A new study published in Cell Metabolism found that a low-protein, amino acid-supplemented 'longevity diet' improved cardiometabolic markers and reduced frailty and fat mass in mice. The diet was associated with longer healthy lifespan and better metabolic health in both mice and humans.
A new study reveals that p38MAP kinase plays a central role in regulating senescence-related changes in human muscle cells. The researchers developed a human cell-based model to investigate how senescence develops in skeletal muscle cells and identified a signaling pathway that appears to drive aging in mature muscle fibers.
A Hiroshima University study finds that practical digital skills, positive financial attitudes, and self-protection are more consistently associated with lower old-age anxiety than traditional financial knowledge alone. The study suggests that financial education may need to move beyond knowledge alone in the digital age.
A new study found that childhood adversity, especially forced childhood migration, is associated with higher cardiometabolic risk and accelerated biological aging in later life. Forced migration was linked to elevated diabetes risk, cardiovascular disease, and hypertension, as well as signs of accelerated biological aging.
A new poll shows nearly all Michiganders age 50 and over value keeping their brains healthy, but less than half know daily habits can reduce dementia risk. Only half practice key brain-protecting habits.
A new review suggests that ageing results from overlapping changes occurring simultaneously at many levels of biological organization. This approach is reflected in the concept of the 'hallmarks of ageing', which are interconnected biological characteristics and processes consistently associated with aging.
A partnership between the National Center and the Pennsylvania Department of Aging is bridging the gap for senior community centers by creating evidence-based communication strategies. The research was informed by input from a representative sample of Pennsylvania residents, highlighting the importance of senior community centers as vi...
A nationwide population-based study found that individuals with neovascular age-related macular degeneration had a modest but statistically significant increase in overall cancer risk. However, the increased risk was only observed for specific malignancies, including thyroid, kidney, and prostate cancers.
A new study by Stanford Medicine investigators found that biological age of organs can predict disease risk and longevity. The researchers used a blood-based indicator to assess the age of 11 organ systems, including brain, heart, and lungs, and found strong associations between these ages and various diseases.
The report highlights the clinical, emotional, and societal impact of psychosis in individuals living with Alzheimer's disease. Nonpharmacologic strategies are recommended to identify triggers and tailor interventions, with pharmacologic options considered when behavioral strategies are insufficient.
The Gerontological Society of America has renewed funding for the Journalists in Aging Fellows Program, which has produced over 900 news stories since its inception in 2010. The program aims to educate journalists about aging issues and disseminate information on scientific findings, policy debates, and innovations.
The Global Conference on Gerophysics brought together researchers from various disciplines to develop predictive models of aging. Key findings include the application of physical principles, such as thermodynamics and network theory, to biological systems. The conference highlighted the importance of collaboration between theory and ex...
Delirium is a common and preventable complication in older surgical patients, with verified geriatric surgery programs screening nearly every patient. Non-accredited hospitals screen only half of their patients for delirium, leading to a stark gap in care.
A new study reveals substantial differences in gene expression patterns between aging mouse and human skeletal muscle. Fewer than 5% of biological pathways show shared changes, emphasizing the need for cross-species targets in aging research.
BIO-VITAL brings together leading scientists in aging biology to support industry partners evaluating novel gerotherapeutics. The program combines Einstein's decades of leadership in aging research with specialized research cores, proprietary models, and translational capabilities.
A recent study found that melanoma disproportionately affects Florida's senior population, with older men experiencing twice as many skin cancer-related deaths as women. The study highlights gaps in prevention and early detection, particularly among men and non-Hispanic populations.
A pilot study of the Participant Engagement Portal (PEP) tool shows that 84% of participants had a positive experience, with high usability and satisfaction rates. PEP facilitates two-way communication between patients and clinicians, allowing for self-reporting of social risk factors and future research opportunities.
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
A large Japanese study found that maintaining a healthier profile with lower lifestyle and health risks can significantly lower dementia risk in people with one or no APOE ε4 alleles. However, individuals carrying two APOE ε4 alleles may require different preventive or therapeutic approaches.
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
LGBTQ+ adults over 50 face disparities in health care, mental health, and social connections compared to non-LGBTQ+ peers. They are more likely to experience discrimination and feel isolated from others.
A new study found that DNA methylation aging biomarkers, such as GrimAge2 and DunedinPoAm, significantly mediate the relationship between social disadvantage and mortality risk. The findings suggest that epigenetic aging measures capture the cumulative effects of multiple social and environmental stressors.
Researchers found that structured lifestyle programs with coaching and accountability can reduce frailty in older adults by promoting healthy habits. The two-year US POINTER trial showed significant improvements in overall health and frailty scores among participants who followed the structured program.
A new study found that handwriting speed and stroke organization can be indicative of cognitive decline in older adults. The research used digital tools to record writing speed and number of strokes in complex tasks, and found that participants with cognitive impairment showed distinct patterns in their handwriting movements.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
The study found that methylene blue significantly enhanced stem cell proliferation and viability while reducing intracellular reactive oxygen species. MB also increased activation of β-catenin signaling, a central pathway involved in hair follicle regeneration, stem cell maintenance, and wound repair.
A new study suggests that an earlier first sexual intercourse may be associated with a less favorable multidimensional aging profile, including shorter longevity and higher frailty. The researchers found that genetic differences in early sexual debut were linked to poorer health outcomes later in life.
Dr. Lauren B. Gerlach has made significant contributions to health services and aging research, particularly in the area of medication safety and prescribing practices for older adults with dementia. Her work aims to support safer, more person-centered care.
New review highlights emerging complexity of senescent cell populations playing both protective and harmful roles in aging. Precision geroprotection aims to selectively eliminate maladaptive senescent cells while preserving beneficial ones.
