Articles tagged with Gerontology
A new study found that choosing ARB drugs from the start can lead to better adherence and improved cardiovascular health. The study, which analyzed data from 340,000 patients, showed that ARB treatment resulted in fewer side effects and higher persistence rates compared to other drug classes.
Research found that older women with younger biological ages were more likely to experience increased depressive symptoms during the pandemic. The study suggests that this may be due to reduced social connections and daily routines, which can affect mental health.
A novel analysis found that financial strain and food insecurity accelerate biological aging and increase mortality risk, surpassing traditional risk factors. The study emphasizes the need for targeted preventive interventions and patient-centered care to address social determinants of health.
A new study found that slower reaction time and lower response accuracy in cognitive tasks are associated with higher levels of frailty. The association can be detected in late midlife among individuals aged 57 to 70 years.
The journal has integrated ResearchGate to improve accessibility and impact of research on aging. This allows authors to connect their work with a wider network of peers, fostering collaboration and advancing understanding of the biology of aging.
Researchers from MIT and Broad Institute develop temporary 'factory' in the liver to generate T-cell-stimulating signals, boosting immune response to vaccination and cancer immunotherapy treatments. Aged mice showed significant increases in T cell population size and function after treatment.
Researchers found that higher levels of theobromine are associated with slower biological aging in humans, as measured by epigenetic markers such as DNA methylation and telomere length. The study suggests that theobromine may support healthy aging by influencing molecular epigenetic processes.
Research by Li-Mei Chen finds that digital tools provide measurable benefits for caregivers and persons living with dementia, improving self-efficacy, emotional well-being, and social connectedness. However, equity gaps remain due to limited access to culturally adapted and inclusive technologies.
Researchers found that glycation stress, caused by methylglyoxal, promotes aortic stiffening and cellular senescence. Natural compound Gly-Low, containing nicotinamide and alpha-lipoic acid, reversed these effects and reduced stiffness in aging mice.
The webinar series aims to increase awareness of anti-amyloid treatment benefits and provide practical guidance for clinicians. Early intervention with these therapies can slow AD progression and preserve brain function.
Researchers found that a mitochondrial protein called COX7RP increases healthy lifespan in mice by improving its mitochondrial energy efficiency. The study also showed improved glucose homeostasis, healthier lipid profiles, enhanced muscle endurance, and lower fat accumulation in the liver.
This study found that older mice blood worsens Alzheimer’s-related changes, while younger blood improves memory and cognitive function. The researchers identified key proteins involved in neurodegeneration and inflammation, suggesting new avenues for targeting blood-borne factors to slow or modify disease progression.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
A study by NYU Rory Meyers College of Nursing found that older, unpaid caregivers who used the internet more often felt less lonely and coped better with stress. The researchers analyzed data from over 3,957 participants ages 65 and older, and discovered a buffering effect: internet use reduced loneliness in caregivers with health issues.
The Gerontological Society of America has selected three new editors-in-chief for its peer-reviewed journals, effective January 1. Jason Flatt will lead the Social Sciences section of The Journal of Gerontology, Series B, while Karen Kopera-Frye will oversee Gerontology & Geriatrics Education. Joyce Siette will take charge of the Medic...
Two Russian scientists' conceptual similarities challenge conventional aging views. Their ideas about hyperfunction and elevation remain relevant to modern research. Golubev explores the historical connections between Dilman and Blagosklonny, highlighting their contributions to aging science.
The Gerontological Society of America has received a three-year grant from the National Institute on Aging to establish the Geroscience Education and Training Network. The network aims to strengthen the geroscience researcher pipeline and build a sustainable geroscience workforce.
Researchers developed a machine learning tool, SAMP-Score, to identify compounds that induce senescence in p16-positive cancer cells. The tool successfully identified a promising candidate, QM5928, which triggers senescence without killing cancer cells.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
A new poll suggests that more than 80% of people over 65 drive at least weekly, but less than half have made a plan for when they can no longer drive safely due to health changes. Only 6% of older drivers have discussed their driving with a healthcare provider.
