A large study found that people with an evening chronotype were more likely to engage in unhealthy lifestyle behaviors such as smoking, poor sleep, and physical inactivity. These individuals had a 72% higher risk of developing diabetes compared to those with a morning chronotype.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeNews article·DateSep 11, 2023
Researchers at Kyoto University have discovered the mechanism by which breast cancer forms in mammalian epithelial cells. The team found that approximately 20 mutations accumulate annually in each cell until menopause, after which the rate decreases significantly.
SourceKyoto University·JournalNature·TypeExperimental study·DateAug 30, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A Swedish study revealed that including all eleven associated genes in the screening test doubled the proportion of women with genetically confirmed hereditary breast cancer. The study included 4759 individuals and found that around 85% of women investigated for suspected hereditary breast cancer had a genetic abnormality.
Researchers have developed an oncolytic virus that can 'warm up' cold tumors and improve immunotherapy outcomes. The virus was engineered to carry a gene encoding a TGF-β inhibitor, which greatly increased survival rates in mice with aggressive melanoma and other cancers.
SourceUniversity of Pittsburgh·JournalJournal of Experimental Medicine·TypeExperimental study·DateAug 14, 2023
Researchers have developed a new gene-editing tool that enables the precise study of single-base mutations in cancer-causing genes. This technology allows for detailed experiments in tissues, which may lead to better understanding of genetic changes influencing patient response to cancer therapies.
SourceWeill Cornell Medicine·JournalNature Biotechnology·DateAug 10, 2023
Researchers at Tel Aviv University have developed a novel approach to fight cancer by inducing cancer cells to produce a toxic protein using mRNA molecules. The treatment was successful in eliminating 44-60% of cancer cells in animal models, with no damage to healthy cells.
SourceTel-Aviv University·JournalTheranostics·DateJul 2, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A new AI tool, MAFDA, tracks individual fruit flies' complex behaviors and compares them with their genetic backgrounds. This enables researchers to study behavior genetics and gain insights into inherited traits.
SourceTulane University·JournalScience Advances·TypeObservational study·DateJun 30, 2023
The study investigates the effects of DPDT on human colon cancer HCT116 cells and non-tumorigenic MRC5 fibroblasts. The results show that DPDT preferentially targets HCT116 cells, inducing apoptosis and G2/M cell cycle arrest, likely through DNA topoisomerase I poisoning.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJun 26, 2023
Researchers developed CrossDome, a tool that uses genetic and biochemical information to predict T-cell immunotherapy's impact on healthy cells. The tool identified high-risk candidates in cases where treatments mistakenly attacked heart cells.
SourceUniversity of Houston·JournalFrontiers in Immunology·DateJun 14, 2023
Researchers found that only 6.8% of cancer patients underwent genetic testing within two years of diagnosis, with lower rates among Black, Hispanic, and Asian patients. The low rates are attributed to lack of integration of test results into cancer management and prevention.
SourceMichigan Medicine - University of Michigan·JournalJAMA·DateJun 6, 2023
Researchers analyzed BORIS mutations and protein expression in breast cancer tissue samples, finding frequent mutations associated with breast carcinoma progression. The study suggests the BORIS gene as a potential biomarker for breast cancer.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateJun 5, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A recent study led by UCLA researchers has identified a potential new strategy for treating glioblastoma by targeting a specific metabolic process in cancer cells. The study found that disrupting this process could make glioblastoma cells more vulnerable to cell death, offering hope for new treatment options.
SourceUniversity of California - Los Angeles Health Sciences·JournalCancer Cell·DateMay 25, 2023
Researchers at Case Western Reserve University have identified a panel of long intergenic non-coding RNAs that are
SourceCase Western Reserve University·JournalGASTROENTEROLOGY·TypeExperimental study·DateMay 15, 2023
A new study has provided insight into the mysterious evolution of DNA rings in tumors, revealing that nearly one-third of all tumors have these genetic structures. The researchers used a technology to trace the path of DNA ring development in neuroblastoma cells, finding that large rings contain cancer genes spurring cell growth.
SourceCharité - Universitätsmedizin Berlin·JournalNature Genetics·DateMay 4, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at the Stowers Institute for Medical Research have revealed the dynamics of a new, young chromosome in fruit flies similar to those found in humans associated with treatment-resistant cancer and infertility. The B chromosomes are maintained by meiotic drive, enabling them to persist in a genome.
