A study published in the Journal of the American Geriatrics Society found that older adults in skilled nursing facilities (SNFs) with higher quality ratings had significantly lower risks for placement in long-term care facilities. The researchers used data from over 500,000 people aged 65 and older to examine the role of SNF quality in...
A peer-reviewed study published in Oncotarget found that OncoDNA's comprehensive testing and analysis services, combining multiple biomarkers, increased oncologists' ability to make informed treatment decisions. The study showed a significant improvement in overall survival for late-stage patients, from six months to over 12 months.
The USPSTF recommends exercise interventions to prevent falls in adults 65 years and older, with moderate evidence supporting this approach. Multi-factorial interventions targeting balance, gait, vision, medication use, and other risk factors are also recommended.
Human activities significantly impacted the Yangtze River's channel evolution between Datong and Xuliujing. Erosion with a volume of 4.7 hundred million cubic meters occurred due to decreased sediment discharge following the Three Gorges Dam closure.
A new study published in JAMA found that SGLT-2 inhibitor and GLP-1 agonist drugs were associated with reduced risk of death, while DPP-4 inhibitor drugs showed no significant benefit. The findings suggest these treatments may not be equally effective in preventing mortality.
Research tracked changes in Arctic arthropod populations in response to warming temperatures, finding more plant-eating and parasitic insects, and fewer detritivores. The study suggests that water availability will play a key role in determining which bug species can thrive in a warming Arctic.
Research found that chlorine can make foodborne pathogens undetectable by standard laboratory culture techniques. Chlorine-induced states enable some bacteria to survive and potentially cause disease. The study's findings have significant implications for food safety, biocidal products, and post-BREXIT trade agreements.
Researchers have identified human-specific cancers that differ from animal counterparts, suggesting potential evolutionary origins. The study reveals cancer patterns in humans vary significantly from those of other species, highlighting the need for further investigation into the evolutionary underpinnings of cancer.
Researchers identified Histone Deacetylase 7 (HDAC7) as a potential target for new autoimmune disease treatments. The study found that altering HDAC7 function in mice can cause autoimmune diseases, while also improving symptoms when the gene is restored.
Researchers from the University of Pittsburgh have developed a new way to store gases using porous materials, known as MOFs. This could lead to more efficient gas storage and alternative energy production methods.
A new model considers three stages of oxidation and predicts that heavy loads compress alloys, absorbing less oxygen, while stresses pull them apart, allowing more oxygen to infiltrate. The team's framework matches data in microelectromechanical devices, aiming to improve device performance.
Researchers discovered that ocean anoxia, a decrease in dissolved oxygen, played a key role in the Permian-Triassic mass extinction. The team's new technique allowed them to analyze uranium isotopes in carbonates, providing insights into global anoxia and its link to climate change.
Researchers at the University of Bristol have discovered a novel type of opal formed by brown algae, exhibiting iridescence due to self-assembled oil droplet nanostructures. The seaweed's chloroplasts-containing cells can switch on and off this dynamic self-assembly, creating changing opals that react to sunlight.
Researchers have developed a model that explains how biological patterns can form and maintain stability even when protein concentrations are altered. The Min system, used to study cell division, has been found to use a conformational switch in the MinE protein to achieve robustness.
Researchers analyzed 729 reports of abnormal animal behavior related to 160 earthquakes, but found that most evidence consists of single observations and anecdotes. The team suggests a series of questions to analyze the data, including whether animal behavior is linked to specific rules or environmental changes.
Scientists have discovered that sarcoptic mange causes significant loss of body heat and increased metabolic rate in Tasmanian wombats, leading to reduced foraging and increased mortality. The research suggests that dietary supplementation may help address these issues, offering new hope for the management of wombat mange.
Researchers have made counter-intuitive observations in hybrid quantum systems, where cooling processes can lead to heating. The study revealed that symmetries in the system can cause decay to excite components of another subdomain, resulting in a heat-up effect.
Adolescents with strong cooking skills tend to eat more vegetables, have family meals, and prepare healthy meals at home. A new study found that these skills are linked to better nutrition outcomes in adulthood. Developing cooking skills early may provide long-term benefits for health and nutrition.
The NSLS-II's Hard X-ray Nanoprobe has demonstrated capabilities to observe materials down to 10 nanometers, enabling scientists to visualize single molecules. This technology will enable the study of various materials properties simultaneously.
A new automated text messaging service aims to curb opioid abuse by providing patients with regular check-ins and a panic button for immediate help. The study found that the service reduced substance use among patients, dropping from 43% to 10%, and saved caregivers $19 per patient annually.
