Articles tagged with Drug Delivery
Researchers have discovered a simple fix to boost mRNA delivery and CRISPR gene editing efficiency by adding three common amino acids to lipid nanoparticle injections, increasing delivery up to 20-fold and efficiency to nearly 90%.
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
A new injection therapy uses self-amplifying RNA to prompt the body's release of the natural heart-protective hormone ANP for several weeks. This approach aims to reduce harmful scarring, preserve healthy heart muscle and improve heart function after a heart attack.
Researchers design nanoagents to carry antibiotics deep into bacterial infections, releasing them upon gentle ultrasound activation. This approach reduces antibiotic resistance and improves treatment of biofilm-related infections.
Researchers developed a light-responsive nanoassembly that enables precise and controllable drug delivery inside tumor cells. The strategy achieves strong tumor suppression while effectively inhibiting tumor spread, without causing noticeable systemic toxicity.
Researchers identified genes that are activated when yeast cells are in the gut, suggesting a roadmap for engineering more efficient drug-delivery vehicles. The study found that yeast cells were digesting more lipids than carbohydrates in the gut, highlighting potential modifications to improve efficiency.
A new study shows that valved holding chambers used to deliver medication to children with acute respiratory diseases differ markedly in their performance. The choice of device can affect treatment outcomes, with higher delivery devices resulting in lower hospital admissions and better physiological recovery.
Researchers at Tokyo Metropolitan University have created a neutral molecule that can carry DNA into biological cells using a process called annealing. This breakthrough promises more effective therapies by reducing inflammation and improving delivery efficiency.
A new study finds salcaprozate sodium may have adverse biological effects on the gut and beyond, including shifts in potentially harmful gut bacteria and elevated inflammatory markers. The research highlights an important gap in understanding the long-term impact of repeated SNAC exposure.
The University of Missouri has launched its first human clinical trial using Eye90 microspheres, a radiopharmaceutical breakthrough device manufactured on campus. The study aims to assess the safety and effectiveness of Eye90 in treating unresectable liver tumors, including hepatocellular carcinoma and metastatic colorectal cancer.
Researchers quantify interactions of P407 micelles in PBS to understand gelation behavior and release mechanisms. The study reveals stronger attractive forces between micelles in saline, affecting gel stability and structural fluctuations.
Researchers have developed a long, needle-thin brain electrode with channels that enables neural signal recording and precisely targeted medication delivery across different brain regions. The technology has primarily been developed for basic research but may be important for future treatments in epilepsy and other neurological diseases.
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
The UH College of Pharmacy is expanding its graduate program to offer a Doctor of Philosophy and Master of Science in Population Health & Pharmacoepidemiology, addressing a growing demand for training in evaluating medication safety and effectiveness.
Researchers developed a solvent-free method to enhance drug bioavailability by transitioning from solid to gas phase. The sealed heating (SH) method increases drug solubility without using organic solvents.
Researchers at Oregon State University developed a new nanomaterial that generates both hydroxyl radicals and singlet oxygen to kill cancer cells. The material showed potent toxicity in multiple cancer cell lines with negligible harm to non-cancerous cells.
Researchers at the University of Oulu have developed a pine-bark-based water-treatment medium that efficiently removes antibiotics and other pharmaceuticals from wastewater treatment plant effluent. The method uses modified pine bark and combination materials, achieving removal efficiencies in the tens of percent to over 90%.
A national clinical trial found that abemaciclib, an oral cancer drug, may slow tumor growth in patients with aggressive meningiomas with specific genetic mutations. The trial showed promising results, with a median progression-free survival of 10 months and a median overall survival of 29 months.
Researchers developed a new system that efficiently transfects targeted immune cells, supports antigen presentation and immune cell maturation, and successfully crosses the mucus barrier in lung models. This breakthrough offers a promising alternative to lipid nanoparticles for next-generation pulmonary mRNA vaccines.
Researchers developed a method to encapsulate nanodroplets of thyme extract, enabling small doses and avoiding evaporation. The technique demonstrates accurate thyme extract nanodosing is possible and can be extended to other aqueous extracts.
