Articles tagged with Drug Delivery
Researchers developed a new photosensitizer, polphylipoprotein (PLP), to improve photodynamic therapy (PDT) efficacy. PLP selectively induces necrosis in cancer cells by exploiting the autophagy mechanism under starvation, leading to high selectivity and potential efficacy.
Researchers found a combination treatment involving high doses of radiation and chemotherapy to be safe and effective in treating locally advanced non-small cell lung cancer. The treatment, which includes an adaptive boost plan, showed promising results in improving progression-free survival and reducing toxic side effects.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
Researchers have designed a nanoparticle-based drug delivery system to target inflammation, addressing issues with conventional anti-inflammatory drugs. The system utilizes targeting moieties to enrich nanoparticles in inflamed tissues, achieving enhanced efficacy.
Scientists at Tokyo Tech developed self-folding polymers to create smaller, safer gadolinium-based contrast agents for cancer diagnosis and neutron capture radiotherapy. These nanosized complexes show enhanced tumor accumulation and penetration, reducing toxicity while increasing MRI performance.
Researchers at Wayne State University aim to extend the lifespan of infusion pumps and injection ports to minimize tissue damage and maintain site integrity. The project seeks to reduce inflammation and fibrosis caused by insulin phenolic preservatives, leading to improved diabetes management practices.
Researchers analyzed FDA and patent records to find that manufacturers extended market exclusivity by filing additional patents after FDA approval and obtaining patents on delivery devices. This resulted in a median of 16 years of protection, surpassing other top-selling small-molecule drugs.
Researchers from Incheon National University create gelatin patches that generate molecular oxygen to accelerate wound healing. The new hydrogels demonstrate improved coagulation, blood closure, and neovascularization in both in vitro and in vivo experiments.
Researchers found that changing treatment can lead to significant improvement in mobility and quality of life for patients with advanced Parkinson's disease. A nationwide registry is planned to develop scientifically sound guidelines for combination therapies.
Researchers have developed soft implantable fibers that can deliver light to major nerves through the body, allowing for precise illumination of nerve pain. The fibers are flexible and stretch with the body, enabling scientists to study peripheral nerve disorders in animal models without constraining movement.
A major study has found that taking benzodiazepines like Valium and Ativan intermittently instead of continuously can lead to significant reductions in side effects such as falls, hip fractures, hospitalizations, and even death. The research showed a 20% decrease in hip fractures, 33% fewer men's falls requiring hospitalization, and a ...
A new study reveals that esketamine nasal spray is effective in treating treatment-resistant depression, with 27.1% of patients achieving remission after 8 weeks compared to 17.6% on quetiapine XR. Long-term data shows sustained remission rates at 21.7% for esketamine NS and 14.1% for quetiapine XR.
Researchers developed statistical models using ultrasound measurements and protein levels to predict stillbirth, neonatal death, or extreme preterm delivery. The findings aim to identify suitable candidates for clinical trials testing novel treatments for fetal growth restriction.
A study of 151 patients with functional dyspepsia found that turmeric's curcumin was as effective as omeprazole in reducing symptoms after 28 days. Patients who took the combination treatment showed stronger improvements after 56 days, suggesting curcumin may be a viable alternative to conventional drugs.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
A weighted lottery system may favor allocation of COVID-19 monoclonal antibody to individuals in disadvantaged neighborhoods and those identifying as Black. However, this approach may also result in lower acceptance rates among Black individuals who receive the drug.
A new nanogel-based carrier delivers a synthetic thyroid hormone mimick to liver cells, resulting in weight loss and improved cholesterol levels. The treatment also resolves liver inflammation with minimal side effects, offering potential for other liver-based diseases.
A study at University of Tsukuba found that pharmacists with higher assertiveness scores are more likely to initiate communication that leads to physicians altering prescriptions. This suggests that effective communication skills can improve the safety of drug therapy.
Exposure to commonly prescribed antiseizure medications during pregnancy does not negatively impact neurodevelopmental outcomes in young children. The MONEAD study found that lamotrigine and levetiracetam pose low risks for cognitive effects, with some caution needed for high dosages of levetiracetam.
