Articles tagged with Insulin Sensitivity
A new study led by UT Southwestern scientists suggests that breastfeeding changes the body's insulin sensitivity, particularly in highly insulin-sensitive organs like the liver and fat tissue. This increase in insulin sensitivity may provide a buffer against insulin resistance even decades later, lowering the risk of Type 2 diabetes.
A genetic variant of the DUSP8 gene impairs brain response to insulin, leading to increased risk of type 2 diabetes. Research reveals protein Dusp8's regulatory effects on hypothalamic insulin sensitivity and inflammatory processes.
A long-term study found that brain insulin sensitivity determines both body weight and the distribution of fat in the body. Participants with high insulin sensitivity in the brain experienced a significant reduction in visceral fat and weight, which was maintained over nine years.
A 16-week vegan diet was shown to increase the abundance of Faecalibacterium prausnitzii and Bacteoides fragilis, leading to significant reductions in body weight, fat mass, and visceral fat. Insulin sensitivity also improved in the vegan group.
A study led by Dr. Stephanie Kullmann found that exercise improves brain function in overweight and obese individuals by normalizing brain functions important for metabolism and increasing regional blood flow in areas of the brain dependent on dopamine. Participants also reported improvements in mood and executive function.
Scientists uncover how light influences insulin sensitivity and metabolic homeostasis, shedding light on the circadian rhythms' impact on diabetes. The study suggests that taking into account time of day can help patients better manage their treatment and reduce risks associated with daily insulin injections.
Research found that sleeping in on weekends doesn't lastingly improve health measures, and even short-term recovery is disrupted by returning to poor sleep habits. The study suggests that consistency matters for getting sufficient sleep and minimizing the risk of obesity and diabetes.
Researchers found that weekend recovery sleep does not reverse sleep loss-induced disruptions of metabolism. Insufficient sleep still leads to increased snacking, weight gain, and decreased insulin sensitivity, even after a weekend of extra sleep.
A six-week high-intensity resistance training program improved insulin sensitivity by 16% and increased muscle size and strength in overweight men. The study suggests that short sessions of exercise to exhaustion are equally effective as longer sessions, making it a time-efficient way to improve health outcomes.
Researchers at Children's Hospital Colorado found that shorter sleep duration, later weekday bedtimes, and poor circadian timing were linked to reduced insulin sensitivity in adolescents with overweight or obesity. The study suggests potential benefits of improving sleep health through interventions like delayed school start times.
New research shows that childhood exercise can counteract the risk of developing type 2 diabetes in offspring born to obese fathers. Early exercise training has been found to reverse low insulin sensitivity and improve muscle function, offering a potential long-term health benefit for these individuals.
Researchers found that trehalose improves insulin sensitivity in mice by activating a gene called Aloxe3, which boosts calorie burning and reduces fat accumulation. Trehalose also has beneficial effects on the liver's metabolism, similar to fasting.
Experts from the University of Stirling have made a breakthrough in understanding how people respond to lifestyle treatment for preventing Type 2 diabetes. A new genomic signature has been discovered that indicates improved insulin sensitivity in individuals whose Type 2 diabetes status improves following a treatment intervention.
Scientists used deep brain stimulation to regulate blood sugar metabolism and increase insulin sensitivity in patients with type 2 diabetes. The treatment showed promising results, reducing insulin requirements and boosting glucose tolerance.
Experts developed a streamlined approach to using Dexcom G5 Mobile Continuous Glucose Monitor (CGM) trend arrow data. The new tool helps individuals with diabetes adjust insulin doses more accurately, reducing dangerous fluctuations and long-term complications.
A new study reveals that AMPK plays a key role in enhancing insulin's ability to stimulate glucose uptake in muscles after physical activity. This discovery may lead to the development of an 'exercise pill' for people with limited mobility or those who struggle with physical activity.
Researchers are enrolling 60 obese children in an eight-week study to examine the impact of vitamin K supplements on their cardiovascular health. The study aims to determine whether vitamin K can improve insulin sensitivity and reduce lipid levels in the blood, potentially reducing the risk of diabetes and cardiovascular disease.
Researchers found that supplementing healthy mice with NMN reduced signs of aging such as weight gain, loss of insulin sensitivity, and declines in physical activity. Long-term effects showed improved energy metabolism, better liver function, and increased tear production.
A high-protein diet eliminates improvements in insulin sensitivity after weight loss in obese postmenopausal women. Women who consumed more protein lost less lean tissue, but the total difference was only about a pound.
A recent study challenges the concept of 'healthy obesity,' revealing nearly identical gene expression changes in obese individuals with varying levels of insulin sensitivity. The research suggests that vigorous health interventions may be necessary for all obese individuals, regardless of their metabolic health status.
