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Explaining the persistence of Hepatitis C

Researchers identify gC1qR as a binding partner for Hepatitis C core protein, allowing the virus to evade immune response and persist in the body. The interaction between gC1qR and core protein may provide new targets for developing therapies to combat chronic hepatitis C.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 12, 2000
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NIH researchers zero in on viral changes that lead to chronic hepatitis C

A study led by the National Institutes of Health (NIH) has identified key changes in surface proteins of the hepatitis C virus (HCV) that enable it to evade the immune system. The research found that these changes occur early in the infection process and can determine whether a person will develop chronic or acute HCV disease.

SourceNIH/National Institute of Allergy and Infectious Diseases·JournalScience·DateApr 12, 2000
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University Of Washington Discovery May Point The Way To New Treatment For Hepatitis C Cases That Do Not Respond To Interferon Therapy

Researchers at the University of Washington have discovered a potential new target for therapeutic drugs to treat hepatitis C. The study found that a protein called NS5A can bind to and inactivate a key component of interferon response, PKR. This could lead to the development of a new treatment for the disease.

SourceUniversity of Washington·JournalVirology·DateApr 15, 1997