Articles tagged with Pathogens
Researchers are examining a cropping system using molasses to stimulate microbial activity, which could replace the fumigant methyl bromide. The study also explores recently developed fumigants dimethyl disulfide and methyl iodide.
A recent study proposes a new method for assessing the societal benefits of mandating more stringent food processing practices. Consumers were surveyed and found willing to pay $305 million annually for a 10% reduction in E. coli contamination, exceeding a previous USDA estimate of $446 million.
Virginia Tech receives a $2.7 million grant to study integrated management of zoosporic pathogens and irrigation water quality for a more sustainable green industry. The project aims to develop biologically based control methods and best management practices to recycle irrigation water safely.
Countries with low risk and stable health systems have higher feasibility for malaria elimination. Latin America is in the best position to achieve this, while sub-Saharan African countries face substantial difficulties due to political instability, weak health systems, and high transmission rates.
USDA scientists have developed vaccines to protect farm-raised catfish against key diseases, including Streptococcus iniae and S. agalactiae. The modified live vaccine has been shown to create a lifelong immunity in fish, with previous research breakthroughs benefiting the catfish industry.
The Virginia Bioinformatics Institute is developing mathematical models to understand immune responses to gut pathogens, aiming to accelerate disease prevention and treatment. The Center for Modeling Immunity to Enteric Pathogens will generate new hypotheses through computer simulations and experimental research.
Researchers found that free heme released from red blood cells during infection causes organ failure, but hemopexin can neutralize its toxic effects. Administering hemopexin improves survival rates in mice and may predict mortality in patients with severe sepsis.
A new study found that HIV-infected individuals who start antiretroviral therapy (ART) soon after acquiring the virus have stronger immune responses to other pathogens compared to those who start ART later. Early treatment restores resting memory B cells and reduces immature B cells, leading to improved immune system function.
Researchers at ASU's Biodesign Institute have developed new technologies to create a potential therapeutic that can protect soldiers against an unknown pathogen in just 7 days, significantly reducing the time needed for production. The project aims to utilize synthetic antibodies or synbodies to rapidly construct a custom-tailored ther...
Researchers at Iowa State University have discovered a special set of sugars that helps certain pathogens evade the body's natural defenses and vaccines. The finding may lead to new research for developing vaccines or cures for diseases like tuberculosis.
Severe inflammatory responses to initial UTI cause bladder damage and allow infection to persist longer. Immunodeficient mice lacking these acute inflammatory responses are protected from chronic bladder infection. Researchers hope to identify patients vulnerable to recurrent infection using markers discovered in the study.
Researchers found that organic farming increases beneficial predator populations, reducing insect pests and promoting larger potato plants. This biodiversity conservation may be the secret behind organic farmers' success in achieving high yields.
Researchers evaluate promising new potato varieties for improved quality and longer storage life, targeting up to 10 months. They've identified genetic causes for early sprouting and are working towards non-chemical solutions.
A new study by North Carolina State University researchers links the number of diseases in a region to its climate and biodiversity, with hot, wet climates having more pathogens. The prevalence of diseases, however, is influenced by health-care spending, particularly in regions with low spending.
A new system developed by Texas AgriLife Research can automatically scan water samples and detect potential pathogens like cryptosporidium and giardia, providing results immediately. This technology has the potential to address key challenges in pathogen detection in food and water, making it accessible globally.
Bdelloid rotifers have evolved to avoid parasites and pathogens by desiccating and drifting away on the wind. This mechanism allows them to establish new, uninfected populations and evade biotic enemies without sex.
The Eukaryotic Pathogen Genome Database Resource has been expanded with a new contract to support worldwide research into human pathogens. The database provides tools for identifying vaccine antigens and drug targets, facilitating the search for effective diagnostics.
Researchers at the Max Planck Institute have discovered how immune cells, such as white blood cells, move on various surfaces. They found that these cells use a 'clutch and wheels' system, involving cell anchors and cytoskeleton deformation to maintain constant speed, enabling them to adapt to different substrates.
Researchers found widespread poor compliance with regular cleaning of public restrooms on cruise ships may predict subsequent norovirus infection outbreaks. The study evaluated the thoroughness of disinfection cleaning and found that toilet seats were best-cleaned objects while baby changing tables were least cleaned.
Researchers have sequenced the genome of Phytophthora infestans, the cause of the Irish potato famine, to aid in its control and development of chemical-free methods. The pathogen's unique genetic traits, including repetitive DNA sequences, play a key role in its virulence and adaptability.
