Articles tagged with Caloric Restriction
Dr. Mey directs the Mitochondrial Energetics and Nutrient Utilization (MENU) Laboratory at Pennington Biomedical, researching precision nutrition and metabolic health. He will represent Pennington Biomedical and the Academy as a Media Spokesperson.
A low-calorie diet and behavioral support program significantly reduced weight in older patients with overweight and persistent atrial fibrillation at 8 months. The study found no safety concerns or impact on atrial fibrillation symptoms, cardiac remodeling, or need for further rhythm control interventions.
A new study suggests that fitspiration content on social media can lead to negative self-esteem, unhealthy dieting, and exercise habits among young adults. Researchers analyzed 26 studies involving 6,111 individuals across seven countries, finding that even brief exposure to idealized images can trigger harmful comparisons.
A study published in Obesity found that young adults exposed to a diet high in ultra-processed foods ate more calories at an all-you-can-eat meal. The researchers, led by Brenda Davy and Alex DiFeliceantonio, used a controlled feeding study to investigate the effects of ultra-processed food on eating habits.
A global review of 71 studies found that short-term fasting has no meaningful difference in mental performance for most adults. However, children and adolescents performed poorly, emphasizing the importance of breakfast before school. Fasting also impaired tasks involving food-related cues.
A Mediterranean-style diet, along with reduced caloric intake and moderate physical activity, has been shown to lower the risk of type 2 diabetes by 31%. The study found that participants in the intervention group lost an average of 3.3 kilograms and reduced their waist circumference by 3.6 centimeters.
A new study found that moderate caloric restriction can preserve youthful ovarian follicles and reduce age-related tissue stiffness in rhesus macaques. This suggests that lifestyle-based strategies may help delay the decline in reproductive function associated with aging.
A Japanese study found that choosing the right type of meal can extend meal duration and encourage more mindful eating. Researchers discovered that traditional bento-style meals with individual components promoted longer meal times and more chewing compared to fast food.
A study published in Appetite found that positioning main course options from lowest to highest calorie amounts increases the likelihood of adolescents choosing healthier meals. The experiment showed a significant reduction in calorie content when lower-calorie options were made more accessible.
A cross-sectional study found that TV football game food ads are often high in sodium, calories, and fat content. This can pose a risk to adults with pre-existing heart conditions, who may be vulnerable to dietary deviations due to frequent exposure to advertising.
Researchers found that people on caloric restriction lost telomeres more rapidly at first and then more slowly after their weight stabilized. The two-year timeline was not sufficient to show benefits, but those may still be revealed in longer-term data collection.
A recent review highlights the positive effects of caloric restriction on cardiovascular health, linked to sirtuin activation and improved lipid metabolism. The study suggests that caloric restriction regulates metabolic processes via NAD+ levels, activating SIRT1 and modulating cardio-protective pathways.
Four studies conclude that longer genes are most susceptible to aging due to increased potential sites for DNA damage. Long genes have more sites for damage, making them prone to degradation with age, contributing to conditions like Alzheimer's disease.
Researchers followed 12 healthy volunteers taking part in a seven-day water-only fast, measuring thousands of proteins in their blood. The study showed that the body undergoes significant changes across multiple organs after three days without food, with potential health benefits visible only after this period.
Weight loss treatments such as nutrition counseling and bariatric surgery increased the patient-level probability of achieving significant weight loss. Current treatment utilization rates are insufficient to impact the population level, highlighting a need for improved access.
Researchers at PLOS discovered that a diet change from glucose to galactose can slow down aging in yeast, similar to the benefits of caloric restriction. The study found that this dietary shift maintains a youthful profile in ageing yeast cells.
Researchers found that a healthy diet from an early age can suppress senescence and loss of fitness in yeast, even late in life. The study proposes an alternative to calorie restriction for improving healthy ageing through dietary change.
A randomized controlled trial found that time-restricted eating produced similar weight loss results to traditional calorie counting in a racially diverse population of adults with obesity. Participants who engaged in 8-hour time-restricted eating had improved insulin sensitivity compared to those in the control group.
Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.
A new study published in the American Journal of Preventive Medicine found that reducing added sugars consumption by an average of 14 to 57 calories per day is sufficient to meet the Healthy People 2030 target. This represents just less than half of a 12-ounce soft drink, and requires minimal changes to dietary habits.