Research finds duodenum-jejunum gastric bypass surgery alters gut microorganisms, leading to improved glucose tolerance and insulin sensitivity, resulting in diabetes remission. Bypass surgery also reduces inflammation in liver and fat tissue without directly affecting brain-derived neurotrophic factor (Bdnf) expression.
Volanesorsen, a novel lipid-lowering medication, significantly improved insulin sensitivity and glucose control in patients with type 2 diabetes and high triglycerides. The study found a 69% reduction in triglycerides and improved hemoglobin A1c levels, suggesting that lowering triglycerides can improve insulin sensitivity.
Researchers found that subcutaneous fat has an intrinsic circadian rhythm in insulin sensitivity, peaking at noon and decreasing by midnight. This internal clock may contribute to daily rhythms in glucose tolerance observed in humans.
Researchers at McMaster University found that a single minute of very intense exercise produces health benefits similar to longer endurance training. Brief bursts of intense exercise are remarkably effective in boosting cardiorespiratory fitness and insulin sensitivity.
A study found that two consecutive nights of extended sleep can counteract the increased risk of diabetes associated with short-term sleep restriction during the work week. Insulin sensitivity and diabetes risk returned to normal after two nights of extended sleep.
A study by University at Buffalo researchers found that testosterone replacement therapy increases insulin sensitivity and reduces body fat in Type 2 diabetic men. Testosterone treatment also improved muscle mass and expression of genes that mediate insulin signaling.
A Vanderbilt study found that sildenafil improves insulin sensitivity in people at risk for diabetes, potentially reducing the risk of developing type 2 diabetes. The researchers discovered that sildenafil inhibits an enzyme called phosphodiesterase 5, resulting in relaxation of smooth muscle and increased blood flow.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that Viagra improves insulin sensitivity in individuals with prediabetes. The medication also reduces a biological marker that signals heightened risk of kidney and heart disease.
A lack of sufficient sleep reduces the body's sensitivity to insulin, impairing blood sugar regulation and increasing diabetes risk. The study found that insufficient sleep impairs insulin sensitivity, leading to a reduced ability to regulate blood sugar levels.
A new study by the University of Colorado shows that sleep deprivation can lead to impaired insulin sensitivity. The longer people are awake during their biological night, the worse their sensitivity to insulin becomes, according to the study's findings.
Researchers at UT Southwestern Medical Center found that introducing an enzyme called ceramidase in diabetic mice rapidly improved insulin sensitivity. The study suggests a new means to potentially treat Type 2 diabetes and nonalcoholic fatty liver disease by lowering ceramide levels, which interfere with insulin signaling.
A genetically engineered mouse with weaker bones has a strong metabolism, suggesting a potential link between bone health and obesity-related type 2 diabetes. The study highlights the endocrine role of bone in regulating metabolism, and its exploration may lead to new avenues for treatment.
A new study published in Diabetes Care found that calorie restriction and exercise both improve insulin sensitivity, with combining the two approaches resulting in greater reductions. This suggests that both diet and exercise play important roles in managing Type 2 diabetes risk.
A new study identifies N-acetyltransferase 2 as a key gene variant linked to insulin resistance, increasing the risk of type 2 diabetes and cardiovascular disease. Inhibition of NAT2 in a mouse model decreased insulin sensitivity, highlighting its role in complex diseases.
A new study published in Diabetologia found that statin use is associated with a 46% increased risk of developing type 2 diabetes. After adjusting for confounding factors, researchers discovered that statins decrease both insulin sensitivity and secretion, leading to an increased risk of diabetes.
A study published in JAMA found that a low-glycemic index diet did not improve cardiovascular risk factors, such as blood pressure and lipid levels, or insulin sensitivity in overweight adults. The researchers also found that high-glycemic index diets had more negative effects on insulin sensitivity and LDL cholesterol levels
A low glycemic diet did not improve insulin sensitivity, lipid levels or blood pressure in a randomized controlled trial of 163 overweight adults. The study found that diets with high-glycemic index carbohydrates, such as the DASH diet, had similar effects on cardiovascular risk factors as those with low-glycemic index carbohydrates.
Researchers at Indiana University School of Medicine have identified Sestrin 3 as a critical regulator of glucose homeostasis and insulin sensitivity in the liver. Mice with the protein showed improved glucose tolerance, while those without it exhibited impaired glucose metabolism.
Researchers found that people with higher levels of brown fat have better blood sugar control, higher insulin sensitivity, and improved metabolism. Brown fat's ability to regulate blood sugar makes it an important anti-diabetic tissue.
A study found that individuals with growth hormone receptor deficiency have increased insulin sensitivity, preventing Type 2 diabetes and lowering their risk for cancer. Despite higher body fat content, their bodies were more responsive to insulin, suggesting a potential protective effect against these diseases.
