Articles tagged with Immune System
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have discovered a new immunotherapy combination that effectively kills cancer cells, with promising results for treating aggressive breast and rare pediatric muscle cancer. The combination uses existing cancer drugs in a whole new way to stimulate the immune system.
A USC study found that the Zika virus targets specific white blood cells in pregnant women, handicapping their immune system and increasing the chances an unborn baby will be harmed. The virus exploits this weakness to infect and replicate, particularly during the first and second trimesters.
A new treatment combines gold nanostars and immunotherapy to treat cancer. The treatment successfully cured two mice and vaccinated one mouse against the disease. By destroying tumors and triggering the immune system, the treatment activates immunity against remaining cancerous cells.
Researchers will investigate regulatory mechanisms and biomarkers of healthy aging, aiming to understand why the immune system weakens with age. The study may lead to new treatments for age-related health issues, such as increased vulnerability to infections and cancers.
Researchers studied viruses from different eras to understand how they evade the host's immune response. Viruses collected in the 1990s are more effective at suppressing immune systems than those from the 1950s, leading to severe symptoms and high mortality rates.
A rare genetic mutation in the POL III sensor can turn chickenpox into a life-threatening infection, leading to brain inflammation and pneumonia. Individuals with this mutation have an increased risk of developing severe illness.
Researchers discovered that a single protein from Group A Streptococcus bacteria can wipe out macrophages but not other immune cells, triggering an early warning system. This finding has implications for vaccine design and treatment of toxic shock syndrome.
Researchers found that T cells from people with PD responded to alpha-synuclein to a greater degree than those gathered from healthy controls. Four genetic variations were associated with T cell reactivity, and over half of people with PD carried at least one variant.
Researchers have discovered a key new mechanism regulating T-cell response to foreign antigens and cancer. LFA-1 on T-cells mediates adhesion to cancer cells, enabling immune-cell rejection of cancer.
A new study published in PLOS Medicine reveals that changes to the immune system occur rapidly after a traumatic injury, with levels of immune cells and molecules altered within minutes. The research aims to improve outcomes for patients who have suffered trauma by identifying those at risk of developing life-threatening complications.
A protein called Blimp-1 regulates the immune system in patients with lupus, leading to an overactive immune response that attacks healthy tissue. The study's findings suggest a link between low Blimp-1 levels and increased risk of lupus in females.
Scientists have found that human immune cells contain particles with neurotransmitters like dopamine, which play a crucial role in immune responses. This discovery opens the door to using available drugs to improve therapies for lymphoma, autoimmunity, and immunodeficiency disorders.
Researchers at the University of Colorado Anschutz Medical Campus discovered a process protecting against autoimmune disease also prevents the body from creating antibodies that can neutralize HIV-1. By temporarily relaxing immunological tolerance, scientists believe they may be able to elicit protective antibodies with vaccination.
Researchers found differences in immune system factors between men and women with bipolar disorder, particularly in zinc levels associated with depression severity in women. This study suggests that biological changes in the body could be used to diagnose the disease and tailor treatments differently for men and women.
A recent study suggests that the human herpesvirus 6 (HHV-6) may impede the brain's ability to repair itself in diseases like multiple sclerosis. The virus produces a protein called U94 that can impair the normal function of cells in the brain, potentially accelerating disease progression.
Aging individuals with implants face unique challenges due to immunosenescence and delayed immune responses. The study investigates the impact of aging on macrophage activity and white blood cell function, seeking ways to optimize implant success and minimize negative effects.
Three case reports published in NEJM demonstrate the efficacy of cancer immunotherapy in gray zone lymphoma, a rare subtype of Hodgkin and Non-Hodgkin forms of the disease. Nivolumab and pembrolizomab showed promising results in treating patients with PD-L1 over-expression.
Researchers at Linkoping University discovered that lutein can suppress long-term inflammation in patients with coronary artery disease. The study found that higher levels of lutein were associated with lower levels of inflammatory markers and reduced inflammatory activity in immune cells.
Researchers found that autoimmunity plays a role in Parkinson's disease, where the immune system attacks the body's own tissues. The study identified alpha-synuclein protein as a trigger for immune response, raising hope for new diagnostic tests and therapies to prevent neuronal death.
Scientists discovered fetal immune system establishment as early as 2nd trimester, allowing independent responses and immune tolerance. Dendritic cells expressing Arginase-2 regulate TNFα production, preventing unwanted inflammatory responses.
