Researchers at IDIBELL have identified a small molecule called enoxacin that inhibits tumor growth by activating the 'dark genome' and microRNA molecules, offering new potential for cancer treatment. The study's findings open up new directions for anti-tumor therapy targeting microRNA as a therapeutic target.
SourceIDIBELL-Bellvitge Biomedical Research Institute·JournalProceedings of the National Academy of Sciences·DateFeb 28, 2011
A Mayo Clinic research team has pinpointed the function of the MMSET gene, revealing how it enables disease-causing mutations to occur. Normally-functioning MMSET plays a restorative role within the genome, but when impaired, cells lose the correct response to DNA damage.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers identified 27 genes that influence the effectiveness of oxaliplatin in treating colorectal cancer. The study highlights the need for further clinical research to improve treatment outcomes and reduce side effects associated with the drug.
SourceThe Translational Genomics Research Institute·JournalMolecular Cancer Research·DateJan 13, 2011
Researchers have documented genetic abnormalities in human embryonic stem cells and induced pluripotent stem cells, including duplications near pluripotency-associated genes and deletions involving tumor suppressor genes. Frequent genomic monitoring of these cell lines is necessary to ensure their stability and clinical safety.
SourceUniversity of California - San Diego·JournalCell Stem Cell·DateJan 6, 2011
Scientists have identified age-related gene-specific accumulation of DNA methylation that suppresses the critical TGF-beta pathway contributing to ovarian carcinogenesis. This finding provides crucial information for future translational research and may lead to targeted therapeutic interventions.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateDec 13, 2010
A team of researchers discovered that mutant enzymes in leukemia create a chemical poison to cause cancer. This finding suggests a new avenue for treating acute myelogenous leukemia and other cancers.
SourceNewYork-Presbyterian·JournalCancer Cell·DateDec 3, 2010
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
The Salk Institute created the Renato Dulbecco Chair in Genomics and Roger Guillemin Chair in Neuroscience, honoring their groundbreaking research contributions. The $6 million gift from Irwin Jacobs will pay tribute to Drs. Dulbecco and Guillemin's leadership and innovation.
Genomic Systems announces a major breakthrough in treating terminal cancer, citing research published in PNAS that shows an anti-PECAM-1 antibody is effective against three common fatal cancers in mice. The treatment targets normal endothelial cells rather than directly attacking cancer cells.
SourceReputation Doctor·JournalProceedings of the National Academy of Sciences·DateOct 15, 2010
The $1.5 million grant will fund Ben Major's work to identify functional human genes contributing to specific cellular processes, such as cancer growth and migration. The goal is to develop a low-cost approach to determine gene function in the human genome.
SourceUniversity of North Carolina Health Care·DateOct 4, 2010
Researchers found a way to shrink tumors in certain cancers by blocking the production of microRNA 380, which disables the P53 gene. This breakthrough provides hope for new treatments and may return cells to normal when blocked.
SourceResearch Australia·JournalNature Medicine·DateSep 27, 2010
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Two assays, GCR and RQPS, are used to investigate the genetic basis of cancer by measuring chromosomal rearrangements and gene copy numbers. These methods provide insight into pathways that suppress genomic instability in yeast and humans.
SourceCold Spring Harbor Laboratory·JournalCold Spring Harbor Protocols·DateSep 1, 2010
A study mapping vitamin D receptor genome-wide connections autoimmune disease and cancer genes reveals novel links of vitamin D with disease predisposition. Vitamin D insufficiency is a growing concern worldwide, especially for individuals genetically predisposed to be sensitive to deficiency.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateAug 23, 2010
Researchers have identified a gene, CACGN2, associated with chronic pain susceptibility in humans. The study suggests that genetic variants in this gene may contribute to individual differences in chronic pain experience.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateAug 4, 2010
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers at Ohio State University found that breast cancer cells can regulate 14 genes simultaneously in response to estrogen-like compounds like BPA. This mechanism may contribute to cancer development and could serve as a marker for studying environmental exposure.
SourceOhio State University Wexner Medical Center·JournalGenome Research·DateJul 19, 2010
Researchers found genetic risk factors for nasopharyngeal carcinoma (NPC) linked to HLA locus and three new genes TNFRSF19, MDSIEVI1, and CDKN2A/2B. The study advances understanding of NPC's role in southern China's high prevalence.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalNature Genetics·DateMay 30, 2010
Researchers discovered that metformin disables the mTOR complex through RAG GTPase, rather than activating TSC proteins via AMPK. This finding raises the possibility of using metformin more widely to treat cancer and diseases linked to TSC deficiency.
