Articles tagged with Cancer Patients
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A new study published in Cancer Management and Research found that 1 in 8 older adults with a history of cancer experienced depression for the first time during the early stages of the pandemic. Those with functional limitations, family conflict, and women were particularly vulnerable to depression.
The Lung-MAP master protocol has enrolled higher percentages of patients who are older, from rural or socioeconomically deprived areas, and have Medicaid or no insurance. In contrast, patients on Lung-MAP were less likely to be female or from certain racial and ethnic groups.
Researchers found that patients with HPV-positive cancers develop recurrent disease significantly later than those that were HPV-negative, and also are more likely to spread to the lungs. A new, highly sensitive blood test has been developed to detect cancer earlier, using a framework for combining routine blood testing and imaging.
A team of clinical psychologists at VCU Massey Cancer Center is implementing a virtual telehealth therapeutic intervention program to treat insomnia among military members, veterans and their family members with brain cancer. Cognitive Behavioral Therapy for Insomnia (CBT-I) will be used as the front-line treatment option.
A recent study from Mayo Clinic found that exercise test abnormalities, such as low functional aerobic capacity, predicted non-cardiovascular causes of death like cancer, alongside cardiovascular-related deaths. The study's findings suggest that clinicians should focus on data beyond ECG results to identify patients at risk.
A new study from the University of Michigan found significant language-based disparities in patients' access to cancer care. English-speaking callers were able to get information on next steps 94% of the time, while Spanish-speakers and Mandarin-speakers were only connected at 38% and 28% respectively.
Researchers have developed a device that can be implanted into tumors during surgery to test new treatments, providing unprecedented insight into the effects of drugs on glioma tumors. The device, which is designed to be used during standard of care surgery, caused no adverse effects on patients in a phase 1 clinical trial.
Patients with cancer had disparate COVID-19 mortality rates during the winter Omicron wave compared to the general US population. The study suggests that immune-evasive SARS-CoV-2 variants pose a significant threat, requiring prioritized efforts to prevent transmission.
A new study from the University of Michigan Department of Neurosurgery and Rogel Cancer Center shows promising early results that a therapy combining cell-killing and immune-stimulating drugs are safe and effective in extending survival for patients with gliomas, a highly aggressive form of brain cancer. The treatment improved survival...
Researchers developed a new formulation of doxorubicin that targets cancer cells while reducing cardiotoxicity. The protein-shell encapsulation increases specificity for cancer cells and decreases harm to healthy heart cells.
A study of 11.7 million adults in Ontario, Canada, reveals that COVID-19 infection is associated with significantly higher mortality rates among cancer patients who do not receive prioritized critical care treatment.
The study validates a comprehensive genomic profiling assay, NeXT Dx, which detects single nucleotide variants, indels, copy number alterations, and gene fusions. The assay demonstrates high analytic sensitivities and specificity, providing personalized recommendations critical to clinical decision-making.
A study found that engaging in administrative payment tasks was associated with an 18% increase in cost-related treatment delays or nonadherence among cancer patients and survivors. The burden of learning about healthcare costs and fixing billing errors often falls to the patient, exacerbating existing health disparities.
Researchers evaluated biochemical recurrence as a surrogate endpoint for overall survival, but found no reliable correlation. Biochemical recurrences occur early in the disease course and may impact quality of life, but high-level data tracking this is lacking.
Cancer patients face reduced co-determination and insufficient information about treatment, while doctors feel pressured to give harmful treatments. Patients struggle to understand options and communicate with healthcare professionals.
A recent analysis of published studies reveals a lack of evidence to determine the dosing, safety, and efficacy of medical marijuana or cannabis-containing products for managing symptoms experienced by children with cancer. The study found that cannabinoids performed better in managing nausea and vomiting, but data are lacking on their...
A new clinical study found that adjuvant treatment with Mitotane is not necessary for patients with low risk of recurrence if they have a complete R0 resection, low tumour stage and Ki-67 levels below 10%. This approach has shown no significant improvement in relapse rate but is associated with side effects.
A new study published in the Journal of Vascular Access found that subcutaneous anchors are more effective than adhesive securement devices in preventing catheter dislodgement. The study showed a significant reduction in unplanned catheter replacements and complications, with SecurAcath demonstrating a 99% success rate.
The CABINET trial showed statistically significant and clinically meaningful improvements in progression-free survival for patients with pancreatic and extra-pancreatic neuroendocrine tumors. The study also demonstrated a consistent safety profile for cabozantinib, with no new safety signals identified.
Researchers from Brigham and Women's Hospital evaluated ChatGPT's recommendations for cancer treatment aligned with National Comprehensive Cancer Network (NCCN) guidelines. They found that approximately one-third of the chatbot's responses were non-concordant, highlighting its limitations in clinical decision-making.
