Articles tagged with Immune System
A research lab at the University of Kansas is analyzing human immune responses to develop an effective vaccine or drug therapy against Epstein-Barr Virus. By studying B cells, researchers aim to understand why some people are protected from EBV-associated diseases while others suffer from health issues.
Researchers developed a novel mathematical model to explore interactions between prostate tumors and common immunotherapies, predicting their effects on patient-specific immune systems. The study highlights a potential therapeutic strategy for managing tumor growth more effectively.
Researchers at the University of Rochester Medical Center have developed a practical way to use light to guide T cells towards tumors, overcoming the challenges of immunotherapy. The innovative method could lead to safer and more effective treatment options for cancer patients.
A comprehensive catalog of diseases associated with human leukocyte antigen (HLA) gene variations has been generated by researchers at Vanderbilt University Medical Center. The catalog identifies individuals at risk for certain autoimmune diseases and potential new associations with multiple sclerosis and cervical cancer.
A study funded by Morris Animal Foundation has shed light on how the deadly facial tumor disease in Tasmanian devils evades the immune system. The research found that DFT cells produce a molecular shield to hide from attacks, offering potential strategies for protection.
Researchers found that wild dolphins have chronically activated immune systems due to exposure to pathogens, parasites, and pollutants. This could lead to immunologic dysregulation and increased vulnerability to disease in both humans and animals. In contrast, dolphins in managed care environments have less activated immune systems.
Wild mice have highly-activated immune systems due to exposure to infections, with more activated myeloid cells compared to laboratory mice. The study's findings emphasize the importance of considering natural variability when interpreting research results.
A study found that malaria parasites in one African village had distinct gene combinations that allowed them to evade the human immune system. This discovery highlights the importance of considering diverse strains of the parasite in malaria-control efforts.
Research reveals that strong feelings about immigrants are controlled by the immune system, particularly in people with a hypersensitive behavioral immune system. This leads to misconceptions about infection risks and a reluctance to interact with immigrants, blocking integration paths.
A comprehensive review examines the role of type I interferon in controlling herpes simplex virus type 1 infection. The study reveals that newborns are more susceptible to HSV-1 infection, which can lead to serious and potentially life-threatening diseases like herpes simplex encephalitis.
Researchers found that strokes damage immune cells, making patients more susceptible to life-threatening infections like pneumonia. Therapies targeting damaged immune cells or bypassing their dysfunction could help recover from stroke, the study suggests.
Cytomegalovirus has evolved to hide from the immune system by presenting decoy markers, tricking NK cells into thinking infected cells are healthy. The immune system responds by evolving new mechanisms to detect and kill the virus, including a molecule called NK1.1.
A team of researchers identified a genetic mutation responsible for an adult's rare and severe immune system disorder. They developed a molecular therapy using Morpholino Antisense Oligonucleotide that corrected the mutation and allowed the patient's immune system to function properly.
A new study links common reovirus infection with the development of celiac disease, an autoimmune disorder caused by an improper immune response to gluten. Reovirus-induced immune responses can lead to the loss of oral tolerance to gluten, setting the stage for celiac disease.
Case Western Reserve University researchers aim to combat chronic inflammation by targeting oral complications in HIV patients, which can lead to malnourishment and further weaken the immune system. The team will investigate regulatory T-cells and study tissues from HIV-positive patients taking common antiretroviral drugs.
Researchers found that a large number of CMV's genes help it evade the immune system by destroying proteins produced during infection. This discovery could lead to novel treatments or a cure for this virus.
Researchers have discovered biological evidence of atypical chronic fatigue syndrome, a complex and debilitating disease. The study found lower levels of certain immune molecules in individuals with atypical ME/CFS compared to those with classical symptoms.
Researchers developed an experimental treatment that tames the immune system in rodents, restoring movement to paralyzed mice. The approach may combat autoimmune diseases in humans, as demonstrated in mouse models of multiple sclerosis and type 1 diabetes.
Researchers have developed a new humanized mouse model of colorectal cancer, allowing them to test immunotherapies and potential combination treatments. The model has shown promise in preclinical studies, including the successful activation of the immune system against cancer cells.
Scientists at UVA have discovered an unexpected connection between the immune system and the testes, which may explain why some cancer vaccines are failing to work. This finding could lead to new treatments for autoimmune disorders and male infertility, as doctors target specific antigens released by the testes.
Researchers at the University of Tokyo have discovered that plants can recognize friendly RNAs by breaking down those without a nucleotide 'tail' using the immune system. This breakthrough paves the way for future biotechnological techniques to modify crops.
