Articles tagged with Pathogens
Researchers found that mice infected with hookworms produce super-killer macrophages that are efficient at killing the worms but also cause tissue damage and inflammation. The study reveals that RELMalpha, an immune protein, helps balance immunity and inflammation by downregulating inflammatory responses.
African trypanosomes confuse immune defense with sugar chains on surface proteins, increasing pathogenic properties. Scientists discover binding sites for sugars in multiple VSGs, hindering antibody binding and immune response.
Researchers isolated ancient viral sequences from human remains and found a common pathogen associated with humans for over 6,900 years. The study reveals the pathogen evolved significantly slower than previously thought, showcasing the utility of ancient viral sequences in studying virus evolution.
In water-limited landscapes, sick animals may have more contact with others due to lethargy, leading to faster pathogen transmission. The study suggests that understanding sickness behavior can help predict and control disease transmission in wildlife and domestic animals.
Scientists at DKFZ and SickKids found that certain antibodies can cooperate with each other to bind stronger to malaria parasites, improving the immune response. This discovery could lead to the development of more effective vaccines against malaria.
At 43% vaccine coverage, a low-efficacy vaccine (20% effective) could avert over 20 million infections, 61,000 deaths, and 2.2 million lost DALYs in the US. The optimal strategy involves targeting elderly populations as efficacy decreases.
A single foodborne outbreak could cost a restaurant millions of dollars in lost revenue, fines, lawsuits, legal fees, insurance premium increases, inspection costs and staff retraining. Foodborne illness outbreaks can have large, reverberating consequences regardless of the size of the restaurant.
Researchers at McMaster University have developed a transparent test patch that can signal contamination as it happens, using harmless molecules. The patch can be incorporated into food packaging and monitor contents for harmful pathogens like E. coli and Salmonella, providing a definitive indication of safety before consumption.
Researchers discovered a key step in blood digestion that can be targeted to disrupt hookworm development. Testing quinolones disrupted hemozoin formation, interrupting development and reproduction, offering promise for new treatments against human-infecting hookworms.
Scientists developed a method to predict how global warming affects disease severity, using the metabolic theory of ecology. The study showed that different processes have unique relationships with temperature, and that linking these theories can describe how disease interactions change with global warming.
Researchers at Washington State University have developed a new method for soil pathogen analysis that is portable, fast and inexpensive. This breakthrough technology allows farmers to detect disease-causing pathogens in their soil quickly and make informed decisions about treatments or management changes before planting.
A study in São Paulo found that mosquitoes that transmit diseases are adapting to urban environments, thriving in smaller green spaces where other species disappear. The research highlights the need for further study on how habitat loss affects vector insects and disease transmission.
A new multiplex test can detect six of eight tick-borne pathogens including Lyme disease simultaneously in a single blood test, offering improved diagnostic accuracy. The test's potential for early detection and treatment is expected to improve patient outcomes for those infected with tick-borne diseases.
Researchers Ryosuke Omori and Jianhong Wu develop an inductive algorithm to study site-specific nucleotide frequencies using a multi-strain SIR model. The algorithm calculates Tajima's D, a statistical test that measures natural selection at a specific site.
Research in Psychological Science finds that thinking about potential infection activates the behavioral immune system, leading individuals to focus on their own physical appearance. Germ-averse participants reported more insecurity and interest in appearance-related behaviors and products after reading scenarios about potential pathog...
Researchers at University of California San Diego have found a new pathway called Intracellular Pathogen Response (IPR) that helps animals cope with certain types of stress and attacks, including heat shock. The study reveals the IPR gene pals-22, which increases tolerance to heat shock when expressed in roundworms.
A new study found that certified nursing assistants frequently failed to change gloves, leading to the spread of dangerous pathogens in nursing homes. The study recommends improved glove use behavior and monitoring to reduce the risk of disease transmission.
A Michigan State University doctor and professor teamed up to document high rates of Group B Streptococcus colonization in Nigeria. They identified new risk factors, allowing for effective treatment and significantly reducing infant mortality rates.
Drexel University researchers found associations between acute gastrointestinal illness and water turbidity, even at low levels. Cloudy drinking water provides a place for germs like norovirus, Giardia, and Cryptosporidium to hide, increasing the risk of illness.
Researchers discovered that innate immune system's DNA-sensing mechanism controls cellular senescence, promoting the secretion of inflammation-mediating proteins. This process plays a role in various contexts of senescence, including oxidative stress, oncogene signaling, and irradiation.
