Articles tagged with Gerontology
The Gerontological Society of America has received a three-year grant from the National Institute on Aging to establish the Geroscience Education and Training Network. The network aims to strengthen the geroscience researcher pipeline and build a sustainable geroscience workforce.
Researchers developed a machine learning tool, SAMP-Score, to identify compounds that induce senescence in p16-positive cancer cells. The tool successfully identified a promising candidate, QM5928, which triggers senescence without killing cancer cells.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
A new meta-analysis published in Aging-US found a significant association between hospitalization for infections and the risk of developing dementia. Adults hospitalized with infections were at an increased risk of all-cause dementia, especially after a single infection-related hospitalization, which can speed up cognitive decline.
A new poll suggests that more than 80% of people over 65 drive at least weekly, but less than half have made a plan for when they can no longer drive safely due to health changes. Only 6% of older drivers have discussed their driving with a healthcare provider.
A national study found that older adults who develop geriatric syndromes after major surgery face higher risks of poor outcomes, including complications, fewer days spent at home, and increased likelihood of dying within a year. The study emphasizes the need for specialized surgical care approaches to optimize outcomes for older adults.
A new study found that embryo arrest in IVF is more common with advancing maternal age but not directly related to chromosomal abnormalities. The research suggests two independent factors contribute to the number of euploid embryos available for transfer and overall ART success.
The report identifies areas necessary for longer lives, including competency in health, financial literacy, and social factors. It also calls for updating the US healthcare system to meet the needs of an aging population, including specialized training in geriatrics.
Researchers found that excess growth hormone disrupts liver metabolism, leading to molecular and cellular patterns similar to those in naturally aged livers. Reducing glycation stress can reverse these negative effects, improving liver health and physical function.
A recent study found that weight loss in midlife can aggravate inflammation in the hypothalamus, a brain region regulating appetite and energy balance. This neuroinflammation persists for several weeks before subsiding, raising concerns about its impact on cognitive decline and neurodegenerative diseases.
Regularly eating meals alone is associated with poorer diet quality and increased risk of weight loss and frailty among community-living adults aged 65 years and over. Social connections at mealtimes can influence appetite, dietary variety, and overall wellbeing.
A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
A recent study found that multilingual individuals experience slower biobehavioral aging compared to monolinguals. The study analyzed data from 86,149 participants across Europe and showed that multilingualism is associated with a lower risk of accelerated aging.
Researchers found that combining L-BAIBA supplementation with voluntary wheel running exercise enhances musculoskeletal properties in middle-aged male mice. The study showed significant improvements in muscle strength, bone density, and reduced bone marrow fat.
Researchers at UVA School of Medicine found that the breakdown of protective brain structures called perineuronal nets leads to social memory loss in Alzheimer's patients. Preventing the degradation of these nets may lead to new treatments to prevent or delay the disease.
A study of nearly 2,500 adults in the US and Brazil found that older participants were more likely to share partisan news and evaluate information based on their party affiliation. Researchers suggest that encouraging less partisan communication and fostering inter-group contact are key to combating misinformation.
The National Center to Reframe Aging is partnering with the Maine Council on Aging to host a Leadership Exchange on Ageism, offering proven communication strategies to eliminate ageism. The program aims to transform leaders' thinking about aging and connect them with tools to build support for policies supporting all ages.
A study of 31 healthy older adults found that consuming 60 grams of peanuts daily for 16 weeks increased global cerebral blood flow by 3.6% and verbal memory by 5.8%. Peanut consumption also improved systolic blood pressure and pulse pressure.
A survey of 4,890 participants found that people are open to using home-care robots as long as they view them beneficially. Collaboration between users and developers is crucial for adoption, with emphasis on ethical considerations. Robots may play a significant role in addressing Japan's aging population and social healthcare challenges.
A new study found that alpha-synuclein triggers early gene expression changes in a Parkinson's disease model, revealing brain region-specific and systemic transcriptomic alterations. These changes may contribute to disease development and serve as potential biomarkers.
