Articles tagged with Disease Susceptibility
Researchers discovered that a lipid called prostaglandin E2 weakens lung immune cells with age. This increased PGE2 production impairs alveolar macrophage health and leads to a suppressed immune response, making older people more vulnerable to flu infections.
Researchers have discovered that mutations in mitochondrial-related genes can trigger hyperinflammation, leading to diseases such as Crohn's disease and tuberculosis. The study found that these mutations lead to a new type of cell death called necroptosis, which causes an aggressive inflammatory immune response.
Researchers have made a surprising discovery that liquid smoke can enhance plant defense against pests and diseases, leading to new farming practices. The study found that sunflowers grown in soil treated with liquid smoke had larger, thicker, and greener leaves and appeared less prone to pests and disease.
Researchers analyzed DNA from victims and survivors of the Black Death to identify genetic differences that determined who lived and died. The study found four genes involved in immune defense against pathogens, with versions of these genes linked to increased susceptibility to autoimmune diseases.
Individuals with Down syndrome experience less frequent but more severe viral infections, attributed to increased type I interferon expression. This leads to hyperactive immune responses initially, followed by overcorrection, resulting in increased vulnerability late in the viral attack.
A new study found that electronic gaming can precipitate life-threatening cardiac arrhythmias in susceptible children with previously unrecognized predispositions. The most common underlying causes were catecholaminergic polymorphic ventricular tachycardia and congenital long QT syndrome types 1 and 2.
A University of California, Berkeley study found that aging and environment are more important than genetic variation in affecting gene expression. As individuals age, their gene expression profiles diverge, making genetics less useful in predicting which genes are ramped up or down.
A mouse study found that female brains express higher levels of an X-linked enzyme called USP11, leading to greater accumulation of tau protein and increased vulnerability to Alzheimer's disease. The results suggest that excessive activity of USP11 drives this increased susceptibility in females.
Researchers used nematode worms to investigate factors influencing virus spillover events. They found that host species susceptibility affects whether a virus takes off in a new population. The study reveals different outcomes depending on the species, with some becoming infected and others remaining uninfected.
Scientists from NTU Singapore have discovered that telomeres are stacked in columns like a spring, leaving DNA exposed to damage. This finding could improve understanding of how humans age and develop cancer, with potential treatments for diseases caused by dysfunctional telomeres.
Researchers found pre-existing differences in gut bacteria between people with and without HIV, including decreased Bacteroides species and increased Megasphaera elsdenii. These changes were present even before infection occurred, suggesting a potential link between gut microbiome and HIV susceptibility.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
A team of researchers found that aged mice infected with SARS-CoV-2 exhibited impaired type I interferon signaling and reduced levels of type II interferon IFN-γ, leading to increased susceptibility to severe disease. Treatment with IFN-γ protected these animals from severe illness.
A UC researcher is using information technology to track and study the endangered little brown myotis bat species in Ohio. The team has established a summer roost at Clendening Marina, where they are collecting data on the population's size and trajectory.
Researchers used E. coli as an indicator of antimicrobial resistance in Canadian turkey flocks. They found that antimicrobial use in feed and injection into eggs were main drivers of resistance. The study suggests that disease treatment also contributes to the development of resistance.
A new study by the University of Georgia finds that current vaccine approaches are unlikely to eradicate measles, with a basic reproduction number of 18 for measles. The researchers propose novel approaches to improve vaccine coverage equity and reevaluate cessation criteria to prevent outbreaks.
Researchers found reduced levels of Histone Deacetylase I (HDAC I) in the brains of patients with Alzheimer's disease, linked to deleterious effects of misfolded beta-amyloid and tau proteins. HDAC inhibitors, currently being tested against mild Alzheimer's disease, may be harming patients rather than helping them.
Researchers have created a new mouse model that mimics brain damage caused by severe RVFV infection, enabling the study of disease mechanisms and high-throughput testing of next-generation drugs. This breakthrough has significant implications for developing therapies and vaccines for this devastating virus.
A new study found that as the globe warms, infected pines starve and disease-causing fungi become more aggressive, reducing the trees' capacity to carry out photosynthesis and invest in growth and defense. This can lead to a decrease in carbon sequestration rates, exacerbating climate change.
Researchers have created a new classification system for coexisting mangrove-coral habitats, identifying four distinct types: lagoons, creeks, fringe areas, and under the mangrove canopy. These habitats are diverse, with about 130 species of corals living in them, and are crucial for coral survival.
