Gerontology
Articles tagged with Gerontology
Aging immune systems show reduced ability to clear tuberculosis during treatment
Fall prevention and delirium screening are the most effective interventions for improving surgical outcomes in older adults
Simple home test predicts mobility decline in older adults
A study published in JMIR Aging predicts early mobility decline in healthy adults aged 45 using a set of home-based measurements and AI. The researchers identified six essential factors, including age, muscle power, and diet, that accurately predict future mobility struggles.
Dietary changes in older people can improve ‘biological age’
A study published in Aging Cell found that reducing dietary fat or animal-based protein can reduce 'biological age' in older adults. After just four weeks, participants showed significant reductions in biomarker profiles indicative of improved health and aging outcomes.
Study identifies post-extubation pneumonia as a distinct condition after surgery and key risk factors
Large-scale multi-omics study aims to decode aging in the Indian population
Lifestyle, not age, predicts smart home success for older adults
A recent study reveals that an individual's readiness to adopt smart technology is deeply tied to their specific experience within their home and community. Researchers identified specific clusters within the older population, ranging from tech-ready urbanites to those in more traditional or isolated residential settings.
Nature-based group activities improve wellbeing among older adults experiencing loneliness
Human telomerase shows selective cross-species activity, revealing limits of animal models
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
NUS Medicine partners MitoQ New Zealand to deepen mitochondria-targeted research for healthy ageing
The partnership aims to generate evidence on the potential of MitoQ to slow or improve markers of biological ageing and support longevity. Mitochondria-targeted antioxidants like MitoQ are crucial in producing energy while reducing oxidative stress, a key contributor to ageing.
Study finds major gaps in dementia care across Mississippi
A new study by University of Mississippi researchers finds significant shortages in adult day services across the state, leaving thousands without daily support. The state would need an additional 910 centers to meet demand, with funding being a primary cause of shortages.
Trial now enrolling seeks to answer key question: Does adding chemotherapy to hormone therapy improve survival for metastatic prostate cancer?
The ASPIRE trial aims to enroll 1,200 participants with advanced prostate cancer and assess the impact of chemotherapy on overall survival and disease progression. Genetic profiling is included to identify patients who benefit most from intensified treatment.
Stage-specific gene expression changes reveal early triggers of cellular aging
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
From hydra to rotifers: A new hypothesis explores pathways to delay aging in humans
A new hypothesis proposes that introducing Hydra-like gene expression patterns into rotifers could delay senescence and extend healthspan. The study focuses on conserved molecular pathways, including FoxO, which plays a central role in maintaining stem cell function and cellular resilience.
Why heat deaths occur during low-level alerts - new UK study
A new UK study found that many heat-related deaths occur during lower-level alerts, highlighting widespread gaps in awareness and response. Older people are particularly vulnerable to these risks, with lower engagement with warnings leaving them exposed.
Digital reminiscence app could reduce grief and improve relationships between dementia patients and caregivers
A web tool called Living Memory Home for Dementia Care Pairs facilitates collaborative reminiscence therapy, reducing feelings of pre-death grief and improving relationship quality. The app promotes well-being and connection between dementia patients and caregivers, leading to better care outcomes.
Care by name, but not by nature
A study reveals that older adults receiving government-funded home care struggle to access the support they need, often feeling overwhelmed by complex systems and limited budgets. The research highlights a significant gap in the program's capacity to provide person-centered care, particularly in areas like nutrition.
Global experts highlight path toward actionable interventions in human aging
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
Gene–phenotype catalogue provides new insights into premature aging disorders
A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
How neighborhood amenities and infrastructure may slow cognitive decline among older immigrants
A Rutgers Health study reveals that neighborhoods with greater access to community amenities, services, and infrastructure can reduce the risk of dementia in older Chinese immigrants. The researchers found that individuals living in more cognitively supportive neighborhoods declined more slowly with age.
New study challenges bleak picture of U.S. state gaps in longevity gains
A new study published in BMJ Open suggests that US states have experienced universal gains in cohort life expectancy between 1941 and 2000, with a two-phase pattern of rapid convergence followed by stagnation. This challenges previous estimates suggesting stark disparities across states, particularly in the South.
New drug combination doubles down on Alzheimer's treatments
Researchers at the University of Waterloo have discovered a safer and more effective way to treat Alzheimer's disease by combining anti-amyloid antibodies with molecules found in grapes, berries, peanuts, and turmeric. This combination approach neutralizes amyloid protein clumping in the brain, leading to better outcomes.
ATF5 required for maintaining mitochondrial homeostasis and skeletal muscle health during aging
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
Italian Society of Gerontology and Geriatrics signs publishing agreement with MDPI
The Italian Society of Gerontology and Geriatrics has partnered with MDPI to publish its Journal of Gerontology and Geriatrics in open access. The journal, which was founded in 1953, will transition to a digital-only format starting with Volume 74, Issue 1 in March 2026.
BOLD variability modulation linked to age-specific bimanual performance
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
Do your genes dictate how your lifestyle choices impact ageing?