A study of 2,000 people found that women report higher stress levels than men for various life events, including death of a loved one, illness, and Brexit. This increased stress can lead to long-term physiological problems, such as ulcers or an increased risk of heart attack.
Researchers have discovered that the protein Myb plays a vital role in regulating the immune response, preventing overreaction and development of inflammatory diseases. The study found that Myb gives regulatory T cells the authority to control their function depending on the level of threat.
Researchers found that early intervention with two anti-HIV antibodies can induce potent immunity to HIV, allowing the immune system to effectively control the virus. In a study using macaque monkeys, treatment suppressed the virus levels for up to six months and enabled some animals to spontaneously regain control of the virus.
Dendritic cells, which help activate and suppress immune responses, play a key role in maintaining the balance between self and non-self in the gut. The discovery of a signaling molecule, CD40, reveals how this balance can be disrupted, leading to severe colitis, but also highlights the importance of regulatory T-cells in maintaining i...
A study by Arizona State University and Mayo Clinic identified several unique biomarkers, called autoantibodies, that can accurately diagnose Crohn's disease. The discovery has the potential to provide early warning for those at risk of major illnesses, including cancer, autism, and diabetes.
An international study has shown that immunotherapy can cure Tasmanian devils of the deadly devil facial tumour disease (DFTD). The treatment successfully triggered the devil's immune system to recognise and destroy established DFTD tumours, with tumours shrinking and disappearing over three months.
Researchers at Cardiff University discovered a genetic link between Ifitm3 and the immune system's inflammatory response. The study found that individuals with a specific gene variant may experience an overactive immune response to viral infections, making anti-inflammatory drugs a potential treatment option.
Scientists have developed a new mouse model with a healthy immune system to study the Zika virus. The model allows researchers to investigate the immune response to Zika, which could lead to advances in vaccine development and treatment strategies.
Grimes, assistant professor in UD's Department of Chemistry and Biochemistry, will use her fellowship to investigate how chronic inflammatory diseases, such as asthma and Crohn's disease, arise from bacterial cell wall fragments. Her work aims to understand the immune system's response to these molecules.
Recent immune research advances the understanding of autism spectrum disorder (ASD), highlighting the role of immune dysregulation in its development. Therapies targeting the immune system may also have benefits beyond ASD, such as preventing attention-deficit/hyperactivity disorder.
A recent study found that using a rabbit virus, myxoma virus, reduced tumor burden in preclinical studies and led to complete eradication of disease in a quarter of animals. The treatment elicited a strong immune response, suggesting its potential as a novel therapy for multiple myeloma.
Researchers from Monash University and Cardiff University have made a breakthrough understanding how HIV evades the immune system by mutating key molecules, which will help design better therapies and vaccines. The study provides new insights into HIV's ability to evade the immune system.
A type of autologous hematopoietic stem cell transplantation (AHSCT) has been shown to slow or stop MS disease progression for up to five years in nearly half of patients, with significant benefits seen in younger patients and those with relapsing-remitting MS. However, the treatment carries a small risk of death and is not suitable fo...
Scientists at Trinity College Dublin discovered how cancers hijack the immune system's wound-healing response to receive help. They found that a molecule called TRAIL can be re-wired in certain tumors to send an inflammatory signal, tricking the immune system into assisting cancer growth.
Research from QUT found that consuming carbohydrates during or immediately after intense exercise helps minimise exercise-induced immune disturbances and aids the body's recovery. The study suggests that stable blood sugar levels reduce the body's stress response, moderating undesirable mobilisation of immune cells.
A researcher is studying how early immune system responses can predict the long-term success of biomedical implants. The study aims to develop methods for modulating macrophage activity to encourage positive outcomes.
Researchers at the University of Maryland School of Medicine have identified a new pathway that recognizes three distinct bacteria, including Lyme disease agent Borrelia burgdorferi. By targeting key molecules, scientists may now try to make ticks less vulnerable to infection by these microbes.
A recent study by Penn researchers has found that signaling proteins in cells lining the heart play a key role in preventing excessive scarring after a heart attack. The proteins, YAP and TAZ, regulate immune responses to prevent inflammation and fibrosis, which can lead to heart failure.
Australian researchers investigated how certain medications impact MAIT cell function, finding some prevent detection of infections while others activate the immune system. This discovery may lead to better understanding and control of immune reactions to drugs, as well as new therapies that manipulate MAIT cell behavior.