Researchers found that alternate-day fasting combined with exercise decreased liver fat, weight, and ALT enzymes in patients with nonalcoholic fatty liver disease. The study suggests that this lifestyle modification may be a good option for treating the condition without pharmaceuticals.
The study, involving 14,000 youths aged 5-18, found a significant decrease in body mass index (BMI) after the Healthy Hunger-Free Kids Act was implemented. This suggests that school meal programs are a crucial avenue for addressing childhood obesity.
A study published in Nature Food found that hyper-palatable foods consistently led to increased calorie intake across four different dietary patterns. These meals were characterized by high energy density, fast eating rates, and specific combinations of fat, sugar, sodium, and carbohydrates.
Researchers found that the F-box gene FBXC-58 is a novel mediator of dietary restriction effects on extending the health span of Caenorhabditis elegans. FBXC-58 prevents muscle aging and extends longevity through an S6 kinase-dependent pathway.
Researchers at the University of Liverpool have found that rilmenidine can extend lifespan and slow ageing in animals, mimicking the effects of caloric restriction. The study identifies a potential longevity target, the I1-imidazoline receptor nish-1, which may be useful for future anti-ageing strategies.
Engaged feeding practices, such as recognizing fullness cues and responsive feeding, can help parents guide their children towards healthier eating habits. By adopting these practices, parents can create a positive relationship with food that lasts into adulthood.
A study of obese women on the 'warrior diet' found no significant change in sex-binding globulin hormone levels but a moderate drop in dehydroepiandrosterone (DHEA) levels, linked to reduced breast cancer risk. Women also experienced weight loss and improved insulin resistance.
Calorie labeling in supermarkets leads to small to moderate decreases in calories purchased, potentially translating to population-level health benefits. The study found declines seven months after labeling implementation, affecting prepared bakery and deli items.
Researchers found global redistribution of histone H3 modifications with time, particularly in intergenic regions and near transcription start sites. Caloric restriction diet feeding reduced the extent of changes occurring during the first year of life in these genomic regions.
Buck Institute researchers found that dietary restriction can extend lifespan in fruit flies due to changes in their circadian rhythms, particularly in the eye. The study suggests that the eye plays a role in regulating lifespan, which may have implications for human health and aging.
A recent study published in Obesity Reviews found that resistance training, in conjunction with a reduced calorie diet, can lead to significant fat mass and muscle loss. This breakthrough highlights the importance of considering non-aerobic exercise options for individuals struggling with obesity.
Researchers at UT Southwestern discovered that timing feedings to match the active period of the circadian cycle extended the life span of lab mice more than three times as much as caloric restriction alone. The findings showed improved metabolic health, lower inflammation and cancer incidence in long-lived animals.
Researchers have discovered a combination therapy that can delay sarcopenia, a condition where muscles shrink and strength declines with age. Calorie restriction and rapamycin have been shown to have additive benefits in mice, promoting healthy muscle function and physical capability.
A new study suggests that dramatic swings in food intake can have long-term impacts on cardiovascular health and metabolism. Researchers found that rats who experienced cycles of weight loss and gain had reduced heart and kidney function, as well as increased insulin resistance.
A new study found that calorie restriction improves metabolic and immune responses, generating more T cells to fight off infections and improve energy efficiency. This could lead to a potential treatment to reduce age-related inflammation and improve metabolic health.
A University of California, Riverside study found that diet impacts taste sensitivity and food choice in fruit flies, using macronutrients like sugars and amino acids for survival. Flies adjusted their taste preferences based on dietary imbalances, influencing food choices to regain a balanced diet.
Researchers found that regular cycles of a fasting-mimicking diet in mice helped counteract the negative effects of a high-fat, high-calorie diet. The study suggests that this diet may have potential as 'medicine' to prevent obesity and heart disease.
A clinical trial found that a green Mediterranean diet rich in leafy greens like Mankai and green tea can elevate fasting ghrelin levels, reducing belly fat and improving insulin sensitivity. This approach may also have additional cardiometabolic benefits.
Researchers propose a model of how caloric restriction contributes to yeast chronological aging delay by remodeling cellular metabolism. The study found that caloric restriction significantly lowers intracellular concentrations of methionine and S-adenosylmethionine, leading to a metabolic pattern of aging delay.
Researchers identified nutraceuticals that mimic caloric restriction effects by modulating insulin-like growth factor 1 receptor signaling and sirtuin activity. These compounds promote longevity and healthspan without malnutrition.
