Articles tagged with Pathogens
Researchers at the University of Illinois are developing a smartphone-based diagnostic system that can detect pathogens in less than 30 minutes using a single drop of blood. The system, which will be handheld and cost less than $10, has the potential to provide fast and affordable results for patients in developing countries.
A study published in Scientific Reports found that Arctic sea ice reduction facilitates the spread of disease among marine mammals, particularly through open water routes. Widespread exposure to Phocine distemper virus (PDV) was observed in sea mammals across the North Pacific Ocean, peaking in 2003-2004 and again in 2009.
Agri-Neo's Neo-Temper technology eliminates harmful pathogens in flour through an organic, non-thermal process, preserving nutritional qualities while integrating seamlessly into existing tempering processes. The solution has been validated in four commercial mills in the US and Canada, with a waiting list for additional millers.
Scientists used X-ray microscopy to study the digestive process of malaria parasites, revealing that they store hemoglobin in their digestive vacuole. The parasites then crystallize toxic hemozoin molecules, which active compounds may prevent from forming by disrupting their detoxification process.
Infections acquired by patients in Canadian hospitals are declining, with a 30% reduction between 2009 and 2017, reveals new research published in CMAJ. Urinary tract infections were the most common type of infection, followed by pneumonia and surgical site infections.
A survey of 16,475 households found that raw pet food was a contaminant in only three households, with most common pathogens being Campylobacteria and Salmonella. Most households did not report any infections, with 99.6% reporting no pathogen transmission from raw food.
Research found that parasitic helminths like Schistosoma mansoni can block HIV-1 interactions with dendritic cells and induce CD4 lymphocytes that down-modulate infection. This could influence disease course in co-infected individuals.
ApoE promotes hepatitis B virus infection and production, but targeting it with inhibitors may serve as an antiviral strategy for chronic HBV infection. Research found that apoE is enriched on the virus envelope and its expression impairs HBV production.
Research found associations between serum antibodies against P. gingivalis and A. actinomycetemcomitans with altered metabolite levels, including lipoprotein particles and fatty acids. These findings suggest exposure to periodontal pathogens may contribute to a proatherogenic state.
Recent research suggests that pathogens may have driven the evolution of warm-blooded animals by providing a selective advantage. By maintaining stable body temperatures, mammals and birds can prime their immune systems to withstand virulent pathogens, making endothermy a more favorable strategy than ectothermy.
A new ventilation system has been shown to reduce the risk of airborne infections in hospital rooms, which can cause serious complications for immunosuppressed patients. The study found that displacement ventilation systems can reduce the risk of exposure to airborne pathogens compared to traditional mixing ventilation systems.
Research reveals that vaccines may be less effective at higher pathogen doses and when individuals have similar susceptibility, such as younger or malnourished populations. Mathematical modeling simulations validated these findings with real-world data from nearly 6,000 articles.
A recent study has identified Corynebacterium ulcerans, a close relative of the diphtheria-causing bacterium, in diseased hedgehogs. The discovery raises concerns about animal-to-human transmission and emphasizes the importance of proper hygiene measures and vaccination for protection against diphtheria.
A handheld biosensor has been developed to quickly and accurately detect cryptosporidium contamination in water samples, providing immediate results. The technology has real potential for use in medical and environmental applications.
A global alliance of researchers has pioneered a new method to rapidly recruit disease-resistance genes from wild plants for transfer into domestic crops. The technique, called AgRenSeq, promises to transform the development of disease-resistant varieties for the global food supply.
Researchers at the University of East Anglia have confirmed cases of RHDV2 in UK hares, contributing to a decline of over 80% in brown hare populations due to agricultural changes. The expanding dataset will help map reported mortalities over time and identify primary causes of the die-off.
Research reveals that trypanosomes use gluconeogenesis and glycerol metabolism to produce ATP and synthesize glucose, challenging the long-held assumption of exclusive reliance on glycolysis. This metabolic flexibility is essential for adaptation to environmental conditions and survival in mammalian host tissues.
Maintaining high negative pressures (-10 Pa in hospital rooms, -5 Pa in renovation sites) effectively limits airborne contaminant dispersion. Local airflow patterns are more important than air change rates for efficient removal of infectious agents.
A recent study of amber-preserved blood-sucking insects and ticks reveals that malaria-causing microorganisms date back at least 100 million years, with evidence of pathogens carried by ancient vectors found in fossilized amber from around the world.
Researchers analyzed over 57,000 publications on swine pathogens from 1966 to 2016, revealing emerging infectious diseases with increased research funding priority. Global networks of swine pathogen research were also mapped, showing regional collaboration patterns and colonial relationships.
