Articles tagged with Drug Delivery
A recent NIH-funded conference aimed to better understand the biological 'pillars of aging', which are interconnected factors driving the aging process. The study focuses on disrupting these hallmarks to contribute to chronic disease and frailty, with potential applications in improving function and independence for older adults.
High-need, high-cost patients account for 50% of US healthcare spending. Patients identify care management, telemedicine, and home health visits as beneficial solutions to prevent ED overuse. Care management helps with appointment scheduling and reminders, while home-based services enhance patient convenience and comfort.
Research on dietary fiber polymers reveals they physically influence the small intestine environment by causing solid particles to group together. This aggregation can impact nutrient and drug absorption, highlighting a previously underappreciated role of dietary fibers in gut function.
The journal BioTM has released a tribute issue dedicated to Robert Langer and Nicholas Peppas, two biotechnology luminaries whose contributions have shaped the fields of drug delivery and biomaterials. The issue features research articles from their former students and colleagues.
Researchers develop silver nanoparticles coated with anti-seizure drugs to kill brain-eating amoebae, increasing human cell survival rates. The drug-nanoparticle combos target protein receptors or ion channels on the amoeba's membrane, offering a potential treatment for deadly infections.
A Massachusetts-based study found that opioid overdose events decreased during pregnancy but increased in the postpartum period, particularly when fewer resources were available to mothers with substance use disorder. The research team developed a unique dataset linking statewide resources and found that women with opioid use disorder ...
The discovery of 'active holes' in droplets of an ionic liquid has led to the creation of a new class of synthetic active matter. The phenomenon is driven by the dissolution of the droplet and the fluctuation of its boundary, resulting in self-propelled motion.
Researchers found that certain antipsychotic medications increased the risk of gestational diabetes by 4.2% to 12% when continued during pregnancy. Women taking olanzapine and quetiapine had an increased risk compared to those who discontinued these medications.
The number of people receiving HCV cure is increasing with new, highly effective treatments available; simplification of treatment delivery can accelerate global scale-up. Cure leads to reductions in liver-related deaths and cancer risk, as well as improvements in comorbidities.
Researchers at Oregon State University have created cell-penetrating nanomaterials that can deliver molecular drugs and cargo into cells. The nanodrills, with distinct shapes resembling drill bits, showed a strong capacity for encapsulating guest molecules for therapy or imaging.
Researchers have created BN/Ag hybrid nanomaterials that demonstrate effectiveness as catalysts, antibacterial agents, and drug delivery systems for treating oncological diseases. The hybrids show high potential for cancer therapy and water disinfection, offering a new approach to combatting these threats.
Researchers are exploring gene delivery strategies for osteoarthritis and rheumatoid arthritis, enabling sustained drug production at the site of disease. Clinical trials are underway in the U.S., with the first arthritis gene therapy recently approved in Korea.
DFNS has been used in various applications including photocatalysis, solar cells, energy storage, CO2 capture, biomedical applications and environmental remediation. Its unique fibrous morphology provides enhanced accessibility to active sites and improved light harvesting properties.
A new study suggests that tracking pulse rate can help determine whether a woman needs blood pressure regulating medication after a spinal block before a Caesarean section. The research recommends considering factors such as pulse rate variability, pulse transit time, and body mass index to identify patients at risk of hypotension.
A pilot study found that patients following cesarean delivery often receive double the number of pain pills they need, leading to unused medication. Using a shared decision-making tool reduced opioid prescriptions by 50%.
A newly discovered mechanism behind reduced insulin production in type 2 diabetes reveals that insulin-producing cells regress and become immature, reducing their function. The study identifies key genes, including SOX5, which affects disease progression and suggests potential new treatments targeting cellular maturity.
A standardized assessment for UK medical students has shown a high pass rate of 95%, with significant variation in performance between schools. The Prescribing Safety Assessment aims to identify students who need further training or supervision before being able to prescribe independently.
A new study published in The BMJ found that medical abortions conducted through online telemedicine were successful in 95% of cases, with low rates of complications. Women were able to identify symptoms of potential issues and seek medical attention when needed, suggesting a safe and effective option for those seeking abortion access.
A new study published in The BMJ found that medication abortion self-sourced and self-managed outside the formal healthcare setting was successful in 95% of cases. Women were able to recognize symptoms of complications and seek medical attention when needed, with only three percent requiring antibiotics.
Researchers have developed a new method using terminal deoxynucleotidyl transferase (TdT) enzyme to produce precise, high molecular weight synthetic biomolecular structures. These structures can be tailored to create single-stranded DNA for self-assembling into ball-like containers for drug delivery or incorporating unnatural nucleotides.
