Articles tagged with Gerontology
Researchers found that waves of cerebrospinal fluid, which clear waste from the brain during sleep, are significantly reduced in older adults. This impairment is linked to decreased slow brain waves during deep sleep and is not solely due to reduced sleep duration.
Researchers propose a 'central dogma of aging' framework that explains how genomic instability, telomere attrition, and metabolic imbalances interact to drive aging. The model suggests that interventions targeting multiple layers of the network are more effective than single-target approaches.
Researchers found potentially beneficial molecular changes in the liver and kidneys of aged mice, alongside signals in the spleen that raise concerns about long-term safety. However, larger controlled studies are needed to assess functional outcomes and safety in humans.
A new framework proposes that communication between cells and organs plays a central role in amplifying age-related changes, shifting focus from cellular damage to systemic signaling. The framework suggests that restoring healthier systemic communication could be important for coordinated late-life rejuvenation.
The GSA KAER Framework will be implemented in primary care settings to improve Alzheimer's care, focusing on brain health conversations, cognitive assessment, and referrals. This initiative aims to strengthen care pathways and support earlier diagnosis and intervention.
Extracellular vesicles, including exosomes, play critical roles in intercellular communication, influencing aging and cancer progression. Research highlights similarities in molecular signals between aging and cancerous cells, suggesting potential links between the two conditions.
Insilico Medicine releases Longevity Grok, a 24/7 AI system that unifies personal health records, tracks biological analysis, and provides personalized lifestyle interventions. The system also drives communal AI-powered geroscience research and features a zero-trust architecture for data privacy.
A new study identifies three genes associated with ferroptosis and immune infiltration in Duchenne muscular dystrophy, suggesting a connection to age-related muscle degeneration. The findings may reveal new approaches to preserving muscle function and guiding future research into molecular biomarkers.
A new review proposes the Polycentric Aging Framework, which suggests that epigenetic regulation is a dominant factor limiting human lifespan. The framework identifies three major constraint layers, including epigenetic regulation, irreversible genetic and physical damage, and the accumulation of damaged proteins and organelles.
Researchers developed a personalized indicator that analyzes ten blood substances to predict health problems and guide healthy aging in middle age. The tool shows promise in reducing the risk of chronic diseases, with a one-point increase corresponding to a 14-year delay in cardiometabolic disease onset.
Researchers found that small extracellular vesicles released by senescent cells can induce senescence in neighboring cells, promoting a stable growth-arrested state without activating classical inflammatory pathways. These findings reveal a key mechanism of intercellular communication and tissue aging.
A study found that body composition, particularly fat-free mass percentage and body fat distribution, is associated with inflammation and growth hormone levels in middle-aged men. However, these associations disappeared after adjusting for body fat, suggesting that body fat may help explain the observed relationships.
Nir Barzilai, Lauren B. Gerlach, and Richard J. Hodes will receive AFAR's Scientific Awards of Distinction for their groundbreaking work in aging research. The ceremony will take place on November 5, 2026, at the GSA Annual Scientific Meeting.
Researchers propose targeting G protein-coupled receptors to slow aging, exploring AI, systems biology, and digital twins for therapy design. The approach could work alongside senolytic, metabolic, and regenerative strategies.
Researchers propose novel therapies to rebalance GPCR signaling, potentially extending healthy years of life and delaying multiple age-related diseases. This network-level approach could give rise to personalized treatments and complement emerging longevity strategies.
Researchers found that hypomagnetic fields extend survival in a fly model of Parkinson's disease, but reduce mobility. The study suggests that magnetic field strength may be a potential therapeutic strategy, particularly in the context of ageing and neurodegenerative disease.
Researchers propose using aging rate indicators to detect interventions that slow aging pace. The study aims to accelerate anti-aging breakthroughs, but regulatory barriers and equitable access are discussed.
The mTOR signaling pathway is a central regulator of cellular metabolism, stress adaptation and tissue maintenance. Carefully controlled modulation of mTOR signaling could support future strategies for healthy aging.
A new control theory framework introduces a mathematical framework for understanding aging and guiding the development of therapies. The framework prioritizes maintaining or recovering acceptable physiological function, rather than targeting every molecular feature to a youthful state.
According to a new poll, 60% of older adults spend less than an hour choosing their Medicare coverage during Open Enrollment, with 27% not reviewing their options at all. 80% stick with their current coverage, and 25% consult Medicare's plan-finding tool or hotline as their most important source of information.