SourceUniversity of Cincinnati·JournalCell Metabolism·DateMay 4, 2010
Researchers analyzed genetic networks of microRNAs in tumors to understand how interactions go awry in disease. The study found that normal network interactions have become disrupted or rewired in cancer, contributing to disease progression.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateMay 2, 2010
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers at Ohio State University discovered that microRNA-155 can silence genes protecting against DNA mutations, contributing to cancer progression. The study suggests miR-155 expression may be a key stratification factor in cancer prognosis and treatment.
SourceOhio State University Wexner Medical Center·JournalProceedings of the National Academy of Sciences·DateApr 29, 2010
Singapore scientists have made significant breakthroughs in understanding early embryonic development using single cell gene expression analysis. The study resolves debates on cellular differentiation events and highlights the importance of fibroblast growth factor signalling in cell fate decisions.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalDevelopmental Cell·DateApr 20, 2010
Cancer genetics expert Bert Vogelstein will review the landscape of cancer genome research and its applications. He predicts that early detection and prevention will be key to reducing cancer deaths in the future.
Researchers at USC have identified a distinct molecular subtype of glioblastoma multiforme (GBM) associated with improved clinical outcomes, including median survival time of over three years. The discovery was made using epigenomics and has potential implications for targeted drug treatments.
SourceUniversity of Southern California·JournalCancer Cell·DateApr 15, 2010
Dr. Von Hoff, TGen's Physician-in-Chief, has been recognized with the David A. Karnofsky Memorial Award and Lecture at ASCO's Annual Meeting. He is a renowned physician-scientist who has contributed to developing numerous anticancer agents.
SourceThe Translational Genomics Research Institute·DateApr 1, 2010
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new study found that one in three early-stage breast cancer patients felt they didn't fully understand their genomic test result discussions, while a quarter experienced distress. The study suggests there is room for improvement in communicating cancer recurrence risks and treatment decisions with patients.
SourceAmerican Cancer Society·JournalCancer·DateMar 8, 2010
A large-scale study reveals over 100 genomic sites with missing or duplicated DNA in tumors, uncovering novel cancer genes and genetic abnormalities shared across multiple cancers. The study highlights the importance of common genomic alterations in driving cancer growth.
SourceBroad Institute of MIT and Harvard·JournalNature·DateFeb 17, 2010
Researchers at the Genome Institute of Singapore have made a significant breakthrough in understanding gene expression and regulation by developing a novel technology called ChIA-PET, which successfully mapped long-range chromatin interactions throughout the human genome.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalNature·DateNov 4, 2009
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers have identified heterochromatin, a gene-poor compartment of DNA, as the key to explaining reproductive isolation. Odysseus, a fruit fly gene, has been found to interact with rapidly evolving DNA in heterochromatin, leading to hybrid sterility.
Researchers aim to understand the 'language' of the human genome by linking proteins to their genomic blueprints. The goal is to enhance efforts to solve pressing health issues like heart disease and cancer.
SourceUniversity of North Carolina Health Care·DateOct 15, 2009
The M.D. Anderson team will use a systems biology approach to analyze multi-gene pathways and combinations of pathways in cancer. The goal is to generate molecular portraits of cancers to personalize therapy choices and improve cancer risk assessment.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateOct 7, 2009
A team of Duke and Singapore scientists have discovered a new way to classify gastric cancers based on the signaling pathways used to grow and spread. This new system may lead to more effective treatments and improved long-term survival for patients, as it allows for stratification according to tumor pathway profiles.
SourceDuke University Medical Center·JournalPLOS Genetics·DateOct 1, 2009
The University of North Carolina has been awarded a $13-20 million Cancer Genome Atlas Grant to better understand the mechanisms responsible for uncontrolled growth of cancer cells. The project aims to develop a comprehensive catalog of genetic and genomic changes in cancers, which could fuel rapid advances in cancer research.
SourceUniversity of North Carolina Health Care·DateSep 30, 2009
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers at Johns Hopkins University developed a highly sensitive test using quantum dots to detect DNA methylation, an early warning sign of cancer. The test could alert people at risk and help doctors determine the effectiveness of cancer treatments.