A study published in JMIR Aging predicts early mobility decline in healthy adults aged 45 using a set of home-based measurements and AI. The researchers identified six essential factors, including age, muscle power, and diet, that accurately predict future mobility struggles.
Research suggests that aging immune systems compromise the body's ability to control Mycobacterium tuberculosis during treatment with rifampicin and isoniazid. The study identified age-associated immune abnormalities linked to impaired bacterial clearance, including chronic inflammatory signaling and mitochondrial dysfunction.
A new study reviews key components of older adult surgical care, including delirium prevention and screening, fall prevention, and bowel regimens. The seven-component perioperative protocol is associated with improved outcomes, such as reduced complications and shorter hospital stays.
A study published in Aging Cell found that reducing dietary fat or animal-based protein can reduce 'biological age' in older adults. After just four weeks, participants showed significant reductions in biomarker profiles indicative of improved health and aging outcomes.
The BHARAT study, led by the Indian Institute of Science, is a groundbreaking initiative that integrates clinical, molecular, lifestyle, and environmental data from diverse demographic groups in India. The study aims to develop population-specific biological aging signatures and predictive models tailored to Indian populations.
A study of over 31,000 patients found that pneumonia occurred more often after breathing tubes were removed than during ventilation, with most cases developing within a 1–2 week window after surgery. Early assessment and intervention focusing on swallowing function are crucial for prevention and improved outcomes.
A recent study reveals that an individual's readiness to adopt smart technology is deeply tied to their specific experience within their home and community. Researchers identified specific clusters within the older population, ranging from tech-ready urbanites to those in more traditional or isolated residential settings.
A study by the University of Helsinki found that nature-based group activities can boost wellbeing, health, and connection to nature in older adults living in care homes. The activities improved sleep, cognition, and social connections, even among those with multiple diseases and mobility issues.
The partnership aims to generate evidence on the potential of MitoQ to slow or improve markers of biological ageing and support longevity. Mitochondria-targeted antioxidants like MitoQ are crucial in producing energy while reducing oxidative stress, a key contributor to ageing.
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
A new study by University of Mississippi researchers finds significant shortages in adult day services across the state, leaving thousands without daily support. The state would need an additional 910 centers to meet demand, with funding being a primary cause of shortages.
The ASPIRE trial aims to enroll 1,200 participants with advanced prostate cancer and assess the impact of chemotherapy on overall survival and disease progression. Genetic profiling is included to identify patients who benefit most from intensified treatment.
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
A new hypothesis proposes that introducing Hydra-like gene expression patterns into rotifers could delay senescence and extend healthspan. The study focuses on conserved molecular pathways, including FoxO, which plays a central role in maintaining stem cell function and cellular resilience.
A new UK study found that many heat-related deaths occur during lower-level alerts, highlighting widespread gaps in awareness and response. Older people are particularly vulnerable to these risks, with lower engagement with warnings leaving them exposed.
A study reveals that older adults receiving government-funded home care struggle to access the support they need, often feeling overwhelmed by complex systems and limited budgets. The research highlights a significant gap in the program's capacity to provide person-centered care, particularly in areas like nutrition.
A web tool called Living Memory Home for Dementia Care Pairs facilitates collaborative reminiscence therapy, reducing feelings of pre-death grief and improving relationship quality. The app promotes well-being and connection between dementia patients and caregivers, leading to better care outcomes.
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
A Rutgers Health study reveals that neighborhoods with greater access to community amenities, services, and infrastructure can reduce the risk of dementia in older Chinese immigrants. The researchers found that individuals living in more cognitively supportive neighborhoods declined more slowly with age.
A new study published in BMJ Open suggests that US states have experienced universal gains in cohort life expectancy between 1941 and 2000, with a two-phase pattern of rapid convergence followed by stagnation. This challenges previous estimates suggesting stark disparities across states, particularly in the South.
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
Researchers at the University of Waterloo have discovered a safer and more effective way to treat Alzheimer's disease by combining anti-amyloid antibodies with molecules found in grapes, berries, peanuts, and turmeric. This combination approach neutralizes amyloid protein clumping in the brain, leading to better outcomes.
The Italian Society of Gerontology and Geriatrics has partnered with MDPI to publish its Journal of Gerontology and Geriatrics in open access. The journal, which was founded in 1953, will transition to a digital-only format starting with Volume 74, Issue 1 in March 2026.
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
A new international study by Adelaide University researchers found that genetics influence how lifestyle-behavioural factors impact ageing. Healthier ageing is associated with greater physical activity, better diet, and higher educational attainment, while smoking and suboptimal sleep duration have negative effects.
Boston University researchers Alice Cronin-Golomb and Plamen Ch. Ivanov have been recognized as AAAS fellows for their pioneering work on aging diseases and network physiology. Their research focuses on understanding the brain's function in healthy aging and age-related neurodegenerative diseases, such as Parkinson's and Alzheimer's.
Douglas P. Kiel, a senior scientist at the Hinda and Arthur Marcus Institute for Aging Research, has been elected to membership in the Association of American Physicians due to his significant contributions to advancing medical knowledge and improving health through scientific research and academic leadership. His research focuses on o...
Researchers found shared aging patterns in brain networks between humans and mice, highlighting a framework for studying cognitive aging and improving brain health. The study uses awake mice to examine how complex brain networks change with age, providing a platform for cross-species investigation.
Researchers found that people following a Mediterranean-style diet have higher levels of humanin and SHMOOSE, which are linked to protection against cardiovascular disease and neurodegeneration. The study suggests that specific components of the Mediterranean diet may directly influence mitochondrial biology.
Researchers developed two neural network models predicting human biological age based on blood biochemistry and gut microbiota. The models demonstrated high predictive accuracy and explainability, holding potential for monitoring intervention effects in clinical trials.