A new international study by Adelaide University researchers found that genetics influence how lifestyle-behavioural factors impact ageing. Healthier ageing is associated with greater physical activity, better diet, and higher educational attainment, while smoking and suboptimal sleep duration have negative effects.
Two Boston University researchers elected AAAS fellows
Boston University researchers Alice Cronin-Golomb and Plamen Ch. Ivanov have been recognized as AAAS fellows for their pioneering work on aging diseases and network physiology. Their research focuses on understanding the brain's function in healthy aging and age-related neurodegenerative diseases, such as Parkinson's and Alzheimer's.
Douglas P. Kiel, MD, MPH, elected to the Association of American Physicians
Douglas P. Kiel, a senior scientist at the Hinda and Arthur Marcus Institute for Aging Research, has been elected to membership in the Association of American Physicians due to his significant contributions to advancing medical knowledge and improving health through scientific research and academic leadership. His research focuses on o...
Mediterranean diet may boost mitochondrial signals linked to heart and brain health
Researchers found that people following a Mediterranean-style diet have higher levels of humanin and SHMOOSE, which are linked to protection against cardiovascular disease and neurodegeneration. The study suggests that specific components of the Mediterranean diet may directly influence mitochondrial biology.
New blood- and microbiome-based neural networks forecast human biological age
Researchers developed two neural network models predicting human biological age based on blood biochemistry and gut microbiota. The models demonstrated high predictive accuracy and explainability, holding potential for monitoring intervention effects in clinical trials.
Shared brain network aging patterns identified in humans, mice
Researchers found shared aging patterns in brain networks between humans and mice, highlighting a framework for studying cognitive aging and improving brain health. The study uses awake mice to examine how complex brain networks change with age, providing a platform for cross-species investigation.
Testosterone improves fat distribution for older women
A novel study found that using a topical testosterone gel in conjunction with exercise can selectively reduce visceral fat in older women who have suffered a hip fracture. This reduction in visceral fat has beneficial health impacts, including decreased risk of diabetes and cardiovascular disease.
Queensland GPs face barriers in supporting VAD: QUT study
A QUT study found wide variation in GP involvement in voluntary assisted dying (VAD) in Queensland, highlighting the need for improved remuneration, streamlined processes, and broader education. GPs reported confusion about who was eligible and how to discuss VAD with patients.
Development of build better bones: A global resource for osteoporosis self management
A new platform, Build Better Bones, offers evidence-based guidance and practical resources for osteoporosis management. The platform, developed by the International Osteoporosis Foundation, provides a trusted place for people with osteoporosis to start their journey, with a focus on exercise, nutrition, and home safety.
BSO recapitulates anti-obesity effects of sulfur amino acid restriction without bone loss
Researchers found that D, L-buthionine-(S, R)-sulfoximine (BSO) replicates the anti-obesity effects of sulfur amino acid restriction without causing bone loss in male mice. The study suggests BSO as a promising tool for dissecting the beneficial versus deleterious axes of sulfur amino acid biology.
VAD law experts talk dementia and critical issues at QUT conference
Experts will address critical issues in voluntary assisted dying and dementia, including community attitudes, Indigenous perspectives, and organ donation. The conference, open to the media and public, features over 130 presentations on VAD and its intersection with dementia.
Alliance trial aims to improve outcomes for chronic lymphocytic leukemia
The Alliance trial explores the combination of zanubrutinib and sonrotoclax for CLL treatment, aiming to send cancer into remission and allow patients to stop treatment earlier. The study has the potential to be life-changing for patients and their families, reducing the burden of ongoing therapy and improving quality of life.
Aging reshapes the electron transfer behavior of pyrogenic carbon in soils and environments
Research reveals that aging significantly alters the electron transfer behavior of pyrogenic carbon in soils and environments, with some materials becoming more electron-conductive while others become less so. These changes can influence nutrient cycling, pollutant degradation, and microbial processes in environmental systems.
Eyes as a window to hidden brain diseases
Researchers developed a fast, non-invasive, and affordable diagnostic tool using retinal images to differentiate between ALS and Alzheimer's disease. The tool, based on polarized light analysis, accurately predicted disease severity and type with high accuracy.
Enhancing gut-brain communication reversed cognitive decline, improved memory formation in aging mice
Aging gut affects memory formation, new study reveals gut microbiome plays a critical role in cognitive decline, but altering gut-brain communication can reverse effects in mice
P38 MAPK linked to epigenetic activation of fibrotic genes in senescent lung fibroblasts
A new study reveals that p38 MAPK plays a key role in epigenetic regulation of fibrotic genes in lung fibroblasts, particularly in senescent cells. Pharmacological inhibition of p38 MAPK significantly reduced α-SMA and Col3A1 expression, suggesting a potential therapeutic target for treating age-related fibrotic diseases like IPF.
Alliance for Clinical Trials in Oncology highlights new and open colorectal cancer trials in March
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
Using digital cognitive assessments for dementia diagnosis: Are primary care providers ready?