Scientists have teamed up to improve drug delivery by designing more effective lipid nanoparticles. Their latest study documents how high-throughput workflows can produce and characterize LNPs at record speed, with neatly ordered structures leading to better silencing of faulty genes in human neurons.
Researchers at Tel Aviv University have developed a novel approach to fight cancer by inducing cancer cells to produce a toxic protein using mRNA molecules. The treatment was successful in eliminating 44-60% of cancer cells in animal models, with no damage to healthy cells.
Scientists create optically controllable liposomes called LiDLs, which can selectively release contents inside cells upon exposure to acidic pH induced by green light. The researchers demonstrated that LiDLs efficiently deliver substances without causing side effects, showcasing exceptional extracellular stability.
Recent studies in the New Journal of Pharmaceutical Analysis feature novel diagnostic tools, RNA sequencing-based workflows, and mechanical property evaluations to enhance cancer and cardiovascular disease treatment outcomes. These innovations aim to improve the therapeutic effect of drugs and promote personalized medicine.
Researchers have designed new light-responsive membrane carriers for the translocation of peptide cargos inside living cells, offering a promising strategy for remotely controlled delivery of large biomolecules. The light-triggered system utilizes azobenzene units to control the transport of cationic peptides across lipid membranes.
A decision analytical model study found that sustained public health interventions can reduce opioid-related overdose deaths. Implementing medications for opioid use disorder and increasing naloxone supply were key factors in reducing death rates.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
A novel gene delivery procedure was successfully applied to baboons, achieving therapeutic levels of human factor IX gene expression lasting up to 200 days. The study demonstrated the efficacy of repeated hydrodynamic gene delivery into the same liver lobes, with no significant adverse events observed.
A Canadian study found that eliminating out-of-pocket medication expenses for patients with cost-related nonadherence results in lower healthcare spending over three years. The analysis suggests that reducing medication costs could lead to significant savings in the overall healthcare system.
Researchers have developed new methods to analyze dry-coated drug particles using 3D Raman mapping, which can effectively slow down dissolution rates. Another study introduces a novel technique for detecting complex traditional Chinese medicines, preventing adulteration and counterfeiting.
A nationwide analysis of prisoner healthcare incidents in England reveals medication-related harm as a major issue, with staff mistakes being the most common cause. The researchers recommend prioritizing timely access to healthcare services, improving processes to mitigate medication-related harm and increasing remote appointments.
Researchers at MIT have designed new 'smart' sutures that can deliver drugs or sense inflammation after surgery. The bioderived sutures use hydrogel coatings to detect early warning signs of complications, such as Crohn's disease, and can also release therapeutic molecules to promote healing.
Patients using medical cannabis reported sustained improvements in health-related quality of life in the study. Adverse events were common but rarely serious, highlighting the need for caution when prescribing medical cannabis.
Scientists have identified a novel mechanism of gel formation in synthetic polymers, which leads to the creation of worm-like structures. This breakthrough has significant implications for biofabrication and could lead to the development of new medical implants, contact lenses, and other applications.
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
Scientists discover carbonated water's impact on low-methoxy pectin hydrogel formation and properties. The study shows that CO2 from carbonated water increases mechanical strength and gelation rate of hydrogels.
The new American Heart Association scientific statement emphasizes the importance of including non-biological factors and social determinants in CVD risk assessment for women. These factors include economic stability, neighborhood safety, education level, and access to quality healthcare, which disproportionately affect women from dive...
Researchers have developed a new ear tube design that combines liquid-infused materials with optimized geometry to improve treatment outcomes for patients with ear infections. The design enables better performance and reduces complications such as impaired hearing and scarring of the eardrum.
Researchers used computational modeling to identify ultrastable MOF structures, which could be useful for gas storage and catalysis. The study found that about 10,000 of the predicted structures were stable enough for these applications, with high deliverable capacities for methane.
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
Researchers have developed a microneedle-based drug delivery technique for plants, which can precisely deliver controlled amounts of agrochemicals to specific plant tissues. This method has the potential to improve crop quality and disease management while minimizing resource wastage and environmental contamination.
