Articles tagged with Drug Delivery
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Researchers have developed chemically modified nanosheets that can effectively deliver drugs to diseased cells, reducing side effects. The nanosheets, made from molybdenum disulphide, can exchange natural thiols with attached ligands, allowing for targeted drug delivery.
Researchers at Tokyo University of Science have developed a unique 3D COF with scu-c topology, exhibiting efficient gas adsorption and drug delivery capabilities. The material has been shown to exhibit excellent hydrogen and methane adsorption properties.
Rice University researchers are developing implants that can produce and deliver monoclonal anti-HIV antibody therapeutics for at least a year. The project aims to reduce the cost and improve the logistics of HIV treatment, making it more accessible and beneficial for patients worldwide.
Researchers found that buprenorphine use was associated with better outcomes for the baby, including lower risk of preterm birth, small size for gestational age, and low birth weight. The study suggests increasing access to buprenorphine treatment among pregnant individuals with opioid-use disorder.
A new tablet-based vaccine has shown long-lasting protection against bacteria that cause urinary tract infections (UTIs) in mice. The vaccine was found to be comparable to antibiotics in efficacy, with durable antibody responses lasting for the lifetime of a mouse.
Researchers at the University of Wisconsin-Madison develop nanoparticles to neutralize molecules implicated in IBD, significantly improving treatment outcomes. The probiotic bacteria are equipped with nano-backpacks that target reactive oxygen species, reducing inflammation and promoting weight gain and colon length restoration.
Researchers at Hokkaido University developed a novel branched ionizable lipid that significantly increases the efficiency of mRNA delivery by LNPs. The new lipid, CL4F 8-6, was found to enhance protein expression in mice and achieve stable formulations.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
Researchers controlled magnetic bacteria to cross blood vessel walls and infiltrate tumor tissue, delivering liposomes with fluorescent dye to demonstrate their ability to carry therapeutic agents. This approach may revolutionize bacterial cancer therapy by increasing efficacy and reducing side effects.
The THERACAT project aims to deliver drugs only to tumor sites using bio-orthogonal catalysis, a promising approach for targeted cancer treatment. Researchers developed nanoparticles bearing metal catalysts to efficiently convert inactive pro-drugs into active drugs at the tumor site.
Research reveals that pregnant smokers decrease their daily cigarette count by an average of one cigarette per day before realizing they are pregnant. This trend continues in the month following pregnancy recognition, with a decline from nine to five cigarettes per day on average.
Researchers from McGill University developed a medical adhesive inspired by flatworms that uses suction to absorb blood and promote blood coagulation. The adhesive can be removed without causing re-bleeding, making it a potential replacement for wound sutures or delivering drugs.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers at NJIT have developed a new lab technique that could speed up drug discovery and development of therapeutic proteins and vaccines. The electrochemistry-based approach allows for safety and quality testing to be done at a fraction of the time required by conventional methods.
A $1 million NIH grant will help MU researchers analyze the effectiveness of a HIPAA-secure text messaging platform in nursing homes. The study aims to improve quality of care and prevent costly hospital transfers by speeding up decision-making.
Researchers have discovered that two distantly related RNA viruses perform chemical choreography in strikingly similar ways, forming a symmetrical icosahedral shell. This finding has potential applications in improving pharmaceutical delivery and engineering, as well as understanding protein folding mechanisms.
Researchers at the University of California San Diego developed microscopic robots called microrobots that can swim around in the lungs and deliver medication. The microrobots safely eliminated pneumonia-causing bacteria in mice, resulting in 100% survival rates, whereas untreated mice died within three days.
A new approach to making nanocarriers for drug delivery features a soft, fat-like liposome interior surrounded by a hard shell of gold nanoparticles. The hybrid nanocarriers are designed to transport medicine across the body's blood brain barrier, a major hurdle protecting the brain from pathogens.
A pioneering behavioural diagnostic tool, SPUR, has been developed to improve medication adherence in type 2 diabetes patients. The study found that the tool can reliably identify patients struggling with their medicines and the reasons why.