A new meta-analysis published in Aging-US found a significant association between hospitalization for infections and the risk of developing dementia. Adults hospitalized with infections were at an increased risk of all-cause dementia, especially after a single infection-related hospitalization, which can speed up cognitive decline.
A new study found that embryo arrest in IVF is more common with advancing maternal age but not directly related to chromosomal abnormalities. The research suggests two independent factors contribute to the number of euploid embryos available for transfer and overall ART success.
The report identifies areas necessary for longer lives, including competency in health, financial literacy, and social factors. It also calls for updating the US healthcare system to meet the needs of an aging population, including specialized training in geriatrics.
A national study found that older adults who develop geriatric syndromes after major surgery face higher risks of poor outcomes, including complications, fewer days spent at home, and increased likelihood of dying within a year. The study emphasizes the need for specialized surgical care approaches to optimize outcomes for older adults.
A recent study found that weight loss in midlife can aggravate inflammation in the hypothalamus, a brain region regulating appetite and energy balance. This neuroinflammation persists for several weeks before subsiding, raising concerns about its impact on cognitive decline and neurodegenerative diseases.
Regularly eating meals alone is associated with poorer diet quality and increased risk of weight loss and frailty among community-living adults aged 65 years and over. Social connections at mealtimes can influence appetite, dietary variety, and overall wellbeing.
Researchers found that excess growth hormone disrupts liver metabolism, leading to molecular and cellular patterns similar to those in naturally aged livers. Reducing glycation stress can reverse these negative effects, improving liver health and physical function.
A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
A recent study found that multilingual individuals experience slower biobehavioral aging compared to monolinguals. The study analyzed data from 86,149 participants across Europe and showed that multilingualism is associated with a lower risk of accelerated aging.
Researchers found that combining L-BAIBA supplementation with voluntary wheel running exercise enhances musculoskeletal properties in middle-aged male mice. The study showed significant improvements in muscle strength, bone density, and reduced bone marrow fat.
Researchers at UVA School of Medicine found that the breakdown of protective brain structures called perineuronal nets leads to social memory loss in Alzheimer's patients. Preventing the degradation of these nets may lead to new treatments to prevent or delay the disease.
A study of nearly 2,500 adults in the US and Brazil found that older participants were more likely to share partisan news and evaluate information based on their party affiliation. Researchers suggest that encouraging less partisan communication and fostering inter-group contact are key to combating misinformation.
The National Center to Reframe Aging is partnering with the Maine Council on Aging to host a Leadership Exchange on Ageism, offering proven communication strategies to eliminate ageism. The program aims to transform leaders' thinking about aging and connect them with tools to build support for policies supporting all ages.
A study of 31 healthy older adults found that consuming 60 grams of peanuts daily for 16 weeks increased global cerebral blood flow by 3.6% and verbal memory by 5.8%. Peanut consumption also improved systolic blood pressure and pulse pressure.
A survey of 4,890 participants found that people are open to using home-care robots as long as they view them beneficially. Collaboration between users and developers is crucial for adoption, with emphasis on ethical considerations. Robots may play a significant role in addressing Japan's aging population and social healthcare challenges.
A new study found that alpha-synuclein triggers early gene expression changes in a Parkinson's disease model, revealing brain region-specific and systemic transcriptomic alterations. These changes may contribute to disease development and serve as potential biomarkers.
The BrainHealthy competition offers real-world experience to talented young brain health researchers. The contest aims to advance new studies on age-related brain changes, brain health biomarkers, and Alzheimer's disease.
Researchers at Ben-Gurion University find that CD4 T cells play a critical role in reducing aging by cleaning out senescence cells. They suggest tracking people in their 30s to assess the pace of aging and developing early interventions.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
Researchers found that TRF1 protein loss led to leaner mice with altered metabolic profiles, including lower LDL cholesterol levels and improved blood sugar regulation. These benefits occurred without any detectable shortening of telomeres.
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
A large study in pet dogs has uncovered molecular clues that could shed light on how aging unfolds in pets and people alike. The researchers found that a type of metabolite called post-translationally modified amino acids (ptmAAs) appeared strongly linked with aging across dogs of all breeds, sizes, and sexes.
