Vertebral fractures are a devastating complication of advanced kidney disease, associated with increased risk of further fractures and cardiovascular events. The first global consensus statement offers practical recommendations for clinicians to identify and manage vertebral fractures in patients with chronic kidney disease stages G4–G5D.
A new study finds that hospitals treating more patients with Medicare Advantage plans face higher readmission penalties despite taking similar actions to prevent repeat hospitalizations. The analysis highlights the need to incorporate Medicare Advantage data into the Hospital Readmissions Reduction Program.
A new review proposes a two-stage model explaining how different determinants of aging interact to generate late-life disease. Early-life damage and late-life genetic activity are identified as key drivers of age-related illnesses.
A new study found that shingles vaccination is associated with lower inflammation, slower epigenetic aging, and overall slower biological aging in older adults. Vaccination showed benefits even four years after the initial dose.
Research finds age-related DNA methylation alterations in sperm may contribute to autism risk in offspring. Advanced paternal age is associated with specific changes in sperm DNA, influencing early development in children.
Researchers found that CD47 knockdown improves glucose homeostasis and alleviates dyslipidemia in aged male mice by reducing visceral fat and enhancing brown fat tissue function. This breakthrough suggests CD47 as a key regulator of age-related metabolic dysfunction.
A 12-year longitudinal study found that nearly three-quarters of older adults in Ireland have high blood pressure not optimally managed. The study highlights the urgent need to improve recognition and treatment of hypertension, which can cause serious health risks like heart disease and dementia.
A new WSU study reveals that medical students receive little or no formal training in end-of-life care, leading to confusion and unwanted treatment. Researchers advocate for integrated educational interventions across the medical school curriculum to address this critical gap.
A recent Buck Institute study revealed that spaceflight accelerates aging due to changes in immune cell composition and epigenetic markers. However, researchers also found evidence of intrinsic rejuvenation factors that can counteract these age-accelerating stressors.
A recent study by researchers at the University of California, Riverside, found that a specific brain region known as the caudate nucleus is strongly linked to physical strength in older adults. The discovery could help detect and prevent frailty before it begins.
The meeting report highlights the emerging importance of infection-driven senescence in understanding chronic diseases, including respiratory viruses like influenza and SARS-CoV-2. Researchers found that senescent cells contribute to persistent inflammation and reduced healing, particularly in older adults during chronic infections.
Researchers identified common aging-related alterations in genes involved in RNA splicing and processing across eight human tissues. These findings suggest a shared biological response to aging, pointing to the importance of RNA processing in accurate protein production.
A new study introduced epigenetic clocks in skeletal muscle from an Asian population, identifying DNA methylation sites associated with age and developing accurate age prediction models using NGS and SBE. The findings offer a reliable method for estimating age and its potential applications in forensic science.
A new study analyzed over 460,000 scientific abstracts to identify key themes, trends, and research gaps in aging research. The study found a growing separation between basic biological studies and clinical research, highlighting the need for integration to translate laboratory discoveries into medical applications.
A new study found that choosing ARB drugs from the start can lead to better adherence and improved cardiovascular health. The study, which analyzed data from 340,000 patients, showed that ARB treatment resulted in fewer side effects and higher persistence rates compared to other drug classes.
Research found that older women with younger biological ages were more likely to experience increased depressive symptoms during the pandemic. The study suggests that this may be due to reduced social connections and daily routines, which can affect mental health.
A novel analysis found that financial strain and food insecurity accelerate biological aging and increase mortality risk, surpassing traditional risk factors. The study emphasizes the need for targeted preventive interventions and patient-centered care to address social determinants of health.
SourceElsevier·JournalMayo Clinic Proceedings·TypeComputational simulation/modeling·DateDec 18, 2025
The journal has integrated ResearchGate to improve accessibility and impact of research on aging. This allows authors to connect their work with a wider network of peers, fostering collaboration and advancing understanding of the biology of aging.
Researchers from MIT and Broad Institute develop temporary 'factory' in the liver to generate T-cell-stimulating signals, boosting immune response to vaccination and cancer immunotherapy treatments. Aged mice showed significant increases in T cell population size and function after treatment.