A recent study by JAMA Internal Medicine calls for federal prosecutors to take a tougher stance on holding corporate executives accountable for problematic behavior. The Park doctrine aims to protect patients from unsafe medical products, but its implementation has been lacking, putting public health at risk.
Researchers have developed a soft, biodegradable, magnetic millirobot inspired by insects, which can grasp, roll and climb, but easily dissolve away. The robot was tested in experiments, delivering a dye solution to a stomach model and gripped various objects.
A University of the Basque Country team has successfully produced starch-based pharmaceutical tablets using 3D printing technology. The tablets display varying release properties depending on the type of starch used, offering promising solutions for personalized medicine and tailored drug delivery.
A new MIT model simulates vaccine allocation strategies to predict the effect on cumulative deaths and infections in the US. The research finds that allocating more than 50% of available doses to non-vaccinated individuals can significantly increase lives saved and reduce infections.
Researchers examined association between direct-to-consumer advertising of prescription drugs and consumer intentions and beliefs related to cardiovascular disease risk. The study found that DTCA may influence consumer attitudes and decisions regarding medication use.
A team of MIT engineers and collaborators have devised a way to overcome the foreign body response, forming a thick layer of scar tissue that blocks insulin release. The device is repeatedly inflated and deflated for five minutes every 12 hours, preventing immune cells from accumulating around it.
Researchers at TIBI developed a minimally invasive method for targeted delivery of immunotherapeutic treatments, resulting in slower tumor growth and higher activation of T-cells. The injectable gelatin biomaterial containing silicate nanoplatelets showed sustained drug release and controlled ICI delivery.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
MIT researchers create microparticles that release their payload at different times, enabling self-boosting vaccines. The particles degrade over time and break down once released, allowing for potential use in regions with limited access to medical care.
Researchers at Aarhus University have developed an easy and inexpensive method for linking molecules to DNA sequences with desired functions. The method uses sulfonyl azides to introduce various functionalities, avoiding the need for expensive and unstable special phosphoramidites.
Researchers assessed buprenorphine coverage and prior authorization requirements in US commercial formularies from 2017 to 2021. The study found that coverage and requirements changed over time, with more stringent regulations in place by 2021.
Researchers from Osaka University have developed a system to coat nematodes with hydrogel sheaths that can carry functional cargo. The study found that the sheaths protect the worms from UV light and hydrogen peroxide while allowing them to deliver anti-cancer agents to kill cancer cells in vitro.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
Researchers created oil-based gels that can deliver a variety of medications, including those for infectious diseases, in a stable and palatable form. The gels can be used to administer drugs to children and adults with difficulty swallowing pills, and could have a significant impact on improving medication adherence.
Researchers at Penn Medicine have developed an imaging agent that detects cancer cells in real-time during biopsies, offering promise for earlier and more accurate diagnoses. The technology, known as NIR-nCLE, uses a combination of near-infrared tracers and confocal laser endomicroscopy to identify microscopic cancer cells.
A study found that regular pharmacist visits reduced medicine-related problems by 60% and improved cognition scores. The research highlights the need for personalized pharmaceutical support within the aged-care sector to prevent harm from medicines.
The University at Buffalo is developing new treatments for ovarian cancer by targeting the apelin receptor. Ovarian cancer cells rely on lipids for energy and survival, making this a promising therapeutic target.
More than half of Michigan pharmacies offer naloxone, a life-saving medication for opioid overdose, without requiring a prescription. The standing order allows pharmacists to dispense the drug in emergency situations.
Non-viral mRNA and pDNA delivery systems have shown promising results in vaccine development against COVID-19 and are being explored for therapeutic applications. These systems aim to improve upon current formulations by enhancing stability, targeting specific tissues, and stimulating innate immune responses.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
The NCCN Annual Conference focuses on the cancer patient journey, featuring state-of-the-art practice algorithms, updates to clinical guidelines, and new therapies. Leading experts present treatment recommendations for various cancer types, including breast, colorectal, and lung cancer.
A new class of membrane carriers, based on halogenated dodecaborate cluster anions, has been discovered to facilitate the cell entry of impermeable molecules. These superchaotropic boron clusters interact with hydrophilic cargos without encapsulating or forming aggregates, allowing for efficient transport across biological membranes.