Research reveals that co-infection with two common gut pathogens, Giardia lamblia and enteroaggregative Escherichia coli, increases weight loss and impairs metabolism in mice. The study provides new insights into the impact of gut microbe interactions on malnutrition in children.
A study published in Nature Physics reveals that small changes in physical parameters can significantly impact the formation and growth of cell-cell contacts. The researchers used computer simulations and experiments to investigate the biophysicics of cadherin proteins, which play a crucial role in maintaining cellular bonds.
A UK research team found Campylobacter on nearly half of the boots worn by volunteer walkers in countryside areas, with prevalence varying by region and season. The study used a novel method to assess human/pathogen interactions, providing insights into potential routes of infection.
Research reveals that strong feelings about immigrants are controlled by the immune system, particularly in people with a hypersensitive behavioral immune system. This leads to misconceptions about infection risks and a reluctance to interact with immigrants, blocking integration paths.
Scientists at Columbia University's Mailman School of Public Health report elevated levels of Babesia microti, a pathogen responsible for babesiosis, in Suffolk County, New York. The new test can strengthen surveillance for tick-borne illnesses, which are underreported and growing rapidly.
A recent study published in Scientific Reports found that individuals sensitive to sexual disgust are more likely to make duty-based moral judgments, similar to those who follow Immanuel Kant's moral philosophy. This is surprising, as previous research has shown no connection between moral disgust sensitivity and moral preferences.
Researchers studied mandrill behavior in Gabon's rainforests, finding they avoid sick individuals through olfactory cues. This 'behavioral immune system' minimizes parasite transmission, influencing social behavior and co-evolution.
Researchers at Fraunhofer Institute develop a prototype lab-on-a-chip platform for automating molecular pathogen detection, enabling diagnostics in previously inaccessible situations. The platform integrates multiple processes without increasing complexity, promising to simplify pathogen analysis.
A recent study published in the American Journal of Infection Control found that hospital floors can be contaminated with harmful pathogens such as MRSA, VRE, and C. difficile. The researchers cultured floor sites from 159 patient rooms and discovered that 41% had high-touch objects in contact with the floor, highlighting the need for ...
A study of 12 years of community-acquired pneumonia data found that while the condition occurs throughout all seasons, winter is the peak season for pathogen variation. The research suggests that community-acquired pneumonia can no longer be classified as a seasonal disease.
The study identifies seven scenarios of pathogen movement and disease epidemics, posing significant threats to economically important eucalypt plantations and native ecosystems. Biosecurity failures are linked to poorly controlled germplasm movement, underscoring the need for enhanced surveillance and regulation.
Scientists have developed machine learning algorithms to recognize insect feeding patterns causing devastating damage worldwide, including citrus greening through probing on host tissues. The technology enables rapid screening and disruption of pathogen transmission, benefiting agriculture, livestock, and human health.
Researchers at the University of Houston developed a smartphone-based water testing system using DotLens technology. The system uses commercially available test kits with a low-cost attachment that provides a narrow-band light source, allowing users to identify waterborne pathogens such as Giardia lamblia and Cryptosporidium parvum.
A new multistate research project aims to educate fruit and vegetable growers on agricultural water treatment systems. The project will develop a curriculum to equip growers with knowledge to successfully implement water treatment systems, reducing the risk of foodborne pathogens.
Researchers found resveratrol reversed mouse heart dysfunction by improving pumping efficiency and reducing oxidative damage. The study suggests potential for resveratrol and similar substances to treat Chagas cardiomyopathy in humans.
Researchers have uncovered two novel virulence mechanisms employed by Leishmania parasites to circumvent the host's antimicrobial defenses. GP63 and CPB proteases play a central role in these processes, allowing the parasite to manipulate host cell membrane fusion machinery and evade phagocytosis.
A study of 869 Tsimane women over 12 years found that high birthrates do not significantly impact maternal health, contrary to expectations. Despite a harsh environment with limited nutrition and high parasite exposure, women experience minimal health costs from their intense reproductive effort.
A new study from UTSA professor Mark Eppinger describes innovative strategies to track disease-causing pathogens like E. coli, featuring whole genome sequence typing of outbreak strains. By analyzing subtle traits among outbreaks, researchers can pinpoint the origin and severity of an outbreak.
Researchers discovered TNF's mechanism to protect against intracellular pathogens like Leishmania major. By inhibiting arginase 1, TNF increases nitric oxide production, which suppresses the pathogens, providing a plausible explanation for increased infection susceptibility during anti-TNF treatments.
