Articles tagged with Cancer Patients
A large clinical trial found that surgery does not increase the number of days patients with advanced cancer are alive and out of the hospital, but improves symptoms and quality of life. Patients who underwent surgery reported fewer bowel-related symptoms after leaving the hospital.
A new open-source software, NMSM Pipeline, enables clinicians and engineers to create personalized computer models of patient movement to optimize treatment designs. The software uses physics-based models to predict and optimize functional outcomes for patients with various mobility impairments.
Researchers discovered that nine percent of esophageal adenocarcinoma patients harbor cancer-predisposing gene mutations, which may trigger progression from Barrett's esophagus. This finding supports the idea that genetic testing can help risk-stratify EAC patients and potentially accelerate development of new treatments.
Researchers discovered that high blood glucose levels make pancreatic cancer cells more sensitive to chemotherapy, which could lead to improved treatment outcomes. In a mouse model and clinical data, the study found a nearly 40% lower risk of death among patients with elevated glucose levels compared to those with normal levels.
PSMA PET imaging provides prognostic information on cancer recurrence risk before treatment, improving personalized treatments and guiding surgical plans. The tool outperforms current standard tests in predicting biochemical recurrence, a critical factor in determining cancer-specific mortality.
A significant fall in Covid-related hospitalisations and mortality among UK cancer patients was found following the vaccine rollout. The study, published in Scientific Reports, revealed that age was a greater predictor of mortality rates than the type of cancer.
Using plasma circulating tumor DNA testing can expedite biomarker testing and time to treatment for patients with suspected advanced lung cancer. The study suggests that this approach may improve patient outcomes.
Researchers found that Syrian refugees with breast cancer were more likely to be younger than Jordanian women and diagnosed with late-stage cancers. The trauma associated with displacement was also a contributing factor to the disparities in treatment gaps for refugees.
A new clinical practice resource provides valuable information for healthcare professionals caring for individuals with pathogenic variants in the CHEK2 gene. The resource assesses personalized risk estimates based on family history, specific variant, and other factors.
A new editorial explores the potential of machine learning to enhance early cancer detection in primary care, leveraging extensive patient data and improving risk stratification accuracy. The authors emphasize the need for responsible implementation, collaboration, and validation across diverse populations.
Researchers discovered that obesity affects ovarian cancer by altering the tumor's immune microenvironment and stiffening surrounding tissue. This change impairs treatment response to chemotherapy, leading to poorer survival rates among patients with high body mass index (BMI).
Scientists identified a process by which enzymes help prevent heart damage in chemotherapy patients. Enzymes normally found in mitochondria move to the nucleus, keeping cells alive. This discovery suggests new methods for testing individual patient responses and potentially preventing heart damage from chemotherapy.
Researchers from CHOP and Penn found that cancer patients who continued to smoke after diagnosis were more likely to receive tobacco treatment when nudges were directed at clinicians through electronic health records. This study strengthens the case for using behavioral economics to improve outcomes for cancer patients.
Conventional psychotherapeutic approaches for women with late-stage gynaecological cancers take too long and require too much stamina. Psilocybin-assisted psychotherapy has shown promise in treating anxiety, depression, and end-of-life distress with rapid and sustained effects.
Researchers report a case of a 15-year-old boy with recurrent intrathoracic synovial sarcoma who achieved partial response with BRAF inhibitor Vemurafenib treatment. The study highlights the importance of routine next-generation sequencing to drive treatment choice and investigate BRAF mutations in SS tumors.
The updated guidelines urge the clinical use of validated geriatric assessments (GA) to guide treatments in patients aged 65 and older. This approach often results in de-escalation or reduction of therapies, reducing side effects and improving quality of life without compromising survival odds.
A group of global oncologists and patient advocates argue that cancer care is driven by commercial interests, not patient needs. The 'Common Sense Oncology' movement aims to prioritize patient outcomes over profit-driven research and treatment development.
A synoptic report improved the completeness of pretreatment CT reports in patients with advanced ovarian cancer. Involvement of surgically established unresectable or challenging-to-resect disease sites was mentioned in all disease-specific synoptic reports, compared to 37% of simple structured reports.
Researchers found that healthy breast adipocytes secrete IGFBP2, which acts as a barrier against invasive breast cancer progression. Lower IGFBP2 levels with age may contribute to increased breast cancer risk.
A team of UVA Health experts warns that surgeon-scientists are struggling to obtain research funding, which could lead to a decline in innovations for patients. The researchers found that internal medicine trainees are six times more likely to secure R01 grants and career development awards.
