human blood cells can reduce the multiplication of the AIDS virus. By targeting a specific protein called Tat, selenium can slow down viral replication, with results showing a 10-fold decrease.
A WHO study suggests that universal voluntary HIV testing combined with immediate treatment after diagnosis could significantly reduce HIV cases in a severe epidemic. The strategy aims to accelerate the transition from an endemic phase to an elimination phase, reducing HIV cases to 1 per 1000 people within 10 years.
A landmark study found that early HIV testing and treatment in infants significantly improves survival rates, reducing mortality by 75% and HIV-related disease by four times. The study's results led to the World Health Organization's new guidelines for treating HIV-infected infants under age 1 immediately after diagnosis.
A meta-analysis published by the American Association for Cancer Research found that individuals with HIV have a higher risk of non-AIDS cancers compared to the general population. The risk is significantly higher for men than women, and incidence rates are similar between those with AIDS and without.
A study by Associate Professor Katherine Samaras reveals that HIV treatment causes inflammation, leading to increased cardiac and metabolic risk. Patients with HIV-infection tend to gain weight around their abdomen, increasing their risk of heart disease and diabetes.
Scientists discovered a key step in HIV's attack on brain cells and were able to reverse its effects by blocking the receptor. The discovery opens up a new avenue for researchers to explore in preventing or treating HIV's neurological effects, which have no currently approved treatment.
Scientists have identified a crucial role for sulfonation in HIV replication, finding that inhibiting this pathway can compromise viral gene expression and render host cells resistant to infection. This discovery provides a promising new target for HIV/AIDS therapy.
Researchers at UCLA discovered a chemical called TAT2 that can prevent or slow telomere shortening in immune cells, potentially making it a key weapon in the fight against HIV. The study found that TAT2 treatment prolonged the ability of killer T-cells to divide and inhibited HIV production.
Researchers have engineered T cells that can recognize HIV-1 strains that evade the immune system, a breakthrough with implications for treating patients with chronic infection. The engineered T cells respond vigorously to HIV, allowing fewer cells to control infection.
Researchers have engineered killer T-cells with a receptor that can recognize and destroy HIV-infected cells, regardless of the virus's disguise. This technology may lead to a powerful therapy for HIV treatment and could also be applied to other infectious agents.
Researchers found that acyclovir can directly slow down HIV infection by targeting the reverse transcriptase enzyme. However, this effect also leads to the emergence of resistant HIV variants, such as the V75I strain, which could compromise current treatments.
The Medical College of Georgia has received a $100,000 grant from the Bill & Melinda Gates Foundation to develop an antibody-based vaccine against HIV-1. Dr. Pandelakis Koni aims to target conserved areas of the virus's sugar coating, which he believes could be vulnerable to attack.
Researchers found that many worries were based on misconceptions about HIV spread and that HIV-infected parents had legitimate concerns about contracting infections while caring for a sick child. Pediatricians can help address children's fears and educate families about proper precautions to reduce risks.
A new study found a correlation between anti-HIV immune response and sexual activity in treatment-suppressed HIV patients. Individuals with regular unprotected receptive anal intercourse showed stronger anti-HIV immune responses.
Researchers at University of Southern California reveal the atomic structure of APOBEC-3G, an enzyme that stops HIV replication. The discovery suggests new directions for developing anti-HIV drugs by targeting a viral protein that blocks the enzyme.
Researchers discovered that HIV-1 group M strain began spreading among humans between 1884 and 1924. The study suggests urbanization played a significant role in the pandemic's emergence. A genetic analysis revealed evidence of common ancestor around 1900, indicating an earlier origin than previously thought.
The study reveals that growing urbanization in colonial Africa allowed the HIV virus to flourish, leading to the outbreak of the epidemic. The researchers used genetic sequencing to analyze ancient samples and found that the pandemic strain emerged around 1900.
The MOTIVATE trials show maraviroc significantly suppresses the virus at 48 weeks, increasing immune system T-cell counts and providing consistent clinical benefit for treatment-experienced patients with R5 HIV-virus infection. Maraviroc provides a valuable additional treatment option for a wide spectrum of treatment-experienced patients.
A binational team of researchers found that brief but personalized behavioral counseling significantly reduced rates and improved condom use among female sex workers. The study showed a 40% decline in new STIs, including HIV, syphilis, gonorrhea, and Chlamydia.
Researchers have discovered that the antiviral drug acyclovir can suppress HIV in patients infected with both herpes and HIV. Acyclovir works by targeting the unique enzyme present in herpes virus HHV-6, converting it into a compound capable of attacking HIV directly.
A study by Indiana University found that rural HIV care providers face significant stigma and discrimination, hindering their ability to provide quality care. This has important health and economic implications, highlighting inefficiencies in the public health system.
The latest child mortality figures show a 27% decrease in global mortality rates for children under five since 1990. Despite progress in some low-income countries, many are not on track to meet the target of reducing child mortality by two-thirds between 1990 and 2015.
African countries are grappling with a growing number of chronic infectious and non-communicable diseases due to scale-up of antiretroviral therapy for HIV. Mortality from all-cause diseases increased by 87% between 1992 and 2005, primarily due to rising deaths from infectious disease affecting both sexes.
Researchers at Gladstone Institutes have discovered a gene, Apobec3, that controls the production of antibodies neutralizing retroviruses, including HIV. This finding may lead to the development of an HIV vaccine by eliciting neutralizing antibodies.
A study led by Yuntao Wu reveals how HIV triggers a cell process that activates cofilin, allowing the virus to cross the cell membrane. This fundamental understanding may lead to the development of new therapeutic tools to block viral interaction.
Iowa State University researcher Robert Jernigan's study reveals proteins have controlled motions, contradicting traditional biochemist views. The research, published in journal Structure, shows that protein motions are restricted and part of the function of the proteins.
Researchers discovered ABC-transporters expressed on vascular endothelial cells, which decrease the intracellular concentrations of anti-HIV drugs like saquinavir and zidovudine. Inhibiting these transporters with verapamil or MK-571 increases drug retention, suggesting a potential therapeutic strategy to improve HAART efficacy.
Researchers at Albert Einstein College of Medicine found that a component of intestinal bacteria helps HIV penetrate the blood-brain barrier, increasing the risk of cognitive disorders. The discovery could lead to new strategies for preventing HIV from entering the brain and causing serious complications.
A novel approach to treating HIV/AIDS uses customized dendritic cells to stimulate immune response, showing potential for innovative therapeutic approach
A study of married Indian women found that those who experienced physical and sexual violence from their husbands had an increased risk of HIV infection. The prevalence of HIV among abused women was approximately four times higher than non-abused women, highlighting the importance of addressing intimate partner violence in preventing H...
Researchers at Johns Hopkins Medicine found a rare case of an individual with HIV who remains symptom-free without treatment, attributed to the strength of their immune system. The study's findings offer hope for vaccine development and understanding of how immune cells can effectively halt disease progression.
Researchers found that 76% of studies on pediatric adherence to ART in low-income countries reported more than 75% adherence, compared to lower rates in high-income countries. The study's findings suggest that children in these countries can maintain comparable or better adherence to ART as those in high-income countries.
Researchers at Wake Forest University Baptist Medical Center are launching a study to investigate the impact of mistrust in medical care on Latino HIV patients' mortality rates. The study aims to understand cultural and social factors contributing to this disparity.
A new study has identified younger, recently diagnosed men and those who binge drink and use substances like methamphetamine as high-risk groups for HIV transmission. These findings suggest the need for more targeted prevention programs to address the rising rates of HIV diagnoses among these men.