Articles tagged with Cancer Patients
Researchers from the UCLA Jonsson Comprehensive Cancer Center are presenting findings on combination therapies for breast cancer and a potential new treatment for patients with recurrent glioma. A phase 3 study evaluating vorasidenib versus placebo in patients with residual or recurrent grade 2 glioma with an IDH1/2 mutation is also be...
A study found that measuring three potential biomarkers on day three after a stem cell transplant can identify patients at risk of sinusoidal obstruction syndrome (SOS). Patients with positive scores were 9.3 times more likely to develop SOS and more likely to die within 100 days.
A recent study analyzing US FDA PATH data found a correlation between current tobacco use and symptom burden among adult cancer survivors. However, symptoms were not related to the desire to quit smoking. The findings suggest that better management of cancer symptoms may help survivors quit smoking.
Researchers discovered that FDA-approved HDAC-inhibitors can impact energy metabolism in solid tumor cells, including glioblastoma. The combination of HDAC-inhibitors and imipridones may synergize to enhance killing of GBM cells by reversing cellular respiration.
Dr. John H. Bushweller's team at UVA Cancer Center is developing novel drugs to block abnormal proteins that cause pediatric leukemia. The new approach aims to improve efficacy and reduce toxicity, potentially leading to better patient outcomes.
Researchers at Koc University have identified a novel molecular mechanism that can slow down or block muscle wasting in cancer patients. The activation of EDA2R signalling promotes skeletal muscle atrophy, and deleting either EDA2R or NIK enzyme can protect the organism from muscle loss.
Researchers at UCLA Jonsson Comprehensive Cancer Center have found a potential therapeutic target, IL-21, to reduce endocrine autoimmune side effects from checkpoint immunotherapy. A specific group of immune cells play a central role in this autoimmune attack and blocking IL-21 prevents thyroid autoimmunity.
Researchers have created a new measure called the LRRC–QoL to assess health-related quality of life in patients with locally recurrent rectal cancer. The tool captures a wide range of issues affecting these patients, providing a more comprehensive understanding of their experiences.
A new study by researchers from the University of Edinburgh found that double testing with a faecal immunochemical test (FIT) increases the detection rate of bowel cancer to nearly 100%. This approach ensures more cases are identified and can potentially reduce demand for colonoscopies.
A new Northwestern Medicine study found young adult cancer survivors (18-39 years old) are 2.6 times more likely to develop heart failure when treated with anthracyclines. The incidence is highest among leukemia and other specific cancer types.
Researchers from China explore the mechanisms of action and clinical data of bispecific antibodies, which have shown promise in increasing cytotoxicity against cancerous cells and enhancing immune response towards tumor clearance. Several bsAbs are being evaluated in phase I-III clinical trials for lung cancer treatment.
Researchers at Dartmouth Cancer Center found that alternating estrogen stimulation and anti-estrogen therapy is an effective treatment for patients with metastatic or advanced ER+ breast cancer. The POLLY trial showed that 42% of patients experienced tumor stabilization, while no patients discontinued treatment due to side effects.
Researchers developed a novel combination therapy that eradicates tumors in select patients, with prolonged survival rates. The therapy has shown promise in treating glioblastoma, a notoriously difficult-to-treat primary brain cancer.
A recent clinical trial, PLATO, demonstrated that lowering the dose and duration of radiotherapy treatments for anal cancer reduces side effects without compromising cancer cure rates. The treatment involves intensity modulated radiotherapy (IMRT), which allows for personalized doses to be applied to visible tumors.
A Phase I/II clinical trial combining intratumoral delivery of an engineered oncolytic virus with subsequent immunotherapy improved survival outcomes in a subset of patients with recurrent glioblastoma. The study demonstrated the combination was well-tolerated, with no dose-limiting toxicities.
Researchers found that fatty liver cells secrete proteins and genetic material that promote the spread of colorectal cancer to the liver. This condition is likely underdiagnosed, affecting over 40% of patients with colorectal cancer, according to a new study published in Cell Metabolism.
Researchers at USC Norris Comprehensive Cancer Center have identified a biomarker, CX3CR1, that can predict which patients with non-small cell lung cancer will respond well to chemoimmunotherapy. Elevated levels of the biomarker in T-cells after six to nine weeks of treatment indicate long-term benefits from the combination therapy.
A randomized clinical trial found that providing palliative care at the time of cancer surgery did not improve patient outcomes, including quality of life and survival. The study suggests that surgeons should not be reluctant to call for palliative care consultations based on fear of upsetting patients.
