Articles tagged with Disease Susceptibility
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A mouse study found that female brains express higher levels of an X-linked enzyme called USP11, leading to greater accumulation of tau protein and increased vulnerability to Alzheimer's disease. The results suggest that excessive activity of USP11 drives this increased susceptibility in females.
Researchers used nematode worms to investigate factors influencing virus spillover events. They found that host species susceptibility affects whether a virus takes off in a new population. The study reveals different outcomes depending on the species, with some becoming infected and others remaining uninfected.
Scientists from NTU Singapore have discovered that telomeres are stacked in columns like a spring, leaving DNA exposed to damage. This finding could improve understanding of how humans age and develop cancer, with potential treatments for diseases caused by dysfunctional telomeres.
Researchers found pre-existing differences in gut bacteria between people with and without HIV, including decreased Bacteroides species and increased Megasphaera elsdenii. These changes were present even before infection occurred, suggesting a potential link between gut microbiome and HIV susceptibility.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
A team of researchers found that aged mice infected with SARS-CoV-2 exhibited impaired type I interferon signaling and reduced levels of type II interferon IFN-γ, leading to increased susceptibility to severe disease. Treatment with IFN-γ protected these animals from severe illness.
Researchers used E. coli as an indicator of antimicrobial resistance in Canadian turkey flocks. They found that antimicrobial use in feed and injection into eggs were main drivers of resistance. The study suggests that disease treatment also contributes to the development of resistance.
A UC researcher is using information technology to track and study the endangered little brown myotis bat species in Ohio. The team has established a summer roost at Clendening Marina, where they are collecting data on the population's size and trajectory.
A new study by the University of Georgia finds that current vaccine approaches are unlikely to eradicate measles, with a basic reproduction number of 18 for measles. The researchers propose novel approaches to improve vaccine coverage equity and reevaluate cessation criteria to prevent outbreaks.
Researchers found reduced levels of Histone Deacetylase I (HDAC I) in the brains of patients with Alzheimer's disease, linked to deleterious effects of misfolded beta-amyloid and tau proteins. HDAC inhibitors, currently being tested against mild Alzheimer's disease, may be harming patients rather than helping them.
A new study found that as the globe warms, infected pines starve and disease-causing fungi become more aggressive, reducing the trees' capacity to carry out photosynthesis and invest in growth and defense. This can lead to a decrease in carbon sequestration rates, exacerbating climate change.
Researchers have created a new mouse model that mimics brain damage caused by severe RVFV infection, enabling the study of disease mechanisms and high-throughput testing of next-generation drugs. This breakthrough has significant implications for developing therapies and vaccines for this devastating virus.
A new study from Keck School of Medicine of USC suggests that willingness to give away money may be linked to the earliest stages of Alzheimer's disease. Participants who gave more money scored significantly lower on cognitive tests known to be sensitive to Alzheimer's disease.
Researchers have created a new classification system for coexisting mangrove-coral habitats, identifying four distinct types: lagoons, creeks, fringe areas, and under the mangrove canopy. These habitats are diverse, with about 130 species of corals living in them, and are crucial for coral survival.
A new study published in Nutrients found that individuals with higher red blood cell DHA levels have a 49% lower risk of developing Alzheimer's disease. The study, conducted on 1,490 participants aged 65 and older, suggests that increasing dietary omega-3 DHA levels may slow the development of the disease.
Researchers have identified an anti-malarial compound, ML901, that inhibits the malaria parasite without harming mammalian cells. The compound works by hijacking a reaction to make the parasite self-destruct, showing rapid and prolonged action against resistant strains.
Researchers used drone data to analyze vegetation indicators, such as color appearances, to predict southern rust outbreaks. The study revealed a positive correlation between the presence of southern rust at grain-filling time and yield, enabling informed decision making for growers.
A new study found that the delta variant surge in the US was partially due to overestimating population immunity, with only 67% of southern New Englanders actually immune. This underestimation led to inaccurate projections and an incorrect assumption about herd immunity.
Researchers discovered a mutated gene, OTULIN, associated with severe staphylococcal infections, which can lead to pneumonia, deep skin infections, and sepsis. Individuals with one functional copy of the gene are susceptible to life-threatening infections, while those without appear healthy.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
Researchers found that baby corals are infected with stony coral tissue loss disease (SCTLD) at similar severity and mortality rates as adult colonies. Growing coral recruits larger and promoting grouping before outplanting may reduce the risk of SCTLD.