Researchers found that divorce and low socioeconomic status are associated with a higher risk of recurrent heart events. Patients with higher education levels and household income had lower risks, suggesting marriage may be protective against recurrence.
Researchers investigated how cells respond to cylindrical surfaces and a sphere-with-skirt geometry, finding that cells change their shapes and internal structures. Cells on stiff surfaces form stress fibers, which are influenced by surface curvature, enabling new tools in biology.
Researchers found that observing others' helping behavior enhances infants' prosocial development, particularly when adults model helpful behaviors. The study suggests that having prosocial role models plays a crucial role in shaping young children's helping habits.
Chronic lymphocytic leukemia (CLL) originates from blood-forming cells and spreads to organs through the bloodstream, suppressing immune response to survive. Researchers propose an immunotherapeutic strategy with two immune checkpoint inhibitors that block disease development in preclinical tests.
Researchers Matthew Alford and Thomas Peacock call for collaborative scientific research to inform the future of seabed mining. The study highlights the importance of sediment plumes in assessing marine life impacts and recommends limited-scale operations with academic researchers.
Researchers found statins increased ApoA-I levels in patients with Friedreich's ataxia, potentially reducing cardiovascular risk. The study suggests a possible treatment for the disease, which is associated with low HDL and apolipoprotein A-I levels.
Researchers at Cedars-Sinai have discovered a new way to treat amyotrophic lateral sclerosis (ALS) by transplanting altered neural cells into the brain. Laboratory rats that received the transplants lived 8 percent longer and were free of paralysis 10 percent longer than untreated animals.
PharmaMar presents newly discovered oncogenic properties of eEF1A2, the target of plitidepsin. The protein's interaction with eEF1A2 favors tumor growth, but plitidepsin inhibits this bond, inducing cell death and apoptosis.
A $15.5 million NCI grant creates a center at five health systems to improve lung cancer screening and address disparities in early diagnosis, treatment, and mortality. The center will develop a shared model data for research on optimizing precision lung cancer screening.
Researchers at the University of Huddersfield are leading a £80,510 project to create an accessible interface for extracting information from millions of words in Hansard. The new website aims to make historical debates more easily searchable and understandable for those without specialized knowledge.
A study published in the Journal of Clinical Psychiatry found that individuals with schizophrenia who experienced childhood trauma had improved health outcomes when they possessed high levels of psychological resilience. The research team evaluated data from 114 participants with schizophrenia and 101 non-psychiatric comparison subjects.
Researchers discovered Zika virus infects hot spots in the brains of chicken embryos, affecting key signaling centers and neural patterning. This finding could lead to targeted therapies and drug testing for complications associated with Zika virus in humans.
Research in Tibetan alpine grasslands found that climate warming does not decrease productivity, but rather changes the composition of plant species to stabilize production. The study's findings suggest that shifting species composition enables communities to access more water and buffer against drought-induced declines.
Researchers at the Abramson Cancer Center have discovered promising immunotherapy combinations for treating glioblastoma, head and neck cancer, and pancreatic cancer. CAR T cell therapy combined with checkpoint inhibitors has shown enhanced effectiveness in glioblastoma, while targeting a novel immune checkpoint in head and neck cancer...
Scientists at Goethe University Frankfurt explore cryobiology's social and biological impacts, including 'suspended life', and study immune defense mechanisms to understand pathogens' evasion strategies.
Engineers at U.S. Army Research Laboratory and University of Maryland developed a technique to control composite material behavior using ultraviolet light, enabling new capabilities for rotorcraft design, performance, and maintenance. The method allows materials to become 93%-stiffer and 35%-stronger after UV exposure.
A new study from the University of Iowa found that statins can save thousands of additional lives when used in people with higher levels of LDL cholesterol. The analysis of 34 previous studies involving over 270,000 participants showed that statins were more likely to reduce death risk at LDL levels of 100 mg/dl or greater.
A new bird-of-paradise species, Vogelkop Superb Bird-of-Paradise, has been confirmed due to its distinct dance movements and vocalizations. The species was found only in the far-western region of New Guinea.
Researchers developed a highly reversible zinc metal anode for aqueous batteries, addressing safety concerns and increasing energy storage capacity. The new technology has the potential to replace conventional lithium-ion batteries in extreme conditions, such as aerospace and military applications.
Researchers at Washington University in St. Louis have developed a new process to generate NP-like cells from human induced pluripotent stem cells (hiPSCs). The team mimicked the embryonic development process to produce nucleus pulposus cells, which could potentially be used to treat degenerative disc disease.
