Articles tagged with Drug Delivery
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
Scientists discover carbonated water's impact on low-methoxy pectin hydrogel formation and properties. The study shows that CO2 from carbonated water increases mechanical strength and gelation rate of hydrogels.
The new American Heart Association scientific statement emphasizes the importance of including non-biological factors and social determinants in CVD risk assessment for women. These factors include economic stability, neighborhood safety, education level, and access to quality healthcare, which disproportionately affect women from dive...
Researchers have developed a new ear tube design that combines liquid-infused materials with optimized geometry to improve treatment outcomes for patients with ear infections. The design enables better performance and reduces complications such as impaired hearing and scarring of the eardrum.
Researchers used computational modeling to identify ultrastable MOF structures, which could be useful for gas storage and catalysis. The study found that about 10,000 of the predicted structures were stable enough for these applications, with high deliverable capacities for methane.
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
Researchers have developed a microneedle-based drug delivery technique for plants, which can precisely deliver controlled amounts of agrochemicals to specific plant tissues. This method has the potential to improve crop quality and disease management while minimizing resource wastage and environmental contamination.
A new cutaquig study found that increasing infusion volume per site resulted in a reduction of injection sites, while increasing infusion rates decreased infusion duration. The research also showed that dosing every other week demonstrated equivalency to trough levels with weekly dosing.
Gene therapy using CRISPR-Cas9 lipid nanoparticles has been shown to be highly effective in reducing target protein expression in mice. The new delivery system increases the efficiency of in vivo gene therapy, paving the way for safe and effective treatment.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
A fast-dissolving insert containing TAF and EVG was found safe and effective in preventing HIV transmission through anal sex. The study delivered high levels of the drugs to rectal tissue and fluid, with potential protection for up to three days after use.
New materials called gas-entrapping materials (GeMs) can carry high concentrations of therapeutic gases directly into tissues, including tumors. This improves the effectiveness of standard chemotherapy and radiation treatments in mouse models of prostate cancer and sarcoma.
Researchers at UW-Madison developed silica nanocapsules that can carry CRISPR tools across the blood-brain barrier, enabling brain-wide gene editing for disorders like Alzheimer's and Parkinson's. The technology has potential for non-invasive delivery of gene therapies.
A new software program developed by Duke Ph.D. student Dan Fu lets users create 3D structures made of DNA, including tiny vases, bowls, and hollow spheres. The software relies on a way to build with DNA described in 2011 by Hao Yan, which works by coiling a long DNA double helix into concentric rings to form the contours of the object.
Researchers have developed chemically modified nanosheets that can effectively deliver drugs to diseased cells, reducing side effects. The nanosheets, made from molybdenum disulphide, can exchange natural thiols with attached ligands, allowing for targeted drug delivery.
Rice University researchers are developing implants that can produce and deliver monoclonal anti-HIV antibody therapeutics for at least a year. The project aims to reduce the cost and improve the logistics of HIV treatment, making it more accessible and beneficial for patients worldwide.
Researchers at Tokyo University of Science have developed a unique 3D COF with scu-c topology, exhibiting efficient gas adsorption and drug delivery capabilities. The material has been shown to exhibit excellent hydrogen and methane adsorption properties.
Researchers found that buprenorphine use was associated with better outcomes for the baby, including lower risk of preterm birth, small size for gestational age, and low birth weight. The study suggests increasing access to buprenorphine treatment among pregnant individuals with opioid-use disorder.
A new tablet-based vaccine has shown long-lasting protection against bacteria that cause urinary tract infections (UTIs) in mice. The vaccine was found to be comparable to antibiotics in efficacy, with durable antibody responses lasting for the lifetime of a mouse.
Researchers at the University of Wisconsin-Madison develop nanoparticles to neutralize molecules implicated in IBD, significantly improving treatment outcomes. The probiotic bacteria are equipped with nano-backpacks that target reactive oxygen species, reducing inflammation and promoting weight gain and colon length restoration.
Researchers at Hokkaido University developed a novel branched ionizable lipid that significantly increases the efficiency of mRNA delivery by LNPs. The new lipid, CL4F 8-6, was found to enhance protein expression in mice and achieve stable formulations.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
The THERACAT project aims to deliver drugs only to tumor sites using bio-orthogonal catalysis, a promising approach for targeted cancer treatment. Researchers developed nanoparticles bearing metal catalysts to efficiently convert inactive pro-drugs into active drugs at the tumor site.
Researchers controlled magnetic bacteria to cross blood vessel walls and infiltrate tumor tissue, delivering liposomes with fluorescent dye to demonstrate their ability to carry therapeutic agents. This approach may revolutionize bacterial cancer therapy by increasing efficacy and reducing side effects.
Research reveals that pregnant smokers decrease their daily cigarette count by an average of one cigarette per day before realizing they are pregnant. This trend continues in the month following pregnancy recognition, with a decline from nine to five cigarettes per day on average.
Researchers from McGill University developed a medical adhesive inspired by flatworms that uses suction to absorb blood and promote blood coagulation. The adhesive can be removed without causing re-bleeding, making it a potential replacement for wound sutures or delivering drugs.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers at NJIT have developed a new lab technique that could speed up drug discovery and development of therapeutic proteins and vaccines. The electrochemistry-based approach allows for safety and quality testing to be done at a fraction of the time required by conventional methods.
A $1 million NIH grant will help MU researchers analyze the effectiveness of a HIPAA-secure text messaging platform in nursing homes. The study aims to improve quality of care and prevent costly hospital transfers by speeding up decision-making.
Researchers at the University of California San Diego developed microscopic robots called microrobots that can swim around in the lungs and deliver medication. The microrobots safely eliminated pneumonia-causing bacteria in mice, resulting in 100% survival rates, whereas untreated mice died within three days.
