Articles tagged with Oncology
Researchers at Nanyang Technological University discover ponatinib, an existing cancer drug, can block key steps in alternative lengthening of telomeres (ALT) mechanism. This could lead to new treatment options for ALT cancers, which currently lack targeted therapies.
Researchers discovered that Nerofe and Doxorubicin can downregulate KRAS signaling, leading to enhanced apoptosis in colorectal cancer cells. The combination also activates the immune system against tumor cells, increasing immunostimulatory cytokines and recruiting NK cells and M1 macrophages.
A new study from Aarhus University found that people with mental health issues are less likely to accept offers of colorectal cancer screening. The research showed that those with severe mental disorders had a 13.8 percentage point lower participation rate compared to those without mental illness.
The study investigates the effects of DPDT on human colon cancer HCT116 cells and non-tumorigenic MRC5 fibroblasts. The results show that DPDT preferentially targets HCT116 cells, inducing apoptosis and G2/M cell cycle arrest, likely through DNA topoisomerase I poisoning.
A systematic review found that cancer survivors experience a higher risk of psychological symptoms compared to healthy siblings and controls. Psycho-oncological intervention is recommended for early detection and prevention.
Rice University engineers developed a low-cost, point-of-care DNA test for HPV infections that can be used to screen for cervical cancer. The test, which requires just two pieces of equipment and delivers results in 45 minutes, has the potential to make cervical cancer screening more accessible in low- and middle-income countries.
Researchers at UC San Diego have discovered that shattered DNA fragments are tethered together during cell division, allowing them to be reassembled in a different order. Destroying the tether may help prevent cancerous mutations and is now being explored as a therapeutic target.
Research suggests that aromatase inhibitors can limit the effectiveness of weight loss medications in breast cancer survivors. Studies have shown that these medications are less effective in women taking aromatase inhibitors, leading to reduced weight loss and increased risk of health complications.
Researchers developed CrossDome, a tool that uses genetic and biochemical information to predict T-cell immunotherapy's impact on healthy cells. The tool identified high-risk candidates in cases where treatments mistakenly attacked heart cells.
A study has identified a potential treatment target for prostate cancer that is resistant to hormone therapy, a protein modification involving TRAF4. The researchers found that TRAF4 promotes the spread of cancer and may be associated with a new treatment option for patients.
A study published in JAMA Oncology suggests that stopping immunotherapy after two years for patients with advanced non–small cell lung cancer who remain responsive may be a reasonable strategy, providing sustained clinical benefit. The findings provide reassurance for patients and their healthcare providers.
Researchers at Karolinska Institutet have identified how memory killer cells are formed and found a correlation between their presence in cancer tissue and improved survival rates in people with melanoma. The study suggests that harnessing the potential of these cells could lead to more effective immunotherapy.
ComboMATCH initiates patient enrollment to test new cancer drug combinations guided by tumor biology, exploring precision medicine and targeting proteins that control cancer growth. The project aims to identify beneficial therapies for patients with rare malignancies and/or rare molecular abnormalities.
A team of researchers from CSI Singapore has identified a transcription factor, TOX2, as a potential target for treating Natural Killer/T-cell Lymphoma (NKTL), an Epstein-Barr virus-associated cancer with poor treatment outcomes. The study found that TOX2 is overexpressed in NKTL patients and negatively associated with patient survival.
A new study published by LSU Health New Orleans found that a diet high in fruits, dark-green vegetables, and beans can significantly lower the risk of genital high-risk-HPV infection, which is associated with cervical cancer. The research also showed that women who eat healthily tend to practice other healthy behaviors.
The number of US cancer survivors with self-reported functional limitations has more than doubled since 2000, according to the study. Cancer survivors without functional limitations have seen relatively little growth over the same period.
Researchers found mailing HPV self-collection tests and offering assistance improved cervical cancer screening nearly two-fold among low-income women. Screening uptake increased to 72% among women who received mailed HPV kits, compared to 37% for those with scheduling assistance alone.
Researchers found that T cells can self-activate by puckering their cell membrane, boosting function and slowing tumor growth in a mouse model. This discovery could inspire new anti-tumor therapeutics and provide insights into treating autoimmune diseases.
A large-scale study of patient experiences with telemedicine and in-person visits found that telemedicine consistently outperformed in-person visits in terms of access to care and provider engagement. The study analyzed survey responses from over 39,000 patients across more than 50,000 visits.
