A decision analytical model study found that sustained public health interventions can reduce opioid-related overdose deaths. Implementing medications for opioid use disorder and increasing naloxone supply were key factors in reducing death rates.
A new metric, space syntax walkability index, is proposed to address limitations in linking cardio-metabolic risk factors to the built environment. The study found that walkability in urban areas is linked to cardio-metabolic risk factors, including blood pressure and obesity.
A new study has determined the atomic-level structure of a zinc-transporter protein, showing how it regulates zinc levels inside cells through a built-in sensor. The protein acts as a dimer, using feedback to control its activity based on zinc levels.
Researchers found that boron species plays a key role in enhancing catalytic activity and selectivity in the selective hydrogenation of cinnamaldehyde over cobalt boride catalysts. The study uncovers a synergistic effect between boron species and water, leading to improved stability and selectivity of the catalysts.
This review examines current evidence for frontline therapeutics in managing COVID-19, highlighting promising antiviral agents and adjunctive therapies. Updates on COVID-19 immunotherapy and vaccine development are also provided, offering insights into the evolving treatment landscape.
A study analyzing de-identified data from almost 11,000 total visits by Penn Medicine employees found that telemedicine visits were 23 percent less expensive than in-person visits for the same conditions. The per-visit costs of the telemedicine program averaged $380 while in-person encounters cost $493 to conduct.
The LHAASO collaboration has measured the complete high-energy light curve of a gamma-ray burst (GRB) for the first time, including its entire phase from rise to decay. This observation provides a perfect dataset for testing theoretical models and could remain one of the best results for decades or centuries.
Researchers at Pohang University of Science & Technology (POSTECH) developed a technology for high-performance organic polymer semiconductors that exhibit both stretchability and electrical functionality. The molecular brake prevents slipping under stretching conditions, preserving up to 96% of electrical performance.
Researchers found that introducing magnetic defects into topological insulators leads to competing ferromagnetic and antiferromagnetic interactions, which control the material's magnetic order. This discovery could have significant implications for reducing energy footprints in computing and electricity transmission.
A new material with enormous magnetoresistance has been discovered, enabling the development of more efficient non-volatile magnetoresistive memory (MRAM) devices. The material, a cobalt-manganese alloy with metastable body-centered cubic crystal structure, exhibits high magnetoresistance ratios at room temperature and near-zero kelvin.
A large-scale randomized clinical trial found that metformin prevents the development of long COVID. Over 1,100 participants reported on their symptoms for up to 10 months after initial COVID-19 diagnosis. The study suggests metformin could have significant public health implications as a preventive measure.
Researchers at the University of the Witwatersrand have outlined a new optical communication protocol that exploits spatial patterns of light for multi-dimensional encoding without recognizing them. This approach results in over 50 vectorial patterns of light being sent virtually noise-free across a turbulent atmosphere.
Researchers have developed a quantum model that can simulate non-Markovian stochastic processes using only one quantum bit, achieving higher accuracy than optimal classical models. This breakthrough demonstrates the potential of quantum technology for complex systems modeling.
A review article by senior investigators at Brigham and Women's Hospital found that long COVID and chronic fatigue syndrome share similar symptoms, including brain, immune system, heart, lung, gut, and energy metabolism abnormalities. The study aims to identify areas requiring further research for improved diagnostic tests and treatments.
Scientists have developed a technique for applying liquid metal to surfaces that don't easily bond with it, using force-responsive adhesion. The method allows for the creation of electronic 'smart devices' from everyday materials like paper and plastic.
Researchers at Brigham and Women's Hospital identified distinct brain network connections for visual and motor anosognosia, as well as a shared network for awareness of deficits. The study found that the hippocampus and precuneus play a key role in memory-based recognition of neurological deficits.
Prof. LIANG Haojun's team proposed a new method to escape from metastability in self-assembly using DNA-functionalized nanoparticles. By introducing a 'catassembler' molecule, they corrected imperfect linkages and assisted the system to escape from metastability while preserving the assembled framework. This strategy has potential appl...
Scientists from NOMAD Laboratory have elucidated fundamental microscopic mechanisms for tailoring materials for heat insulation. They found that temporary formation of defect structures can trigger lower thermal conductivities in strongly heat insulators.
The African-led PrEPVacc trial has completed participant enrolment at all four sites in East and Southern Africa. The trial is testing two different ways to prevent HIV, including HIV vaccine regimens and a new form of oral pre-exposure prophylaxis (PrEP).
Researchers have designed a helmet with liquid shock absorbers that could significantly reduce the impact of blows to the head, potentially cutting injuries. The helmet performed better than existing models, producing the lowest 'Helmet Performance Score' in key areas, including the side upper portion of the helmet.
A research team used a new seismic inversion algorithm to study lithospheric delamination and its controls on the Mesozoic Magmatic Province in South China. High-velocity anomalies were found at depths of less than 90 kilometers, suggesting lithosphere blocks began to delaminate at 180-170Ma.
Researchers used machine learning to build predictive models for nine common diseases based on genetic information and blood biomarkers. Blood biomarkers provided better prediction in nearly all cases, especially for near-term risk, suggesting direct links between some measures and the pre-symptomatic phase of disease.
Researchers found that people with secure national identity are more supportive of pro-environmental solutions, while narcissists show lower support. The study also suggests that addressing psychological needs can mobilize political support for climate policies.
