Articles tagged with Drug Delivery
A weighted lottery system may favor allocation of COVID-19 monoclonal antibody to individuals in disadvantaged neighborhoods and those identifying as Black. However, this approach may also result in lower acceptance rates among Black individuals who receive the drug.
A new nanogel-based carrier delivers a synthetic thyroid hormone mimick to liver cells, resulting in weight loss and improved cholesterol levels. The treatment also resolves liver inflammation with minimal side effects, offering potential for other liver-based diseases.
A study at University of Tsukuba found that pharmacists with higher assertiveness scores are more likely to initiate communication that leads to physicians altering prescriptions. This suggests that effective communication skills can improve the safety of drug therapy.
Exposure to commonly prescribed antiseizure medications during pregnancy does not negatively impact neurodevelopmental outcomes in young children. The MONEAD study found that lamotrigine and levetiracetam pose low risks for cognitive effects, with some caution needed for high dosages of levetiracetam.
Scientists have teamed up to improve drug delivery by designing more effective lipid nanoparticles. Their latest study documents how high-throughput workflows can produce and characterize LNPs at record speed, with neatly ordered structures leading to better silencing of faulty genes in human neurons.
Researchers at Tel Aviv University have developed a novel approach to fight cancer by inducing cancer cells to produce a toxic protein using mRNA molecules. The treatment was successful in eliminating 44-60% of cancer cells in animal models, with no damage to healthy cells.
Scientists create optically controllable liposomes called LiDLs, which can selectively release contents inside cells upon exposure to acidic pH induced by green light. The researchers demonstrated that LiDLs efficiently deliver substances without causing side effects, showcasing exceptional extracellular stability.
Recent studies in the New Journal of Pharmaceutical Analysis feature novel diagnostic tools, RNA sequencing-based workflows, and mechanical property evaluations to enhance cancer and cardiovascular disease treatment outcomes. These innovations aim to improve the therapeutic effect of drugs and promote personalized medicine.
Researchers have designed new light-responsive membrane carriers for the translocation of peptide cargos inside living cells, offering a promising strategy for remotely controlled delivery of large biomolecules. The light-triggered system utilizes azobenzene units to control the transport of cationic peptides across lipid membranes.
A decision analytical model study found that sustained public health interventions can reduce opioid-related overdose deaths. Implementing medications for opioid use disorder and increasing naloxone supply were key factors in reducing death rates.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
A novel gene delivery procedure was successfully applied to baboons, achieving therapeutic levels of human factor IX gene expression lasting up to 200 days. The study demonstrated the efficacy of repeated hydrodynamic gene delivery into the same liver lobes, with no significant adverse events observed.
A Canadian study found that eliminating out-of-pocket medication expenses for patients with cost-related nonadherence results in lower healthcare spending over three years. The analysis suggests that reducing medication costs could lead to significant savings in the overall healthcare system.
Researchers have developed new methods to analyze dry-coated drug particles using 3D Raman mapping, which can effectively slow down dissolution rates. Another study introduces a novel technique for detecting complex traditional Chinese medicines, preventing adulteration and counterfeiting.
A nationwide analysis of prisoner healthcare incidents in England reveals medication-related harm as a major issue, with staff mistakes being the most common cause. The researchers recommend prioritizing timely access to healthcare services, improving processes to mitigate medication-related harm and increasing remote appointments.
Researchers at MIT have designed new 'smart' sutures that can deliver drugs or sense inflammation after surgery. The bioderived sutures use hydrogel coatings to detect early warning signs of complications, such as Crohn's disease, and can also release therapeutic molecules to promote healing.
Patients using medical cannabis reported sustained improvements in health-related quality of life in the study. Adverse events were common but rarely serious, highlighting the need for caution when prescribing medical cannabis.
Scientists have identified a novel mechanism of gel formation in synthetic polymers, which leads to the creation of worm-like structures. This breakthrough has significant implications for biofabrication and could lead to the development of new medical implants, contact lenses, and other applications.