A new study from the USC Norris Comprehensive Cancer Center found that immigrant adults with liver cancer have a significantly higher five-year survival rate compared to those born in the US. The study identified disparities in survival rates across different racial and ethnic groups, with immigrants demonstrating better outcomes.
Researchers developed a predictive model to identify tumor biomarkers of cachexia in lung cancer patients. The study used machine learning to build a muscle loss prediction model based on muscularity, clinical data, and the transcriptional profile from the tumor microenvironment.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
The new Winship Cancer Institute at Emory Midtown offers a unique patient-centered, multidisciplinary cancer care model integrated with innovative research. The $200 million gift from the Robert W. Woodruff Foundation enabled the construction of a state-of-the-art facility featuring five 'care communities' and 80 inpatient beds.
Researchers have identified a standard for gallbladder cancer surgery, highlighting its impact on short- and long-term postoperative outcomes. The benchmark group showed significantly better overall survival rates compared to non-benchmark groups.
A recent clinical trial showed that cemiplimab plus platinum chemotherapy can prolong survival in patients with advanced lung cancer, improving their quality of life. The treatment also reduced symptoms such as pain and cough, and delayed clinically meaningful deterioration.
Researchers created organoids from patient tissues to test chemotherapy drugs and identified genetic signatures that predict treatment response, offering high accuracy in personalized drug screening. This breakthrough may help select effective drugs for individual patients, reducing trial and error.
A large-scale study of patient experiences with telemedicine and in-person visits found that telemedicine consistently outperformed in-person visits in terms of access to care and provider engagement. The study analyzed survey responses from over 39,000 patients across more than 50,000 visits.
Quitting smoking early after a lung cancer diagnosis was associated with lower mortality rates. Detailed smoking history collection can improve lung cancer prognosis and treatment selection. The study's findings suggest that smoking cessation timing may impact overall survival, particularly at different clinical stages.
A multi-institutional phase 3 clinical trial found that a cancer stem cell test can accurately decide more effective treatments and lead to increased survival for patients with recurrent glioblastoma. ChemoID, a CLIA-accredited diagnostic test, was used to select chemotherapy treatments, resulting in significantly lower risk of death a...
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
Researchers developed a calculator to identify patients with multiple myeloma and primary systemic amyloidosis who have a more benign profile, allowing for personalized treatment. The tool predicts survival based on clinical-biological characteristics and has been validated in international series.
A study of 1,340 women with high-risk breast cancer found that strongest collective adherence to lifestyle recommendations was associated with significant reductions in disease recurrence and mortality. Education strategies to help patients adhere to cancer prevention recommendations are warranted.
A phase 2 clinical trial testing a treatment combining standard chemotherapy with azacitidine showed nearly 90% of patients with aggressive T-cell lymphoma achieved complete remission. The treatment, which targets gene-silencing marks on DNA, has an estimated two-year progression-free survival rate of 69.2%.
Researchers at West Virginia University found that bariatric surgery significantly reduces the risk of major cardiovascular events and death in patients with NAFLD. The study included 9,374 adult patients with NAFLD and obesity, who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy.
A clinical trial of 406 patients found that a fluorescent agent allowed surgeons to identify and remove residual tumor tissue with favorable results. The technique showed promising results in detecting tumor tissue missed by standard lumpectomy procedures, potentially avoiding second surgeries for positive margins.
A new study suggests combining digital cancer risk assessment with point-of-care genetic testing can help overcome clinical workflow challenges that prevent at-risk patients from accessing genetic testing. The approach more than doubled the average uptake of genetic testing, showing promise for cancer prevention and detection.
A multicentre registry study found that medicinal cannabis can safely relieve cancer pain while reducing the total number of medications and opioids taken. Products with an equal balance of THC and CBD were particularly effective in reducing pain intensity and symptoms.
Researchers discuss the importance of biomarkers in breast lump management, enabling patients to make informed decisions between proactive treatment and watchful waiting. The development of biomarkers could provide personalized risk assessments and guide treatment strategies for women with breast lumps.
Scientists successfully opened the blood-brain barrier using a novel ultrasound device, delivering chemotherapy to treat glioblastoma patients. The treatment increased drug concentrations by 4-6 times and was safe and well-tolerated.
New Finnish studies show that short bouts of light or moderate exercise can increase the number of immune cells capable of destroying cancer cells in cancer patients. The exercises were enough as short as 10 minutes to boost the immune system, with a positive impact on quality of life and prognosis.
A new study found that cannabis use by cancer patients leads to reduced pain levels, improved sleep quality, and enhanced cognitive function. After two weeks of sustained use, patients reported better thinking clarity and objective measures of cognition also showed improvements.