A new targeted treatment called zolbetuximab has been shown to extend survival for patients with advanced gastric or gastroesophageal junction cancer that overexpresses a specific biomarker. The treatment significantly increased progression-free and overall survival, with improved results compared to standard chemotherapy.
Cancer patients undergoing certain treatments are at higher risk of COVID-19 infection, but boosting can significantly reduce this risk. Boosting every three months cuts the risk in half, according to a study published in the Journal of the National Cancer Institute.
Researchers have identified a neoplastic fusion transcript RAD51AP1-DYRK4 in luminal B breast cancer, associated with higher ki67 expression and aggressive clinical characteristics. MEK inhibitor trametinib may be effective in blocking the MEK-ERK signaling driven by this fusion.
Patients with cancer who live in rural Pennsylvania counties are more likely to receive complex surgeries at high-volume hospitals due to their perceived better outcomes. However, for less complex surgeries, rural patients are less likely to opt for high-volume hospitals despite potential benefits from centralization.
Researchers found a 19% annual increase in Medicaid-insured cancer patients participating in publicly funded clinical trials after the Affordable Care Act Medicaid expansion. The study shows that targeted policies can increase access to health care and cancer clinical trials for those with Medicaid insurance.
Researchers found a combination of ipilimumab and nivolumab can extend progression-free survival and improve response rates in patients with resistant metastatic melanoma. The treatment showed a 37% improvement in progression-free survival compared to ipilimumab alone.
Glutamine metabolism plays a crucial role in cancer cell growth and survival, with its inhibition shown to block cancer cell growth in vivo and in vitro. A recent editorial paper suggests that glutamine dysregulation may also impact the tumor microenvironment, potentially leading to increased oxidative stress and cancer cell death.
A multidisciplinary team at Hollings Cancer Center has launched a trial to reduce delays in starting radiation therapy after surgery, which can worsen outcomes. The ENDURE approach addresses organizational, team, and patient-level barriers to care, with promising preliminary results.
National guidelines recommend mindfulness meditation, yoga, and music therapy for cancer patients experiencing anxiety and depression. The guidelines are based on strong evidence from clinical studies, providing a comprehensive approach to managing these common side effects of cancer treatment.
A promising molecular diagnostic tool uses a single biomarker to detect primary bladder cancer in patients with hematuria, showing high sensitivity and accuracy. The noninvasive test offers advantages such as shorter turnaround time and efficient analysis of results.
Researchers studied over 800 clinical assays on renal tumors with MiTF family genes TFE3 and TFEB. The findings show significant age differences between patients with TFEB amplification and those with TFE3 or TFEB translocation, with TFEB amplification being associated with poorer prognosis.
Researchers developed tomoelastography, an imaging technique that maps tumor mechanical properties using MRI. Studies found consistent patterns between changes in tumor stiffness and increasing aggressiveness. The technique allows for precise measurement of tumor fluidity, enabling more accurate diagnoses and tailored treatment options.
Researchers found that ranolazine, a heart medication, slows down tumor progression and increases visibility of melanoma cells to the immune system. This combination could improve response rates for immunotherapies in patients with melanoma.
Researchers from Dana-Farber Cancer Institute have developed an AI model to diagnose sarcopenia, a predictor of poor outcomes in head and neck cancer. The tool provides fast, automated, and accurate assessments that can trigger interventions to improve patient care.
A new approach to immunotherapy has shown long-term survival rates exceeding 50% in children with high-risk neuroblastoma. Stem cell transplantation from a parent provides a renewed immune system that responds better to immunotherapies, improving outcomes.
Researchers at Dana-Farber Cancer Institute developed an AI-based tool, OncoNPC, that uses tumor gene sequencing data to predict the primary source of a patient's cancer. The model improved survival outcomes and enabled more targeted treatments for patients with cancers of unknown primary.
A new study published in JNCCN found that the adoption of clinical research results led to a significant increase in the use of shorter adjuvant chemotherapy periods, with CAPOX becoming more widely used. The study also revealed disparities in treatment patterns, with Black patients being more likely to receive shorter chemotherapy reg...
A study found that breast cancer patients with higher body mass index (BMI) are more likely to experience heart damage, or cardiotoxicity, during chemotherapy. The study suggests that addressing obesity and considering the potential risk of cardiotoxicity requires a comprehensive approach.
Researchers found that translating consent documents can discourage investigators from recruiting patients with limited English proficiency, contributing to low rates of participation from underrepresented groups. By relieving investigators of these costs, studies can become more inclusive and results more accurate and generalizable.
Researchers investigated H3K27me3 expression patterns in pediatric brain tumors, finding a global loss of this epigenetic mark in diffused midline glioma (DMG). This loss was associated with high relapse rates and poor survival, highlighting the potential for targeting H3K27me3 as an epigenetically guided cancer therapy.