A new study by Salk scientists shows that caloric restriction can protect against aging in cellular pathways, reducing inflammation and increasing life span. The study found that 57% of age-related changes in cell composition were not present in rats on a restricted diet.
Researchers at Joslin Diabetes Center have discovered a mechanism linking caloric restriction to immune system regulation, leading to increased longevity. Caloric restriction reduces innate immunity by decreasing p38 activity, triggering a chain reaction effect.
Researchers found that a ketogenic diet improved neurovascular function and reduced neurodegeneration risk in young healthy mice. The diet also showed beneficial effects on the microbiome, blood glucose levels, and body weight.
A study on grey mouse lemurs found that chronic caloric restriction increased their median survival time to 9.6 years, compared to 6.4 years in control groups. Calorie restriction also delayed the onset of age-related pathologies and preserved motor capacities.
Research published in Frontiers in Molecular Neuroscience found that a combination of caloric restriction and low-fat diet prevents activation of brain's immune cells, called microglia, in aging mice. Exercise was significantly less effective than caloric restriction in preventing these changes.
Excessive calcium influx in brain cells can cause excitotoxicity, damaging and killing neurons. Caloric restriction increases mitochondrial calcium retention, protecting against this condition. SIRT3 protein modification inhibits cyclophilin D, allowing mitochondria to retain more calcium.
Researchers at the Buck Institute discovered a small molecule that tricks C. elegans into a state of caloric restriction, extending its lifespan by 50%. This study suggests that primary sensory pathways represent new targets for human pharmacology to mimic the positive effects of a Spartan diet.
A 25-year study of 76 rhesus monkeys found that those with calorie-restricted diets experienced a significant reduction in mortality and age-associated diseases. The study contradicts an earlier report on monkeys, which suggested no differences in survival rates between caloric restriction and control groups.
A University at Buffalo study suggests that high-carbohydrate diets in infancy may lead to increased weight gain and obesity in later life. Researchers found that even moderate caloric restriction could not reverse the programming effect.
Researchers created an atlas that maps molecular connections between caloric restriction and aging, identifying pathways in mitochondria that control metabolism. The study suggests therapies targeting Sirt3 function could provide novel interventions to prevent age-related illnesses.
Italian scientists at Catholic University of Rome discovered a molecule called CREB1 triggered by low-calorie diets, activating genes linked to longevity and brain functioning. Caloric restriction has been shown to extend life and prevent brain diseases in mice.
Researchers at the University of Gothenburg have identified an enzyme required for caloric restriction to work effectively, which can slow down ageing and delay the development of age-related diseases. Increasing the production of another enzyme, Srx1, repairs damaged Prx1, potentially counteracting genetic defects and cancer.
A Stanford study found that caloric restriction may not be beneficial for infected fruit flies, contradicting previous findings. The research suggests that diet-restricted animals may fare poorly when infected with certain pathogens.
A study of rhesus macaques has shown that consuming fewer calories leads to a longer, healthier life, with a reduced risk of age-related diseases such as cancer, diabetes, and cardiovascular disease. The diet also preserved brain health, particularly in regions responsible for motor control and executive functions.
Researchers have discovered that yeast cells can extend their lifespan by up to 5-fold when converted to use glycerol instead of glucose for energy, offering an alternative to caloric restriction. This metabolic switch also enhances the cells' resistance to damage and may provide insights into human aging.
A new study found that caloric restriction does not extend the life of lean mice, contradicting previous findings. Obese mice, however, benefited from caloric restriction, suggesting it may be a useful strategy for weight loss. The researchers propose that energy expenditure and intake should be in balance.
A new study found that low doses of resveratrol mimic the heart-healthy effects of caloric restriction, suggesting a possible explanation for France's low incidence of heart disease. The compound may also promote mitochondrial health and have anti-aging benefits.
Researchers found that low doses of resveratrol, a natural constituent in red wine, mimic the effects of caloric restriction on aging. The study shows that small doses can elicit many benefits as a reduced-calorie diet, including prevention of heart decline associated with aging.
A mouse study has found that caloric restriction leads to beneficial hormonal changes, which play a role in extending life. The study suggests that calorie restriction is more effective than exercise in promoting longevity.
Research published in American Journal of Lifestyle Medicine suggests that lifestyle changes can mitigate the risks associated with metabolic syndrome. The study highlights exercise and caloric restriction as valid treatment strategies for this prevalent condition, which affects 23% of adults in the US.