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Nomogram to determine individualized estimates of screen-detected prostate cancer overdiagnosis

A new nomogram developed by Roman Gulati et al. estimates the likelihood of overdiagnosis for screen-detected prostate cancers, considering patient age, Gleason score, and PSA level at diagnosis. The model predicts risks ranging from 2.9% to 88.1% depending on individual characteristics.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateJan 6, 2014

Embargoed news from Nov. 19, 2013 Annals of Internal Medicine tip sheet

A new study published in Annals of Internal Medicine suggests that calculating comorbidity-adjusted life expectancy may help physicians determine whether to continue or stop cancer screening in elderly patients. The researchers found that patients with higher levels of comorbidity had shorter life expectancies than healthy patients of ...

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateNov 18, 2013

Primary HPV screening provides 60–70 percent greater protection against invasive cervical cancer than cytology-based screening

A study of four European trials found that HPV-based screening provided greater protection against invasive cervical cancer than cytological screening. The analysis showed that HPV-based screening protected 60-70% more women from invasive cancers, with increased protection seen in women aged 30-35 years and those screened every 5 years.

SourceThe Lancet_DELETED·JournalThe Lancet·DateNov 2, 2013

Imaging breast cancer with light

Researchers at the University of Twente in the Netherlands have developed a new imaging tool called the photoacoustic mammoscope, which uses a combination of infrared light and ultrasound to create a 3-D map of the breast. The device has shown promise in detecting breast cancer early, when it is most treatable.

SourceOptica·JournalBiomedical Optics Express·DateOct 23, 2013

Capturing live tumor cells in the blood

Researchers develop a new microfluidic chip that can capture over 90% of circulating tumor cells from patient blood, providing potential applications for cancer screenings, treatment assessments, and disease progression determination. The technique shortens processing time and improves efficiency compared to existing methods.

SourceAmerican Institute of Physics·JournalBiomicrofluidics·DateAug 8, 2013

Regenstrief, IU study: Caregivers open to stopping cancer screening as dementia progresses

A study found that many family caregivers of older adults with dementia are willing to consider stopping cancer screening, which can reduce patient burden, healthcare costs, and family caregiver distress. Caregivers are most open to discussions when focusing on quality of life and burdens and benefits for the person with dementia.

SourceIndiana University·JournalJournal of the American Geriatrics Society·DateJul 19, 2013

Outdated practice of annual cervical-cancer screenings may cause more harm than good

A recent study found that many obstetrician-gynecologists continue to provide annual cervical-cancer screenings despite updated guidelines. The research suggests less frequent screening every three years can retain most benefits while reducing harms and costs. Experts recommend a more balanced approach to cervical cancer screening.

SourceUniversity of North Carolina at Chapel Hill·JournalAmerican Journal of Preventive Medicine·DateJul 9, 2013

'Scent device' could help detect bladder cancer

Researchers from the University of Liverpool and University of the West of England have developed a device that can detect bladder cancer through urine scent analysis. The ODOREADER device analyzes chemicals in gas emitted from urine to produce a 'profile' that can be used to diagnose cancer cells in the bladder.

SourceUniversity of Liverpool·JournalPLOS ONE·DateJul 8, 2013

Novel RNA-based classification system for colorectal cancer

A novel transcriptome-based classification of colon cancer has been developed, improving disease stratification based on clinicopathological variables and common DNA markers. The analysis identified six molecular subtypes associated with distinct clinical and pathological characteristics.

SourcePLOS·JournalPLOS Medicine·DateMay 21, 2013

Some minorities believe they are less likely to get cancer compared to whites, Moffitt study shows

A Moffitt Cancer Center study found that minority groups, including blacks, Asians, and Hispanics, hold differing beliefs about cancer prevention and feel they are less likely to get cancer. The researchers concluded that more culturally relevant information is needed to reach these populations.

SourceH. Lee Moffitt Cancer Center & Research Institute·JournalAmerican Journal of Health Promotion·DateApr 17, 2013