The article discusses the challenges in managing common ankle fractures, particularly those above and below the level of the syndesmosis. Researchers recommend assessing medial clear space on radiographs and patient pain ratings to guide management. They also emphasize the importance of dynamic imaging with stress radiographs to detect...
Researchers at University of Pittsburgh's Swanson School of Engineering have developed a new method to treat hydrofracturing wastewater by leveraging waste heat from drilling sites. The membrane distillation technology reduces the need for fresh water and produces high-quality water suitable for agriculture, industry, and other uses.
The Alzheimer's Association has awarded six international researchers with $1 million each over two years to explore innovative treatments for early-stage Alzheimer's disease. The goal is to discover effective drugs that can rejuvenate brain cells and slow or halt the progression of the disease.
The Paul G. Allen Frontiers Group has awarded $13.5 million to 10 researchers studying lymphoma, neuroimmunology, nuclear biophysics, and brain cell function. These studies aim to shed light on Alzheimer's disease and develop new treatments for blood cancers.
Researchers have found that CRISPR-Cas9 generates a strong immune response in humans, with T cells reacting to the Cas9 protein in almost all healthy subjects. However, the study also highlights the need for new solutions to prevent dangerous immune reactions, particularly for genetic diseases requiring in vivo modifications.
Scientists at the University of Leeds have used powerful microscopy techniques to reveal the structure of amyloid proteins, a build-up of abnormal proteins that causes disease. The research has provided significant insights into how these proteins form aggregates and contribute to disease, paving the way for potential treatments.
A new ocean mixed layer model reproduces a more realistic sea surface temperature (SST) diurnal cycle than existing models. The 31-year global diurnal sea surface temperature dataset reveals significant seasonal and interannual variations of SST, with potential implications for ENSO prediction.
Researchers found that a genetic defect tied to ALS and other neurodegenerative diseases leads to increased lipid production in starved cells. The mutation alters the regulation of lipid metabolism pathways, increasing levels of enzymes like NOX2, which can damage cells.
The study explores the implications of applying utilitarian, deontological, and virtue ethical standards to superstition in the marketplace. It highlights the need for researchers to clearly state the rationality of consumers' behaviors and assess their irrationality to promote consumer well-being.
Conspiracy theorists on Reddit discuss recurring elements such as Big Pharma, US elections, and government corruption. The study found that narrative-motifs expose commonalities between multiple conspiracy theories, even when referring to different events or circumstances.
Researchers at Tohoku University create a technique to generate large amounts of giant vesicle (liposome) dispersions using a porous silicone material. The method involves adsorbing lipids into the material and squeezing out buffer solutions, producing giant vesicles with high efficiency.
Researchers developed a hybrid photoelectrochemical and voltaic (HPEV) cell that turns sunlight into both hydrogen fuel and electricity, overcoming the limitations of current materials. The device achieves a combined efficiency of 20.2%, three times better than conventional solar hydrogen cells.
A study published in PLOS Biology reveals a new neural circuitry linking olfaction to locomotion in lampreys, a parasitic fish that has decimated large populations of fish. The discovery demonstrates how smell can activate locomotor centers via two distinct brain pathways.
The California Academy of Sciences has described 17 new species of sea slugs, shedding light on the evolution of color patterns and their significance in coral reefs. The discovery highlights the importance of nudibranchs as indicators of ocean health and reveals diverse ecosystems across the Indo-Pacific region.
Researchers observed a powerful outflow of hydrogen gas from the Small Magellanic Cloud, a tiny dwarf galaxy. The discovery provides the first clear observational measurement of mass lost from a dwarf galaxy, shedding light on its slow death and potential impact on the surrounding Milky Way galaxy.
Researchers found that ignoring income mobility exaggerates life expectancy inequality, leading to a half-life reduction in the difference between income percentiles. The study suggests that accounting for mobility provides a more accurate measure of inequality.
A genome-wide study confirms six distinct tiger subspecies, providing context for conservation strategies. The research highlights the urgent need for individual protection planning for these endangered species.
The article highlights the impact of mass shootings on blood donation rates and transfusion needs. A report by Vanderbilt University Medical Center shows that mass shootings can lead to a significant increase in blood component transfusions, with some hospitals requiring up to 2.7 units per admission.
Researchers are conducting a randomized controlled trial to investigate the effects of treadmill walking exercise training on learning and memory performance, hippocampal volume, and resting-state functional connectivity in people with Multiple Sclerosis (MS). The study aims to determine if aerobic exercise can improve cognitive defici...
