Articles tagged with Drug Delivery
LMU researchers used coarse-grained molecular dynamics (CG-MD) to simulate and visualize the particles, revealing how changes in polymer structure and environmental conditions impact particle formation. The study highlights CG-MD's value in predicting and explaining the properties of RNA nano-formulations.
Researchers developed an ingestible capsule that releases a burst of drugs into the stomach or other organs, eliminating the need for injections. The capsule uses compressed carbon dioxide or tightly coiled springs to propel liquid drugs out, targeting specific parts of the digestive tract.
The study presents a lignin-based hydrogel that combines mechanical strength with bioactivity, promoting wound healing and sustained drug release. The hydrogel's controlled-release properties make it an ideal candidate for treating complex wounds and reducing medication side effects.
A study published in JAMA found that drug-related reports of supply chain issues were 40% less likely to result in meaningful drug shortages in Canada compared to the US. This highlights the importance of global cooperation to curb the effects of drug shortages and strengthen pharmaceutical supply chains.
A new study published in JAMA found that reports of drug supply-chain issues were 40% less likely to result in drug shortages in Canada compared to the US. The analysis looked at drugs with reports of supply-chain disruptions between 2017 and 2021 in both countries, and found nearly half resulted in shortages in the US within 12 months.
Researchers at MIT have designed tiny particles that can be implanted at a tumor site, delivering heat and chemotherapy to treat cancer. The treatment approach has been shown to completely eliminate tumors in most mice and prolong their survival.
Dr. Wai Hong Lo, PhD, has been appointed as the new Editor-in-Chief of ASSAY and Drug Development Technologies, succeeding Dr. Bruce Melancon. Dr. Lo aims to enhance online accessibility, incorporate visuals, and increase social media engagement to reach a broader audience.
Researchers from IOCB Prague have created new-generation prodrug activators that can enhance the effectiveness of anti-cancer therapies by targeting malignant tumours more precisely. These compounds allow for faster release of drugs in the body, increasing the utilization of administered doses.
The third annual TCT MedTech Innovation Forum will address pressing cardiovascular medicine challenges and unveil disruptive solutions. Visionary leaders from the medtech landscape will convene to explore bold solutions, share pioneering insights, and shape the future of cardiovascular care.
Researchers developed a novel approach to optimizing siRNA-loaded lipid nanoparticles using NMR-based molecular-level characterization. Pre-mixed LNPs exhibit superior gene-silencing effects due to a stacked bilayer structure that enhances gene silencing.
A new trial suggests that adding immunotherapy to chemoradiation can extend survival in patients with limited-stage small cell lung cancer. However, the findings also indicate that delivering the treatments at different times yields varying results, with concurrent treatment not offering improved survival benefits.
Patients using transparent capsules delivered more medication due to visual feedback on their inhalation technique, leading to better management of chronic airway diseases. The study found a significant 30.1% reduction in capsule weight after inhalation.
Researchers developed a tri-culture heart-on-a-chip model of cardiomyocytes, fibroblasts, and endothelial cells to mimic in vivo cardiac behavior. The study successfully replicated endothelial cell morphology and functionality, as well as cardiac function with increased contractility.
Researchers found that omitting the bolus-specific 5-fluorouracil (5-FU) portion from common chemotherapy regimens improves tolerability without sacrificing treatment effectiveness. The study of 11,765 patients shows no decrease in overall survival but a notable reduction in cytopenias.
Researchers investigated peptide clumping behavior using molecular dynamics simulations and AI techniques. They discovered that aromatic amino acids enhance aggregation, while hydrophilic ones inhibit it, offering insights into peptide structure and function.
Researchers at the University of Virginia School of Engineering and Applied Science have designed a drug-carrying molecule that can slip past the lung's natural defenses. The nanocarrier, called PEG-BB, is shaped like a bottlebrush and mimics the properties of mucus, allowing it to move quickly through the airway.
A major new study by Karolinska Institutet has found that women with epilepsy are four times more likely to die during pregnancy and their babies have a 50 percent higher risk of illness or death. Despite the high relative risks, most pregnancies for women with epilepsy go well.
A new study by Prof. Daniel Mandler and his team found that organic molecules can significantly influence the electrical properties of gold nanoparticles, up to 71 mV. The research highlights the importance of capping agents in controlling nanoparticle behavior and provides insights for customizing their interactions.
Researchers at Rice University have developed ultrasmall gas-filled protein nanostructures that can penetrate tissue and reach immune cells, opening up new possibilities for ultrasound imaging and drug delivery. The breakthrough could revolutionize treatment for cancers and infectious diseases.