The BrainHealthy competition offers real-world experience to talented young brain health researchers. The contest aims to advance new studies on age-related brain changes, brain health biomarkers, and Alzheimer's disease.
Researchers at Ben-Gurion University find that CD4 T cells play a critical role in reducing aging by cleaning out senescence cells. They suggest tracking people in their 30s to assess the pace of aging and developing early interventions.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
Researchers found that TRF1 protein loss led to leaner mice with altered metabolic profiles, including lower LDL cholesterol levels and improved blood sugar regulation. These benefits occurred without any detectable shortening of telomeres.
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
A large study in pet dogs has uncovered molecular clues that could shed light on how aging unfolds in pets and people alike. The researchers found that a type of metabolite called post-translationally modified amino acids (ptmAAs) appeared strongly linked with aging across dogs of all breeds, sizes, and sexes.
A recent study by Willa Granger examines the transformation of nursing homes in postwar America, tracing the development of the modern nursing home industry through the lens of the Americana Corporation. The research reveals how federal programs and corporate models reshaped eldercare, prioritizing scale and replication over community ...
A new poll reveals that 19% of people age 50 and over identify as a person with a disability, while half may be entitled to protections and accommodations due to physical or mental conditions. Despite this, only 18% receive accommodations for healthcare visits.
Dr. Ana Daugherty, a cognitive neuroscientist with expertise in aging and Alzheimer's disease, joins Wayne State University's Institute of Gerontology as its new director. She will lead interdisciplinary collaboration, training for emerging scholars, and research on risk and resiliency in aging and dementia.
Vaccination provides multiple benefits, including preventing illness, reducing healthcare costs, and enabling individuals to remain active contributors. Economically, vaccines save $11 in avoided medical costs for every $1 spent on childhood vaccines.
Longevity clinics have emerged globally, offering advanced diagnostic services and customized lifestyle interventions to extend healthspan. However, concerns arise from lack of scientific validation, high costs, and limited access to populations most at risk for premature aging.
Dr. Sandra Shi has been recognized as a 2025 STAT Wunderkind for her innovative research using national Medicare claims to create a frailty index, which measures the health status of older adults. Her work aims to predict how people will respond to surgeries and medications, tailoring treatment based on results.
Researchers found that overactive Runx1 gene accelerates age-related degeneration of intervertebral discs, causing premature cellular aging and unhealthy tissue changes. Targeting Runx1 may be a promising strategy to prevent or slow disc aging.
Scientists found that CtBP2 levels decrease with age, but are higher in long-lived individuals. This biomarker may estimate the degree of aging and overall health status.
A new study from Wake Forest University School of Medicine found that individuals living in socially vulnerable neighborhoods showed measurable differences in brain structure and function, including a thinner outer layer of the brain and white matter changes. These findings suggest that the environment in which people live can shape th...
The $3 million National Institute on Aging grant will support the WECARE intervention, a culturally tailored digital health program designed to enhance caregiving skills and improve wellbeing in dementia caregivers. The 7-week program provides informational content, quiz games, social networking, personalized feedback, and individualiz...
A new study finds that benzodiazepines and antipsychotics prescribed to patients with dementia receiving hospice care may carry major unintended risks, including increased mortality. The study highlights two policy issues: lack of oversight of medication use in hospice and a mismatch between hospice policy and dementia care.
Researchers found that a supplement containing high-molecular-weight hyaluronan preserves muscle mass and exercise capacity in aging mice. The study suggests that targeting the glycocalyx may be a viable therapeutic strategy to treat age-related physical dysfunction.
The new centre supports multiple clinical trials in parallel, enabling comprehensive evaluations of organ health across physiological systems. It also provides hands-on training opportunities for healthcare professionals, bridging the gap between theoretical knowledge and practical application.
Research found that defense cells of trained older adults are more effective against inflammation and metabolically efficient. Regular exercise modulates inflammatory response over time, reducing markers of inflammation and increasing anti-inflammatory markers.
New traumatic brain injuries in older adults are associated with a higher risk of developing dementia. Research published in the Canadian Medical Association Journal found that TBI is linked to an increased rate of incident dementia, even when sustained in late life, and how this risk changes over time.