The study found that disrupting PLA2G15 reduced stress-induced cellular senescence in mouse kidney cells while altering the composition of phospholipids involved in lysosomal function. This suggests a possible connection between lipid metabolism, mitochondrial pathways, and kidney aging.
A new commentary proposes expanding gerophysics to include behavioral complexity, which may complement molecular and biological markers of aging. Measuring changes in movement, physiological rhythms, and other behavioral patterns could help identify declining resilience and the transition to frailty. The concept of complexity reserve m...
The Gerontological Society of America has awarded fellowships to 15 US journalists to cover aging-related topics, including social isolation, long-term care, and healthcare. The selected journalists will produce in-depth stories and series in 2027, with funding from several organizations.
Researchers investigated the effects of mini-GRID radiotherapy on glioma cells, finding it reduced senescence and preserved growth inhibition, whereas conventional radiotherapy induced senescence. The study suggests that mini-GRID's spatial dose distribution may be responsible for this difference.
Researchers have identified a Sardinian village as a potential new 'blue zone' for exceptional longevity, with women living nearly 21 years longer than men. The study found that 13.8% of women in Bolotana reach 100 after 70, compared to 3.5% in Italy and 3.6% in the US.
The 11th International Cell Senescence Association Conference brings together researchers worldwide to advance understanding of cellular senescence and its roles in aging, cancer, and disease. Aging supports the conference through a $200 cash poster prize recognizing outstanding scientific research.
A new review outlines clinical, digital trial, and AI strategies to bring tai ji quan into routine fall-prevention care, reducing falls and improving mobility among older adults. The proposed three-pillar roadmap aims to close the evidence-to-practice gap, emphasizing human expertise and AI-enabled technologies.
The editorial highlights the need for disaster preparedness tailored to older adults' unique circumstances, including chronic health conditions and social supports. It suggests interventions that integrate disaster planning into routine clinical care and build organizational capacity in assisted living communities and nursing homes.
Research found that unfavorable social determinants of health are associated with a higher risk of dementia in adults with and without type 2 diabetes, with particularly strong associations observed among women with T2D. The study also found that diabetes-related dementia risk varies across social environments.
A study analyzing 2,928 Spanish-speaking participants found that machine-learning clocks based on speech can estimate chronological age and brain aging. The speech clock was associated with biological aging, cognitive health, cumulative burden, and dementia.
CHARGE syndrome is a rare developmental disorder that may be linked to developmental senescence, a tightly controlled cellular program involved in embryonic tissue remodeling. Disruption of this program may contribute to the characteristic abnormalities associated with the disorder.
Researchers discovered that moderate-intensity exercise significantly improved cartilage health and tissue resilience in aging-related osteoarthritis. The molecular cargo of extracellular vesicles was found to be enriched with microRNA-29, which restored youthful characteristics in cartilage cells and reduced joint degeneration features.
Wiley has launched two new research journals, Advanced Medicine and Advanced Healthy Aging, as part of its expanding Advanced Portfolio. The new journals aim to elevate breakthrough science that impacts lives, reflecting Wiley's commitment to accelerating science that addresses humanity's most pressing challenges. Led by expert editori...
Long-lived organisms exhibit better DNA maintenance, stress resistance, regenerative capacity, and stem-cell populations compared to shorter-lived species. Comparative genomic studies have identified longevity-associated pathways, including apoptosis, protein homeostasis, and oxidative-stress resistance.
A new study from Wake Forest University School of Medicine found that chronic stress and social support levels are associated with changes in cognitive abilities across different demographic groups. Higher social support was linked to less decline in attention over time, while women and Hispanic participants with higher chronic stress ...
Participants with mild disabilities experienced a $1,177 annual reduction in care costs, compared to non-participants. Community gathering places promote social participation, exercise, and mutual support, contributing to healthy aging and mitigating long-term care costs.
The Gerontological Society of America's 2026 Annual Scientific Meeting will take place in National Harbor, Maryland, from November 4 to 7. The event is expected to feature nearly 600 scientific sessions, making it the country's largest interdisciplinary conference in the field of aging.
A Tulane University study found that loneliness and social isolation can cost people nearly six years of life free from mental disorders like depression and anxiety. The study, published in Nature Communications, also found a smaller but still significant toll on physical health.
The Neighborhoods Study, a nationwide NIH-funded research initiative, investigates the relationship between social and environmental factors and Alzheimer's disease risk. Emory Goizueta Brain Health Institute is part of the study, which aims to understand how environmental exposures influence brain health and dementia risk.