SourceStowers Institute for Medical Research·JournalCurrent Biology·TypeExperimental study·DateMay 4, 2023
A new study suggests combining digital cancer risk assessment with point-of-care genetic testing can help overcome clinical workflow challenges that prevent at-risk patients from accessing genetic testing. The approach more than doubled the average uptake of genetic testing, showing promise for cancer prevention and detection.
SourceBoston University School of Public Health·JournalGenetics in Medicine·TypeObservational study·DateMay 3, 2023
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
SourceMass General Brigham·JournalJournal of the American Medical Association·TypeCase study·DateMay 1, 2023
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers identify SRSF1 as a key player in promoting pancreatitis and pancreatic cancer growth. High levels of SRSF1 are associated with worse patient outcomes, highlighting its potential as a target for new therapies.
SourceCold Spring Harbor Laboratory·JournalCancer Discovery·DateApr 26, 2023
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalBlood Cancer Discovery·DateApr 17, 2023
Researchers discuss rapamycin's potential to delay cancer onset by slowing cell proliferation and tumor progression. The mTOR pathway is involved in both cancer and aging, making rapamycin a promising chemopreventive agent.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 17, 2023
A study published in the journal Cancer found that long-term pancreatic cancer survivors have a robust immune response and enriched gut microbiome species, including Faecalibacterium prausnitzii. The research suggests that these bacterial species may promote immune response to pancreas cancer.
SourceUniversity of Cincinnati·JournalCancer·TypeObservational study·DateApr 3, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers have generated artificial mice that mimic the genetic and immunological diversity of multiple myeloma in patients, allowing for more effective and personalized treatments. The mouse avatars can also predict treatment outcomes and identify correlations between genetic traits and response to preclinical therapies.
SourceUniversidad de Navarra·JournalNature Medicine·DateMar 29, 2023
Researchers develop unsupervised machine learning algorithm to classify osteosarcoma at diagnosis based on gene expression modules. This approach enables personalized treatment strategies for osteosarcoma patients.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMar 20, 2023
Researchers at Medical College of Georgia identified an increased prevalence of disease-causing genetic variants in females with unexplained infertility. The study found that 17% of these women had gene variants known to cause heart problems and cancer.
SourceMedical College of Georgia at Augusta University·JournalNew England Journal of Medicine·DateMar 17, 2023
Two novel genetically defined mouse models replicate two subtypes of human multiple myeloma, revealing the interaction of genetic aberrations as a key factor in development. The models will aid in identifying specific therapeutic strategies for individualized treatment.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMar 16, 2023
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers used PET and electron microscopy to create detailed maps of mitochondrial networks in lung tumors. They found distinct subpopulations of mitochondria organizing with organelles to support tumor cell metabolism.
SourceUniversity of California - Los Angeles Health Sciences·JournalNature·TypeExperimental study·DateMar 15, 2023
Researchers from Northwestern University discuss the multifaceted tumorigenic functions of EZH2, including its role in regulating translation and coactivating transcription. This new understanding may provide novel insights into advancing EZH2-targeting strategies for prostate cancer patients.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMar 3, 2023
Researchers at Rutgers University used artificial intelligence to analyze genes associated with cardiovascular disease, identifying key factors such as age, gender, and race. The study aims to accelerate early diagnosis and treatment of conditions like atrial fibrillation and heart failure.
SourceRutgers University·JournalGenomics·TypeExperimental study·DateFeb 27, 2023
A new study found that women with BRCA1 or BRCA2 mutations have a cumulative risk of 49% developing any type of cancer after age 50. Risk-reducing surgeries like mastectomies and BSOs can lower this risk, but many women opt out despite elevated risk. Genetic testing is crucial for accurate risk assessment and personalized care.
SourceUniversity of Toronto·JournalCancer·TypeSurvey·DateFeb 24, 2023
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateFeb 21, 2023
Researchers Jack Griffith and Taghreed Al-Turki found that telomeres at chromosome tips can encode two small proteins with potent biological properties. The VR protein is elevated in some human cancer cells and may serve as a biomarker for age-related diseases.
SourceUniversity of North Carolina Health Care·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 20, 2023
Researchers discovered a causal mechanism behind BPTA syndrome by identifying a change in the HMGB1 protein that disrupts cellular self-organization. This disruption leads to developmental disorders and predisposition to cancer, with hundreds of comparable genetic changes associated with various conditions.