Studies showed mRNA vaccines provided long-term immunity against severe COVID-19 outcomes in cancer patients. The study found waning immunity after up to 4 mRNA vaccine doses, highlighting the need for booster shots.
Amplified Sciences has received a $400,000 NCI grant to develop and validate an assay testing for the detection of pancreatic cancer in patients diagnosed with pancreatic cystic lesions. The company aims to improve the accuracy of diagnoses, reducing unnecessary surgical interventions.
A new study found that cetuximab plus radiotherapy is an active treatment option for locally advanced cutaneous squamous cell skin cancer, with an objective response rate of 83.2%. The treatment was well-tolerated, with most patients experiencing mild acneiform skin rash or fatigue.
A new study by Yale University reveals that combining pembrolizumab with other treatments reduces tumor size and improves response rates for patients with advanced NSCLC. The treatment regimens resulted in higher survival outcomes, particularly in patients with specific biomarker-defined subgroups.
Researchers at Mass General Cancer Center treated 16 patients with a BRAF/MEK inhibitor, resulting in a 91% reduction in tumor size and complete response in all patients who received one or more cycles of therapy. The treatment showed unprecedented success in targeting brain tumors using precision medicine approaches.
Researchers at UCLA Jonsson Comprehensive Cancer Center confirmed genetic variants of unknown significance are verified mutations that increase the risk of kidney cancer. The findings could lead to new treatment options for people with hereditary leiomyomatosis and renal cell cancer (HLRCC).
Researchers identified methylation in normal tissues in some patients with mismatch repair deficiency, leading to undiagnosed Lynch syndrome. This study suggests revising current screening guidelines to include this poorly recognized cause of hereditary cancer.
A new study reveals Indigenous men in Canada are more likely to be diagnosed with advanced prostate cancer and experience cancer spread, despite universal healthcare access. Researchers identify key infrastructure changes needed to improve screening and treatment outcomes.
A new study reveals that preoperative hydroxyprogesterone administration can improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, such as DSCAM-AS1, play a regulatory role in this process.
A study found that 79 patients experienced high financial toxicity, with 89% reporting hardship, and highlighted patient characteristics and coping strategies. Patients made personal sacrifices to remain compliant with treatments, including reducing spending and borrowing money.
A University of Minnesota-led study demonstrated the safety of microbiota transplant therapy (MTT) in patients with acute myeloid leukemia (AML) and recipients of hematopoietic cell transplantation (HCT). MTT showed improved gut bacteria balance but did not significantly reduce infections. The study's results will inform a larger follo...
Researchers have found that PD-L1 triggers signaling that intrinsically alters cancer cell phenotype, impacting immune milieu. The study's findings suggest a new approach to treating patients with limited response to immunotherapy.
A new study by the American Cancer Society found that Medicaid expansion is associated with an increase in palliative care services for patients with advanced cancers. The study discovered that eligible patients who received palliative care increased from 17% to 18.9% in states with Medicaid expansion.
Researchers at Moffitt Cancer Center found that higher c-reactive protein levels were associated with greater depression and less physical activity among patients with gynecologic cancers. However, most inflammatory markers were not linked to treatment-related symptoms.
A team of researchers has identified a unique genetic signature in CAR T-cells that enables them to persist in the body for a longer time, leading to improved remission rates for children with leukaemia. This discovery provides a new understanding of why some CAR T-cells last longer and can help improve treatment outcomes.
Researchers at Paul Scherrer Institute have developed a beamline modification called momentum cooling to increase the transmission of proton beams, allowing for shorter treatment times. This breakthrough could enable faster treatments while maintaining accuracy and sparing healthy tissue, with potential benefits including reduced costs...
A Mayo Clinic study reveals that minimally invasive surgical procedure staging laparoscopy can identify cancer spread early and determine the stage of pancreatic cancer. The research found a higher risk of cancer spread in patients with certain factors, such as age and tumor markers.
A new study from Aarhus University found that people with mental health issues are less likely to accept offers of colorectal cancer screening. The research showed that those with severe mental disorders had a 13.8 percentage point lower participation rate compared to those without mental illness.
Cancer survivors rely on primary care clinicians for follow-up treatments, especially in rural areas. Researchers found that clinicians lack access to information and online trainings, making treatment and outreach more difficult. The study suggests equipping primary care physicians with tools and using technology to expand reach.
Researchers developed a risk calculator using persistent homology scores from CT scans, which is the strongest predictor of overall survival among standard clinical measures. The calculator has the potential to guide clinicians in choosing treatment options and transform the way outcomes are predicted.