Children's Hospital Los Angeles researchers have identified a disruption in early kidney progenitor cell development linked to the formation of Wilms tumor. The study found that these cells can reproduce the original tumor and are aggressive, drug-resistant, and metastasize like cancer cells.
A first-of-its-kind study has estimated that transgender women taking estrogen are at a higher risk for prostate cancer, with 14 cases per 10,000 people. The study found disparities in diagnosis rates among different racial groups.
A study identified a protein, UBE2C, present in brain metastases associated with worse disease prognosis. Researchers found that high levels of UBE2C increase the spread of tumor cells in the central nervous system.
Researchers found that spinal cord stimulation reduced pain response in rats with human lung cancer tissue without compromising paclitaxel effectiveness. The study also showed SCS improved antitumor efficacy of paclitaxel, providing evidence for its potential as a companion treatment.
The NRG Oncology study found that stereotactic radiosurgery was not superior to conventional external beam radiotherapy in terms of pain response, and even showed worse pain response at 3 months. Conventional radiotherapy remained effective with a 50-60% pain relief rate, but only lasting four months.
Researchers developed a biomarker signature test to predict which bladder cancer tumors will respond to immunotherapy, potentially improving survival rates. The study identified three types of responsive tumors and two non-responsive ones, providing insights into potential new treatments.
Researchers at the University of Colorado Cancer Center have made a breakthrough in treating pancreatic cancer by combining radiation and immunotherapy. The treatment eradicates tumors while stopping the cancer from spreading, offering new hope for patients. Clinical trials are planned to further develop this therapy.
Researchers analyzed genetic changes in organs of recently deceased patients with metastatic cutaneous melanoma to understand how the disease spreads and evolves. They found that cancer cells take advantage of specific organ environments, pointing to the need for distinct treatment approaches.
A new study found that unintentional weight loss is grossly under-recognized in primary care, with only 21% recognized by doctors. The researchers recommend using electronic health record alerts to prompt clinicians to ask about intentional or unintentional weight loss, which can be a sign of a serious underlying condition.
The guideline provides guidance on definitive local therapy options for non-small cell lung cancer with limited extracranial metastases. It emphasizes the need for a patient-centered, multidisciplinary approach to treatment decisions.
Researchers found that checkpoint inhibitors are not effective in treating relapsed aggressive lymphomas after CAR T therapy. The study involved 96 patients from 15 centers and showed only 19% response to checkpoint inhibitor therapy.
Research suggests that patients with advanced melanoma who receive immunotherapy medications may benefit from maintaining normal vitamin D levels. The study found a favorable response rate in 56% of patients with normal baseline vitamin D levels, compared to 36% with low levels.
A novel cell signaling pathway has been identified that could be targeted to treat aggressive pancreatic cancers. The High Mobility Group A1 (HMGA1) protein functions as a 'molecular switch' that activates genes required for tumor growth and invasion. Silencing HMGA1 or disrupting FGF19 signals in mouse models resulted in decreased tum...
A meta-analysis of 33,541 cancer patients found that advance care planning was associated with lower odds of aggressive end-of-life care, including chemotherapy and intensive care. Patients who engaged in advance care planning were also more likely to complete do not resuscitate orders.
Researchers developed a gene signature called CisSig to predict cancer patients' response to cisplatin. The approach aims to overcome the obstacle of interpreting gene signatures in the human body and has been validated in muscle-invasive bladder cancer patients.
Researchers at Indiana University School of Medicine have identified a new target for breast cancer treatment, the gene TONSL, which can make breast cells proliferate indefinitely. The study found that TONSL is amplified in about 20% of breast cancers and more than 30% of metastatic breast cancers.
Researchers found that bad medical news can make patients more likely to choose brand name drugs over generics, resulting in increased healthcare expenditures. The study suggests that simply reminding patients of the equivalency of generic drugs via text message could improve their decision-making.
A study of 415,000 US female breast cancer deaths from 2011 to 2020 found that Black women should start screening earlier than previously recommended. Health policy makers and clinicians may consider an alternative approach with race- and ethnicity-adapted age recommendations for breast cancer screening.
A multicenter study found stereotactic radiosurgery to be highly effective in controlling vestibular schwannoma growth in NF2 patients while maintaining serviceable hearing. The procedure was also shown not to cause radiation-related tumor development or malignant transformation, addressing long-standing concerns.
Researchers found that young adults with previously had cancer have a 70% increased risk for HPV-related cancers. This includes oropharyngeal cancers and cervical HPV-related cancers, particularly among Hispanic survivors.