Researchers have identified three types of bacteria associated with natural purple photosynthetic bacteria that show strong anticancer efficacy. The bacteria can thrive in hypoxic tumor environments and trigger the immune system to kill tumor cells.
An international study of 1,044 patients with head and neck squamous cell carcinoma found that combining radiotherapy with chemotherapy significantly improves survival rates compared to radiotherapy alone. The benefit was particularly notable in patients between 65-79 years old with good general health.
Blinatumomab immunotherapy significantly improves the survival rate of babies with aggressive acute lymphoblastic leukemia (ALL), from 66% to 93%, while reducing side effects. The treatment is now standard for babies worldwide.
A retrospective study found that elevated CA 19-9 and CEA levels were associated with worsened outcomes in duodenal adenocarcinoma patients. The study, which included 68 patients, suggests that these tumor markers may show promise as prognostic tools for this rare malignancy.
Jeong Min Lee, KSR President and professor at Seoul National University Hospital, is honored with ARRS membership. He has published over 470 scientific articles and serves on the editorial board of several publications.
The CHEST journal April issue features cutting-edge research on asthma, chronic obstructive pulmonary disease (COPD), and sarcoidosis. Key findings include the potential of efzofitimod as a treatment for managing sarcoidosis. The journal also showcases innovative approaches to clinical practice and education in chest medicine.
A randomized clinical trial found that using smartphone apps for home monitoring after oncologic surgery leads to improved quality of recovery and equal patient satisfaction. The study compared this approach with conventional in-person follow-up, revealing no significant differences in these outcomes.
Researchers found that a protein associated with liver cancer, ATF4, protects the liver by promoting the expression of SLC7A11, which suppresses ferroptosis and slows liver cancer progression. This unexpected result could inspire new treatments for preventing liver disease and cancer.
A team of scientists created a new, fast, and precise method for analyzing cells in tissue samples from cancer patients without the need for a trained pathologist. The method uses artificial intelligence to evaluate data produced by a technique called real-time deformability cytometry.
A population-based study found that pregnancy-associated cancers have a higher overall 5-year mortality rate compared to non-pregnancy associated cancers. The study highlights the need for improved cancer screening and treatment options during pregnancy.
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
Impact Journals' Oncotarget participates in the AACR Annual Meeting 2023, highlighting its focus on oncology and biomedical sciences. The meeting theme of Advancing the Frontiers of Cancer Science and Medicine aligns with Oncotarget's research goals.
Researchers at Georgia Institute of Technology developed a synthetic tumor model to understand the impact of microenvironment on targeted therapies for Activated B Cell-like Diffuse Large B cell lymphoma. The model showed promise in demonstrating how combining therapeutics can overcome tumor resistance to inhibitors.
Researchers at Karolinska Institutet discovered an immune cell in women with pancreatic cancer that blocks the immune response, leading to poor survival. The study identifies a specific protein FPR2 as a potential therapeutic target for immunotherapy in women.
The ProtecT trial found that active monitoring of prostate cancer has the same high survival rates after 15 years as radiotherapy or surgery. Men on active monitoring were more likely to see their cancer progress, but this didn't reduce their likelihood of survival.
A new technique involving a small flap in the peritoneum can reduce postoperative complications in prostate cancer surgery by allowing lymphatic fluid to escape and be absorbed. The study found that this technique significantly reduced the incidence of lymphocele, a common complication where lymphatic fluid collects in the pelvis.
A new study found that military veterans are at higher risk of developing human papillomavirus (HPV)-related cancers due to low vaccination rates. The study suggests that 'catch-up' HPV vaccination campaigns are needed to boost vaccination rates among veterans and reduce deaths from these largely preventable cancers.
Researchers from Northwestern University discuss the multifaceted tumorigenic functions of EZH2, including its role in regulating translation and coactivating transcription. This new understanding may provide novel insights into advancing EZH2-targeting strategies for prostate cancer patients.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
The NCCN Annual Conference will debut a new hybrid format featuring in-person events at a new venue, allowing for hallway conversations and networking opportunities. The conference will also showcase more than 100 abstract poster presentations on various oncology-related categories.
Researchers identify the minimum contribution of TACC3 for FGFR3-TACC3 fusion protein activation, revealing a novel target for treating FGFR translocation-driven cancers. The study shows that clinically identified FGFR3-TACC3 fusion proteins differ in biological activity depending on specific breakpoints.
The ESMO Targeted Anticancer Therapies Congress 2023 features presentations on drug discovery and development for various targets, precision medicine, and early clinical trial methodology. Keynote lectures highlight novel insights in mutational signatures and epigenetic therapies.