Researchers used PET/CT scans to determine the potential effectiveness of bevacizumab treatment in children with diffuse intrinsic pontine glioma (DIPG). The study found that non-invasive imaging can help predict therapeutic potential and toxicity, paving the way for personalized medicine approaches.
A new article evaluates the Oregon Death with Dignity Act, finding 64% of patients who used lethal medication had cancer. The study also reveals an increase in prescriptions written annually from 24 to 218 between 1998 and 2015.
A study published in the American Journal of Obstetrics and Gynecology found that a commonly prescribed drug for pregnant women with a history of early delivery provides no benefits, while potentially increasing the risk of gestational diabetes. The researchers also noted a higher rate of preterm births among those treated with the dru...
Researchers at FSU have made a breakthrough in understanding nanoparticles' potential for delivering medicine to cells. They found that specific silicon particles can be toxic, but also enhance cellular uptake of therapeutic agents.
Researchers at the University of Pennsylvania have broken the limit of organic synthesis, allowing for more efficient gene and drug delivery. The study suggests that the conformation of the core molecule plays a role in this self-limiting growth phenomenon.
Researchers at Carnegie Mellon University and Magee-Womens Research Institute have developed a framework to understand vesicle formation, which can help create non-invasive diagnostic tools like liquid biopsies. The study also provides insights into optimizing artificial vesicles for drug delivery devices.
Carnegie Mellon scientists develop synthetic gold nanoparticles with hierarchical structures similar to proteins, revealing mechanisms of self-assembly and potential applications in drug delivery and electronics. The study achieves the complexity of protein molecules through atomic-level understanding.
A new ingestible capsule can deliver drugs for weeks, potentially revolutionizing treatment against malaria and other diseases with poor adherence. The star-shaped capsule was successfully tested in pigs and showed promise in boosting local malaria elimination when combined with standard anti-malarial drugs.
Researchers have found Zika virus genetic material in human tears and live virus in mouse eyes, raising questions about transmission through bodily fluids. The study's findings have implications for corneal transplantation and potential new diagnostic methods, such as testing tear samples for viral RNA or antibodies.
A study found that providing antiretroviral treatment (ART) to both members of a couple and offering pre-exposure prophylaxis (PrEP) to the HIV-negative partner significantly reduced HIV transmission rates, with a 96% decrease in transmission compared to expected rates.
Calixarenes can amplify enzyme catalytic capacity, enabling novel therapeutics in cancer treatment. They also serve as drug delivery vehicles, refining pharmacokinetic profiles and releasing drugs selectively to cancer cells.
Upsalite's pore size control allows for tuning of amorphous phase stabilization and release rate of poorly soluble drugs like itraconazole. This breakthrough simplifies the synthesis of mesoporous materials, enabling industrial up-scaling.
A team of experts has proposed a standard list of essential diagnostic tests to support the use of medicines listed on the Model List of Essential Medicines. The list includes 147 critical laboratory tests across 57 categories, which can guide the use of many different EML drugs and improve healthcare quality in developing nations.
Researchers design a new type of extended-release pill that can attach to the gastrointestinal tract lining and release its contents slowly. The dual-sided device uses mucoadhesives and omniphobic materials to resist being pulled away by food and liquids.
The US Preventive Services Task Force recommends against routine screening for COPD in asymptomatic adults due to lack of evidence on benefits and potential harms. Screening may divert resources from other preventive services, such as smoking cessation.
Researchers at the National Addiction Centre criticize the widespread use of improvised nasal naloxone kits without testing and regulatory approval. The kits have been shown to have limited absorption rates, with only 4% of naloxone being absorbed when administered nasally.
Pharmaceutical sales representatives are screening people in India for their products, raising concerns about unchecked conflicts of interest and potential harm to patients. Local residents receive medical testing at 'health camps,' some organized by Indian drug firms and pharmaceutical companies like Abbott and Roche.
A new study found that shared financial incentives between physicians and patients result in improved low-density lipoprotein cholesterol (LDL-C) levels. Patients in the shared physician-patient incentives group achieved reductions in LDL-C levels statistically different from those in other groups, with 49% meeting the LDL-C goal.
Scientists develop a novel drug delivery platform that combines ionic and covalent binding to improve the solubility and bioactivity of pharmaceutical ingredients. The approach uses ionic liquids as a key component, offering tunable hydrophobicity/lipophilicity, modulated ionic binding, and variable linkers for targeted release.
