Articles tagged with Oncology
Research emphasizes the importance of ethnically diverse prostate cancer genomics data and accessible genetic testing. Variations in genomic landscape of prostate cancer were observed in Chinese men compared to Western cohorts, with lower mutation rates in driver genes such as TP53 and PTEN.
A new study found that less frequent CT scans may reduce health-care costs and patient anxiety without compromising patient outcomes. The researchers analyzed medical records of over 6,000 patients with stage 1 non-small cell lung cancer who underwent surgery between 2006 and 2016.
A new study published in JAMA Surgery compares robotic liver resection with open liver resection for treating hepatocellular carcinoma. Robotic liver resection is found to be a safe treatment option for patients with compromised liver function, achieving comparable oncologic efficacy to traditional open surgery.
A recent study found that MRI-guided adaptive radiation therapy, also known as SMART, has shown promising safety and patient outcomes data for treating locally advanced and borderline resectable pancreatic cancer. The study, led by Henry Ford Health, reported no incidence of acute grade 3 or higher gastrointestinal toxicity, with preli...
A systematic review and meta-analysis of ADC clinical trials found that 91.2% of patients experienced treatment-related adverse events, with serious side effects including neutropenia, hypoesthesia, and thrombocytopenia. The study highlights the need for clinicians to address these toxicities in ADCs' use.
The UC San Diego Alpha Stem Cell Clinic will receive $8 million in funding to launch new clinical trials and improve accessibility of stem cell therapies. The clinic has already launched 59 clinical trials and treated 277 patients with various diseases.
The ESMO Asia Congress 2022 will focus on the latest scientific and clinical advances in oncology, with a special emphasis on the Asia-Pacific region. Media representatives can register for coverage through the official media registration form.
Researchers at Clinica Universidad de Navarra found that ultrasound-guided surgery (IOUS) is more effective and quicker than traditional wire-localisation methods for treating ductal carcinoma in situ (DCIS). This technique reduces the risk of positive margins, a common cause of second operations.
Researchers evaluated modified CEUS using perfluorobutane for diagnosing hepatocellular carcinoma in high-risk patients. The study found no significant difference in sensitivity, specificity, or accuracy between modified CEUS and CT/MRI LI-RADS v2018.
The Princess Máxima Center has been awarded a Marie Sklodowska-Curie COFUND grant to train 28 PhD students from around the world in pediatric oncology research. The program aims to advance the field and promote international collaboration.
The November issue of CHEST journal features new guidelines for perioperative management, studies on COVID-19 treatment and COPD treatment, as well as research on sleep apnea and long COVID. These findings have significant implications for patient care and healthcare resource use.
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
Researchers have discovered two novel drugs that can block the growth and shrink the size of schwannoma tumors, a type of nerve sheath tumor found in the nervous system. The treatment works by inhibiting the Hippo signaling pathway, which is dysregulated in multiple types of cancer.
Research at Linköping University suggests that dense breasts have unique biological characteristics that promote cancer growth, leading to a fivefold increased risk. The study used MRI and microdialysis techniques to measure proteins in breast tissue, finding elevated levels of inflammatory markers and growth factors.
The TRIDENT-1 trial suggests that repotrectinib could be effective for treating ROS1 positive non-small cell lung cancer (NSCLC) in patients who have received other targeted treatments and those who have not. The drug showed promising results, with an objective response rate of 79% in patients not previously treated with a ROS TKI.
Researchers controlled magnetic bacteria to cross blood vessel walls and infiltrate tumor tissue, delivering liposomes with fluorescent dye to demonstrate their ability to carry therapeutic agents. This approach may revolutionize bacterial cancer therapy by increasing efficacy and reducing side effects.
Ruben van Boxtel's research focuses on understanding the origins of late treatment effects in children with blood cancer, exploring the role of stem cells. His work aims to find solutions to prevent these effects and predict their likelihood.
Researchers analyzed 408 patients receiving immune checkpoint inhibitor therapy and found no increased risk of side effects from receiving both immunotherapy and the vaccine. The study supports NCCN's recommendations for COVID-19 vaccination in people with cancer, citing strong protection against severe COVID-19 for all variants.
WayPath Pharma has been awarded a $225,000 Phase I Small Business Technology Transfer (STTR) award to develop new metabolic drugs targeting tumor stem cells and crossing the blood-brain barrier. The funding aims to advance treatment options for glioblastoma, a highly aggressive brain cancer with limited treatment options.