A new study from Keck School of Medicine of USC suggests that willingness to give away money may be linked to the earliest stages of Alzheimer's disease. Participants who gave more money scored significantly lower on cognitive tests known to be sensitive to Alzheimer's disease.
A new study published in Nutrients found that individuals with higher red blood cell DHA levels have a 49% lower risk of developing Alzheimer's disease. The study, conducted on 1,490 participants aged 65 and older, suggests that increasing dietary omega-3 DHA levels may slow the development of the disease.
Researchers used drone data to analyze vegetation indicators, such as color appearances, to predict southern rust outbreaks. The study revealed a positive correlation between the presence of southern rust at grain-filling time and yield, enabling informed decision making for growers.
Researchers have identified an anti-malarial compound, ML901, that inhibits the malaria parasite without harming mammalian cells. The compound works by hijacking a reaction to make the parasite self-destruct, showing rapid and prolonged action against resistant strains.
A new study found that the delta variant surge in the US was partially due to overestimating population immunity, with only 67% of southern New Englanders actually immune. This underestimation led to inaccurate projections and an incorrect assumption about herd immunity.
Researchers discovered a mutated gene, OTULIN, associated with severe staphylococcal infections, which can lead to pneumonia, deep skin infections, and sepsis. Individuals with one functional copy of the gene are susceptible to life-threatening infections, while those without appear healthy.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
Researchers found that baby corals are infected with stony coral tissue loss disease (SCTLD) at similar severity and mortality rates as adult colonies. Growing coral recruits larger and promoting grouping before outplanting may reduce the risk of SCTLD.
A study has identified disease mechanisms in children with severe COVID-19, including blood clotting and immune protein pathways. The research found specific proteins involved in multisystem inflammatory syndrome and acute respiratory distress syndrome, which are major potential outcomes of severe COVID-19.
Research finds that intestinal inflammation liberates chemicals that nourish E. coli's growth and promote inflammation, highlighting new treatment targets for Crohn's disease. The study identifies key compounds that feed E. coli, such as phospholipids and amino acids, and shows that these compounds can enhance the bacteria's virulence.
Researchers at Florida Atlantic University found that increasing sun exposure in rehabilitation facilities can enhance health and recovery in green sea turtles with fibropapillomatosis. Vitamin D levels increased significantly in turtles exposed to higher UV light, leading to less tumor regrowth and improved overall health.
Researchers at UCF have identified 116 new gene variants in sea turtles that may protect them from a tumor-causing disease. The discovery sheds light on the role of MHC class I alleles in potentially safeguarding sea turtles against fibropapillomatosis.
A new study reveals that American Indian communities are less likely to benefit from recent downward trends in fine particulate matter (PM2.5) concentrations in the US. Average PM2.5 concentrations were higher in AI-populated counties compared to non-AI populated counties by 2018, contrary to previous declines.
Researchers at Clemson University have identified a genetic variation associated with congenital idiopathic megaesophagus (CIM) in German shepherd dogs, which is often fatal if left untreated. A genetic test using melanin-concentrating hormone receptor 2 and dog's sex can predict the risk of CIM with 75% accuracy.
A Rice University study analyzing COVID-19 death data found that Black and Hispanic communities experienced a disproportionately high fraction of losses from COVID-19 mortality. The study also examined the relationship between air pollution and COVID-19 deaths, but found no statistically significant correlations at a countywide level.
A study by Harvard T.H. Chan School of Public Health researchers found a strong association between Epstein-Barr virus infection and multiple sclerosis. The risk of MS increased 32-fold after EBV infection, while serum levels of neurofilament light chain, a biomarker of nerve degeneration, only increased after EBV infection.
Researchers at South Ural State University have identified biomarkers for post-traumatic stress disorder (PTSD) in veterans with long-lasting symptoms. Gamma-aminobutyric acid levels were found to be the most sensitive indicator, differing from reference values even years after traumatic events.
Researchers at the University of Missouri have developed a free online resource that speeds up data analysis of human genomes three times faster than current methods. This enables scientists to see how an individual's genome makes them susceptible to different diseases in different ways, ultimately reducing associated costs and increas...
A new study links the composition of gut microbiome before infection to HIV susceptibility and progression. Men who contracted HIV in the early days of the pandemic had a greater relative abundance of pro-inflammatory vs. anti-inflammatory gut microbes, which contributed to their increased risk of developing AIDS.
To combat basil downy mildew, researchers recommend using resistant basil varieties, as well as environmental modifications like keeping leaves dry and dehumidifying the air. Fungicides are also effective in controlling the disease, but their use must be alternated to prevent resistance development.