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
Scientists discover carbonated water's impact on low-methoxy pectin hydrogel formation and properties. The study shows that CO2 from carbonated water increases mechanical strength and gelation rate of hydrogels.
The new American Heart Association scientific statement emphasizes the importance of including non-biological factors and social determinants in CVD risk assessment for women. These factors include economic stability, neighborhood safety, education level, and access to quality healthcare, which disproportionately affect women from dive...
Researchers have developed a new ear tube design that combines liquid-infused materials with optimized geometry to improve treatment outcomes for patients with ear infections. The design enables better performance and reduces complications such as impaired hearing and scarring of the eardrum.
Researchers used computational modeling to identify ultrastable MOF structures, which could be useful for gas storage and catalysis. The study found that about 10,000 of the predicted structures were stable enough for these applications, with high deliverable capacities for methane.
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
Researchers have developed a microneedle-based drug delivery technique for plants, which can precisely deliver controlled amounts of agrochemicals to specific plant tissues. This method has the potential to improve crop quality and disease management while minimizing resource wastage and environmental contamination.
A new cutaquig study found that increasing infusion volume per site resulted in a reduction of injection sites, while increasing infusion rates decreased infusion duration. The research also showed that dosing every other week demonstrated equivalency to trough levels with weekly dosing.
Gene therapy using CRISPR-Cas9 lipid nanoparticles has been shown to be highly effective in reducing target protein expression in mice. The new delivery system increases the efficiency of in vivo gene therapy, paving the way for safe and effective treatment.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
A fast-dissolving insert containing TAF and EVG was found safe and effective in preventing HIV transmission through anal sex. The study delivered high levels of the drugs to rectal tissue and fluid, with potential protection for up to three days after use.
New materials called gas-entrapping materials (GeMs) can carry high concentrations of therapeutic gases directly into tissues, including tumors. This improves the effectiveness of standard chemotherapy and radiation treatments in mouse models of prostate cancer and sarcoma.
Researchers at UW-Madison developed silica nanocapsules that can carry CRISPR tools across the blood-brain barrier, enabling brain-wide gene editing for disorders like Alzheimer's and Parkinson's. The technology has potential for non-invasive delivery of gene therapies.
A new software program developed by Duke Ph.D. student Dan Fu lets users create 3D structures made of DNA, including tiny vases, bowls, and hollow spheres. The software relies on a way to build with DNA described in 2011 by Hao Yan, which works by coiling a long DNA double helix into concentric rings to form the contours of the object.
Researchers have developed chemically modified nanosheets that can effectively deliver drugs to diseased cells, reducing side effects. The nanosheets, made from molybdenum disulphide, can exchange natural thiols with attached ligands, allowing for targeted drug delivery.
Researchers at Tokyo University of Science have developed a unique 3D COF with scu-c topology, exhibiting efficient gas adsorption and drug delivery capabilities. The material has been shown to exhibit excellent hydrogen and methane adsorption properties.
Rice University researchers are developing implants that can produce and deliver monoclonal anti-HIV antibody therapeutics for at least a year. The project aims to reduce the cost and improve the logistics of HIV treatment, making it more accessible and beneficial for patients worldwide.
Researchers found that buprenorphine use was associated with better outcomes for the baby, including lower risk of preterm birth, small size for gestational age, and low birth weight. The study suggests increasing access to buprenorphine treatment among pregnant individuals with opioid-use disorder.
A new tablet-based vaccine has shown long-lasting protection against bacteria that cause urinary tract infections (UTIs) in mice. The vaccine was found to be comparable to antibiotics in efficacy, with durable antibody responses lasting for the lifetime of a mouse.
Researchers at the University of Wisconsin-Madison develop nanoparticles to neutralize molecules implicated in IBD, significantly improving treatment outcomes. The probiotic bacteria are equipped with nano-backpacks that target reactive oxygen species, reducing inflammation and promoting weight gain and colon length restoration.