Researchers at UC Davis will use genomics to combat downy mildew in lettuce, a pathogen causing $3 billion industry losses annually. The project aims to reduce crop losses and improve profitability for farmers, while providing consumers with produce using fewer chemicals.
A study by North Carolina State University found that sunflower pollen reduces infection rates in bees and improves colony health. However, it also had a deleterious effect on honey bees, leading to higher mortality rates compared to other diets.
Researchers analyzed ancient DNA from a human skeleton in Scandinavia to determine the genomic blueprint of the louse-borne relapsing fever pathogen Borrelia recurrentis. The study found that the ancient strain had fewer genes for antigenic variation and retained a regulatory gene, suggesting reductive evolution.
A 10-year US study found the highest Salmonella enterica serotype Newport infection incidence in the South and among children under 5. Antimicrobial resistance rates were also highest, with 88% of isolates susceptible to all tested antimicrobials.
Researchers found that mice infected with hookworms produce super-killer macrophages that are efficient at killing the worms but also cause tissue damage and inflammation. The study reveals that RELMalpha, an immune protein, helps balance immunity and inflammation by downregulating inflammatory responses.
African trypanosomes confuse immune defense with sugar chains on surface proteins, increasing pathogenic properties. Scientists discover binding sites for sugars in multiple VSGs, hindering antibody binding and immune response.
Researchers isolated ancient viral sequences from human remains and found a common pathogen associated with humans for over 6,900 years. The study reveals the pathogen evolved significantly slower than previously thought, showcasing the utility of ancient viral sequences in studying virus evolution.
In water-limited landscapes, sick animals may have more contact with others due to lethargy, leading to faster pathogen transmission. The study suggests that understanding sickness behavior can help predict and control disease transmission in wildlife and domestic animals.
Scientists at DKFZ and SickKids found that certain antibodies can cooperate with each other to bind stronger to malaria parasites, improving the immune response. This discovery could lead to the development of more effective vaccines against malaria.
At 43% vaccine coverage, a low-efficacy vaccine (20% effective) could avert over 20 million infections, 61,000 deaths, and 2.2 million lost DALYs in the US. The optimal strategy involves targeting elderly populations as efficacy decreases.
A single foodborne outbreak could cost a restaurant millions of dollars in lost revenue, fines, lawsuits, legal fees, insurance premium increases, inspection costs and staff retraining. Foodborne illness outbreaks can have large, reverberating consequences regardless of the size of the restaurant.
Researchers at McMaster University have developed a transparent test patch that can signal contamination as it happens, using harmless molecules. The patch can be incorporated into food packaging and monitor contents for harmful pathogens like E. coli and Salmonella, providing a definitive indication of safety before consumption.
Researchers discovered a key step in blood digestion that can be targeted to disrupt hookworm development. Testing quinolones disrupted hemozoin formation, interrupting development and reproduction, offering promise for new treatments against human-infecting hookworms.
Scientists developed a method to predict how global warming affects disease severity, using the metabolic theory of ecology. The study showed that different processes have unique relationships with temperature, and that linking these theories can describe how disease interactions change with global warming.
Researchers at Washington State University have developed a new method for soil pathogen analysis that is portable, fast and inexpensive. This breakthrough technology allows farmers to detect disease-causing pathogens in their soil quickly and make informed decisions about treatments or management changes before planting.
A study in São Paulo found that mosquitoes that transmit diseases are adapting to urban environments, thriving in smaller green spaces where other species disappear. The research highlights the need for further study on how habitat loss affects vector insects and disease transmission.
A new multiplex test can detect six of eight tick-borne pathogens including Lyme disease simultaneously in a single blood test, offering improved diagnostic accuracy. The test's potential for early detection and treatment is expected to improve patient outcomes for those infected with tick-borne diseases.
Researchers Ryosuke Omori and Jianhong Wu develop an inductive algorithm to study site-specific nucleotide frequencies using a multi-strain SIR model. The algorithm calculates Tajima's D, a statistical test that measures natural selection at a specific site.
Research in Psychological Science finds that thinking about potential infection activates the behavioral immune system, leading individuals to focus on their own physical appearance. Germ-averse participants reported more insecurity and interest in appearance-related behaviors and products after reading scenarios about potential pathog...
Researchers at University of California San Diego have found a new pathway called Intracellular Pathogen Response (IPR) that helps animals cope with certain types of stress and attacks, including heat shock. The study reveals the IPR gene pals-22, which increases tolerance to heat shock when expressed in roundworms.