This study examined the impact of neighborhood characteristics on the growth of alcohol outlets from 2000 to 2013 in 53 California cities. It found that lower-income areas with larger populations and higher incomes experienced greater growth in bars, restaurants, and liquor stores.
Researchers from University of Seville analyzed geodynamic behavior of Tenerife island and found millimetric coming together with Gran Canaria, potentially caused by a fault between the two islands. The islands' gravitational sinking has been detected through GPS data since 2004.
A new study reveals that most Americans overestimate the low concern levels of minorities and lower-income people for environmental threats. The research found a paradoxical pattern where those groups report high levels of concern despite being underestimated.
Typhoon Yutu's heavy rainfall was revealed by NASA's GPM satellite, affecting an area the size of Luzon. The storm's southwestern eye wall showed extreme precipitation falling at over 178 mm per hour.
Lifestyle interventions, medication, and surgery can effectively delay or prevent type 2 diabetes in the majority of patients, but limited access to these treatments is a major issue. Evidence-based interventions show that weight loss through lifestyle changes or metabolic surgery can reduce the risk of diabetes by up to 78%.
Researchers found that adolescent deviancy training, such as crude talk among friends, signals a pathway to antisocial behaviors and unhealthy adult relationships. Adults who exhibited more deviancy training at age 16-17 were more likely to display coercive behavior in their relationship at age 28-30.
Researchers discovered that modified LDL particles trigger an immune response in macrophages, leading to chronic inflammation. The study found 27 transcription factors involved in the process, highlighting the importance of inflammation in atherosclerosis pathogenesis.
Researchers are studying how variations in federally qualified health centers impact efficiency and patient health outcomes. They aim to develop models to better understand the strengths and challenges facing Montana's healthcare system, with a focus on pregnancy-related health outcomes and disparities.
Researchers from ITMO University created a non-invasive system to measure blood flow in the upper limbs using video recording of skin surface under green light. The method is comparable in accuracy to traditional methods but is easier to use, cheaper, and suitable for most patients.
A representative survey of over 1,200 US adults found that racial minorities and low-income Americans report higher levels of environmental concern than other groups. Stereotypes may hinder efforts to address environmental inequities and increase public involvement in environmental action.
A NIH study found that astrocytes alter neuron signal speed by changing myelin thickness and node width, impairing reflexes. The researchers propose thrombin inhibitors as a potential treatment for multiple sclerosis.
Researchers found that targeting tumor sites with radiation or surgery after initial treatment can significantly improve overall survival time for patients. Progression-free survival and toxicity data also showed benefits, with median overall survival times of up to 41.2 months.
Neuroene Therapeutics is developing a vitamin K analogue to improve seizure control in patients with drug-resistant epilepsy. The company will test the efficacy and safety of its lead compounds with assistance from the University of Utah's Anticonvulsant Drug Development Program.
Adults with severe obesity experienced greater initial and sustained weight loss with gastric bypass surgery compared to sleeve gastrectomy or adjustable gastric banding. The study, involving over 46,000 patients, found that gastric bypass led to a 19-pound weight loss difference at 5 years.
Exercise has been shown to decrease fall risk among older adults with Alzheimer's disease and neuropsychiatric symptoms. The study found that those who exercised had a lower risk of falls compared to non-exercising individuals, while also highlighting the increased risk for falls in those with depression and anxiety.
Historically, 4-12% of western US land burned annually, while current trends underestimate future risks. Climate-driven drying and excess vegetation have led to low wildfire rates, shifting assessment towards inevitable future fires. The authors highlight the need for more widespread effective management strategies.
New study finds stone tools and cut-marks at Ti's al Ghadah site in Saudi Arabia, dated to 500,000-300,000 years ago, suggesting early hominins inhabited relatively humid grasslands. Stable isotope analysis reveals aridity levels similar to those in eastern Africa's open savanna settings.
Researchers developed a machine-learning program that can predict atomic responses to magnetic fields in record time, combining with NMR spectroscopy to identify complex compound structures. This breakthrough accelerates drug discovery and makes larger molecules accessible.
A research collaboration found that Haiti has lost over 99% of its primary forests, triggering an ongoing mass extinction of reptiles, amphibians, and other species. The country is expected to lose all remaining primary forest cover in less than two decades, resulting in the disappearance of most endemic species.
The University of British Columbia study suggests that cacao was domesticated around 1,500 years earlier than previously thought in South America. Archaeological evidence from Ecuador shows that people were harvesting and consuming cacao 3,900 years ago.
A study analyzing methane emissions in a natural gas production basin revealed significant diurnal variation in emission rates. Peak emissions occurred during working hours and coincided with aircraft-based measurements, potentially explaining discrepancies between top-down and bottom-up estimates.