Researchers from Geneva and Fribourg have developed a rapid screening method to select the most promising nanoparticles for medical applications. The new approach can determine biocompatibility in under two days, reducing the need for animal testing and enabling personalized treatment.
A team at Rockefeller University has discovered an antibody signature that may increase the risk of severe secondary dengue infections. The study found that patients with more serious disease have high levels of antibodies whose Fc regions lack a particular sugar, which strongly activate immune cells and lead to bleeding disorders.
Researchers discovered that the twin with shorter sleep duration had a depressed immune system compared to their sibling. The findings suggest that chronic short sleep shuts down programs involved in immune response, leading to lower antibody responses and increased susceptibility to illnesses.
A new study found that abnormal antibody production in the intestine of people with HIV-1 may lead to chronic inflammation and AIDS despite treatment. The research revealed that immune system cells in the intestines have decreased capacity to produce mature antibodies.
A recent study published in Science has identified a previously unknown means by which plants regulate their immune systems to prevent further response once an infection is dealt with. This discovery could lead to the improvement of immune systems in food crops, addressing a significant challenge for global food security.
Researchers found that antiretroviral drugs used to treat HIV infection may increase susceptibility to syphilis by boosting immune system activity and leading to more sexual partners. This could explain the rise in new cases of syphilis among gay/bisexual men over the past decade.
A study by researchers at the University of Basel found that meals trigger an inflammatory response in the body, which plays a crucial role in regulating blood sugar levels. This mechanism is dependent on bacteria and nutrients ingested during meals, highlighting the importance of adequate nutrition for immune function.
The new therapy uses a kilohertz frequency electrical block of afferent vagus nerve pathways to stimulate the nerve while inhibiting unwanted nerve activity, increasing clinical efficacy and therapeutic benefit. This approach is reversible, controllable, and clinically feasible, providing a potential solution for chronic inflammatory d...
Researchers at the University of Michigan have successfully tested nanodiscs in mice for personalized cancer immunotherapy. The therapeutic vaccine targets cancer mutations and generates T-cells that recognize unique neoantigens, leading to the elimination of cancer cells.
Researchers developed a dual strategy combining biomimetic beads and anti-PD1 therapy to boost killer T cell immunity against skin cancer. The combination technique increased T cell activation by 35% compared to artificial beads alone and 72% compared to anti-PD1 alone.
Researchers discovered that nanoparticles, resembling caterpillars, trigger immune system activation when internalized. To counteract this detection, three possible strategies are proposed: modifying the coating, understanding absorbed proteins, or attracting natural inhibitors.
Researchers discovered that radiotherapy can be less effective due to inflammation and immune response modulation. Combining immunotherapy with radiotherapy may enhance treatment benefits.
Researchers at La Jolla Institute for Immunology found that the loss of TET proteins hinders T cell maturation and promotes aberrant proliferation, leading to a lethal disease resembling lymphoma. The study's findings suggest that TET proteins serve as tumor suppressors and may help block malignancy in cancers marked by TET mutations.
Scientists have discovered how the human immune system targets Mycobacterium tuberculosis, the bacteria that causes TB. The study provides key insight into how the immune system can recognize TB-infected cells, which could lead to the development of new diagnostic tools and novel immunotherapies.
A study found that farm dust exposure stimulates production of a protein called A20, which suppresses inflammatory immune responses in the lungs. This leads to lower rates of asthma and allergies in children who grow up on farms.
A combination of brentuximab vedotin and nivolumab has been found to be safe and effective in treating recurrent Hodgkin lymphoma, with 64% of patients experiencing significant tumor reduction. The therapy has manageable side effects and shows promise as an alternative curative regimen for relapsed disease.
Researchers at Cornell University developed a chemical tool that controls inflammation using UV light, allowing for targeted therapy with minimal side effects. The method has potential applications in treating inflammatory diseases such as asthma and rheumatoid arthritis.
Researchers found that IL-12 has a positive effect on skin affected by psoriasis, preventing pathogenic immune cell infiltration and inhibiting inflammatory reactions. The current treatment ustekinumab neutralizes both IL-23 and IL-12, potentially leading to counterproductive effects.
Dr. Jean-Sébastien Delisle's research uncovers the unexpected role of Neuropilin-1 and dendritic cell maturation in the immune response to infection and disease. His discovery is timely, helping improve cancer treatment and potentially enhancing responses in unfavourable conditions.
Researchers discovered that Immunoglobulin D (IgD) keeps 'traitor cells' in lockdown, preventing auto-antibodies from damaging body tissues. IgD promotes the formation of germinal centres, allowing these cells to target invaders when needed.