Researchers have identified a previously unknown bacterial enzyme that can produce a new type of biodegradable polysaccharide called acholetin. Acholetin has wide-ranging potential as a biocompatible, biodegradable material for biomedical applications.
The National Comprehensive Cancer Network has published new consensus recommendations to improve the safety and efficiency of research studies involving investigational drugs. The recommendations focus on seven areas, including pharmacy workflows and collaboration with sponsors.
Researchers at the University of Bath have developed a new coating method for soft robots that allows them to change shape and movement through human-controlled activity. This breakthrough in active matter could lead to the creation of machines governed by individual units that cooperate to determine movement and function.
Researchers at the University of Bologna have developed a new targeted cancer therapy based on a genetically modified phage that selectively eliminates tumour cells. The virus is engineered to transport a drug activated by light to target tumour cells, reducing side effects.
Biohybrid micro- and nanorobots promise to deliver drugs to body tissues with high precision, enabling tasks such as cancer treatment, cell microsurgery, and tissue engineering. Researchers envision incorporating novel biological components into robots to overcome immune responses and increase efficiency in manufacturing.
A new form of drug delivery microparticle mimics the properties of a red blood cell, enabling controlled release of drugs and targeting specific destinations. The goal is to bypass the body's filtration systems, allowing for improved efficacy and reduced negative side effects.
A multidisciplinary research team from the University of Pittsburgh seeks to improve vascular graft integration by developing fully biodegradable tissue-engineered vascular grafts. The goal is to keep compliance-matched as it degrades and remodels, reducing long-term graft failure rates.
Researchers have identified the impact of protein corona formation on nanoparticles' physiochemical and biological properties. This knowledge can be used to optimize carriers for nanomedical applications, improving the efficiency and effectiveness of biopharmaceutical delivery.
A study of 236,000 individuals found patient- and prescription-related factors significantly linked to opioid-related fatal or nonfatal overdose. The research highlights the need for careful prescribing practices and post-discharge follow-up to prevent such overdoses.
Researchers at Kumamoto University developed a novel 'supermolecular' material that binds to protein drugs, prolongs their effect without impairing activity, and improves overall drug performance. The material, called PEG-PRX, adds polyethylene glycol chains to proteins without compromising biological action.
A new framework evaluates medicines' impact on global health, calculating the impact of drugs used to treat diseases like TB, HIV/AIDS, malaria, and NTDs. The Global Health Impact Index model saves about 62 million disability-adjusted life-years, equivalent to saving almost a year of life for 1% of the world's population.
A study of 1.1 million patients with type 2 diabetes found disparities in the use of GLP-1 receptor agonists by racial and ethnic groups, as well as by sex and socioeconomic status. The findings highlight concerns about unequal access to effective diabetes care.
Between 2015 and 2019, Medicare spending on drugs with an accelerated approval indication more than doubled, reaching $9.1 billion in 2019, primarily driven by Part B drugs. The study's findings highlight the growing concern of rapidly increasing costs associated with these medications.
The 2022 Pharmacy Forecast Report notes that COVID-19 disruptions have led to increased roles for pharmacists in patient care, emergency preparedness, and technology. The report also emphasizes the need for equitable access to digital tools and explores strategies to mitigate supply chain issues.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Scientists at UC San Diego create nanoparticles that mimic the flu virus's ability to escape endosomes, enabling efficient delivery of mRNA into cells. This breakthrough could lead to improved delivery of mRNA vaccines and therapies.
Pharmacy standing orders led to a significant increase in naloxone dispensing in Massachusetts, but gaps in access persist in rural communities and Hispanic neighborhoods. Communities with higher rates of opioid overdose deaths and buprenorphine treatment also dispensed more naloxone.
Researchers have developed fish-shaped microrobots that can guide themselves to cancer cells using magnets, where a pH change opens their mouths to release chemotherapy. The microrobots demonstrate promising capabilities for targeted cancer treatment, but need further improvements in size and tracking methods.