A new study found that slower reaction time and lower response accuracy in cognitive tasks are associated with higher levels of frailty. The association can be detected in late midlife among individuals aged 57 to 70 years.
Researchers found that higher levels of theobromine are associated with slower biological aging in humans, as measured by epigenetic markers such as DNA methylation and telomere length. The study suggests that theobromine may support healthy aging by influencing molecular epigenetic processes.
Research by Li-Mei Chen finds that digital tools provide measurable benefits for caregivers and persons living with dementia, improving self-efficacy, emotional well-being, and social connectedness. However, equity gaps remain due to limited access to culturally adapted and inclusive technologies.
Researchers found that glycation stress, caused by methylglyoxal, promotes aortic stiffening and cellular senescence. Natural compound Gly-Low, containing nicotinamide and alpha-lipoic acid, reversed these effects and reduced stiffness in aging mice.
The webinar series aims to increase awareness of anti-amyloid treatment benefits and provide practical guidance for clinicians. Early intervention with these therapies can slow AD progression and preserve brain function.
Researchers found that a mitochondrial protein called COX7RP increases healthy lifespan in mice by improving its mitochondrial energy efficiency. The study also showed improved glucose homeostasis, healthier lipid profiles, enhanced muscle endurance, and lower fat accumulation in the liver.
This study found that older mice blood worsens Alzheimer’s-related changes, while younger blood improves memory and cognitive function. The researchers identified key proteins involved in neurodegeneration and inflammation, suggesting new avenues for targeting blood-borne factors to slow or modify disease progression.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
A study by NYU Rory Meyers College of Nursing found that older, unpaid caregivers who used the internet more often felt less lonely and coped better with stress. The researchers analyzed data from over 3,957 participants ages 65 and older, and discovered a buffering effect: internet use reduced loneliness in caregivers with health issues.
The Gerontological Society of America has selected three new editors-in-chief for its peer-reviewed journals, effective January 1. Jason Flatt will lead the Social Sciences section of The Journal of Gerontology, Series B, while Karen Kopera-Frye will oversee Gerontology & Geriatrics Education. Joyce Siette will take charge of the Medic...
Two Russian scientists' conceptual similarities challenge conventional aging views. Their ideas about hyperfunction and elevation remain relevant to modern research. Golubev explores the historical connections between Dilman and Blagosklonny, highlighting their contributions to aging science.
The Gerontological Society of America has received a three-year grant from the National Institute on Aging to establish the Geroscience Education and Training Network. The network aims to strengthen the geroscience researcher pipeline and build a sustainable geroscience workforce.
Researchers developed a machine learning tool, SAMP-Score, to identify compounds that induce senescence in p16-positive cancer cells. The tool successfully identified a promising candidate, QM5928, which triggers senescence without killing cancer cells.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
A new poll suggests that more than 80% of people over 65 drive at least weekly, but less than half have made a plan for when they can no longer drive safely due to health changes. Only 6% of older drivers have discussed their driving with a healthcare provider.
A new meta-analysis published in Aging-US found a significant association between hospitalization for infections and the risk of developing dementia. Adults hospitalized with infections were at an increased risk of all-cause dementia, especially after a single infection-related hospitalization, which can speed up cognitive decline.
A new study found that embryo arrest in IVF is more common with advancing maternal age but not directly related to chromosomal abnormalities. The research suggests two independent factors contribute to the number of euploid embryos available for transfer and overall ART success.
The report identifies areas necessary for longer lives, including competency in health, financial literacy, and social factors. It also calls for updating the US healthcare system to meet the needs of an aging population, including specialized training in geriatrics.
A national study found that older adults who develop geriatric syndromes after major surgery face higher risks of poor outcomes, including complications, fewer days spent at home, and increased likelihood of dying within a year. The study emphasizes the need for specialized surgical care approaches to optimize outcomes for older adults.
