Researchers identify key factor in hair loss disorder
Researchers found that proteins produced by melanocytes trigger attacks on immune cells, leading to hair loss. The discovery could pave the way for more effective treatments for alopecia areata.
T Lymphocytes
Articles tagged with T Lymphocytes
New findings explain T-cell loss in HIV infection
Two independent studies show that HIV infection increases T-cell death and proliferation, leading to a decline in CD4+ T cells. The accelerated division of existing T cells contributes to the immunodeficiency associated with HIV, rather than blocking new cell production.
Genetically engineered T cell tackles kidney cancer
Researchers at Rotterdam University Hospital develop genetically engineered T cells to target kidney cancer. The therapy combines the cellular immune system with the humoral immune system, offering a promising treatment option for patients with metastases.
High HIV levels shut down anti-HIV immune responses
A new study reveals that HIV-specific CD4+ T cells persist in infected individuals, but high virus levels suppress their proliferative response. The research provides clues on how the virus manipulates the immune system for its own survival and challenges the notion of long-term nonprogressors.
Dendritic cell-based vaccination to prevent opportunistic fungal infections
Researchers developed a dendritic cell-based vaccination that targets opportunistic fungal infections, offering hope for prevention and treatment of these infections. The vaccine demonstrated promise in preclinical studies, paving the way for further investigation and potential clinical implementation.
T cells can halt development of skin cancer, Yale researchers find
Researchers found that gamma-delta T cells play a crucial role in local immunity and can kill tumor cells by expressing NKG2d protein. In contrast, alpha-beta T cells surprisingly promote skin cancer development and progression in models of skin cancer.
T cell responses in aplastic anemia
Research in aplastic anemia reveals crucial insights into immune system dysfunction and potential therapeutic targets. Patients with aplastic anemia display impaired T cell responses, indicating a critical link between immunodeficiency and disease progression.
Researchers discover how immune system rids nervous system of mosquito-borne viruses
Scientists at Johns Hopkins Bloomberg School of Public Health have identified a protein that clears viruses from neurons in the spinal cord and brain stem but not those in the cerebral cortex. The study suggests that different combinations of antibody and T-cell immunity may be needed to control infection and recovery from encephalitis.
Profiling T cell gene expression in anergy and arthritis
The study identifies six transcripts whose up- or down-regulation in rheumatoid arthritis (RA) parallels the changes seen in anergic cells. Calmodulin suppression in RA is consistent and dramatic, suggesting a link between anergic cells and disease-associated T cells.
Gamma/Delta T cells essential to regulating airway hyperresponsiveness in asthma, other lung diseases, according to National Jewish researchers
A recent study published in Nature Medicine has found that gamma/delta T cells are essential for regulating airway hyperresponsiveness, which is characterized by an exaggerated response to stimuli. The research suggests that these cells have a suppressive effect on airway constriction and may be a key target for future treatments.
St. Jude researchers discover genetic reason why some patients resist HIV therapy
Researchers at St. Jude Children's Research Hospital found the gene MRP4 is responsible for drug resistance in HIV patients, leading to lower drug concentrations and increased virus replication. This discovery could lead to developing new therapies to fight HIV infection and other diseases.
National Jewish researchers first to identify component in thymus that positively selects T cells
National Jewish researchers identified the specific peptide, ND1, on MHC molecules that controls positive selection of T cells. This discovery helps expand understanding of how the immune system develops and may lead to new treatments for cancer and autoimmune diseases.
'Silent' HIV Infection Lasts A Lifetime
A study published in Nature Medicine found that silent HIV infections can persist for decades, making long-term medication necessary. Researchers discovered that patients taking strict anti-HIV regimens could keep the virus suppressed and experience no symptoms of AIDS, highlighting the importance of adherence to therapy.
Blocking Sex Hormones Might Help Restore Immunity
Researchers have found that temporarily blocking sex hormones can boost the immune system of people with HIV, cancer, and those who have received immunosuppressive treatments. The study suggests that drugs that suppress sex hormone production may help restore immune function and combat diseases.
Finding Suggests Immune System Mounts Robust Response To An Opportunistic Infection After Aggressive HIV Therapy
Researchers at UCSF found that patients with HIV who undergo aggressive therapy have a robust response to cytomegalovirus, which causes blindness in people with AIDS. This suggests that CD4+ T cells replenished by therapy can mount effective responses against specific pathogens.
Researchers Discover New Clues For The Initiation And Regulation Of Immune Response
Natural T cells are specialized cells that are part of white blood cells and help the body fight disease. Researchers at Penn State's College of Medicine have discovered that CD1d1 associates with glycolipids to transduce signals that 'turn-on' natural T cells, which helps the body fight disease.
Novel AIDS-Directed Technology: Approach Permits Optimization Of Existing Drug Therapies And Targeted, Patient-Specific Treatment
Researchers have developed a new diagnostic technique to measure T cell proliferation rates in AIDS patients, revealing that the body's capacity to form new cells is key to T cell counts. The technique allows for personalized treatment optimization and real-time disease monitoring.
New Finding Underscores Importance Of Controlling Opportunistic Infection
A new study reveals that tissue macrophages play a critical role in triggering the production of HIV in patients with AIDS, leading to increased virus levels despite declining CD4 T cell counts. This finding highlights the importance of controlling opportunistic infections to slow the cycle of virus production.
National Jewish Medical And Research Center Shows Rush Immunotherapy Results In Allergen-Specific Changes In T Cells
Researchers found that rush immunotherapy targeting a single allergen makes distinct changes in T cells and prevents allergic reactions. The study showed that T cells produce more interferon gamma, an element that lowers allergic responses, and shut off production of pro-allergic cytokines.