Researchers identify essential virulence genes in Phytopthora infestans that can be targeted for host resistance. This discovery paves the way for novel strategies to control crop losses and improve global food security.
The University of Pittsburgh has received a $13.4 million NIH grant to establish a Center of Excellence in Modeling of Infectious Diseases. The center will develop and test computer simulations to predict the spread of infectious diseases and evaluate effective intervention strategies.
A new species of malaria parasite, Plasmodium gaboni, has been discovered in chimpanzees in Central Africa. The parasite is closely related to the human malaria agent Plasmodium falciparum and sequencing its nuclear genome may help discover new potential drug targets.
Researchers found that 80% of tested sea otters in Washington State had morbillivirus and 60% had Toxoplasma, with implications for the ecosystem's balance. The study highlights the need to monitor the health of the state's otter population, as they are 'sentinels' for environmental problems.
US Department of Homeland Security scientist Mark Nicas builds mathematical models of spittle dispersal to inform countermeasures against potential biological attacks and pandemics. His research aims to reduce the risk of infection transmission on airplanes and in other public spaces, advising people to sit at least three rows away fro...
A new review sparks debate over climate change's effect on pathogens, with some arguing it may reduce their ranges in affluent regions. However, others believe disease expansion could occur in areas where humans settle high latitudes and altitudes.
Researchers identified a novel pathway contributing to severe malaria's high mortality in sub-Saharan African children. Disrupted endothelium causes ultra-large von Willebrand factor release, leading to ADAMTS13 inhibition. This study sheds new light on the interaction between malaria parasites and their human host.
A graphical analysis assesses the vulnerability of different US crops to pests, identifying soybean and maize as highly connected, while cotton and wheat are less connected. The study suggests encouraging cropping patterns that disrupt connectivity to minimize pest spread.
Research reveals that California sea otters living in coastal areas with limited resources are more susceptible to diseases caused by parasites. The study found that diet diversity among individual otters can lead to higher infection rates, highlighting the importance of habitat quality for maintaining healthy populations.
Researchers at Centenary Institute in Australia used high-powered multi-photon microscopy to visualize the spread of a parasite through the body, gaining insights into how pathogens are recognized by the immune system. This discovery has potential to improve current vaccinations and inform vaccine design.
Genetic research reveals black rats carried a pathogenic protozoan that exterminated two endemic species on Christmas Island. The study is the first to demonstrate extinction in a mammal due to disease, contradicting most scientists' view of pathogens' effect on species.
A novel topical treatment for cold sores has demonstrated equivalent efficacy to oral systemic drugs without safety or toxicity concerns. The treatment, NB-001, speeds up healing of lesions by 1.3 days and is well-tolerated with no adverse events.
Researchers have discovered a link between Epstein-Barr virus (EBV) protein and cancer development. EBNA1 protein disrupts structures in the nucleus of nasopharyngeal carcinoma cells, interfering with tumor-suppressive processes. This finding raises the possibility that EBV could play a role in other cancers.
Researchers at Boston Children's Hospital have discovered a new mechanism of immunity that could lead to the development of a more effective pneumococcal vaccine. The study identified specific protective T-cells called TH17 cells, which release protein IL-17 to kill pneumococcus in the nose, significantly reducing the risk of infection.
Research identifies PKG as essential molecule for malaria parasite's reproductive cycle. The protein is necessary for 'rounding up' transformation, allowing fertilization to occur.
Researchers identified BILBO1 as crucial for Flagellar Pocket formation in trypanosomes. The protein is essential for the structure's functions, including endo- and exocytosis. Inhibition of BILBO1 function is fatal to the parasite.
Researchers at Kansas State University have validated a new method to destroy pathogens in beef jerky production, making it safer for consumers. The process involves additional drying time at 68 degrees Celsius to ensure both E. coli O157:H7 and Salmonella are eliminated.
The researchers have developed the first animal model of the chikungunya virus infection, which allows them to study the pathophysiology of the disease. The mouse model reveals that young age and inefficient type-I interferon signaling are risk factors for severe disease.
A recent article in Developmental and Comparative Immunology reveals that plants possess elements of specificity and responsiveness to disease-causing agents, similar to animal immunity. The study suggests that the plant immune surveillance genes diversify at a rate stimulated by pathogen presence, shedding new light on plant immunity.
A team of researchers has discovered a means of inhibiting Entamoeba histolytica, a parasite that causes colitis and kills nearly 100,000 people each year. By targeting a protein called PATMK, the study successfully prevented the parasite from eating dead cells.