Researchers developed a library of 27 polymers to improve RNA drug delivery, using design-of-experiment approach and statistical analysis. The study improves quality, efficiency, and precision of RNA drugs with optimized polymer nanoparticles.
Researchers found that a 10-nanometer-sized nanoruler achieves the highest brain tumor accumulation, outperforming larger sizes. This discovery offers guidance for designing future brain tumor nanomedicines.
Researchers from CiQUS have established the first set of rational design principles for chaotropic membrane transporters, governed by cluster size and polarizability. The study investigates the modulation of chaotropic transport by decoupling halogen composition from boron core size, revealing a window of carrier utility.
Researchers develop new method to create azetidines, a stable form of heterocycle that don't oxidize under physiological conditions, expanding toolkit for drug developers to improve medication safety and reduce side effects. This breakthrough enables the creation of more useful chemical transformations with better medical functions.
A Massachusetts statewide standing order policy led to a 32% increase in emergency contraceptive fills at pharmacies. The policy's impact was largely attributed to increased prescription-only ulipristal fill rates, which more than doubled after the policy was implemented.
During the pandemic, humanitarian organizations showed remarkable flexibility and ingenuity in responding to supply chain disruptions. They sourced supplies from local vendors, secured long-term contracts with reliable suppliers, and leveraged good relationships with governments to continue aid delivery.
A new study led by researchers at UC San Francisco found that a virtual emotion-centered program called TunedIn can reduce diabetes distress by half and improve glucose control. The program incorporates elements of Acceptance and Commitment Therapy and was delivered virtually to 276 adults with Type 1 diabetes.
Researchers developed a human pancreatic cancer fibrotic barrier model to assess treatment strategies and test efficacy of therapeutic interventions. Inhibition of ROCK2 pathway resulted in reduced ECM remodeling and improved tissue permeability for drugs, highlighting its potential for enhancing drug delivery in PDAC.
Scientists aim to create a spray-on bandage that breaks down within 48 hours, providing time for proper treatment. The project uses enzymes to degrade polymer complexes, which will allow for controlled degradation and potential applications in drug delivery.
Researchers have designed a method to 'cloak' proteins for targeted delivery into cells, utilizing lipid nanoparticles. The cloaked proteins can be captured by the nanoparticles and exert their therapeutic effect once inside the cell. This approach shows promise for repurposing antibodies and other proteins for cancer treatment.
Researchers developed a microneedle patch that delivers immune-regulating molecules to the scalp, teaching T cells not to attack hair follicles and helping hair regrow. In mouse studies, this treatment reduced inflammation and allowed hair to regrow without systemic immune effects.
MIT engineers have developed a closed-loop drug-delivery system that can improve chemotherapy outcomes by continuously monitoring patients and adjusting dosage. The new system, called CLAUDIA, uses commercially available equipment to analyze blood samples every five minutes and adjust infusion rates in real-time.
The NCCN 2024 Annual Conference shared updates on improving cancer care worldwide, including plenary sessions on drug shortages and hereditary cancer risk. Key takeaways include the need for transparency around oncology supply chains and the importance of genetic testing to reduce cancer risk.
The COVID-19 pandemic exacerbated pre-existing supply chain issues, leading to increased drug shortages in the US. Clinically valuable drugs at greatest shortage risk need prioritization to protect future supplies.
A groundbreaking study demonstrates that intradermal administration of naked mRNA induces robust vaccination against SARS CoV-2 in mice and primates. The novel approach avoids the use of lipid nanoparticles, which can cause adverse reactions, allowing for multiple doses over a lifetime.
Researchers are evaluating two prototype placebo rings in a study to determine their safety and usability for women. The goal is to inform the final design of a dual-purpose ring that can prevent both HIV and unplanned pregnancy for a month at a time.
Researchers at Xi'an Jiaotong-Liverpool University developed a new method that enables the efficient production of cysteine-rich peptides and microproteins in their naturally folded 3D structure. The approach uses organic solvents to mimic nature's oxidative folding process, resulting in speeds of over 100,000 times faster than aqueous...
Researchers have developed diverse nanoparticles for cancer therapy, including micelles, liposomes, and hybrid nanoparticles, which can overcome challenges and deliver drugs with enhanced targeting abilities.
Researchers have created molecular crystal motors that move in response to light, using photoisomerization to drive coordinated movements. The motors show remarkable durability and resistance to corrosion, making them suitable for biomedical applications.
Researchers have introduced a more efficient processing technique that enables scalable fabrication of custom microscale particles for applications in drug delivery, microelectronics, and abrasives. This process, called roll-to-roll CLIP, achieves unprecedented fabrication rates while preserving high resolution.