A new cutaquig study found that increasing infusion volume per site resulted in a reduction of injection sites, while increasing infusion rates decreased infusion duration. The research also showed that dosing every other week demonstrated equivalency to trough levels with weekly dosing.
Gene therapy using CRISPR-Cas9 lipid nanoparticles has been shown to be highly effective in reducing target protein expression in mice. The new delivery system increases the efficiency of in vivo gene therapy, paving the way for safe and effective treatment.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
A fast-dissolving insert containing TAF and EVG was found safe and effective in preventing HIV transmission through anal sex. The study delivered high levels of the drugs to rectal tissue and fluid, with potential protection for up to three days after use.
New materials called gas-entrapping materials (GeMs) can carry high concentrations of therapeutic gases directly into tissues, including tumors. This improves the effectiveness of standard chemotherapy and radiation treatments in mouse models of prostate cancer and sarcoma.
Researchers at UW-Madison developed silica nanocapsules that can carry CRISPR tools across the blood-brain barrier, enabling brain-wide gene editing for disorders like Alzheimer's and Parkinson's. The technology has potential for non-invasive delivery of gene therapies.
A new software program developed by Duke Ph.D. student Dan Fu lets users create 3D structures made of DNA, including tiny vases, bowls, and hollow spheres. The software relies on a way to build with DNA described in 2011 by Hao Yan, which works by coiling a long DNA double helix into concentric rings to form the contours of the object.
Researchers have developed chemically modified nanosheets that can effectively deliver drugs to diseased cells, reducing side effects. The nanosheets, made from molybdenum disulphide, can exchange natural thiols with attached ligands, allowing for targeted drug delivery.
Researchers at Tokyo University of Science have developed a unique 3D COF with scu-c topology, exhibiting efficient gas adsorption and drug delivery capabilities. The material has been shown to exhibit excellent hydrogen and methane adsorption properties.
Rice University researchers are developing implants that can produce and deliver monoclonal anti-HIV antibody therapeutics for at least a year. The project aims to reduce the cost and improve the logistics of HIV treatment, making it more accessible and beneficial for patients worldwide.
Researchers found that buprenorphine use was associated with better outcomes for the baby, including lower risk of preterm birth, small size for gestational age, and low birth weight. The study suggests increasing access to buprenorphine treatment among pregnant individuals with opioid-use disorder.
A new tablet-based vaccine has shown long-lasting protection against bacteria that cause urinary tract infections (UTIs) in mice. The vaccine was found to be comparable to antibiotics in efficacy, with durable antibody responses lasting for the lifetime of a mouse.
Researchers at the University of Wisconsin-Madison develop nanoparticles to neutralize molecules implicated in IBD, significantly improving treatment outcomes. The probiotic bacteria are equipped with nano-backpacks that target reactive oxygen species, reducing inflammation and promoting weight gain and colon length restoration.
Researchers at Hokkaido University developed a novel branched ionizable lipid that significantly increases the efficiency of mRNA delivery by LNPs. The new lipid, CL4F 8-6, was found to enhance protein expression in mice and achieve stable formulations.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
Researchers controlled magnetic bacteria to cross blood vessel walls and infiltrate tumor tissue, delivering liposomes with fluorescent dye to demonstrate their ability to carry therapeutic agents. This approach may revolutionize bacterial cancer therapy by increasing efficacy and reducing side effects.
The THERACAT project aims to deliver drugs only to tumor sites using bio-orthogonal catalysis, a promising approach for targeted cancer treatment. Researchers developed nanoparticles bearing metal catalysts to efficiently convert inactive pro-drugs into active drugs at the tumor site.
Research reveals that pregnant smokers decrease their daily cigarette count by an average of one cigarette per day before realizing they are pregnant. This trend continues in the month following pregnancy recognition, with a decline from nine to five cigarettes per day on average.
Researchers from McGill University developed a medical adhesive inspired by flatworms that uses suction to absorb blood and promote blood coagulation. The adhesive can be removed without causing re-bleeding, making it a potential replacement for wound sutures or delivering drugs.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.