SourceCharité - Universitätsmedizin Berlin·JournalNature·DateFeb 8, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers have identified a molecular finger that switches on genes in one-cell embryos, revealing a potential link to cancer. The discovery sheds light on the mechanisms regulating embryonic development and may lead to new insights into cancer detection.
SourceUniversity of Bath·JournalCell Reports·TypeExperimental study·DateFeb 1, 2023
Pusan National University researchers have identified a novel gene, SURF4, that regulates cell death and differentiation in acute myeloid leukemia (AML). The study found that suppressing SURF4 expression increases cell differentiation, cell death, and accumulation of ROS, leading to arrested tumor growth in mice.
SourcePusan National University·JournalCancer Communications·TypeExperimental study·DateJan 31, 2023
A new study led by Mayo Clinic researchers found that women carrying specific genetic changes, such as BRCA1 and BRCA2, have a twofold increased risk of developing contralateral breast cancer. Premenopausal women with these mutations are more likely to develop cancer in both breasts.
SourceMayo Clinic·JournalJournal of Clinical Oncology·DateJan 20, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Scientists at Cold Spring Harbor Laboratory have found a way to reprogram cells causing Ewing sarcoma to behave like normal connective tissue cells. By blocking the protein ETV6, cancer cells can be forced to take on a new identity and grow less aggressively.
SourceCold Spring Harbor Laboratory·JournalNature Cell Biology·DateJan 19, 2023
A new personalized treatment for bile duct cancer has shown remarkable results, with patients surviving for up to two years when treated with the drug futibatinib. The Phase II clinical trial found that the drug was more effective at reducing tumor size and producing modest side effects compared to chemotherapy.
SourceUniversity College London·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateJan 18, 2023
Researchers identified two broad categories of MPNSTs based on their molecular makeup, one of which has a higher number of immune cells and tends to be more survivable. This discovery may lead to new treatment approaches for NF1 patients with MPNSTs, including immunotherapy and genetic testing.
SourceBoston Children's Hospital·JournalCancer Discovery·DateJan 4, 2023
Scientists have decoded the signals plants send themselves to initiate photosynthesis, a process turning sunlight into sugars. The newly identified proteins control communication between plant cells and organelles, potentially leading to breakthroughs in cancer research and improving crop yields.
SourceUniversity of California - Riverside·JournalNature Communications·DateDec 21, 2022
Researchers have developed a comprehensive tool to predict prostate cancer risk, incorporating genetic and family history data. The algorithm aims to identify men at highest risk for targeted screening and diagnostic tests, reducing unnecessary tests for those at low risk.
SourceUniversity of Cambridge·JournalJournal of Clinical Oncology·TypeComputational simulation/modeling·DateDec 9, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A study using spatial single-cell transcriptomics reveals the spatial organization of cancer cells in patient tissues across ages and locations. The research highlights age- and location-dependent differences in tumor biology, suggesting that kids and adults with diffuse midline gliomas may need different treatments.
SourceBoston Children's Hospital·JournalNature Genetics·DateDec 5, 2022
Researchers at VCU Massey Cancer Center discovered the inactivation of NF1 as a potential genetic driver for pancreatic cancer. The study suggests that targeting NF1 could create vulnerabilities for therapeutic advantage in mutant KRAS-bearing tumors.
SourceVirginia Commonwealth University·JournalCell Reports·DateNov 30, 2022
Researchers from Children's Hospital of Philadelphia identified several genetic variants associated with increased cancer risk in children with non-chromosomal birth defects. The study found that these variants were more commonly found in genes related to birth defects and cancer, suggesting a potential basis for early detection.
SourceChildren's Hospital of Philadelphia·JournalBiomarker Research·TypeData/statistical analysis·DateNov 30, 2022
A study published in Oncotarget found that APOE genotype is associated with the presence and severity of cancer treatment-related side effects and symptoms, as well as the response to exercise-based interventions in cancer survivors. ApoE4 carriers showed a lower fall rate after exercise intervention compared to non-carriers.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateNov 22, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers found that genetic copy-number alterations drive HPV-negative head and neck cancers, providing new insights for immune checkpoint inhibitors. The study identified key determinants of resistance and suggests a novel diagnostic biomarker test, potentially leading to improved treatment outcomes.
The ESMO Asia Congress 2022 will focus on the latest scientific and clinical advances in oncology, with a special emphasis on the Asia-Pacific region. Media representatives can register for coverage through the official media registration form.