A new framework proposes that chronic overactivation of the DNA damage response may drive biological aging. Persistent DDR signaling can stabilize p53, increase p21 and p16INK4a, promoting cell-cycle arrest and senescence. This forms the basis of the
Researchers at MIT have developed a noninvasive way to detect biomarkers of senescence, a state of cells that stop dividing but do not die, using Raman microscopy and gene expression data. This method could lead to better diagnosis and treatment of age-related disorders.
A new Cochrane review suggests that personalized programs to prevent falls in older people may not be effective in reducing falls. The review found that multifactorial programs, which are tailored to individual risk, have little or no benefit in preventing falls compared to standard medical care, exercise, or falls prevention education.
The new NCCN Guidelines for Patients with Cancer explain the importance of assessments to tailor cancer care to every person, regardless of age. The guidelines stress the need for support and validation for older adults, who face unique issues such as memory function and treatment interactions with other medications and conditions.
A new study published in Aging reveals that a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, showing improved glucose metabolism can coexist with immune-cell accumulation and liver fibrosis. The findings separate liver inflammation and fibrosis from insulin resistance, obesity and lipi...
A study of 7,500 adults found that healthy eating is associated with slower biological aging, with no single diet being superior. The researchers examined ten dietary patterns and found that all were linked with slower aging, with some more effective than others.
Researchers found that exosomes from people with shingles pain caused nerve cells to remain inflamed and transmit pain signals even after the virus clears the body. This discovery opens the door to new approaches for predicting, preventing, and treating post-herpetic neuralgia.
Cellular senescence is recognized as a key driver of aging, linked to telomere dysfunction, chronic inflammation, and stem cell exhaustion. Experimental evidence supports its causal role, with removal of senescent cells delaying age-related pathologies.
Research shows broad consensus among ICU recommendations for elderly patients, with female clinicians agreeing more on multidisciplinary input, such as pharmacist involvement and dietitian advice. Male clinicians showed stronger agreement on life-sustaining therapy decisions.
Research reveals that targeting insulin/IGF-1 signaling pathway in C. elegans extends male lifespan by 446% and improves reproductive healthspan, with whole-body degradation required for reproductive benefits. The study highlights the importance of coordinated effects across multiple tissues and physiological systems.
A new framework proposes 'movement span' as a third dimension of aging beyond life span and health span. Movement span is defined as the duration of life during which an individual can move with confidence, responsiveness, and adaptive control.
Researchers found three herbal extracts protect mitochondrial function in a cellular model of Parkinson’s disease, suggesting a potential treatment. The extracts, including Uncaria rhynchophylla, Gardenia jasminoides, and Scutellaria baicalensis, improved cell viability and mitochondrial function in cells with reduced VPS13C expression.
The Gerontological Society of America (GSA) is partnering with Plans4Care, Inc. to offer a certificate course on engaging family caregivers. The course,
The Gerontological Society of America supports the 2026-27 respiratory season vaccine evidence review, highlighting the importance of evidence-based immunization recommendations across the life course. Vaccinations continue to provide meaningful protection against severe illness, hospitalization, and death for individuals of all ages.
The study found that Indy gene reduction is associated with lower bacterial load and higher bacterial diversity in aging fruit flies compared to controls. Reduced Indy activity also linked to improved intestinal homeostasis, reduced oxidative stress, and maintenance of gut integrity.
The Starr Healthspan Innovation Alliance will bridge the gap between scientific discovery and life-changing treatments for age-related diseases. The partnership will expand clinical trials and support groundbreaking laboratory research to extend healthy lifespan.
A community-adapted brain health program in Kikuyo Town, Japan, has achieved significant improvements in attention scores and dietary balance among older adults. The 24-week program, combining aerobic exercise, cognitive exercises, and lifestyle guidance, resulted in high attendance rates and positive feedback.
A comprehensive molecular study of ageing found that genetic factors and environmental influences continuously interact to shape an individual's ageing journey. Researchers identified distinct biological shifts, including correlations between environmental exposures and molecular profiles, which may indicate higher risk of disease and ...
A study found that older adults prefer chatbots that are authentic and responsive, rather than human-like, to provide companionship and support. The chatbot's ability to remember past conversations and adapt to user preferences is crucial for its success.
Researchers found that GLP-1 treatment improved muscle and cognitive function, and reduced hallmarks of natural aging in older mice. The treatment also extended lifespan by nearly 100 days, suggesting a potential therapeutic route for slowing physiological aging.
Researchers propose targeting the PGAM1-Chk1 interaction to stabilize HIF-2alpha and support senescent cell survival. Preclinical studies suggest the compound Nutlin 3b selectively removes senescent cells with improved safety profiles in aged mice models.