Researchers at UMD's Jewell Laboratory have developed a precision system using quantum dots to control the display of self-antigens, promoting tolerance and elimination of paralysis in pre-clinical mouse models. This breakthrough could pave the way for more selective and effective therapies for MS and other autoimmune diseases.
Macrophages, known as the Pac-Man of the immune system, promote healing by regrowing severed nerves in rats, offering a promising alternative to current treatments like autografts. The approach uses biological signals to recruit younger, undifferentiated cells destined to become pro-healing macrophages.
Researchers at Michigan State University are studying how DHA prevents the onset of lupus when triggered by inhaling toxic minerals. The study aims to understand the cellular mechanisms behind this phenomenon and explore potential nutritional interventions to prevent disease flaring and progression.
Researchers at the University of Birmingham discovered a breakthrough in how genetic makeup affects the immune system and cancer treatment. The study focused on the ULBP6 protein, which plays a crucial role in removing damaged cells and signals to white blood cells to kill them.
Okinawa Institute of Science and Technology researchers identified JunB as a key target to selectively disable toxic T Helper 17 cells, reducing the risk of auto-immune diseases. By inhibiting JunB, these cells can still accumulate in the gut and respond to infections without turning rogue.
Researchers have created artificial viruses that can specifically target and destroy cancer cells by stimulating the immune system. The unique combination of alarm signals and cancer cell proteins enables the creation of a powerful army of killer cells to identify and destroy cancer cells.
Researchers at the University of Delaware have developed a new method to label and visualize the sugar backbone of bacterial cell walls, also known as the 'cell jacket'. This breakthrough allows scientists to better understand how the immune system misidentifies beneficial bacteria, leading to chronic inflammatory diseases. By using th...
Researchers at the Center for Cell-Based Therapy found that patients with more autoreactive lymphocytes before treatment have a shorter therapeutic effect. In contrast, those with fewer autoreactive lymphocytes experience a longer-lasting response to stem cell therapy.
A new combination immunotherapy has shown promise in treating advanced kidney cancer, with the potential to identify biomarkers for many cancers. The study's principal investigator, Dr. Timothy Kuzel, hopes that this treatment will help more patients benefit from immunotherapy.
In a breakthrough study, Johns Hopkins researchers identified a new way that the brain communicates with the immune system, using vesicles and small fat-like molecules to send signals. This discovery may lead to the development of new treatments for brain injuries by targeting the inflammatory response.
Scientists have created a vaccine that boosts specific parts of the immune system attacking HIV viral genes, prolonging resistance and allowing for more efficient defense. This approach may lead to an effective HIV vaccine by targeting weak immunostimulatory parts of viruses.
A research lab at the University of Kansas is analyzing human immune responses to develop an effective vaccine or drug therapy against Epstein-Barr Virus. By studying B cells, researchers aim to understand why some people are protected from EBV-associated diseases while others suffer from health issues.
Researchers developed a novel mathematical model to explore interactions between prostate tumors and common immunotherapies, predicting their effects on patient-specific immune systems. The study highlights a potential therapeutic strategy for managing tumor growth more effectively.
Researchers at the University of Rochester Medical Center have developed a practical way to use light to guide T cells towards tumors, overcoming the challenges of immunotherapy. The innovative method could lead to safer and more effective treatment options for cancer patients.
A comprehensive catalog of diseases associated with human leukocyte antigen (HLA) gene variations has been generated by researchers at Vanderbilt University Medical Center. The catalog identifies individuals at risk for certain autoimmune diseases and potential new associations with multiple sclerosis and cervical cancer.
A study funded by Morris Animal Foundation has shed light on how the deadly facial tumor disease in Tasmanian devils evades the immune system. The research found that DFT cells produce a molecular shield to hide from attacks, offering potential strategies for protection.
Researchers found that wild dolphins have chronically activated immune systems due to exposure to pathogens, parasites, and pollutants. This could lead to immunologic dysregulation and increased vulnerability to disease in both humans and animals. In contrast, dolphins in managed care environments have less activated immune systems.
Wild mice have highly-activated immune systems due to exposure to infections, with more activated myeloid cells compared to laboratory mice. The study's findings emphasize the importance of considering natural variability when interpreting research results.
A study found that malaria parasites in one African village had distinct gene combinations that allowed them to evade the human immune system. This discovery highlights the importance of considering diverse strains of the parasite in malaria-control efforts.
Research reveals that strong feelings about immigrants are controlled by the immune system, particularly in people with a hypersensitive behavioral immune system. This leads to misconceptions about infection risks and a reluctance to interact with immigrants, blocking integration paths.