SourceJohns Hopkins University·JournalGenome Research·DateAug 17, 2009
Researchers at the University of North Carolina have decoded the entire structure of an HIV genome, revealing intricate patterns and structures that play a previously unappreciated role in the virus's lifecycle. This breakthrough opens doors for further research and potential antiviral drug development.
SourceUniversity of North Carolina Health Care·JournalNature·DateAug 5, 2009
A study has pinpointed a genetic link for increased risk of urinary bladder cancer, finding that people with a specific variant have a 30-40% higher risk. The research suggests potential for targeted prevention and early treatment efforts to save lives.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Genetics·DateAug 2, 2009
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
A new region of the genome associated with an increased risk of melanoma has been identified by researchers at Leeds University and IDIBAPS, funded by the European Commission. The study found a link between this region and skin pigmentation, as well as two previously identified regions linked to melanoma risk.
SourceIDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer·JournalNature Genetics·DateJul 5, 2009
A team of researchers from Ben-Gurion University discovered a link between the mitochondria genome and an increased susceptibility to complex diseases like cancer. The study analyzed 98 unrelated individuals and found that certain mutations, which were advantageous in ancestral environments, are now associated with disease.
SourceAmerican Associates, Ben-Gurion University of the Negev·JournalGenome Research·DateJul 2, 2009
Researchers at UNC have redefined the process of X-inactivation, a genetic phenomenon that helps females avoid toxic genes. The new findings suggest Xist gene's role is more nuanced, and its absence may not trigger X-inactivation but rather allow genes to become active again.
SourceUniversity of North Carolina Health Care·JournalNature·DateJul 1, 2009
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Scientists have identified novel epigenetic markers in melanoma that can be used to develop new treatments. The markers, which are alterations to DNA chemical modifications, were found to be correlated with gene repression and can be reversed by treating cancer cells with a drug called decitabine.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateJun 29, 2009
Researchers identified a novel mechanism linking a common single-base variant in chromosome 8 to an increased risk of colorectal cancer. This variant is carried by nearly all African populations and contributes significantly to the disease at a population level, yet its impact on individual susceptibility is minimal.
SourceAcademy of Finland·JournalNature Genetics·DateJun 29, 2009
A team of scientists and clinicians co-led by Joe Gray and Dennis Slamon will study three subtypes of breast cancer: estrogen receptor positive, HER2 positive, and triple negative. Their goal is to match a tumor's genetic profile with the best therapy, using cutting-edge biological, genomic, and computational techniques.
SourceDOE/Lawrence Berkeley National Laboratory·DateMay 27, 2009
Researchers have identified a common genetic variation associated with the risk of colorectal cancer and its functional implications. The study found that this variation causes the expression of a nearby gene, SMAD7, to decrease, leading to critical signaling events that can set cells on the path to cancer.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateApr 23, 2009
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers found Rad60 DNA repair factor mimics SUMO to maintain genome stability during replication, preventing genetic defects and promoting cell viability. The study provides new insights into the mechanisms of genome protection and potential implications for cancer and aging.
SourceScripps Research Institute·JournalNature Structural & Molecular Biology·DateApr 13, 2009
Researchers at Singapore's Genome Institute of Singapore and the US have identified microRNA-125b as a novel regulator of the p53 tumor suppressor gene. The study found that this microRNA keeps p53 levels low during embryonic development, but allows for an increase in p53 to prevent tumor formation if DNA is damaged. Elevated levels of...
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalGenes & Development·DateMar 17, 2009
A study mapping epigenetic marks in three oncogenic viruses found that viral genomes become progressively methylated in patients who developed cancer. This modification may help viruses evade the immune system and is a promising target for new prevention, diagnosis, and treatment methods.
SourceCold Spring Harbor Laboratory·JournalGenome Research·DateFeb 9, 2009
Researchers have identified a genetic signature in normal tissue surrounding liver tumors that can help predict patient recurrence. This finding has the potential to unlock biological information in millions of clinical samples previously inaccessible to genomic study.
SourceBroad Institute of MIT and Harvard·JournalNew England Journal of Medicine·DateOct 15, 2008
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers used a new technique to study gene expression in stored liver tissue samples, identifying a tell-tale genetic profile that indicates likelihood of recurrence. The analysis revealed a characteristic gene expression signature in 186 genes that reliably correlated with high tumor recurrence rates.