A study has identified disease mechanisms in children with severe COVID-19, including blood clotting and immune protein pathways. The research found specific proteins involved in multisystem inflammatory syndrome and acute respiratory distress syndrome, which are major potential outcomes of severe COVID-19.
Research finds that intestinal inflammation liberates chemicals that nourish E. coli's growth and promote inflammation, highlighting new treatment targets for Crohn's disease. The study identifies key compounds that feed E. coli, such as phospholipids and amino acids, and shows that these compounds can enhance the bacteria's virulence.
Researchers at Florida Atlantic University found that increasing sun exposure in rehabilitation facilities can enhance health and recovery in green sea turtles with fibropapillomatosis. Vitamin D levels increased significantly in turtles exposed to higher UV light, leading to less tumor regrowth and improved overall health.
Researchers at UCF have identified 116 new gene variants in sea turtles that may protect them from a tumor-causing disease. The discovery sheds light on the role of MHC class I alleles in potentially safeguarding sea turtles against fibropapillomatosis.
A new study reveals that American Indian communities are less likely to benefit from recent downward trends in fine particulate matter (PM2.5) concentrations in the US. Average PM2.5 concentrations were higher in AI-populated counties compared to non-AI populated counties by 2018, contrary to previous declines.
Researchers at Clemson University have identified a genetic variation associated with congenital idiopathic megaesophagus (CIM) in German shepherd dogs, which is often fatal if left untreated. A genetic test using melanin-concentrating hormone receptor 2 and dog's sex can predict the risk of CIM with 75% accuracy.
A Rice University study analyzing COVID-19 death data found that Black and Hispanic communities experienced a disproportionately high fraction of losses from COVID-19 mortality. The study also examined the relationship between air pollution and COVID-19 deaths, but found no statistically significant correlations at a countywide level.
A study by Harvard T.H. Chan School of Public Health researchers found a strong association between Epstein-Barr virus infection and multiple sclerosis. The risk of MS increased 32-fold after EBV infection, while serum levels of neurofilament light chain, a biomarker of nerve degeneration, only increased after EBV infection.
Researchers at South Ural State University have identified biomarkers for post-traumatic stress disorder (PTSD) in veterans with long-lasting symptoms. Gamma-aminobutyric acid levels were found to be the most sensitive indicator, differing from reference values even years after traumatic events.
Researchers at the University of Missouri have developed a free online resource that speeds up data analysis of human genomes three times faster than current methods. This enables scientists to see how an individual's genome makes them susceptible to different diseases in different ways, ultimately reducing associated costs and increas...
A new study links the composition of gut microbiome before infection to HIV susceptibility and progression. Men who contracted HIV in the early days of the pandemic had a greater relative abundance of pro-inflammatory vs. anti-inflammatory gut microbes, which contributed to their increased risk of developing AIDS.
To combat basil downy mildew, researchers recommend using resistant basil varieties, as well as environmental modifications like keeping leaves dry and dehumidifying the air. Fungicides are also effective in controlling the disease, but their use must be alternated to prevent resistance development.
The University of Maryland Center for Environmental Science has sequenced the genome of the blue crab, revealing approximately 24,000 genes and a genome length that is one third of the human genome. This breakthrough will aid in fisheries policies, aquaculture, and potentially track food source origins.
A study analyzed genetic material from 86 discordant couples infected by SARS-CoV-2 and found associations between certain genetic variants and efficient activation of natural killer cells. These cells play a crucial role in the innate immune response, destroying infected cells to prevent disease development.
Researchers at Queen Mary University of London have created an experimental model of cardiomyopathy in inflammatory arthritis, replicating symptoms in RA patients. The study identifies a potential therapeutic approach to treat cardiomyopathy in RA patients.
Research reveals that stronger lettuce stems are a key part of disease resistance against Sclerotinia spp., the causative agent of lettuce drop. The study found that wild lettuce species exhibit increased stem strength and reduced symptom development, while modern commercial cultivars are susceptible to rapid basal stem rot.
Researchers created a model to estimate viral population variability using epidemiological data, predicting the emergence of novel variants. The study suggests that lack of vaccination increases mutation frequency and spread.
A review of scientific literature found pregnant women infected by SARS-CoV-2 have a higher risk of developing pre-eclampsia due to reduced ACE2 availability. ACE2 plays a crucial role in placental development, blood pressure control, and fetal development, making its impairment more susceptible to serious complications.
Scientists discovered a new mitochondrial recycling pathway that may help prevent Parkinson's disease. The study, published in Science Advances, reveals that genes associated with Parkinson's disease play key roles in this process and that disruptions can contribute to neurodegeneration.