Researchers found a key protein switch in Chikungunya Virus that allows it to infect and transmit through the Asian tiger mosquito, increasing its ability to spread to new locations. This mutation enables the virus to adapt to areas without typical vectors, posing a global health threat.
Researchers found seven cases of HIV-1 superinfection in 36 high-risk women over five years after initial infection. The study suggests that immune responses from natural HIV-1 infection may not be effective against re-infection, raising questions about the reliability of current vaccines.
Researchers at the University of Iowa and Veterans Affairs Medical Center discovered how African trypanosomes shed their VSG surface protein to evade the immune system of tsetse flies. This enzyme synergy is a key step in the pathogenesis of sleeping sickness, which affects 60 million people in Sub-Saharan Africa.
Research suggests human activities are amplifying the impact of Sudden Oak Death, a forest-destroying disease caused by an invasive water mold. The study found that connected forests with high host species abundance have higher pathogen loads, while smaller, isolated forests have lower disease levels.
A new virus has been identified as the cause of death in three organ transplant recipients in Australia, who received organs from the same donor. The virus is related to known strains of lymphocytic choreomeningitis virus but has a distinct genetic sequence that could not be detected with existing diagnostic methods.
A new triplex assay developed by Ingeneus Research enables direct detection of base sequences in human genomic DNA, eliminating the need for PCR. The assay uses YOYO-1 to de-condense duplex targets, allowing specific oligo probes to bind and detect sequence variations.
US crops are susceptible to attack by terrorists, who could use devastating plant pathogens as weapons. The need for prevention and preparedness strategies is crucial, including border inspections, crop surveillance, and rapid pathogen identification.
Scientists at the University of Illinois have discovered that a combination of ozone, high-intensity ultrasound, electrolyzed water, irradiation, and temperature is most effective in reducing E. coli 0157:H7 pathogens to meet FDA standards.
A population-based study of 13,613 brain tumor cases in Sweden found that people with four or more siblings were twice as likely to develop a brain tumor. Children under 15 with three or more younger siblings had a two to fourfold increase in brain tumors compared to those with no siblings.
American researchers have created a new basis for portable, multiplexed biodetection systems using silver and gold striped nanowires as supports for simultaneous immunological tests. The unique patterns of stripes act like barcodes, allowing for fast and accurate identification of multiple pathogens.
The Program in Systems Immunology and Infectious Disease Modeling (PSIIM) aims to understand complex biochemical networks regulating interactions between pathogens and human cells. The program employs Simmune software to simulate biological systems, enabling scientists to predict how drugs affect cell behavior and develop new treatments.
Researchers found that malaria and potato famine pathogens use similar protein sequences to infect cells, but deliver different toxic proteins. This discovery could lead to the development of a dual-purpose drug targeting both Plasmodium falciparum and Phytophthora infestans.
A study analyzing 35 soldiers' remains identified lice carrying DNA from Bartonella quintana and Rickettsia prowazakii, linking these diseases to Napoleon's retreat from Russia. The findings suggest louse-borne diseases were a major factor in the army's decline.
The BEADS system detects toxin from environmental samples, then uses antibodies to purify and concentrate the pathogen or toxin for accurate detection. The system has been commercially licensed and can detect multiple pathogens simultaneously.
Researchers at the University of Toronto have developed a detection technique using DNA to pinpoint diseases and pathogens. The system, which involves a fluorescent dye attached to probe DNA, can detect target DNA sequences in a matter of seconds and is being seen as a potential game-changer for clinical care and environmental monitoring.
A new program aims to reduce food-related illnesses by investigating the causes of these illnesses and identifying effective interventions. Led by Canadian researcher Jan Sargeant at McMaster University, this US-funded initiative brings together a multidisciplinary team of experts from 18 colleges and universities.
PathPort is a life sciences interoperability framework providing access to biological characterizations of known pathogens and their near relatives. The project aims to aid in detection, identification, and analysis of high-priority pathogens using its analytical tools and data models.
Changes in land use have implications for disease distribution and human health, with activities like deforestation and urban sprawl contributing to the spread of Lyme disease and malaria. The report calls for policy changes and research investments to address these issues.
Researchers found that climatic factors are the most important determinant of human pathogen distribution, contradicting conventional assumptions about disease control. Understanding ecological links between disease and environment could inform effective preventive strategies.
A recent study has identified 14 resistant vegetable varieties that can help pumpkin growers wait out the deadly P. capsici pathogen. Rotating these crops may provide a temporary solution until the pathogen is safe to plant pumpkins again, which could mitigate yield losses of up to 100 percent.