SourceHoward Hughes Medical Institute·JournalNew England Journal of Medicine·DateOct 15, 2008
Researchers have identified RMI2, a novel protein essential for genome stability and DNA repair in Bloom's syndrome. The study sheds new light on the disease's underlying mechanisms.
SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateOct 14, 2008
The Cancer Genome Atlas reports findings on the MGMT gene, which makes brain cancer cells more responsive to treatment but also leads to mutations in other genes essential for DNA repair. These mutations contribute to cancer recurrence and resistance to treatment.
SourceJohns Hopkins Medicine·JournalNature·DateSep 8, 2008
The study identifies frequently mutated genes, including ERBB2 and NF1, which were previously underestimated in their role in glioblastoma. The analysis also provides a wide view of how cell pathways are altered during the initiation and growth of glioblastoma, offering insights into strategies to diagnose and treat the disease.
SourceBaylor College of Medicine·JournalNature·DateSep 4, 2008
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A team of researchers has conducted a comprehensive analysis of genomic variation in glioblastoma, the most common and aggressive primary brain tumor. The study's findings highlight the importance of integrating genomic and epigenomic measurements to better understand cancer genetics.
SourceHudsonAlpha Institute for Biotechnology·JournalNature·DateSep 4, 2008
Researchers found a gene enhancer, HACNS1, that may have contributed to the evolution of the human opposable thumb and adaptations for walking on two legs. The discovery provides significant insights into genetic differences between humans and chimpanzees.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalScience·DateSep 4, 2008
A new study identifies three groups of cancers distinguished by early developmental signatures, shedding light on their gene expression patterns. This research provides a reference framework for interpreting smaller-scale functional studies and has implications for understanding human disease from a 'macrobiological' approach.
SourceBMC (BioMed Central)·JournalGenome Biology·DateAug 15, 2008
IGV integrates multiple types of genomic data, allowing for rapid analysis and visualization. The tool provides flexible zooming and panning across all resolution scales.
SourceBroad Institute of MIT and Harvard·DateAug 4, 2008
The University of Alabama at Birmingham has joined a national consortium working to improve treatment and survival for patients with glioma, a type of malignant brain tumor. The Ivy Genomics-Based Medicine Project will use advanced molecular profiling and testing to identify personalized treatments for patients.
SourceUniversity of Alabama at Birmingham·DateJul 8, 2008
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
The Damon Runyon Cancer Research Foundation has awarded fellowships to 14 promising young scientists conducting innovative cancer research projects. The three-year award provides independent funding to support their work in basic and translational cancer research.
SourceDamon Runyon Cancer Research Foundation·DateJun 19, 2008
Researchers at A*STAR have discovered a novel approach to kill colon cancer cells using a genetic regulator called DACT3. The team developed a pharmacological strategy to restore DACT3 expression, leading to effective inhibition of Wnt/β-catenin signaling and massive death of colon cancer cells.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalCancer Cell·DateJun 9, 2008
A new study combines clinical characteristics with genomic profiles to predict breast cancer prognosis and guide treatment. By matching the right drugs with the right patients, researchers aim to provide more personalized treatment strategies.
SourceDuke University Medical Center·JournalJAMA·DateApr 1, 2008
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers investigated germline homozygosity in patients with solid tumors, finding high frequencies of this characteristic associated with increased cancer risk. The study suggests that germline homozygosity at specific loci may contribute to cancer predisposition and could be considered in future cancer risk assessments.
Genetic tests marketed directly to consumers may be premature and lack scientific validity. Dr. Kenneth Offit warns of the risks of self-ordering these tests without guidance from healthcare professionals. He advocates for cautious introduction of new 'whole genome' testing in clinical trials.
SourceMemorial Sloan Kettering Cancer Center·JournalJAMA·DateMar 18, 2008
Genomic medicine shows modest positive effects on psychological outcomes and consumer interest in genetic testing to identify disease risks, but faces significant barriers to integration, including inadequate workforce knowledge and confidence.
Researchers found that viruses associated with microbialites are distinct from those in other environments and indicate the structures' connection to ancient ecosystems. The study provides insights into the evolution of life on Earth and the origins of these unique ecosystems.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalNature·DateMar 17, 2008