Researchers at Hokkaido University developed a novel branched ionizable lipid that significantly increases the efficiency of mRNA delivery by LNPs. The new lipid, CL4F 8-6, was found to enhance protein expression in mice and achieve stable formulations.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
Researchers controlled magnetic bacteria to cross blood vessel walls and infiltrate tumor tissue, delivering liposomes with fluorescent dye to demonstrate their ability to carry therapeutic agents. This approach may revolutionize bacterial cancer therapy by increasing efficacy and reducing side effects.
The THERACAT project aims to deliver drugs only to tumor sites using bio-orthogonal catalysis, a promising approach for targeted cancer treatment. Researchers developed nanoparticles bearing metal catalysts to efficiently convert inactive pro-drugs into active drugs at the tumor site.
Research reveals that pregnant smokers decrease their daily cigarette count by an average of one cigarette per day before realizing they are pregnant. This trend continues in the month following pregnancy recognition, with a decline from nine to five cigarettes per day on average.
Researchers from McGill University developed a medical adhesive inspired by flatworms that uses suction to absorb blood and promote blood coagulation. The adhesive can be removed without causing re-bleeding, making it a potential replacement for wound sutures or delivering drugs.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers at NJIT have developed a new lab technique that could speed up drug discovery and development of therapeutic proteins and vaccines. The electrochemistry-based approach allows for safety and quality testing to be done at a fraction of the time required by conventional methods.
A $1 million NIH grant will help MU researchers analyze the effectiveness of a HIPAA-secure text messaging platform in nursing homes. The study aims to improve quality of care and prevent costly hospital transfers by speeding up decision-making.
Researchers at the University of California San Diego developed microscopic robots called microrobots that can swim around in the lungs and deliver medication. The microrobots safely eliminated pneumonia-causing bacteria in mice, resulting in 100% survival rates, whereas untreated mice died within three days.
Researchers have discovered that two distantly related RNA viruses perform chemical choreography in strikingly similar ways, forming a symmetrical icosahedral shell. This finding has potential applications in improving pharmaceutical delivery and engineering, as well as understanding protein folding mechanisms.
A new approach to making nanocarriers for drug delivery features a soft, fat-like liposome interior surrounded by a hard shell of gold nanoparticles. The hybrid nanocarriers are designed to transport medicine across the body's blood brain barrier, a major hurdle protecting the brain from pathogens.
A pioneering behavioural diagnostic tool, SPUR, has been developed to improve medication adherence in type 2 diabetes patients. The study found that the tool can reliably identify patients struggling with their medicines and the reasons why.
A recent study by JAMA Internal Medicine calls for federal prosecutors to take a tougher stance on holding corporate executives accountable for problematic behavior. The Park doctrine aims to protect patients from unsafe medical products, but its implementation has been lacking, putting public health at risk.
Researchers have developed a soft, biodegradable, magnetic millirobot inspired by insects, which can grasp, roll and climb, but easily dissolve away. The robot was tested in experiments, delivering a dye solution to a stomach model and gripped various objects.
A University of the Basque Country team has successfully produced starch-based pharmaceutical tablets using 3D printing technology. The tablets display varying release properties depending on the type of starch used, offering promising solutions for personalized medicine and tailored drug delivery.
A new MIT model simulates vaccine allocation strategies to predict the effect on cumulative deaths and infections in the US. The research finds that allocating more than 50% of available doses to non-vaccinated individuals can significantly increase lives saved and reduce infections.
Researchers examined association between direct-to-consumer advertising of prescription drugs and consumer intentions and beliefs related to cardiovascular disease risk. The study found that DTCA may influence consumer attitudes and decisions regarding medication use.
A team of MIT engineers and collaborators have devised a way to overcome the foreign body response, forming a thick layer of scar tissue that blocks insulin release. The device is repeatedly inflated and deflated for five minutes every 12 hours, preventing immune cells from accumulating around it.
Researchers at TIBI developed a minimally invasive method for targeted delivery of immunotherapeutic treatments, resulting in slower tumor growth and higher activation of T-cells. The injectable gelatin biomaterial containing silicate nanoplatelets showed sustained drug release and controlled ICI delivery.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.