A comprehensive review examines the role of type I interferon in controlling herpes simplex virus type 1 infection. The study reveals that newborns are more susceptible to HSV-1 infection, which can lead to serious and potentially life-threatening diseases like herpes simplex encephalitis.
Researchers found that strokes damage immune cells, making patients more susceptible to life-threatening infections like pneumonia. Therapies targeting damaged immune cells or bypassing their dysfunction could help recover from stroke, the study suggests.
Cytomegalovirus has evolved to hide from the immune system by presenting decoy markers, tricking NK cells into thinking infected cells are healthy. The immune system responds by evolving new mechanisms to detect and kill the virus, including a molecule called NK1.1.
A new study links common reovirus infection with the development of celiac disease, an autoimmune disorder caused by an improper immune response to gluten. Reovirus-induced immune responses can lead to the loss of oral tolerance to gluten, setting the stage for celiac disease.
Case Western Reserve University researchers aim to combat chronic inflammation by targeting oral complications in HIV patients, which can lead to malnourishment and further weaken the immune system. The team will investigate regulatory T-cells and study tissues from HIV-positive patients taking common antiretroviral drugs.
A team of researchers identified a genetic mutation responsible for an adult's rare and severe immune system disorder. They developed a molecular therapy using Morpholino Antisense Oligonucleotide that corrected the mutation and allowed the patient's immune system to function properly.
Researchers have discovered biological evidence of atypical chronic fatigue syndrome, a complex and debilitating disease. The study found lower levels of certain immune molecules in individuals with atypical ME/CFS compared to those with classical symptoms.
Researchers found that a large number of CMV's genes help it evade the immune system by destroying proteins produced during infection. This discovery could lead to novel treatments or a cure for this virus.
Researchers developed an experimental treatment that tames the immune system in rodents, restoring movement to paralyzed mice. The approach may combat autoimmune diseases in humans, as demonstrated in mouse models of multiple sclerosis and type 1 diabetes.
Researchers have developed a new humanized mouse model of colorectal cancer, allowing them to test immunotherapies and potential combination treatments. The model has shown promise in preclinical studies, including the successful activation of the immune system against cancer cells.
Scientists at UVA have discovered an unexpected connection between the immune system and the testes, which may explain why some cancer vaccines are failing to work. This finding could lead to new treatments for autoimmune disorders and male infertility, as doctors target specific antigens released by the testes.
Researchers at the University of Tokyo have discovered that plants can recognize friendly RNAs by breaking down those without a nucleotide 'tail' using the immune system. This breakthrough paves the way for future biotechnological techniques to modify crops.
A study of 2,000 people found that women report higher stress levels than men for various life events, including death of a loved one, illness, and Brexit. This increased stress can lead to long-term physiological problems, such as ulcers or an increased risk of heart attack.
Researchers have discovered that the protein Myb plays a vital role in regulating the immune response, preventing overreaction and development of inflammatory diseases. The study found that Myb gives regulatory T cells the authority to control their function depending on the level of threat.
Researchers found that early intervention with two anti-HIV antibodies can induce potent immunity to HIV, allowing the immune system to effectively control the virus. In a study using macaque monkeys, treatment suppressed the virus levels for up to six months and enabled some animals to spontaneously regain control of the virus.
Dendritic cells, which help activate and suppress immune responses, play a key role in maintaining the balance between self and non-self in the gut. The discovery of a signaling molecule, CD40, reveals how this balance can be disrupted, leading to severe colitis, but also highlights the importance of regulatory T-cells in maintaining i...
A study by Arizona State University and Mayo Clinic identified several unique biomarkers, called autoantibodies, that can accurately diagnose Crohn's disease. The discovery has the potential to provide early warning for those at risk of major illnesses, including cancer, autism, and diabetes.
An international study has shown that immunotherapy can cure Tasmanian devils of the deadly devil facial tumour disease (DFTD). The treatment successfully triggered the devil's immune system to recognise and destroy established DFTD tumours, with tumours shrinking and disappearing over three months.
Researchers at Cardiff University discovered a genetic link between Ifitm3 and the immune system's inflammatory response. The study found that individuals with a specific gene variant may experience an overactive immune response to viral infections, making anti-inflammatory drugs a potential treatment option.
Scientists have developed a new mouse model with a healthy immune system to study the Zika virus. The model allows researchers to investigate the immune response to Zika, which could lead to advances in vaccine development and treatment strategies.