Researchers aim to treat pancreatic ductal adenocarcinoma by targeting amino acid transporter SLC6A14 and compensatory nutrient scavenging mechanisms autophagy and macropinocytosis. Using alpha-methyl-L-tryptophan and hydroxychlorquine, the study seeks to improve therapeutic outcomes in patients with pancreatic cancer.
A study published in JAMA Network Open found that providing equal access to healthcare reduces disparities in treatment outcomes between Black and white patients with advanced prostate cancer. The research suggests that addressing racial disparities in healthcare may improve survival rates for this patient group.
Researchers identified a specific type of CD8 T cell that characterizes inflammatory arthritis induced by ICI therapies. A unique population of CD8 T cells was found to promote joint inflammation and persist in the bloodstream, explaining why ICI-arthritis continues after therapy is discontinued.
A large clinical trial found that surgery does not increase the number of days patients with advanced cancer are alive and out of the hospital, but improves symptoms and quality of life. Patients who underwent surgery reported fewer bowel-related symptoms after leaving the hospital.
A new open-source software, NMSM Pipeline, enables clinicians and engineers to create personalized computer models of patient movement to optimize treatment designs. The software uses physics-based models to predict and optimize functional outcomes for patients with various mobility impairments.
Researchers discovered that nine percent of esophageal adenocarcinoma patients harbor cancer-predisposing gene mutations, which may trigger progression from Barrett's esophagus. This finding supports the idea that genetic testing can help risk-stratify EAC patients and potentially accelerate development of new treatments.
Researchers discovered that high blood glucose levels make pancreatic cancer cells more sensitive to chemotherapy, which could lead to improved treatment outcomes. In a mouse model and clinical data, the study found a nearly 40% lower risk of death among patients with elevated glucose levels compared to those with normal levels.
PSMA PET imaging provides prognostic information on cancer recurrence risk before treatment, improving personalized treatments and guiding surgical plans. The tool outperforms current standard tests in predicting biochemical recurrence, a critical factor in determining cancer-specific mortality.
A significant fall in Covid-related hospitalisations and mortality among UK cancer patients was found following the vaccine rollout. The study, published in Scientific Reports, revealed that age was a greater predictor of mortality rates than the type of cancer.
Using plasma circulating tumor DNA testing can expedite biomarker testing and time to treatment for patients with suspected advanced lung cancer. The study suggests that this approach may improve patient outcomes.
Researchers found that Syrian refugees with breast cancer were more likely to be younger than Jordanian women and diagnosed with late-stage cancers. The trauma associated with displacement was also a contributing factor to the disparities in treatment gaps for refugees.
A new clinical practice resource provides valuable information for healthcare professionals caring for individuals with pathogenic variants in the CHEK2 gene. The resource assesses personalized risk estimates based on family history, specific variant, and other factors.
A new editorial explores the potential of machine learning to enhance early cancer detection in primary care, leveraging extensive patient data and improving risk stratification accuracy. The authors emphasize the need for responsible implementation, collaboration, and validation across diverse populations.
Researchers discovered that obesity affects ovarian cancer by altering the tumor's immune microenvironment and stiffening surrounding tissue. This change impairs treatment response to chemotherapy, leading to poorer survival rates among patients with high body mass index (BMI).
Scientists identified a process by which enzymes help prevent heart damage in chemotherapy patients. Enzymes normally found in mitochondria move to the nucleus, keeping cells alive. This discovery suggests new methods for testing individual patient responses and potentially preventing heart damage from chemotherapy.
Researchers from CHOP and Penn found that cancer patients who continued to smoke after diagnosis were more likely to receive tobacco treatment when nudges were directed at clinicians through electronic health records. This study strengthens the case for using behavioral economics to improve outcomes for cancer patients.
Conventional psychotherapeutic approaches for women with late-stage gynaecological cancers take too long and require too much stamina. Psilocybin-assisted psychotherapy has shown promise in treating anxiety, depression, and end-of-life distress with rapid and sustained effects.
Researchers report a case of a 15-year-old boy with recurrent intrathoracic synovial sarcoma who achieved partial response with BRAF inhibitor Vemurafenib treatment. The study highlights the importance of routine next-generation sequencing to drive treatment choice and investigate BRAF mutations in SS tumors.
The updated guidelines urge the clinical use of validated geriatric assessments (GA) to guide treatments in patients aged 65 and older. This approach often results in de-escalation or reduction of therapies, reducing side effects and improving quality of life without compromising survival odds.
A group of global oncologists and patient advocates argue that cancer care is driven by commercial interests, not patient needs. The 'Common Sense Oncology' movement aims to prioritize patient outcomes over profit-driven research and treatment development.