A new AI model has been developed to help doctors determine the extent of cancer within the prostate gland, improving the effectiveness of focal therapy. The model was found to be more accurate than magnetic resonance imaging (MRI) in predicting tumor margins, reducing the chance of cancer recurrence.
A new global study published in the leading cancer journal finds that funding for cancer patient navigators improves medical outcomes, increases screening rates, and reduces healthcare costs. Navigators provide personalized care, support patients with diagnosis, treatment options, and relevant medical information.
A retrospective analysis of ambulatory cancer patients found that unmet supportive care needs are associated with increased risk for emergency department visits and hospitalizations. Patients with Black race, Hispanic ethnicity, or low health-related quality-of-life scores were more likely to experience these outcomes.
Scientists found that CXCL13-mediated recruitment of B cells helps predict response to immunotherapy treatment. This cooperation between T cells and B cells is associated with improved survival in patients treated with immunotherapy.
A study published in the Journal of the American Academy of Dermatology found that curettage and cryosurgery is an effective and safe treatment method for basal cell carcinoma. The procedure involves scraping the lesion with a curette followed by freezing, resulting in good outcomes with minimal side effects.
The FRESCO-2 phase III study demonstrated statistically significant improvements in overall survival and progression-free survival in patients with refractory metastatic colorectal cancer treated with fruquintinib. Fruquintinib showed a favorable safety profile, with patients staying on treatment almost twice as long as those on placebo.
Researchers found that patients producing high levels of Cystatin C, a protein linked to immune system suppression, had worse survival rates and were less likely to benefit from immunotherapy. This suggests that Cystatin C may play a role in the failure of cancer immunotherapy.
Researchers at the University of Malaga develop a new therapy using manual techniques and stretching to reduce pain and improve mobility in women with axillary web syndrome after breast cancer. The therapy, consisting of 15 sessions, has shown significant results in reducing evolution time of lymphatic thrombi.
Cancer cells can hide and escape therapies leading to recurrence. Researchers identify three possible mechanisms: cancer stem cells, polyploidy, and senescence. Combination treatments involving chemoradiation-induced transitory senescence and senolytic therapies may be effective in preventing repopulation.
Researchers at University Hospital Bonn have developed a new approach to predict therapy response in patients with metastatic renal cell carcinoma by incorporating two simple blood parameters, CRP and albumin. This method improves the prediction of treatment response, especially in patients with disease control in the first follow-up.
Researchers discuss the potential of glucocorticoid-induced TNFR-related protein (GITR) as a target for cancer immunotherapy. Preclinical studies have shown potent anti-tumor efficacy, but clinical trials have yielded inconsistent results due to complexities in immune responses and antibody structure.
Researchers have found a hidden mechanism connecting cancer and diabetes, where cancer cells don't respond well to insulin, leading to faster cancer growth. Insulin resistance can also cause muscle loss and strength decline in cancer patients.
A randomized phase II study found that adding metformin to androgen deprivation therapy did not reduce the risk of metabolic syndrome or improve PSA response in patients with advanced prostate cancer. Metformin showed some antitumor effects through mTOR inhibition, but these were not significant.
Researchers have created a new prediction tool to evaluate the benefits of blood cancer treatments, filling a gap in previous versions. The ESMO-MCBS:H v1.0 tool uses a validated algorithm to assess clinical benefits, survival data, and quality of life, providing a transparent assessment for clinicians.
Researchers developed outcome indicators to measure health issues in children with cancer, allowing for improvement in care and treatment. The indicators consider physical, psychosocial, and neurocognitive outcomes, providing a clear and comparable measurement of quality of survival.
Fruquintinib has shown statistically significant improvement in overall survival and progression-free survival rates for patients with metastatic colorectal cancer. The median survival rate was 7.4 months, with a 34% reduction in death compared to the placebo group.
A study by Martin-Luther-University Halle-Wittenberg found a link between high levels of IGF2BP2 and faster-growing bowel cancer tumours with chemotherapy resistance. The protein's role in cell growth and metabolism may lead to the development of new diagnostic procedures and therapeutic strategies.
A patient with kidney cancer overcame several metastases with temsirolimus, leading researchers to identify key mutations that make this treatment effective. The study found that patients with USP9X mutations have altered autophagy and respond better to temsirolimus.
The Ontario Institute for Cancer Research (OICR) has awarded six research teams with two-year funding to pursue innovative cancer treatments and technologies. The projects focus on personalized medicine, accessible genetic testing, and improving patient engagement.
A new study published in JNCCN found that taking alectinib, a medication for advanced lung cancer, with a full breakfast or lunch resulted in higher drug concentrations than with a low-fat breakfast. This could impact treatment efficacy and survival rates for patients.