A study published in CANCER found that children with acute lymphoblastic leukemia living along the US-Mexico border had a lower five-year survival rate compared to those in non-border areas. The research highlights existing disparities in pediatric cancer outcomes, particularly among Hispanic and Black communities.
The ESMO Gynaecological Cancers Congress 2023 will present the latest treatments and insights for ovarian, uterine, cervical, and rare gynaecological cancers. Around 80 studies will be presented on strategies to overcome PARP inhibitors mechanisms of resistance in ovarian cancer.
The Cleveland Clinic has launched a phase 1b clinical trial to evaluate the safety and immune response of a preventive breast cancer vaccine in high-risk individuals who have undergone prophylactic mastectomy. The study aims to recruit 6-12 patients and is expected to be completed by the end of 2023.
Pusan National University researchers have identified a novel gene, SURF4, that regulates cell death and differentiation in acute myeloid leukemia (AML). The study found that suppressing SURF4 expression increases cell differentiation, cell death, and accumulation of ROS, leading to arrested tumor growth in mice.
A recent study estimated that shifting from in-person visits to telemedicine for patients with cancer can result in substantial carbon emissions savings. By reducing the need for transportation, telemedicine can significantly decrease greenhouse gas emissions and contribute to a more sustainable healthcare system.
A new study finds that andiroba oil accelerates wound healing, increases contraction rates, and promotes local re-epithelialization. The oil also presents a similar potential to low-level laser therapy (LLLT) in treating oral mucositis, a common side effect of chemotherapy.
Most children in the continental US have adequate access to pediatric cancer care, but disparities exist among racial and ethnic groups and in rural areas. Reducing these disparities requires innovative approaches such as expanding local facilities and partnerships with adult oncology centers.
The January issue of the CHEST journal features a range of clinically relevant research on COPD, bronchiectasis, and pulmonary vascular disease. The journal's education portal offers continuing medical education (CME) credit for select articles.
Researchers discovered a molecular pathway critical to the initiation of pancreatic tumors, which can contribute to disease resistance and metastasis. Targeting this pathway could limit tumor progression, relapse, and spread by disrupting the interaction between cancer cells and their microenvironment.
A significant risk of suicide is observed among cancer surgery patients, especially those who are male, white, and divorced. These demographic factors are associated with the highest risk, highlighting the need for suicide screening in high-risk patient groups
Researchers discovered that pre-surgery immunotherapy significantly improved patient outcomes for locally advanced colorectal cancer. The treatment showed substantial longer survival benefits, including low recurrence rates, in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) CRC.
Researchers at the Princess Máxima Center found that concentrating surgery for children with neuroblastoma resulted in shorter operation times and reduced blood loss. The study also showed a decrease in side effects, although further research is needed to confirm improved survival rates.
The December issue of CHEST journal features articles on COVID-19 lessons learned and future pandemic preparedness. The journal also explores various topics in chest medicine, including asthma, critical care, and sleep medicine.
A recent study by City of Hope found that only 30% of patients with advanced neuroendocrine tumors prioritize living longer as their top goal. Instead, 70% focus on addressing pain, fatigue, and losing function. The research highlights the need for better communication between care providers and patients to develop personalized treatme...
A new treatment protocol has been shown to significantly reduce the risk of aggressive childhood leukemia returning after chemotherapy. The ALL-11 protocol, which includes an extra year of maintenance chemotherapy for children with specific genetic mutations, has improved five-year survival rates and quality of life for these patients....
A new mechanism has been uncovered that enables cancer cells to move throughout the body, allowing them to spread and form metastases. This discovery provides a potential new target for stopping these deadly spreads, which are responsible for 90% of cancer deaths.
The Máxima Butterfly program offers 28 PhD positions in pediatric oncology, focusing on international collaboration and multidisciplinary exchange. Researchers will receive training from leading experts and gain access to innovative techniques and insights.
Researchers review myeloid-derived suppressor cells' phenotypes, mechanisms of immunosuppression, and roles in cancer treatment. Studies on non-malignant diseases, such as autoimmune disorders and obesity, are lacking, highlighting the need for further investigation.
The ESMO Immuno-Oncology Congress 2022 will present results from over 240 studies worldwide, exploring new insights on immune checkpoint inhibitors, biomarkers for treatment response, and combination therapy efficacy. The congress aims to accelerate progress in immuno-oncology.