UofL researchers advocate for greater diversity in immunogenomics studies to better understand disease susceptibility and develop tailored treatments. The team aims to include a broader range of populations in their research to improve patient care and address health disparities.
A new study confirms that surgical masks effectively block expired particles from talking or coughing, even with leakage around the edges. The results show a significant reduction in disease transmission via expiratory particles when both infected and susceptible individuals wear masks.
A new study reveals that a specific antibody molecule, missing fucose, can indicate when dengue virus infection will become deadly. Patients with severe disease have unusually high levels of these antibodies, which bind too strongly to white blood cells, leading to inflammation and platelet destruction.
Scientists have discovered the potential progenitor of the domestic watermelon, the Kordofan melon, which has more disease-resistant genes. The study could help breed more disease-resistant watermelons in the future.
A study found that a plant's evolutionary history predicts its susceptibility to powdery mildew disease. Researchers tested 126 sunflower species and found no association with common traits like biomass or trichome density.
A large-scale genetic analysis found specific biological mechanisms contributing to muscle weakness in older adults, with diseases like osteoarthritis and diabetes playing a significant role. The study identified 15 areas of the genome associated with muscle weakness, highlighting potential therapeutic interventions for prevention.
A new study published in PLOS ONE found that males are more susceptible to severe illness and death from COVID-19, with higher rates of hospitalization and mechanical ventilation. The authors analyzed data from a large US metropolitan area and found a strong association between male sex and poor outcomes.
Scientists discovered that metabolites from a wild potato relative inhibit the production of enzymes and communication in the pathogenic bacteria, leading to increased disease resistance. The findings offer insights into how to improve crop yields by studying wild relatives of food plants.
A new study identifies five large-scale 'megatrends' impacting forests globally, including droughts, urbanization, consumer demand, digital technologies, and infrastructure development. These megatrends are likely to have both positive and negative effects on forest ecosystems, biodiversity, and human livelihoods.
A new UK study sheds light on the effects of benzopyrene exposure on human cells, revealing new insights into DNA repair mechanisms and their connection to cancer development. The research suggests that understanding these mechanisms could help predict individuals more susceptible to cancer-causing agents.
Researchers at Princeton University found that non-pharmaceutical interventions during the COVID-19 pandemic may delay but not prevent future outbreaks of respiratory infections. These delays could lead to large outbreaks when NPIs are lifted, posing a significant public health risk.
Researchers at UC San Diego report that Kawasaki disease clusters have distinct demographic and clinical features, suggesting different triggers and genetic susceptibilities. The study's findings support the idea that KD is not a single homogenous disease, but rather a complex condition with multiple causes.
A new study reveals that higher COVID-19 mortality in men may be attributed to variations in circulating inflammatory proteins and immune cell populations compared to women. The research found lower counts of certain white blood cells and higher levels of inflammation-related molecules in healthy male participants.
A groundbreaking LSU Health study reveals that nonharmful stress can protect against disease in offspring, reprogramming heritability to promote resilience. The research used mild systemic hypoxia to trigger adaptive changes in adult mice, which were then passed on to their offspring.
Research from Southern Cross University found that imidacloprid, a common agricultural pesticide, can impact the feeding behavior of prawns, leading to nutritional deficiency and reduced flesh quality. Sydney rock oysters are also vulnerable to imidacloprid exposure.
Researchers at the University of Illinois have developed a new method to speed up breeding for Miscanthus hybrids, which could improve renewable energy crops. The study uses genomic selection to predict phenotypic outcomes and optimize winter hardiness, biomass, disease tolerance, and flowering time in Miscanthus.
A study by researchers at the National Human Genome Research Institute suggests that genetic variants associated with familial Mediterranean fever (FMF) may confer increased resistance to the bubonic plague. The findings propose a link between FMF and protection against Yersinia pestis, the bacterium responsible for the plague.
A new study found that early signs of type 2 diabetes can be detected in children as young as 8 years old through metabolic changes measured by blood samples. The research identified subtle differences in metabolism among participants who were more genetically prone to developing the disease later in life.
Italian scientists have identified common genetic susceptibility genes linked to COVID-19 outcomes, including severe pneumonia. The study's findings suggest that these genes may determine disease progression and could aid in the development of new treatments.
Researchers found that climate conditions are unlikely to significantly impact the early stages of the COVID-19 pandemic due to widespread susceptibility and rapid virus transmission. However, warmer climates may influence the size and timing of future pandemics.