A new study calls for standardized, transparent, and reproducible methods to evaluate frailty in preclinical aging studies. The researchers analyzed 18 rodent studies and found substantial variation in how frailty is defined and measured.
Researchers found that a combination of oxytocin and an Alk5 inhibitor significantly extended the lifespan and healthspan of frail, elderly male mice, but not female mice. This dual-drug approach reduced chronic inflammation and tissue damage, leading to improved physical endurance and memory in males.
The Singapore government has launched a nationwide initiative to help seniors age well through dance, combining movement, rhythm, and storytelling. The program, co-developed by NUS Nursing and Lions Befrienders, benefits over 280 seniors with improved physical health, cognition, and emotional well-being.
A new study found no clear clinical evidence that rapamycin can extend healthspan or delay aging in healthy adults, despite promising results in animal studies. The review suggests that off-label use of rapamycin should be approached with caution due to limited evidence and potential side effects.
A new national study found nearly one in four older adults who started off in poor health and lower well-being can fully recover within three years. Strong psychological and emotional wellness, maintaining a healthy body weight, regular physical activity, and social engagement were key factors associated with recovery.
Researchers found that cells exiting the cell cycle show stronger signs of senescence and are more sensitive to senolytic drugs. DNA content plays a crucial role in how aging cells function and respond to treatment.
Researchers at Hebrew SeniorLife discovered a U-shaped relationship between home ambient temperature and self-reported attention difficulty in older adults. Attention was optimal between 20°C and 24°C, with worsening difficulties outside this range.
Researchers discovered that FGF21, a muscle hormone released during exercise, is elevated in people with ALS and may play a protective role. Higher levels of FGF21 were associated with slower disease progression and longer survival in patients.
A study led by Syracuse University researchers found that simple resistance training can improve nerve function in older adults, potentially leading to greater independence and quality of life. The training reactivated fast neurons in the muscles, which deteriorate with age, allowing for faster muscle activation and improved strength.
A study found that older adults with Parkinson's disease have a higher rate of brain amyloid positivity compared to younger patients, even without dementia. The researchers suggest this may indicate an accelerated transition from healthy cognition to dementia in PD patients.
The Gerontological Society of America invites journalists to its 2025 Annual Scientific Meeting, featuring over 600 scientific sessions on aging research and innovations. More than 4,000 professionals are expected in Boston from November 12-15.
Researchers discovered elevated TSPO levels in the brain of genetically engineered mouse models and human patients with familial Alzheimer's disease, indicating a potential biomarker for early detection. The study aims to explore how blocking or enhancing TSPO could halt disease progression.
A new report from The Gerontological Society of America provides summaries of key articles on brain health, focusing on early diagnosis and interventions for dementia. The selected articles address topics such as biomarkers, cognitive assessments, and caregiver support, offering actionable strategies for primary care providers.
Researchers used AI to identify shared biological features between aging and fibrosis, finding new potential targets for therapy. The study found that IPF is not simply accelerated aging, but a unique biological condition shaped by age-related dysfunction.
A study found that older adults are discontinuing benzodiazepines soon after hospital discharge, but many continue use for months, posing health risks. Researchers recommend targeting high-risk patients with deprescribing strategies to prevent chronic use.
Researchers evaluated a tool based on NCCN Guidelines to identify high-risk medications and their association with frailty and outcomes in over 380,000 older adults diagnosed with cancer. The study found that each additional high-risk medication increased the odds of being mildly or moderately-to-severely frail by 66%.
Researchers found significant causal relationships between gut microbiome characteristics and age-related traits, including ApoM protein levels. The study suggests targeting the gut microbiota may help delay or reduce age-related inflammation and disease.
The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.
A new perspective suggests that food-derived signals can modulate biological aging by influencing lifestyle choices such as diet, physical activity, and sleep. Targeted nutritional approaches have been shown to slow down aging and preserve cognitive function, highlighting the potential of precision nutrition interventions.