A new study found that certified nursing assistants frequently failed to change gloves, leading to the spread of dangerous pathogens in nursing homes. The study recommends improved glove use behavior and monitoring to reduce the risk of disease transmission.
A Michigan State University doctor and professor teamed up to document high rates of Group B Streptococcus colonization in Nigeria. They identified new risk factors, allowing for effective treatment and significantly reducing infant mortality rates.
Drexel University researchers found associations between acute gastrointestinal illness and water turbidity, even at low levels. Cloudy drinking water provides a place for germs like norovirus, Giardia, and Cryptosporidium to hide, increasing the risk of illness.
Researchers discovered that innate immune system's DNA-sensing mechanism controls cellular senescence, promoting the secretion of inflammation-mediating proteins. This process plays a role in various contexts of senescence, including oxidative stress, oncogene signaling, and irradiation.
Research reveals that co-infection with two common gut pathogens, Giardia lamblia and enteroaggregative Escherichia coli, increases weight loss and impairs metabolism in mice. The study provides new insights into the impact of gut microbe interactions on malnutrition in children.
A study published in Nature Physics reveals that small changes in physical parameters can significantly impact the formation and growth of cell-cell contacts. The researchers used computer simulations and experiments to investigate the biophysicics of cadherin proteins, which play a crucial role in maintaining cellular bonds.
A UK research team found Campylobacter on nearly half of the boots worn by volunteer walkers in countryside areas, with prevalence varying by region and season. The study used a novel method to assess human/pathogen interactions, providing insights into potential routes of infection.
Research reveals that strong feelings about immigrants are controlled by the immune system, particularly in people with a hypersensitive behavioral immune system. This leads to misconceptions about infection risks and a reluctance to interact with immigrants, blocking integration paths.
Scientists at Columbia University's Mailman School of Public Health report elevated levels of Babesia microti, a pathogen responsible for babesiosis, in Suffolk County, New York. The new test can strengthen surveillance for tick-borne illnesses, which are underreported and growing rapidly.
A recent study published in Scientific Reports found that individuals sensitive to sexual disgust are more likely to make duty-based moral judgments, similar to those who follow Immanuel Kant's moral philosophy. This is surprising, as previous research has shown no connection between moral disgust sensitivity and moral preferences.
Researchers studied mandrill behavior in Gabon's rainforests, finding they avoid sick individuals through olfactory cues. This 'behavioral immune system' minimizes parasite transmission, influencing social behavior and co-evolution.
Researchers at Fraunhofer Institute develop a prototype lab-on-a-chip platform for automating molecular pathogen detection, enabling diagnostics in previously inaccessible situations. The platform integrates multiple processes without increasing complexity, promising to simplify pathogen analysis.
A recent study published in the American Journal of Infection Control found that hospital floors can be contaminated with harmful pathogens such as MRSA, VRE, and C. difficile. The researchers cultured floor sites from 159 patient rooms and discovered that 41% had high-touch objects in contact with the floor, highlighting the need for ...
A study of 12 years of community-acquired pneumonia data found that while the condition occurs throughout all seasons, winter is the peak season for pathogen variation. The research suggests that community-acquired pneumonia can no longer be classified as a seasonal disease.
The study identifies seven scenarios of pathogen movement and disease epidemics, posing significant threats to economically important eucalypt plantations and native ecosystems. Biosecurity failures are linked to poorly controlled germplasm movement, underscoring the need for enhanced surveillance and regulation.
Scientists have developed machine learning algorithms to recognize insect feeding patterns causing devastating damage worldwide, including citrus greening through probing on host tissues. The technology enables rapid screening and disruption of pathogen transmission, benefiting agriculture, livestock, and human health.
Researchers at the University of Houston developed a smartphone-based water testing system using DotLens technology. The system uses commercially available test kits with a low-cost attachment that provides a narrow-band light source, allowing users to identify waterborne pathogens such as Giardia lamblia and Cryptosporidium parvum.
A new multistate research project aims to educate fruit and vegetable growers on agricultural water treatment systems. The project will develop a curriculum to equip growers with knowledge to successfully implement water treatment systems, reducing the risk of foodborne pathogens.
Researchers found resveratrol reversed mouse heart dysfunction by improving pumping efficiency and reducing oxidative damage. The study suggests potential for resveratrol and similar substances to treat Chagas cardiomyopathy in humans.
Researchers have uncovered two novel virulence mechanisms employed by Leishmania parasites to circumvent the host's antimicrobial defenses. GP63 and CPB proteases play a central role in these processes, allowing the parasite to manipulate host cell membrane fusion machinery and evade phagocytosis.