A recent study by Willa Granger examines the transformation of nursing homes in postwar America, tracing the development of the modern nursing home industry through the lens of the Americana Corporation. The research reveals how federal programs and corporate models reshaped eldercare, prioritizing scale and replication over community ...
A new poll reveals that 19% of people age 50 and over identify as a person with a disability, while half may be entitled to protections and accommodations due to physical or mental conditions. Despite this, only 18% receive accommodations for healthcare visits.
Vaccination provides multiple benefits, including preventing illness, reducing healthcare costs, and enabling individuals to remain active contributors. Economically, vaccines save $11 in avoided medical costs for every $1 spent on childhood vaccines.
Longevity clinics have emerged globally, offering advanced diagnostic services and customized lifestyle interventions to extend healthspan. However, concerns arise from lack of scientific validation, high costs, and limited access to populations most at risk for premature aging.
Dr. Ana Daugherty, a cognitive neuroscientist with expertise in aging and Alzheimer's disease, joins Wayne State University's Institute of Gerontology as its new director. She will lead interdisciplinary collaboration, training for emerging scholars, and research on risk and resiliency in aging and dementia.
Researchers found that overactive Runx1 gene accelerates age-related degeneration of intervertebral discs, causing premature cellular aging and unhealthy tissue changes. Targeting Runx1 may be a promising strategy to prevent or slow disc aging.
Dr. Sandra Shi has been recognized as a 2025 STAT Wunderkind for her innovative research using national Medicare claims to create a frailty index, which measures the health status of older adults. Her work aims to predict how people will respond to surgeries and medications, tailoring treatment based on results.
Scientists found that CtBP2 levels decrease with age, but are higher in long-lived individuals. This biomarker may estimate the degree of aging and overall health status.
A new study from Wake Forest University School of Medicine found that individuals living in socially vulnerable neighborhoods showed measurable differences in brain structure and function, including a thinner outer layer of the brain and white matter changes. These findings suggest that the environment in which people live can shape th...
The $3 million National Institute on Aging grant will support the WECARE intervention, a culturally tailored digital health program designed to enhance caregiving skills and improve wellbeing in dementia caregivers. The 7-week program provides informational content, quiz games, social networking, personalized feedback, and individualiz...
Researchers found that a supplement containing high-molecular-weight hyaluronan preserves muscle mass and exercise capacity in aging mice. The study suggests that targeting the glycocalyx may be a viable therapeutic strategy to treat age-related physical dysfunction.
A new study finds that benzodiazepines and antipsychotics prescribed to patients with dementia receiving hospice care may carry major unintended risks, including increased mortality. The study highlights two policy issues: lack of oversight of medication use in hospice and a mismatch between hospice policy and dementia care.
The new centre supports multiple clinical trials in parallel, enabling comprehensive evaluations of organ health across physiological systems. It also provides hands-on training opportunities for healthcare professionals, bridging the gap between theoretical knowledge and practical application.
Research found that defense cells of trained older adults are more effective against inflammation and metabolically efficient. Regular exercise modulates inflammatory response over time, reducing markers of inflammation and increasing anti-inflammatory markers.
New traumatic brain injuries in older adults are associated with a higher risk of developing dementia. Research published in the Canadian Medical Association Journal found that TBI is linked to an increased rate of incident dementia, even when sustained in late life, and how this risk changes over time.
A new study calls for standardized, transparent, and reproducible methods to evaluate frailty in preclinical aging studies. The researchers analyzed 18 rodent studies and found substantial variation in how frailty is defined and measured.
Researchers found that a combination of oxytocin and an Alk5 inhibitor significantly extended the lifespan and healthspan of frail, elderly male mice, but not female mice. This dual-drug approach reduced chronic inflammation and tissue damage, leading to improved physical endurance and memory in males.
The Singapore government has launched a nationwide initiative to help seniors age well through dance, combining movement, rhythm, and storytelling. The program, co-developed by NUS Nursing and Lions Befrienders, benefits over 280 seniors with improved physical health, cognition, and emotional well-being.