A team of scientists discovered that the microbiome of a native plant, Nicotiana attenuata, is more resilient than expected. The study shows that different strains of bacteria within the soil microbiota can form partnerships with the plant and resist antimicrobial peptides, defying previous assumptions about their impact.
A study published in Immunity reveals that T follicular helper cells play a crucial role in determining the fate of B cells, with stronger interactions leading to plasma B cell formation. The researchers identified a subset of B cells expressing IRF4 and CD69 as precursors to plasma B cells.
A KAIST research team developed a new anode material using copper sulfide, exhibiting 1.5 times better cyclability and 40% reduced cost compared to existing materials. The discovery may contribute to the commercialization of sodium ion batteries and reduce battery costs in consumer electronics.
A pre-clinical study has revealed that combining OX40 agonist antibody and GSK2366771 may enhance the immune system's ability to kill melanoma tumors deficient in PTEN. The combination appears to 'step on the gas', revving up T cells and providing extra power to more efficiently kill cancer cells.
A simple one-page form given to patients ahead of their doctor visit can significantly improve satisfaction with the care they receive. The low-tech tool helps patients focus on what's important to them and provides real-time feedback to doctors on how well they're addressing their patients' concerns.
A study by University of Texas Medical Branch researchers found that opioid-related hospitalization rates increased among Medicare patients without prescribed opioids after the 2014 federal change limiting hydrocodone product dispensing. This increase may indicate illegal use of these drugs.
Researchers found that plasmoid reconnection in Mercury's magnetotail could accelerate energetic electrons, solving a puzzle left by previous space missions. The study also revealed that turbulence enhances reconnection, leading to improved predictions for future missions like Bepi-Colombo.
Researchers found that a drug called nalfurafine hydrochloride can deliver itch relief by targeting kappa opioid receptors on neurons in the spinal cord, potentially treating many types of chronic itching.
Researchers at Nagoya University have successfully determined the crystal structure of the gastric proton pump, a key enzyme in stomach acid secretion. The study sheds light on how the pump expels hydrogen ions into the stomach despite its acidic environment.
Researchers are investigating the impact of antioxidant vitamins C and E, alpha lipoic acid, resveratrol, and Sirt1 on blood vessel health in premenopausal women with type 1 diabetes. Early evidence suggests that treatment may restore protection against cardiovascular disease.
Chemotherapy-induced DNA damage triggers apoptosis in oocytes due to p63 activation. Researchers found that inhibiting specific enzymes can prevent this process, offering new hope for fertility preservation.
Researchers discovered that plant DNA repair works more efficiently on active genes, which are transcribed into RNA and proteins. The system's efficiency varies according to the day/night cycle, reflecting normal daily variations in transcription activity.
A network meta-analysis found that SGLT-2 inhibitors and GLP-1 agonists improved survival rates compared to DPP-4 inhibitors in patients with type 2 diabetes. The study analyzed data from 236 clinical trials involving 176,310 participants.
Researchers at the University of Münster have developed a new method to study inflammatory cells in mice, allowing for genetic modification, multiplication, and visualization in living organisms. This approach reduces the number of animal experiments needed.
A vaccine combining a cancer molecule with Listeria bacteria aims to improve longevity and quality of life for dogs with osteosarcoma. Researchers will conduct clinical trials to evaluate the vaccine's effectiveness in 80 dogs.
A team of researchers and botanists collaborated with Twitter to identify a globally imperiled plant species, Heuchera alba. They found seven new populations, expanding the species' range beyond previously known small populations in Virginia and West Virginia.
Scientists studied China's terrestrial ecosystems, revealing significant carbon stock changes driven by climate change, ecological restoration projects, and land-use practices. The study identified four major ecosystems with varying carbon sink or source capabilities.
Researchers are using machine learning techniques to analyze protein dynamics data and uncover hidden cause-effect relationships. Their study reveals that the signal initiated at the stimulation site of a protein weakens as it moves away from the stimulation site.
Researchers have discovered a faster, more cost-effective way to determine which DNA mutations cause human bowel cancer. A new preclinical pipeline uses gene editing technology (CRISPR) to rapidly engineer normal colon cells with DNA changes, allowing for real-time monitoring of growing cancers.
Triple negative breast cancer brain metastases typically have lower numbers of immune cells, but those present are responsive to checkpoint inhibitor therapies. Researchers aim to increase immune cell presence and responsiveness to improve treatment outcomes.