Researchers have made a groundbreaking discovery about how bacteria swim upstream to cause infections, pointing to new designs for biomedical devices that can prevent contamination. The study found that wider channels with faster counterflows are more prone to invasion, but sharp corner designs can inhibit bacterial growth.
Researchers at MIT have designed a pill that can report when it has been swallowed, using a biodegradable radio frequency antenna to communicate with an external receiver. This technology could improve medication adherence for patients who need to take immunosuppressive drugs or treatment for extended periods.
A new nanodrug called Nano-273 could offer improved survival for patients with pancreatic and lung cancers by activating the immune system and blocking tumor growth. The drug, developed by University of Houston researcher Wei Gao, has shown promising results in early studies.
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
Researchers from Okayama University and Tohoku University have identified a promising way to breach the physical and biochemical barrier created by fibrosis in pancreatic cancer. By blocking collagen signaling through DDR1, they improve drug delivery and enhance treatment response.
A research team developed a computational framework called Bits2Bonds to design and optimize polymeric RNA carriers. The tool combines molecular dynamics simulations and machine learning to rapidly screen thousands of potential molecules before experimental validation.
A new patch developed by Texas A&M University researcher Dr. Ke Huang may offer a way to help the heart heal after a heart attack by delivering interleukin-4 directly to damaged heart tissue. The patch uses a microneedle system to promote repair and improve heart function without affecting the rest of the body.
Researchers have shown that disabling the NRF2 gene with CRISPR technology can restore drug sensitivity and slow tumor growth in lung cancer. The approach, which targets a master switch for resistance, has potential across multiple tumor types.
A team of four scientists from European universities has been awarded €10 million to overcome the challenge of delivering biotherapeutics into cells. They plan to explore a novel approach using covalent chaotropic membrane transport to ferry impermeable molecules into cells.
MIT engineers have developed a programmable drug-delivery patch that can reduce damaged heart tissue by 50 percent and improve cardiac function. The patch is designed to release different drugs at specific times, promoting healing and regeneration of cardiac tissue.
Scientists have discovered a promising new treatment for nail infections using hydrogen sulphide, a naturally occurring gas that can penetrate the nail plate efficiently. The research has shown strong antimicrobial activity against a range of nail pathogens, including fungi resistant to common antifungal treatments.
Scientists re-engineered a common chemotherapy drug to make it more soluble and effective, targeting cancer cells while leaving healthy tissues unharmed. The new nanomedicine significantly extended survival in animal models of leukemia, showing promise for improved cancer treatment.
Researchers have developed lipid-based nanoplatforms (LBNCs) to overcome liver disease treatment barriers, including low drug accumulation and side effects. LBNCs exhibit biocompatibility, versatile drug-loading capacity, and tunable targeting, improving therapeutic effects on fatty liver and HCC.
A UH crystals expert has shown how to bend and twist crystals without physical force, using a molecule called a tautomer. This discovery has potential applications in drug delivery and material properties, such as optoelectronics and soft robotics.
Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
A team of scientists has created a detailed model of how cells regulate traffic through the nuclear pore complex, revealing that flexible protein chains create an entropic barrier that admits only properly escorted cargo. This breakthrough sheds light on diseases like cancer, Alzheimer's, and ALS, where this transport system fails.
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
This review highlights the potential of nanocarriers in cancer treatment, including liposomes, solid lipid nanoparticles, polymeric nanoparticles, dendrimers, and inorganic nanoparticles. The combination of these technologies with magnetic hyperthermia and viral nanoparticles offers a promising approach to treating malignant tumors.
Researchers have created a new class of lipid nanoparticles (LNPs) with complex internal arrangements, expanding their potential for carrying small-molecule drugs, proteins, metal ions, and mRNA. The breakthrough offers flexibility in designing delivery systems for different therapeutic molecules.
A research team led by Professor Shikha Dhiman has discovered that the speed of receptors in model cell membranes plays a crucial role in binding to biomaterials. When ligands move at similar speeds, they can bind to receptors, enabling effective tissue engineering and medical applications.