Research reveals that individuals with inflammatory breast cancer are at a higher risk of brain metastases, which can lead to improved survival rates and quality of life. The study suggests that patients with triple-negative breast cancer face an even higher risk, emphasizing the need for earlier detection and more aggressive treatment.
The NCCN Annual Congress on Hematologic Malignancies will address key findings on chronic lymphocytic leukemia management and CAR T-cells in diffuse large B-cell lymphoma. The event also features updates on immunotherapies in multiple myeloma treatment.
A new blood test has shown promising results for detecting multiple types of cancer from tumor DNA in the blood, enabling early detection and potentially changing cancer screening practices. The test's accuracy and effectiveness have been demonstrated in a recent study, with high sensitivity and specificity rates.
The DeFi trial shows targeting the Notch pathway with nirogacestat improves progression-free survival and reduces symptoms in patients with desmoid tumours. Patients reported a statistically significant benefit in reduced pain, symptom burden, and improved quality of life.
Scientists have discovered a link between air pollution and lung cancer in people who have never smoked. Exposure to particulate matter (PM2.5) has been shown to promote cancerous changes in airway cells with EGFR and KRAS gene mutations, driving them towards a cancer stem cell-like state.
A phase 3 study shows that tumour-infiltrating lymphocytes (TIL) therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma. The treatment reduces disease progression or death by 50% in patients treated with TILs.
Late-breaking results at ESMO Congress 2022 reveal a strong association between air pollution and non-small cell lung cancer, with exposure to particulate matter linked to increased risk. The research underscores the need for environmental sustainability in oncology, particularly in cancer prevention and early detection.
Researchers at Mayo Clinic Comprehensive Cancer Center found that metabolic imaging, combined with traditional treatment response assessment methods, can provide critical information to guide therapy for pancreatic cancer patients. The use of positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) tracer adds significant pr...
A large retrospective study found that visceral fat area from fully automated and normalized abdominal CT analysis predicts subsequent myocardial infarction or stroke in Black and White patients. The study suggests that body composition analysis using machine learning could be widely adopted to add prognostic utility to clinical practice.
A Swedish study of 1,275 women with breast cancer found no increased risk of disease recurrence or death after fertility preservation procedures. The research provides new hope for women who want to preserve their fertility after cancer treatment.
Researchers at Karolinska Institutet have developed a potential curative treatment for neuroblastoma, using DHODH blockers in combination with chemotherapy to cure mice with the disease. The treatment has shown promising results and could improve survival rates for children with neuroblastoma.
Researchers at Texas Biomed have developed a modified tuberculosis vaccine that can treat non-muscle invasive bladder cancer without strong side effects. The delipidated vaccine triggers well-regulated immune responses and reduces inflammation, making it more effective than traditional treatments.
A 3-dose Moderna COVID-19 vaccination schedule significantly improved SARS-CoV-2 antibody concentrations in immunocompromised patients. This improvement was comparable to those obtained by healthy individuals after the standard two-dose Moderna vaccination schedule.
The August issue of the CHEST journal features 47 articles on clinically relevant topics such as asthma, COPD, and pulmonary vascular disease. A highlighted article examines barriers to palliative care in interstitial lung disease.
A University of Michigan-led analysis found that training patients to voice their concerns and advocate for themselves can reduce the impact of physicians' racial biases on care. The study showed that 'patient activation' creates more equitable interactions between patients and physicians.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
A study of 3,028 patients with COVID-19 reveals that race, ethnicity, and severity of infection are key factors contributing to delayed cancer treatment. Researchers found that these patient demographic factors are strongly associated with delays in receiving timely medical care.
A multi-national study found that over half of clinical trials leading to FDA-approved anticancer medicines are not available for independent scrutiny. The lack of transparency hinders the use of data for further research into the safety and efficacy of medicines.
A recent study published in Blood Advances found a significant disparity in the representation of women among medical educators, with women comprising just 37.7% of speakers at hematology and medical oncology board review lectures. The study also highlights the importance of increasing diversity in educational opportunities to promote ...
A large cohort study found that hormone replacement therapy for breast cancer survivors is not associated with an increased risk of recurrence. The study included over 8,400 Danish postmenopausal women and found no link between vaginal estrogen or menopausal hormone therapy and breast cancer reoccurrence.
Occupational exposure to firefighting has been linked to increased cancer risk, including mesothelioma and bladder cancer. The new classification aims to reduce firefighter exposures and prevent cancer through interventions and research collaborations.
The July issue of CHEST journal features 62 articles on clinically relevant topics, including asthma and COPD. The journal has received an Impact Factor of 10.262, an increase from 2020's Impact Factor of 9.410.