A new study found that ethnic differences significantly impact insulin response, with East Asians showing improved insulin sensitivity but poorer insulin release. Healthy individuals of all ethnicities maintained normal glucose levels but did so differently, with some groups releasing more or less insulin in response to changes.
A study by LA BioMed found that men who get more sleep on the weekend can improve their insulin sensitivity, reducing their risk of developing type 2 diabetes. The research, conducted over six months, involved 19 non-diabetic men who slept an average of 6.2 hours per night during the week and caught up on sleep on weekends.
A 8% reduction in BMI improves insulin sensitivity and glucose tolerance in obese teenagers, a threshold found consistent with adult results. The study suggests that modest weight loss can lead to significant improvements in metabolic health.
Research suggests that longer periods of low-intensity exercise improve insulin sensitivity and blood lipid levels more effectively than shorter bursts of intense activity. Standing and walking for extended durations are particularly beneficial.
A study found a 21% drop in insulin sensitivity among first-born children, leading to higher daytime blood pressure and increased risk of conditions like type 2 diabetes. First-borns tend to be taller and slimmer than their later-born counterparts due to changes in the mother's uterus during pregnancy.
A new study found that resveratrol supplementation did not improve metabolic function or prevent health problems in healthy, post-menopausal women. The study suggests that resveratrol may have a synergistic effect when combined with other compounds in red wine.
A recent study found that short-term sleep deprivation significantly decreases insulin sensitivity in fat cells, a key finding with implications for metabolic disorders. The researchers also discovered that regular sleep deprivation may lead to metabolic problems such as diabetes and obesity over time.
A study published in the New England Journal of Medicine reveals that mutations in the PTEN gene can improve metabolism and increase insulin sensitivity in people with Cowden syndrome. The researchers found that those with Cowden syndrome had higher levels of obesity, but the extra weight was caused by extra fat storage, not muscle mass.
Researchers discovered that GPR21 inhibition improves insulin sensitivity and energy expenditure in mice with obesity. The absence of GPR21 also reduces inflammation and decreases body weight under normal diet conditions. Additionally, another study found that FOXO1 plays a critical role in regulating energy balance and glucose metabol...
Researchers found that deleting GPR21 improves insulin sensitivity in diet-induced obese mice by reducing inflammation. The study suggests that GPR21 inhibitors could be promising treatments for type 2 diabetes.
Researchers found that inhibiting only mTORC1, a protein complex regulating growth and differentiation, prolongs life in mice without adverse effects on glucose tolerance or insulin sensitivity. This discovery may lead to the development of a drug specifically targeting mTORC1 to promote longevity while preventing diabetes.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that intermittent exercise with low oxygen concentrations significantly improves glycemic control in patients with type 2 diabetes. Exercise under hypoxic conditions provides greater improvements than intermittent exercise alone.
Researchers found that elderly individuals with high insulin sensitivity had larger brains and better verbal fluency skills compared to those with low insulin sensitivity. Higher insulin sensitivity was also associated with more grey matter in regions important for language skills.
Researchers at UC San Diego and EPFL found that removing a regulatory protein called NCoR dramatically improved insulin sensitivity in mice. The study reveals a new role for NCoR in regulating fatty acid storage and glucose metabolism, which could lead to the development of targeted treatments for type 2 diabetes.
A Scripps Research Institute scientist has been awarded a $1 million grant to study adropin, a peptide hormone that may improve insulin sensitivity and treat type 2 diabetes. The research aims to explore adropin's potential role in glucose homeostasis and its application as a protein-based therapy.
A daily dose of safflower oil improved health measures such as good cholesterol, blood sugar, and inflammation in obese postmenopausal women with Type 2 diabetes. The researchers found a significant association between safflower oil supplementation and reduced cardiovascular disease risk.
A new study suggests that consuming an almond-enriched diet can improve insulin sensitivity and decrease LDL-cholesterol levels in individuals with prediabetes. The study found significant improvements in insulin levels, homeostasis model analysis for insulin resistance, and clinically significant reductions in LDL-cholesterol.
A new study found that obese individuals exhibit lower functional brain response in one region and impaired insulin sensitivity compared to normal-weight peers. This suggests a potential link between midlife obesity and cognitive decline later on.
Children of mothers with high blood sugar during pregnancy are more likely to have low insulin sensitivity, a risk factor for type 2 diabetes. Obesity does not account for the association, and children exposed to high maternal blood sugar levels in the womb also exhibit exaggerated insulin secretion after meals.
A new study by Columbia University researchers found that bariatric surgery significantly improves insulin sensitivity in diabetic adults, even with equal weight loss compared to a low-calorie diet. The study suggests hormonal changes may be responsible for the improvements, paving the way for further medical therapies.