A new report finds that nearly nine in 10 primary care providers use standardized paper assessments, but are interested in adopting digital cognitive assessments. The surveys revealed key priorities for enabling broader adoption, including providing more support to clinicians.
Study offers guidance on the therapeutic use of mindfulness, yoga to boost mental health for dementia patients
A scoping review found that shorter, simpler programs with caregiver support lead to better outcomes for dementia patients. Mind-body interventions can improve depression, anxiety, stress, and quality of life, especially when tailored to individual needs.
Next-generation metabolic theory suggests glycolytic ATP decline may limit lifespan
A new metabolic theory proposes that a decline in glycolytic ATP production is the fundamental mechanism limiting lifespan. Species with an optimal rate of decline survived, suggesting that maintaining a stable glycolytic flux may support repair processes and tissue regeneration. The authors propose testing this hypothesis through expe...
Fecal transplants from older mice significantly improve ovarian function and fertility in younger mice
A new study reveals that fecal transplants from older female mice significantly improve ovarian function and fertility in young mice. The transplants show a direct link between the gut microbiome and ovarian health, with potential implications for fertility and overall health as women age.
Study identifies opposing roles for IL6 and IL6R in long-term mortality
A recent study found that higher IL6 levels are associated with increased mortality, while genetically higher IL6R levels reduce all-cause mortality through cardiovascular mechanisms. The researchers suggest that IL6R antagonism may be a potential strategy for preventing cardiovascular disease.
Middle-aged men are most vulnerable to faster aging due to ‘forever chemicals’
Researchers found that perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA) accelerate biological aging in middle-aged men, with effects being strongest in this age group due to lifestyle factors. PFAS pollution has been linked to human cancers, obesity, infertility, and hormonal imbalances.
New blood test signals who is most likely to live longer, study finds
A new study from Duke University Medical Center suggests that a simple blood test can accurately predict short-term survival in older adults by detecting specific piRNA molecules. Lower levels of these molecules are linked to longer survival, echoing patterns seen in simple organisms where reducing them can extend lifespan.
New research finds peanut butter consumption builds muscle power in older adults
A six-month study found that consuming 43 grams of peanut butter daily significantly increased muscle power in older adults. This improvement enables them to perform daily activities like stair climbing and rising from a chair more efficiently.
Barshop Institute to receive up to $38 million from ARPA-H, anchoring UT San Antonio as a national leader in aging and healthy longevity science
The Barshop Institute will conduct the VITAL-H trial, evaluating the repurposing of FDA-approved medications to delay age-related health decline in generally healthy middle-aged adults. The trial aims to preserve everyday abilities during a critical window of midlife aging.
Pets can help older adults’ health & well-being, but may strain budgets too
A new poll finds that pets contribute to healthy aging benefits for older adults, including increased sense of purpose and reduced stress. However, 31% of pet owners aged 50+ report that owning a pet strains their budget, mainly due to financial costs.
New single-cell transcriptomic clock reveals intrinsic and systemic T cell aging in COVID-19 and HIV
Researchers developed a new single-cell transcriptomic clock called Tictock to measure aging in specific immune cells. The study found that COVID-19 and HIV alter T cell composition and accelerate the biological age of naïve CD8 T cells, while long-term antiretroviral therapy stabilizes T cell proportions.
Polyploidy-induced senescence may drive aging, tissue repair, and cancer risk
Researchers highlight polyploidy-induced senescence as a coordinated biological program that may drive aging, tissue repair, and cancer risk. Polyploidization in healthy tissues could help maintain organ structure and barrier integrity, but its instability can promote chromosomal instability and malignant transformation.
A holiday to better recovery
A study of 77,947 patients found that those over 80 and with low initial ADL scores benefited from holiday rehabilitation. This suggests prioritizing interventions for elderly and independent individuals can lead to better outcomes.
ASU researchers showcase scalable tech solutions for older adults living alone with cognitive decline at AAAS 2026
Researchers from Arizona State University are addressing the challenges of aging, loneliness and cognitive decline through innovative technology-enabled interventions. The university's Edson College is leading a panel discussion on scalable solutions for older adults living alone with cognitive decline.
GSA video series guides primary care teams to implement comprehensive dementia care
The new GSA video series highlights the KAER framework's four steps to improve timely detection of cognitive impairment and enhance dementia care. Clinicians share insights on implementing the framework, emphasizing the importance of early conversations and activated ecosystems of care.
One in eight older people in Ireland require medical attention for a fall each year
A new study from Trinity College Dublin shows that one in eight older people in Ireland require medical attention for falls annually, with significant gaps in prevention and access to specialist services. The study highlights the need for a coordinated national approach to address this growing issue.
Journal documents 20 years of public health progress on dementia
The supplement issue documents unprecedented progress in establishing dementia as a public health priority, with brain health and caregiving now core components of public health practice. The Healthy Brain Initiative and BOLD Act have built a robust framework prioritizing brain health.