The Cu2+-coordinated NLG919 nanoplatform induces immunogenic cell death and inhibits indoleamine 2,3-dioxygenase-1 to activate antitumor immunity. It also reverses the tumor microenvironment by blocking IDO1 inhibition.
Researchers create peptide hydrogel that controls drug release, improving treatment adherence and efficacy for conditions like tuberculosis and diabetes. The SABER platform uses reversible chemical bonds to slow down drug release, offering a promising solution for precise delivery.
Researchers developed wearable microneedle patches that improve drug absorption while reducing pain in long-term delivery. The new technology, inspired by bee stings, enables continuous drug release and anchors securely into the skin.
Researchers create nanoparticles shaped like bottlebrushes with antibodies guiding them to tumor sites, delivering a large range of chemotherapy drugs directly to cancer cells. This approach reduces the need for potent drugs and enhances customizability of treatment options.
Researchers have developed an artificial cartilage material that responds to pH changes in the body, releasing anti-inflammatory drugs precisely where and when needed. This approach could improve arthritis treatment outcomes by continuously delivering pain-relieving medication.
A new luteolin nanomedicine is designed to deliver the fat-clearing compound precisely to atherosclerotic plaques, boosting fat clearance and improving artery stability. The treatment reduces plaque size, lipid burden, and inflammation, making it more stable and reducing the risk of rupture.
Researchers have created a human vascularized liver cancer-on-a-chip model to evaluate vessel remodeling and cell death in response to embolic agents. This innovative platform replicates the microenvironment of liver tumors, providing unprecedented insight into how tumors respond to embolization.
Researchers have created a new technique to control synthetic cells using magnetic fields, enabling precise targeting of medicines for cancers or bacterial infections. This approach reduces side effects and increases effectiveness, with potential applications in treating tumors or detecting bacteria.
Researchers at Northwestern University have developed a new CRISPR delivery system that triples efficiency using DNA-wrapped nanoparticles, improving safety and effectiveness. The new system, called LNP-SNAs, targets specific cells and tissues, reducing toxicity and boosting gene-editing efficiency by threefold.
A new study published in The New England Journal of Medicine and the European Heart Journal finds that beta blockers, commonly prescribed after a heart attack, provide no clinical benefit for patients with preserved heart function. Women treated with beta blockers had a higher risk of death, heart attack, or hospitalization for heart f...
Researchers developed a new model and theory to explain nanoparticle growth dynamics, accounting for six essential characteristics of nanoparticle growth. The new theory provides fresh physical insights into the role of nanoparticle motion and configurational degeneracy on their nucleation and growth.
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
Researchers at Stanford University developed a new delivery platform that allows drugs to be stored and delivered in much higher concentrations, enabling quicker and smoother injections. The new formulation method has been tested on three different proteins and reached concentrations exceeding 500 mg/mL.
Researchers used machine-learning models to design nanoparticles that can deliver RNA to cells more efficiently. The approach accelerated the identification of optimal ingredient mixtures in lipid nanoparticles, leading to better delivery vehicles for RNA vaccines and mRNA therapies. This could dramatically speed up the development of ...
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Initiation of semaglutide in adults leads to reductions in weight and cardiovascular risk factors, while increasing health care expenditures. These findings suggest potential clinical benefits, highlighting the need for long-term evaluation of semaglutide's economic impact.
Newly developed DNA nanostructures form flexible, fluid, and stimuli-responsive condensates without chemical cross-linking. These findings pave the way for adaptive soft materials with potential applications in drug delivery, artificial organelles, and bioengineering platforms.
Researchers Dr. Sharday Mosurinjohn and Dr. Richard Ascough critique the 'psychedelic mysteries hypothesis' in a new article, arguing that it relies on circumstantial evidence rather than solid historical scholarship. They advocate for responsible curiosity and a focus on living traditions to unlock psychedelic wisdom.
Researchers at University of Bath have developed a system that can transport therapeutic proteins across the gut wall and into the bloodstream, enabling medication delivery via pill. The new technology has shown consistent delivery rates, with potential to transform lives of patients who currently inject themselves daily.