The University of Maryland Center for Environmental Science has sequenced the genome of the blue crab, revealing approximately 24,000 genes and a genome length that is one third of the human genome. This breakthrough will aid in fisheries policies, aquaculture, and potentially track food source origins.
A study analyzed genetic material from 86 discordant couples infected by SARS-CoV-2 and found associations between certain genetic variants and efficient activation of natural killer cells. These cells play a crucial role in the innate immune response, destroying infected cells to prevent disease development.
Researchers at Queen Mary University of London have created an experimental model of cardiomyopathy in inflammatory arthritis, replicating symptoms in RA patients. The study identifies a potential therapeutic approach to treat cardiomyopathy in RA patients.
Research reveals that stronger lettuce stems are a key part of disease resistance against Sclerotinia spp., the causative agent of lettuce drop. The study found that wild lettuce species exhibit increased stem strength and reduced symptom development, while modern commercial cultivars are susceptible to rapid basal stem rot.
Researchers created a model to estimate viral population variability using epidemiological data, predicting the emergence of novel variants. The study suggests that lack of vaccination increases mutation frequency and spread.
A review of scientific literature found pregnant women infected by SARS-CoV-2 have a higher risk of developing pre-eclampsia due to reduced ACE2 availability. ACE2 plays a crucial role in placental development, blood pressure control, and fetal development, making its impairment more susceptible to serious complications.
Scientists discovered a new mitochondrial recycling pathway that may help prevent Parkinson's disease. The study, published in Science Advances, reveals that genes associated with Parkinson's disease play key roles in this process and that disruptions can contribute to neurodegeneration.
UofL researchers advocate for greater diversity in immunogenomics studies to better understand disease susceptibility and develop tailored treatments. The team aims to include a broader range of populations in their research to improve patient care and address health disparities.
A new study confirms that surgical masks effectively block expired particles from talking or coughing, even with leakage around the edges. The results show a significant reduction in disease transmission via expiratory particles when both infected and susceptible individuals wear masks.
A new study reveals that a specific antibody molecule, missing fucose, can indicate when dengue virus infection will become deadly. Patients with severe disease have unusually high levels of these antibodies, which bind too strongly to white blood cells, leading to inflammation and platelet destruction.
Scientists have discovered the potential progenitor of the domestic watermelon, the Kordofan melon, which has more disease-resistant genes. The study could help breed more disease-resistant watermelons in the future.
A study found that a plant's evolutionary history predicts its susceptibility to powdery mildew disease. Researchers tested 126 sunflower species and found no association with common traits like biomass or trichome density.
A large-scale genetic analysis found specific biological mechanisms contributing to muscle weakness in older adults, with diseases like osteoarthritis and diabetes playing a significant role. The study identified 15 areas of the genome associated with muscle weakness, highlighting potential therapeutic interventions for prevention.
A new study published in PLOS ONE found that males are more susceptible to severe illness and death from COVID-19, with higher rates of hospitalization and mechanical ventilation. The authors analyzed data from a large US metropolitan area and found a strong association between male sex and poor outcomes.
Scientists discovered that metabolites from a wild potato relative inhibit the production of enzymes and communication in the pathogenic bacteria, leading to increased disease resistance. The findings offer insights into how to improve crop yields by studying wild relatives of food plants.
A new study identifies five large-scale 'megatrends' impacting forests globally, including droughts, urbanization, consumer demand, digital technologies, and infrastructure development. These megatrends are likely to have both positive and negative effects on forest ecosystems, biodiversity, and human livelihoods.
A new UK study sheds light on the effects of benzopyrene exposure on human cells, revealing new insights into DNA repair mechanisms and their connection to cancer development. The research suggests that understanding these mechanisms could help predict individuals more susceptible to cancer-causing agents.
Researchers at Princeton University found that non-pharmaceutical interventions during the COVID-19 pandemic may delay but not prevent future outbreaks of respiratory infections. These delays could lead to large outbreaks when NPIs are lifted, posing a significant public health risk.
Researchers at UC San Diego report that Kawasaki disease clusters have distinct demographic and clinical features, suggesting different triggers and genetic susceptibilities. The study's findings support the idea that KD is not a single homogenous disease, but rather a complex condition with multiple causes.
A new study reveals that higher COVID-19 mortality in men may be attributed to variations in circulating inflammatory proteins and immune cell populations compared to women. The research found lower counts of certain white blood cells and higher levels of inflammation-related molecules in healthy male participants.