Researchers at MIT developed GastroShield, a sprayable gel that prevents bleeding and leakage from weakened gastrointestinal tissues during endoscopic procedures. The gel forms a protective layer that reinforces tissue integrity and promotes healing.
Researchers are developing minimally invasive techniques to repair and regenerate tissue in aortic aneurysms using actively targeted, drug-releasing nanoparticles. The team found that rod-shaped particles with high aspect ratios were selectively taken up by diseased endothelial cells, leading to improved therapy outcomes.
Researchers have made a breakthrough in developing genetic treatments for hereditary conditions like cystic fibrosis and inherited vision loss. They created a new type of lipid nanoparticle, called Thio-lipids, that can deliver therapeutic payloads to the lungs and retina.
A study by the University of Tsukuba found that keratin microsphere gel enhanced cell proliferation and gene expression related to hair growth. The gel's stimulatory impact on papilla cells was validated through genetic analysis, demonstrating its potential as a safe and effective hair growth agent.
A survey study reveals primary care pediatricians lack preparedness in managing adolescent OUD, with a notable gap compared to other substance use disorders. The results underscore the importance of workforce training programs to address this critical healthcare issue.
Researchers optimized a chromium-containing MOF to expand its pore size and surface area, increasing its ability to carry and deliver therapeutic compounds. The puffed-up MOFs showed improved performance as potential drug-delivery vehicles, releasing drugs substantially faster than the original version.
Researchers developed a new photosensitizer, polphylipoprotein (PLP), to improve photodynamic therapy (PDT) efficacy. PLP selectively induces necrosis in cancer cells by exploiting the autophagy mechanism under starvation, leading to high selectivity and potential efficacy.
Researchers found a combination treatment involving high doses of radiation and chemotherapy to be safe and effective in treating locally advanced non-small cell lung cancer. The treatment, which includes an adaptive boost plan, showed promising results in improving progression-free survival and reducing toxic side effects.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
Researchers have designed a nanoparticle-based drug delivery system to target inflammation, addressing issues with conventional anti-inflammatory drugs. The system utilizes targeting moieties to enrich nanoparticles in inflamed tissues, achieving enhanced efficacy.
Scientists at Tokyo Tech developed self-folding polymers to create smaller, safer gadolinium-based contrast agents for cancer diagnosis and neutron capture radiotherapy. These nanosized complexes show enhanced tumor accumulation and penetration, reducing toxicity while increasing MRI performance.
Researchers at Wayne State University aim to extend the lifespan of infusion pumps and injection ports to minimize tissue damage and maintain site integrity. The project seeks to reduce inflammation and fibrosis caused by insulin phenolic preservatives, leading to improved diabetes management practices.
Researchers analyzed FDA and patent records to find that manufacturers extended market exclusivity by filing additional patents after FDA approval and obtaining patents on delivery devices. This resulted in a median of 16 years of protection, surpassing other top-selling small-molecule drugs.
Researchers from Incheon National University create gelatin patches that generate molecular oxygen to accelerate wound healing. The new hydrogels demonstrate improved coagulation, blood closure, and neovascularization in both in vitro and in vivo experiments.
Researchers found that changing treatment can lead to significant improvement in mobility and quality of life for patients with advanced Parkinson's disease. A nationwide registry is planned to develop scientifically sound guidelines for combination therapies.
Researchers have developed soft implantable fibers that can deliver light to major nerves through the body, allowing for precise illumination of nerve pain. The fibers are flexible and stretch with the body, enabling scientists to study peripheral nerve disorders in animal models without constraining movement.
A major study has found that taking benzodiazepines like Valium and Ativan intermittently instead of continuously can lead to significant reductions in side effects such as falls, hip fractures, hospitalizations, and even death. The research showed a 20% decrease in hip fractures, 33% fewer men's falls requiring hospitalization, and a ...
A new study reveals that esketamine nasal spray is effective in treating treatment-resistant depression, with 27.1% of patients achieving remission after 8 weeks compared to 17.6% on quetiapine XR. Long-term data shows sustained remission rates at 21.7% for esketamine NS and 14.1% for quetiapine XR.
Researchers developed statistical models using ultrasound measurements and protein levels to predict stillbirth, neonatal death, or extreme preterm delivery. The findings aim to identify suitable candidates for clinical trials testing novel treatments for fetal growth restriction.
A study of 151 patients with functional dyspepsia found that turmeric's curcumin was as effective as omeprazole in reducing symptoms after 28 days. Patients who took the combination treatment showed stronger improvements after 56 days, suggesting curcumin may be a viable alternative to conventional drugs.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.