Researchers have discovered that two distantly related RNA viruses perform chemical choreography in strikingly similar ways, forming a symmetrical icosahedral shell. This finding has potential applications in improving pharmaceutical delivery and engineering, as well as understanding protein folding mechanisms.
A pioneering behavioural diagnostic tool, SPUR, has been developed to improve medication adherence in type 2 diabetes patients. The study found that the tool can reliably identify patients struggling with their medicines and the reasons why.
A new approach to making nanocarriers for drug delivery features a soft, fat-like liposome interior surrounded by a hard shell of gold nanoparticles. The hybrid nanocarriers are designed to transport medicine across the body's blood brain barrier, a major hurdle protecting the brain from pathogens.
A recent study by JAMA Internal Medicine calls for federal prosecutors to take a tougher stance on holding corporate executives accountable for problematic behavior. The Park doctrine aims to protect patients from unsafe medical products, but its implementation has been lacking, putting public health at risk.
Researchers have developed a soft, biodegradable, magnetic millirobot inspired by insects, which can grasp, roll and climb, but easily dissolve away. The robot was tested in experiments, delivering a dye solution to a stomach model and gripped various objects.
A University of the Basque Country team has successfully produced starch-based pharmaceutical tablets using 3D printing technology. The tablets display varying release properties depending on the type of starch used, offering promising solutions for personalized medicine and tailored drug delivery.
A new MIT model simulates vaccine allocation strategies to predict the effect on cumulative deaths and infections in the US. The research finds that allocating more than 50% of available doses to non-vaccinated individuals can significantly increase lives saved and reduce infections.
Researchers examined association between direct-to-consumer advertising of prescription drugs and consumer intentions and beliefs related to cardiovascular disease risk. The study found that DTCA may influence consumer attitudes and decisions regarding medication use.
A team of MIT engineers and collaborators have devised a way to overcome the foreign body response, forming a thick layer of scar tissue that blocks insulin release. The device is repeatedly inflated and deflated for five minutes every 12 hours, preventing immune cells from accumulating around it.
Researchers at TIBI developed a minimally invasive method for targeted delivery of immunotherapeutic treatments, resulting in slower tumor growth and higher activation of T-cells. The injectable gelatin biomaterial containing silicate nanoplatelets showed sustained drug release and controlled ICI delivery.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
MIT researchers create microparticles that release their payload at different times, enabling self-boosting vaccines. The particles degrade over time and break down once released, allowing for potential use in regions with limited access to medical care.
Researchers at Aarhus University have developed an easy and inexpensive method for linking molecules to DNA sequences with desired functions. The method uses sulfonyl azides to introduce various functionalities, avoiding the need for expensive and unstable special phosphoramidites.
Researchers assessed buprenorphine coverage and prior authorization requirements in US commercial formularies from 2017 to 2021. The study found that coverage and requirements changed over time, with more stringent regulations in place by 2021.
Researchers from Osaka University have developed a system to coat nematodes with hydrogel sheaths that can carry functional cargo. The study found that the sheaths protect the worms from UV light and hydrogen peroxide while allowing them to deliver anti-cancer agents to kill cancer cells in vitro.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
Researchers created oil-based gels that can deliver a variety of medications, including those for infectious diseases, in a stable and palatable form. The gels can be used to administer drugs to children and adults with difficulty swallowing pills, and could have a significant impact on improving medication adherence.
Researchers at Penn Medicine have developed an imaging agent that detects cancer cells in real-time during biopsies, offering promise for earlier and more accurate diagnoses. The technology, known as NIR-nCLE, uses a combination of near-infrared tracers and confocal laser endomicroscopy to identify microscopic cancer cells.
A study found that regular pharmacist visits reduced medicine-related problems by 60% and improved cognition scores. The research highlights the need for personalized pharmaceutical support within the aged-care sector to prevent harm from medicines.
The University at Buffalo is developing new treatments for ovarian cancer by targeting the apelin receptor. Ovarian cancer cells rely on lipids for energy and survival, making this a promising therapeutic target.
More than half of Michigan pharmacies offer naloxone, a life-saving medication for opioid overdose, without requiring a prescription. The standing order allows pharmacists to dispense the drug in emergency situations.
Non-viral mRNA and pDNA delivery systems have shown promising results in vaccine development against COVID-19 and are being explored for therapeutic applications. These systems aim to improve upon current formulations by enhancing stability, targeting specific tissues, and stimulating innate immune responses.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
The NCCN Annual Conference focuses on the cancer patient journey, featuring state-of-the-art practice algorithms, updates to clinical guidelines, and new therapies. Leading experts present treatment recommendations for various cancer types, including breast, colorectal, and lung cancer.
A new class of membrane carriers, based on halogenated dodecaborate cluster anions, has been discovered to facilitate the cell entry of impermeable molecules. These superchaotropic boron clusters interact with hydrophilic cargos without encapsulating or forming aggregates, allowing for efficient transport across biological membranes.
Researchers have identified a previously unknown bacterial enzyme that can produce a new type of biodegradable polysaccharide called acholetin. Acholetin has wide-ranging potential as a biocompatible, biodegradable material for biomedical applications.
The National Comprehensive Cancer Network has published new consensus recommendations to improve the safety and efficiency of research studies involving investigational drugs. The recommendations focus on seven areas, including pharmacy workflows and collaboration with sponsors.
Researchers at the University of Bath have developed a new coating method for soft robots that allows them to change shape and movement through human-controlled activity. This breakthrough in active matter could lead to the creation of machines governed by individual units that cooperate to determine movement and function.
Researchers at the University of Bologna have developed a new targeted cancer therapy based on a genetically modified phage that selectively eliminates tumour cells. The virus is engineered to transport a drug activated by light to target tumour cells, reducing side effects.