Researchers report genome assemblies of Eurasian trembling aspen and North American quaking aspen, highlighting the influence of gene network connectivity on genetic diversity. The study suggests that genetic variation is shaped by gene expression levels and regulation in these species.
A study found that maternal opioid use disorder diagnoses are increasing among rural residents, with over half of these cases occurring in rural hospitals. Rural women with opioid use disorder are more likely to give birth in urban teaching hospitals, highlighting the need for resources in both rural and urban settings.
A combination of buprenorphine and samidorphan has shown significant symptom reduction in patients with major depression, with no evidence of dependence or withdrawal. The trials suggest a new class of antidepressants with a novel mechanism of action could have a significant impact for patients with persistent symptoms.
Researchers from Lund University have developed a more effective technique to search for dark matter in the universe. By analyzing larger amounts of data generated at CERN, they hope to find signs of new particles that could connect visible and dark matter.
Valentin Dragoi of UTHealth receives $1.6M NIH BRAIN award for studying visual cortex and executive control in social interactions, which may help address autism-related social awkwardness.
Research suggests that leptin levels play a crucial role in protecting the cardiovascular system from damage. When leptin levels are optimal, they help restore balance to the body's physiological processes, reducing inflammation and oxidative stress.
Researchers identified a dominantly inherited mutation that makes cotton bollworms resistant to genetically engineered cotton. The study's findings suggest that this dominant gene is spreading rapidly and may soon threaten cotton production in China.
Astronomers have discovered that fast radio bursts, which are exceptionally bright flashes of energy coming from deep space, do not emit at low frequencies. The Murchison Widefield Array and Australian SKA Pathfinder telescopes were synchronized to observe the same point in the sky, allowing researchers to capture the same view and gai...
PhasorSec, developed at Dartmouth's Trust Lab, uses Language-theoretic Security principles to filter out inputs that compromise the power system. The tool provides a validation filter for network data packets, addressing concerns over potential vulnerabilities in IEEE C37.118 protocol.
Researchers at Tel Aviv University have developed a new platform that uses biology and nanotechnology to carry mRNA directly to target cells. The system demonstrates safe and effective passage of therapies for treating various diseases, including cancer and inflammatory disorders.
Scientists have discovered intricate glycan structures in royal jelly, a substance believed to influence honeybee development. These findings challenge previous assumptions and may lead to a deeper understanding of the complex interactions between glycosylated proteins and signaling pathways.
Researchers have developed a new method to identify outliers in air quality monitoring data, which can automatically flag erroneous data and improve forecasting accuracy. The method uses probability of residuals to discriminate outliers, allowing for simultaneous evaluation of spatial and temporal consistencies.
Rare earth ions exhibit potential for storing quantum states and interacting with each other, enhancing computation capacity. Researchers aim to establish scalable quantum technologies using these elements.
Researchers reviewed published studies and found at least seven patients who experienced devastating harm from unapproved cell therapy. Clinics that offer such treatments often omit poor outcomes in their reports, leading to a significant under-reporting of complications.
Researchers at the University of Adelaide modelled the transition to a sustainable energy future, examining the relative productivity of fossil fuels and renewables. The study shows that fuel productivity determines the viability of renewable energy and how economies will transition from fossil fuels to sustainable sources.
A new study from Berkeley Lab found that accounting for plant nutrient uptake at night and during non-growing seasons can weaken terrestrial ecosystem feedbacks with the atmosphere, leading to weaker greenhouse gas emissions. The study's findings imply that plants may be able to take up more carbon dioxide and soils lose less nitrous o...
Researchers found Haiti's primary forest declined from 4.4% to 0.32% between 1988 and 2016, with 42 of 50 highest peaks deforested in the same period. The study predicts near-total loss by 2035, with up to 83% of species becoming extinct due to deforestation.
A new study suggests up to 13% of US beekeepers are in danger of losing their colonies due to pesticides sprayed to contain the Zika virus. The researchers calculated the percentage of colonies that could be affected by comparing data on bee densities with areas at risk from Zika.
The MODIS instrument aboard NASA's Terra satellite analyzed water vapor within Hurricane Oscar, providing valuable insights into the storm's potential for development and heaviest rainfall. The analysis revealed coldest cloud top temperatures as cold as -70 degrees Fahrenheit, indicating a high risk of heavy rainfall.
A study published in Scientific Reports found that forced expression of the natural protein FGFBP3 in obese mice reduced their fat mass by over a third. The treatment also improved obesity-related disorders such as hyperglycemia and fatty liver disease, with no side effects observed.