Researchers have created a new technique to produce 3D 'micro-printed' arrays of needles capable of drug delivery, offering treatments for melanoma cancers. The arrays are fabricated using microstereolithography and can withstand stresses and strains when inserted into the body.
Researchers discovered that genetic variations in opioid receptors are associated with more severe neonatal abstinence syndrome (NAS) in newborn babies. These variations can help identify infants at risk of requiring medication to curb NAS symptoms, enabling tailored treatment plans and improved outcomes.
Researchers found antidepressants during pregnancy lowered the risk of preterm birth by 16% and very preterm birth by nearly 50%. However, they also increased the risk of neonatal problems, including breathing issues and longer hospital stays.
Researchers create remote controlled, next-generation tissue implant that allows neuroscientists to inject drugs and shine lights on neurons deep inside the brains of mice. The device has potential for mapping brain circuit activity and understanding disorders like stress, depression, addiction, and pain.
Researchers explore nanocarriers and microbubbles for efficient thrombus treatment, addressing limitations of existing drugs. The review highlights potential solutions for improving outcomes in ischemic heart disease and stroke, where millions die annually.
A new study suggests pharmacies can reduce asthma-related illnesses by dispensing more asthma controller medications. Pharmacies located in high utilization census tracts dispense more rescue medications than controller medications.
A new UTMB study found that most patients using epinephrine autoinjectors incorrectly, with only 16% using the device properly. Inhaler users also made significant mistakes, with 63% missing three or more steps. Improving patient training is crucial to maximize medication effectiveness.
Researchers at the University of California, San Diego, have developed a new process for self-driving phospholipid membrane assembly, similar to those found in living cells. This non-enzymatic technique can be used for artificial cell studies and potentially for drug delivery packets.
Researchers at the University of Southern Denmark have developed a natural sugar polymer that can carry drugs through the nasal wall and release them in the brain, addressing two major challenges in nasal delivery of brain drugs. The breakthrough could lead to more efficient treatment for chronic patients
Researchers have developed electronically controlled drugs that can minimize side effects by releasing medication in response to specific cues. These tailored approaches could be useful in treating conditions such as epilepsy, where medication could be released at the onset of a seizure.
A study by Brown University researchers found that Medicare Advantage health plans significantly understated their rate of high-risk medication prescriptions. The average plan reported a 5.8 percentage point difference in favor, resulting in about 500,000 more seniors receiving high-risk medications than reported.
Researchers at McGill University have created DNA 'cages' that can encapsulate small-molecule drugs and release them in response to a specific stimulus. The discovery has the potential to revolutionize drug delivery methods, offering precise control over drug release and reducing toxicity.
English stop smoking services have increased their reach and impact threefold over 10 years, helping more than 20,000 smokers achieve long-term abstinence. However, considerable variability exists in outcomes across local areas, requiring further investigation.
The study found that men face more difficulty accessing treatment due to occupational roles, while women are more likely to receive treatment. However, pregnant and breastfeeding women often lack awareness of safe medicine use, leading to missed treatments.
Researchers have developed a concept to improve cancer drug delivery using nanoparticles that concentrate and expand in acidic environments. The concept involves using nanoparticles made of weak polybases that expand when transported into environments mimicking tumor cells, accumulating long enough to deliver anticancer drugs.
Scientists at The University of Akron have developed a simple method to synthesize double-network hydrogels, which exhibit high mechanical properties and are promising replacements for load-bearing soft tissues like cartilage. These hydrogels can also be loaded with drugs and placed into the body, where they biodegrade and release the ...
A new computational model analyzes the potential usefulness of drug-coated balloons, which may pose fewer risks than current treatments. The model explains how factors like balloon size and drug coating influence drug release and distribution.
Researchers developed a medicated chewing gum formulation that improves patient compliance and faster absorption through the cheek, alleviating motion sickness sooner. Dimenhydrinate-based gum has great potential for commercialization and can be used to incorporate other active ingredients with objectionable taste into chewing gum.
Researchers develop a new technique to predictably generate complex wavy shapes from hydrogels, which may help design more efficient drug-delivery systems. The technique uses an experimental setup that projects images onto a photosensitive hydrogel, causing it to assume the desired shape.
The Southeast Minnesota Beacon Community, led by Mayo Clinic, is showcasing its work on health information exchange (HIE) technology at the HiMSS Conference. The team has developed a system that enables the transfer of patient data between healthcare providers in real-time, improving continuity of care and reducing costs.
USC Associate Professor Ellis Meng is selected for the NSF's Innovation Corps award to develop and commercialize her tiny, implantable medication-delivery system. The system has a better volume efficiency, allowing it to be powered wirelessly and used in animal studies.