SourceEuropean Society for Medical Oncology·DateNov 17, 2022
A study by Leiden University Medical Center found six proteins in blood samples that were altered one to two years before a breast cancer diagnosis. The researchers believe these proteins could be used to develop a blood test for early detection of breast cancer in high-risk women.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeObservational study·DateNov 16, 2022
Researchers at the University of Pittsburgh School of Medicine have discovered a genetic link between melanoma tumors and telomere maintenance, which could lead to new treatments for the disease. The study found that mutations in the TPP1 gene stimulate telomerase activity, promoting long telomeres that enable cancer cells to divide in...
SourceUniversity of Pittsburgh·JournalScience·DateNov 10, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers discovered that X chromosome is actively silenced in about 4% of male cancer samples, a phenomenon previously seen only in female cells. This finding could lead to new insights into the development and treatment of various types of cancers.
SourceCell Press·JournalCell Systems·TypeMeta-analysis·DateNov 9, 2022
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateNov 9, 2022
Researchers at Kyoto University have developed a prodrug form of curcumin called TBP1901, which has shown anti-tumor effects without causing harm. The study found that TBP1901's conversion to active curcumin is dependent on the enzyme GUSB, suggesting its potential therapeutic targets.
SourceKyoto University·JournalEuropean Journal of Pharmacology·TypeExperimental study·DateOct 27, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
In a patient trial, the AKT inhibitor ipatasertib showed signs of effectiveness in treating advanced cancers. 22% of patients experienced tumor shrinkage, while 56% had stable disease. Further research is needed to understand why some patients responded and others did not.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeExperimental study·DateOct 26, 2022
A study published in European Journal of Nuclear Medicine and Molecular Imaging identified specific genetic markers associated with high risk of head and neck cancer. The research used DNA sequencing, artificial intelligence, and positron emission tomography to analyze cellular characteristics of tumors. These markers can facilitate mo...
SourceMedical University of Vienna·JournalEuropean Journal of Nuclear Medicine and Molecular Imaging·DateOct 25, 2022
Researchers at Mount Sinai's Tisch Cancer Institute have discovered a new gene, PDZK1IP1, essential to colon cancer growth. The study found that surrounding inflammation activates the super enhancer, promoting tumor cell survival and growth.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNature Communications·DateOct 17, 2022
Researchers developed a computational platform to identify metabolic vulnerabilities in ovarian cancer genes, suggesting opportunities for targeted therapies. The study found that certain genetic alterations can create vulnerabilities in cancer cell metabolism, which can be exploited to selectively kill cancer cells.
SourceMichigan Medicine - University of Michigan·JournalNature Metabolism·TypeExperimental study·DateSep 28, 2022
A study published in JCI Insight has found that genetic variation plays a crucial role in the racial disparity of esophageal cancer cases. Researchers used artificial intelligence-guided tools to pinpoint a specific type of immune cell as the disease driver, and a protective genetic factor associated with African Americans.
SourceUniversity of California - San Diego·JournalJCI Insight·DateSep 22, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers at UEA discovered that 'normal' prostate cells in men with prostate cancer have specific genetic changes that facilitate the growth and spread of cancer. The study suggests treating the whole prostate, not just affected areas, may be more effective.
SourceUniversity of East Anglia·JournalMolecular Oncology·TypeExperimental study·DateSep 21, 2022
A recent study found that low-level mosaic methylation of the BRCA1 gene is associated with an increased risk of triple-negative breast cancer and high-grade serous ovarian cancer. The study confirms that such methylation may be a cancer risk factor, raising questions about its potential impact on other known cancer genes.
SourceThe University of Bergen·JournalJAMA Oncology·DateSep 20, 2022
New research estimates the overall disease burden of genetic risk factors on healthy life years lost, prioritizing interventions using genetic information. The study found that common genetic variants for cardio-vascular diseases and Alzheimer’s disease have a substantial population-level impact.
SourceUniversity of Helsinki·JournalNature Medicine·DateSep 13, 2022
Researchers at Cleveland Clinic link HSD3B1 genotype to higher risk of type 2 endometrial cancer, which is more aggressive and has lower survival rates than type 1. The study builds on previous associations with breast and prostate cancer, suggesting the gene could serve as a biomarker for certain subtypes.
SourceCleveland Clinic·JournalJNCI Cancer Spectrum·DateSep 12, 2022