Researchers have identified potential new antimalarial drugs targeting the parasite's heat shock protein 90 (Hsp90), a key player in its survival and resistance to treatments. The study uses innovative modelling technology to isolate compounds that can destroy the pathogen without affecting human cells.
A new study by Kaitlin Wowak and colleagues reveals that time pressures, supply chain permeation, and product characteristics hinder traceability. To overcome these barriers, firms can adopt different traceability requirements for perishable products and use 'nicknames' to track blended products.
The study analyzed 1,297 invasive insect pests on 124 countries, finding the US, China, India, and Brazil to be the highest potential cost impacters. Smaller developing countries like those in sub-Saharan Africa are disproportionately vulnerable due to their reliance on agriculture.
Researchers developed a new technique to study the gene shuffling process that creates diverse immune cell receptors. By analyzing the frequency of use of different V segment genes, they uncovered complex regulatory mechanisms involved in receptor diversity.
Researchers at Michigan State University have developed a new packaging method that enhances the safety and quality of onions, one of the highest-volume vegetables sold worldwide. The package and sanitizer combination led to diced onions being acceptable for purchase after two weeks of storage.
Researchers at UC Riverside have identified an immune protein called RELMalpha that protects the body from damage caused by hookworm infections. The protein is found in mice and is expected to function similarly in humans.
A study found that adjunctive use of minocycline microspheres significantly reduced levels of subgingival bacterial species and improved clinical outcomes for patients with peri-implantitis. This resulted in a greater reduction in pocket depth compared to mechanical debridement alone.
Pathogens and Immunity, an online, open-access journal, simplifies the submission and review process, reducing it from one day to five minutes. Senior editors at Case Western Reserve University School of Medicine revise biomedical publications standards in immunology and infectious diseases.
A recent study suggests that the Bombus occidentalis bumble bee may be making a comeback in the Pacific Northwest. The population's resurgence is believed to be linked to evolution and a decline in the impact of the Nosema parasite. This reversal could have significant implications for local ecosystems.
A World Health Organization task force found that up to 33 million healthy life years are lost each year due to foodborne diseases. Diarrheal disease agents were the most frequent causes of foodborne illness, particularly norovirus and Campylobacter spp.
Researchers found that urban areas have higher pathogen abundance and lower honey bee survival rates compared to rural environments. The study suggests that increased transmission rates in urban areas may be the primary cause of this effect.
The study reveals that vultures have a strong immune system due to their diet and genetic adaptations. The cinereous vulture's genome shows variations in genes related to immunity and defense against microbial and viral infections, which may help combat pathogens in their diet.
Helper T cell proteins Oct1 and OCA-B work together to put immune response genes on standby, allowing for rapid activation upon re-exposure. This study sheds light on the molecular mechanisms controlling immunological memory in CD4+ cells.
Three new species of trombiculid mites and 23 new records of previously-known species have been found in Taiwan, increasing the total number of chigger species to 47. The discovery highlights the potential for more species to be discovered in mountainous regions.
Engineers at the University of California, Riverside discovered that nearly 15% of baby spinach leaf surface area may reach concentrations as low as 1000 times that of bleach disinfectant, allowing bacteria to survive and spread. The study highlights the limitations of current disinfection methods in reducing cross-contamination.
Kasturi Haldar and Grant McFadden emphasize the importance of basic research in their articles on PLOS Pathogens. They share their personal experiences and highlight how fundamental research can lead to breakthroughs in fields like malaria, cancer, and inflammatory diseases.
Researchers at Northeastern University have identified dormant persister cells in Borrelia burgdorferi that evade antibiotics. Two potential methods to eradicate the infection were also found, including pulse-dosing an antibiotic to eliminate persisters.
Researchers at Norwich BioScience Institutes have discovered plant receptors with built-in decoys that detect pathogens, triggering the plant's defense mechanism. These receptors are designed to trick pathogens into binding with them, which then triggers a shutdown of the cell to contain the pathogen.
A joint study reveals the power of citizen science in predicting the emergence and spread of sudden oak death, a fungus-like disease that has felled hundreds of thousands of trees in California. The SOD Blitz model, created using crowdsourced data, correctly predicts the presence of the pathogen 74% of the time.
Researchers tracked protein coats on sleeping sickness parasite, finding up to 80 distinct disguises present at any time. This challenges conventional understanding of antigenic variation and its role in parasite survival.
Research finds mice infected with Lyme disease pathogen facilitate spread of babesiosis, a lesser-known emerging disease. Lyme disease and babesiosis share symptoms, but babesiosis is potentially fatal in immunocompromised patients and poses additional public health threat.