Researchers at Osaka University identified Src as a key molecule in the process of epithelial cells becoming invasive and cancerous. The study found that CDCP1 forms a molecular scaffold that activates Src, promoting cancer cell invasion.
Researchers from University Hospitals developed a transfusion appropriateness algorithm to analyze blood transfusions for adult patients. The algorithm led to a decrease in transfusions and an increase in appropriate use, resulting in cost savings of $2.5 million over 12 months.
A recent survey revealed significant gaps in cancer screening among women aged 50-64, with rates as low as 50% for colorectal cancer and 46.5% for both cancers. The study found that patient-centered approaches to screening can facilitate timely testing and management of abnormal results.
A new study found that transitioning from in-person to virtual conferences significantly reduces travel-related carbon dioxide emissions, with an estimated 80% reduction during the COVID-19 pandemic. The researchers estimated CO2 emissions associated with conference attendance before and during the pandemic.
This volume of Oncotarget features groundbreaking research on various cancers, including breast, lung, colorectal, and neuroblastoma, as well as novel drug targets for bladder cancer. The studies also delve into the role of BRCA in breast and colorectal cancers.
A study of 45,000 women found significant racial and ethnic disparities in the time it takes to receive a biopsy after an abnormal screening mammogram result. Factors such as individual characteristics, neighborhood socioeconomic status, and healthcare access were also associated with delays in biopsies.
A population-based study found that patients with estrogen receptor-positive breast cancer who experienced hot flashes while on adjuvant hormone therapy had worse outcomes and a higher risk of early treatment discontinuation. The study suggests that managing side effects may not be enough to prevent treatment discontinuation, highlight...
A study by Washington State University researchers found that Native Americans have to travel up to 103 miles farther than non-Hispanic whites to reach the nearest radiation therapy facility. This significant burden can lead to delayed or foregone treatment, resulting in poorer cancer outcomes.
The American College of Chest Physicians' flagship journal CHEST published its June issue featuring 58 articles on various chest medicine topics, including asthma and COPD. The journal is set to expand with two new open-access journals, CHEST Pulmonary and CHEST Critical Care.
A recent study identified 34 novel genes that contribute to endocrine resistance in breast cancer using dynamic gene expression analysis. The researchers found that these genes are differentially expressed in both estrogen receptor-positive and triple-negative breast cancers, suggesting shared genetic mechanisms underlying resistance d...
A single-center study found lower pneumonia frequency and severity in fully vaccinated patients compared to unvaccinated patients. The study included 467 patients who underwent chest CT during hospitalization for symptomatic COVID-19, with significant reductions in pneumonia frequency and severity observed in those fully vaccinated.
A meta-analysis published in The Lancet Oncology suggests that targeted radiation therapy, which spares healthy brain tissue, is equitable to whole brain radiation therapy for patients with small cell lung cancer and brain metastases. This approach may improve their care experience with fewer negative cognitive consequences.
Researchers developed CancerOmicsNet, a graph neural network model that integrates multiple heterogeneous data to predict cancer cell growth rate after drug treatment. The model achieved significantly higher cross-validated accuracy than other approaches on the same data.
The article proposes a new framework for understanding the hallmarks of cancer and aging, highlighting their shared underlying principles. Dr. Blagosklonny's hyperfunction theory arranges these hallmarks in a hierarchical structure, revealing common signaling pathways involved in both aging and cancer.
A nationwide study of 100 million hospitalizations found that percutaneous coronary intervention is safe and increasing among cancer patients. The study suggests that PCI can nearly double from 2016 to 2018 among patients with thrombocytopenia, without significantly increasing mortality.
A recent study found that 70% of adults with stage 3 or 4 cancer were at risk of drug-drug interactions, highlighting the importance of deprescribing medications to avoid harm. The study's results emphasize the need for education and problem-solving to address polypharmacy in older adults with cancer.
The American Journal of Roentgenology has published best practices for managing an iodinated contrast media (ICM) shortage in radiology practices. To mitigate the shortage, practice leaders should prioritize examination findings and reduce overall ICM usage.
Researchers are developing a novel MRI nanotechnology that targets specific markers in solid tumours, including high-grade brain cancers. The new imaging technology has shown promising preclinical results and is set to be tested in a first-in-human clinical trial.
A new study published in the Journal of the National Comprehensive Cancer Network (JNCCN) found that incorporating the Electronic Health Record-Enabled Evidence-Based Smoking Cessation Treatment (ELEVATE) program into electronic health records can significantly improve smoking cessation rates among cancer patients. The research demonst...