A recent study found that weight loss in midlife can aggravate inflammation in the hypothalamus, a brain region regulating appetite and energy balance. This neuroinflammation persists for several weeks before subsiding, raising concerns about its impact on cognitive decline and neurodegenerative diseases.
Regularly eating meals alone is associated with poorer diet quality and increased risk of weight loss and frailty among community-living adults aged 65 years and over. Social connections at mealtimes can influence appetite, dietary variety, and overall wellbeing.
Researchers found that excess growth hormone disrupts liver metabolism, leading to molecular and cellular patterns similar to those in naturally aged livers. Reducing glycation stress can reverse these negative effects, improving liver health and physical function.
A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
A recent study found that multilingual individuals experience slower biobehavioral aging compared to monolinguals. The study analyzed data from 86,149 participants across Europe and showed that multilingualism is associated with a lower risk of accelerated aging.
Researchers found that combining L-BAIBA supplementation with voluntary wheel running exercise enhances musculoskeletal properties in middle-aged male mice. The study showed significant improvements in muscle strength, bone density, and reduced bone marrow fat.
Researchers at UVA School of Medicine found that the breakdown of protective brain structures called perineuronal nets leads to social memory loss in Alzheimer's patients. Preventing the degradation of these nets may lead to new treatments to prevent or delay the disease.
The National Center to Reframe Aging is partnering with the Maine Council on Aging to host a Leadership Exchange on Ageism, offering proven communication strategies to eliminate ageism. The program aims to transform leaders' thinking about aging and connect them with tools to build support for policies supporting all ages.
A study of 31 healthy older adults found that consuming 60 grams of peanuts daily for 16 weeks increased global cerebral blood flow by 3.6% and verbal memory by 5.8%. Peanut consumption also improved systolic blood pressure and pulse pressure.
A study of nearly 2,500 adults in the US and Brazil found that older participants were more likely to share partisan news and evaluate information based on their party affiliation. Researchers suggest that encouraging less partisan communication and fostering inter-group contact are key to combating misinformation.
A survey of 4,890 participants found that people are open to using home-care robots as long as they view them beneficially. Collaboration between users and developers is crucial for adoption, with emphasis on ethical considerations. Robots may play a significant role in addressing Japan's aging population and social healthcare challenges.
A new study found that alpha-synuclein triggers early gene expression changes in a Parkinson's disease model, revealing brain region-specific and systemic transcriptomic alterations. These changes may contribute to disease development and serve as potential biomarkers.
The BrainHealthy competition offers real-world experience to talented young brain health researchers. The contest aims to advance new studies on age-related brain changes, brain health biomarkers, and Alzheimer's disease.
Researchers at Ben-Gurion University find that CD4 T cells play a critical role in reducing aging by cleaning out senescence cells. They suggest tracking people in their 30s to assess the pace of aging and developing early interventions.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
Researchers found that TRF1 protein loss led to leaner mice with altered metabolic profiles, including lower LDL cholesterol levels and improved blood sugar regulation. These benefits occurred without any detectable shortening of telomeres.
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
A large study in pet dogs has uncovered molecular clues that could shed light on how aging unfolds in pets and people alike. The researchers found that a type of metabolite called post-translationally modified amino acids (ptmAAs) appeared strongly linked with aging across dogs of all breeds, sizes, and sexes.
A recent study by Willa Granger examines the transformation of nursing homes in postwar America, tracing the development of the modern nursing home industry through the lens of the Americana Corporation. The research reveals how federal programs and corporate models reshaped eldercare, prioritizing scale and replication over community ...
A new poll reveals that 19% of people age 50 and over identify as a person with a disability, while half may be entitled to protections and accommodations due to physical or mental conditions. Despite this, only 18% receive accommodations for healthcare visits.
Vaccination provides multiple benefits, including preventing illness, reducing healthcare costs, and enabling individuals to remain active contributors. Economically, vaccines save $11 in avoided medical costs for every $1 spent on childhood vaccines.
Longevity clinics have emerged globally, offering advanced diagnostic services and customized lifestyle interventions to extend healthspan. However, concerns arise from lack of scientific validation, high costs, and limited access to populations most at risk for premature aging.