Articles tagged with Anaphylaxis
A study analyzed data from 688,183 recipients of IV iron products and identified a higher risk of anaphylaxis with certain formulations, including iron dextran. The researchers found that the cumulative risk of anaphylaxis was highest with iron dextran and lowest with iron sucrose.
A survey of over 6,000 schools found that nearly 22% of anaphylactic events occurred in individuals with no previously known allergies. The majority were treated with epinephrine auto-injectors, and the most common triggers included food and insect stings.
A recent case series highlights the risk of EpiPen-related injuries in children, particularly thigh lacerations and embedded needles. The study recommends improving product design and instructions for use to reduce these risks, citing a safer alternative device as Auvi-Q.
A new article from the American College of Allergy, Asthma and Immunology recommends using epinephrine for all severe allergic reactions, regardless of symptom certainty. Experts stress that delays can have severe consequences, making epinephrine the most effective tool in combatting anaphylaxis.
A small study found that UK trainee doctors still struggle to recognize and treat anaphylaxis, a potentially fatal allergic reaction. Despite updated guidelines and training, many doctors lack basic knowledge of treating the condition, which causes breathing and circulatory problems.
Researchers found that estrogen enhances an enzyme driving life-threatening allergic reactions in female mice, leading to more severe and longer-lasting reactions. Blocking estrogen or reducing eNOS activity eliminated the gender disparity, suggesting a potential role for estrogen in allergic reactions.
A study published by Northwestern Medicine found that emergency epinephrine was administered to 38 Chicago Public School students and staff during the 2012-2013 school year. Most of those receiving epinephrine had no known history of allergic reaction, emphasizing the need for widespread access to this life-saving medication.
A comprehensive study found that medications are the leading cause of allergy-related sudden deaths in the US, particularly among older people and African-Americans. The study analyzed death certificates from 1999-2010 and identified antibiotics as the most common culprit drug.
A new study found that dying from a food allergy is less likely than being murdered, with risks of 1.81 in a million and 3.25 in a million for adults and children respectively. The study aimed to put the risk of anaphylaxis into perspective, as anxiety and quality of life impacts are significant concerns.
Anaphylaxis from shrimp allergy is rare in children, affecting only 7.8 percent of cases, according to a study. The most common reactions are angioedema and skin symptoms like hives, with asthma being a potential risk factor for anaphylactic reactions.
A study by the American College of Allergy, Asthma, and Immunology found that individuals with severe anaphylaxis are less likely to have seen an allergist in the previous year. Regular care from an allergist can prevent severe allergic reactions and reduce hospitalization rates.
A new study at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting found that only 15% of patients with anaphylaxis received epinephrine from paramedics. The authors recommend improving paramedic education on epinephrine use for allergic reactions and anaphylaxis.
Researchers discover tick bites trigger alpha-gal antibodies in patients, leading to delayed anaphylaxis after eating red meat. The study highlights a previously unknown food-induced severe allergic reaction due to a carbohydrate, not protein.
A new study published in the Journal of Rheumatology shows that KRYSTEXXA significantly improves pain, physical function, and health-related quality of life in adult patients with refractory chronic gout. The treatment resulted in clinically meaningful improvements in these areas compared to placebo.
Research published in the Archives of Disease in Childhood found that vaccination-induced anaphylactic shock is extremely rare. In a study of children under 16 in the UK and Ireland who were suspected of experiencing anaphylaxis after vaccination between 2008 and 2009, only seven cases were confirmed, resulting in no fatalities.
Researchers at the University of Pittsburgh discovered a new nitric oxide pathway that protects against intimal hyperplasia in rats. The study found that supplementing rats with nitrate before vessel injury markedly limited damage, while a diet low in nitrate exacerbated it.
The Wilderness Medical Society (WMS) supports the administration of epinephrine to treat anaphylaxis by trained non-medical professionals in emergency situations. This practice is recommended for organizations with staff who provide first aid, particularly those working with students at risk for anaphylaxis.
Researchers have identified SphK1 and SphK2 as crucial proteins involved in generating the molecule S1P, which affects blood vessels and the immune system. Mice lacking these proteins showed improved recovery from anaphylaxis, while those lacking only SphK1 recovered poorly.
A large six-year review found that many children with severe food-related allergic reactions needed a second dose of epinephrine, highlighting the importance of carrying multiple doses. The study recommends that all children at risk for food-related anaphylaxis carry two doses of epinephrine.
A CMAJ study found significantly higher rates of anaphylaxis in young women after HPV vaccination, with a rate of 2.6 per 100,000 doses administered. However, the overall rates were low and no serious lasting effects were observed.
Twelve investigators receive $5 million in grants to study food allergy causes, treatment, and prevention. The initiative aims to improve understanding of the condition and ultimately end its limitations on lives.
A protein called RGS13 has been found to suppress allergic responses in mice, including severe anaphylaxis. Researchers believe RGS13 may be a target for developing new drugs to treat certain allergic diseases.
Researchers found mast cells with mutated cell surface receptor in patients with idiopathic anaphylaxis, suggesting a genetic trigger. The mutation may predispose people to idiopathic anaphylaxis and respond to inhibitors targeting the mutated cell surface receptor.
The study suggests that eczema and hay fever prevalence has plateaued or declined in recent years, while hospital admissions for these conditions have stabilized. Systemic allergies, including anaphylaxis, food allergy, and urticaria, have shown a significant increase in rates over the past few decades.
Researchers found that children exposed to polychlorinated biphenyls (PCBs) receive lower antibody protection after vaccinations. The study suggests that reducing exposure to chemicals that harm immune systems is crucial for young children.
Researchers find that inhibition of eNOS or PI3K provides total protection against anaphylactic shock. The study reveals a new mechanism underlying the condition, with eNOS-derived NO playing a crucial role.
A nationwide survey found that approximately 11 million people in the US have food allergies, with shellfish being the most commonly reported severe allergy in adults. The study also revealed that seafood allergies often begin later in life, with a prevalence of at least 2.5% among adults and 0.8% among children.
People with idiopathic anaphylaxis experience unpredictable, life-threatening symptoms without an external cause. Prompt diagnosis and preventive therapy with a combination of prednisone, hydroxyzine, and albuterol are critical to prevent death.