Researchers found 7 aerophones made from bird bones at the Eynan-Mallaha site, dating back to circa 12,000 years ago. The flutes imitate raptor calls, similar to those of kestrel and sparrowhawk birds hunted by Natufian people.
An international team of scientists has successfully measured the electron spin in matter for the first time using kagome materials. The results could revolutionize the study of quantum materials, with potential applications in renewable energy, biomedicine, electronics, and quantum computing.
Researchers have developed a new AI model that can quickly screen large libraries of potential drug compounds against target proteins. The ConPLex model uses language analysis to match potential drugs with proteins without needing to calculate molecular structures, enabling fast screening of over 100 million compounds per day.
Researchers from Universitat de Barcelona and Universitat Internacional de Catalunya discuss the non-receptor protein tyrosine kinase Src as a good example of an oncogene. Targeting the Src N-terminal regulatory element (SNRE) has potential as oncotargets to inhibit Src activity only in cancer cells.
Scientists have identified a genetic locus associated with voice pitch, found in the ABCC9 gene, which influences voice characteristics in both men and women. The study also reveals links between voice pitch and cardiovascular health, highlighting the complex relationship between vocal traits and human biology.
Researchers have summarized advances in eco-friendly gas insulating medium for next-generation SF6-free equipment, highlighting various categories and molecular design methods. The latest applications of eco-friendly gases in medium-voltage and high-voltage scenarios are also discussed.
A research team from USTC found that the pre-emergence magnetic rope structure undergoes a complex series of stripping, disintegration and reconstruction during the outburst. This study reveals the details of the process of three-dimensional magnetic reconnection and its role in forming coronal mass ejections.
A recent study found that pre-teen girls who drank 100% fruit juice had long-term positive dietary benefits and met Dietary Guideline recommendations for whole fruit. The study also showed racial differences in fruit consumption, with black girls consuming more 100% juice throughout adolescence.
Research in mice suggests that prostate cancer cells adapt to testosterone-deprivation therapy by producing cholesterol and generating their own testosterone. Treating aggressive tumors with inhibitors slows tumor growth. The study also points to a possible drug combination and sheds light on racial disparities in prostate cancer.
Researchers at Carnegie Mellon University and Penn State University have discovered novel ferroelectric materials that can switch at the atomic level, enabling more efficient microelectronics. The findings hold promise for applications such as non-volatile memory, electro-optics, and energy harvesting.
A survey study found that patients with health insurance, a primary care provider, and ongoing health needs are more likely to use online patient portals. Portal users tend to have higher levels of education and live in urban areas, while non-users cite lack of awareness and technical issues as reasons for not using the platforms.
Researchers have investigated the impact of eddies on the Indonesian Throughflow, a vital current that transports warm waters between the Pacific and Indian Oceans. The study found large flow fluctuations in certain areas, leading to significant changes in seawater temperature and circulation patterns.
Scientists have determined the chemical composition of supercritical fluids in deep subduction zones for the first time, shedding light on their critical role in the Earth's carbon and sulfur cycle. The study reveals that these fluids play a vital part in transporting elements between the Earth's surface and the deep mantle.
Research from Johns Hopkins Medicine found that Black and Hispanic female breast cancer survivors have higher death rates from second cancers compared to other ethnic groups. The risk of death from a second cancer is 12% higher among non-Hispanic Black survivors and 8% higher among Hispanic survivors.
Researchers found immune markers associated with myocardial injury in hypertensive patients with Covid-19, including altered cytokine levels and immune cell activation. These findings suggest a key role for immune dysregulation in the development of cardiac muscle injury.
Researchers developed a method using machine learning to estimate high-resolution precipitation characteristics from low-resolution climate model simulations. This enables evaluation of the impact of recent global warming on local precipitation and clarifies climate-related characteristics of precipitation variability.
A new study by University of Arkansas researchers found that local newspaper coverage significantly improved the general information about public companies, leading to lower stock volatility and more accurate financial forecasts. Conversely, declining local news coverage increased stock volatility, information asymmetry, and illiquidity.
Researchers at the University of Minnesota have developed a new strategy to detect axions using particle collider experiments. By analyzing the decay product of unstable heavy particles into muons, they hope to locate and prove the existence of these hypothetical particles.
Researchers at UCL and INGV found that parts of the Campi Flegrei volcano have been stretched nearly to breaking point, indicating a higher risk of rupture. The study used a model of volcano fracturing to interpret patterns of earthquakes and ground uplift, suggesting that an eventual eruption could be preceded by weaker signals.
The Shape Up! Keiki research study aims to create a better way to measure and describe health from body shape, focusing on identifying obesity risks in young children. Participants aged 5 years or younger will be compensated $200 for their time.
Researchers identified candidate genes and loci associated with aquaculture-relevant traits in tilapia, providing valuable insights to breed more resilient fish. The findings aim to guide selective breeding programmes and enhance the climate resilience of freshwater aquaculture.
A powerful new stem cell technique has enabled large-scale studies of the relationship between human genetics and biology, accelerating research and potential personalized treatments.
When healthy food options are no longer discounted, consumers tend to opt for cheaper alternatives. A new study found that temporary incentives to buy healthier foods have a limited impact on long-term purchasing habits.
Researchers found that doctors' use of Bayesian vs. diagnostic approaches in communicating statistical information to patients impacts accuracy and understanding. Diagnostic approach clarifies the probability of a patient having the disease given a positive test result, leading to improved comprehension by 72% compared to Bayesian appr...
Researchers from USTC enhance fluorescence brightness of single silicon carbide spin color centers by leveraging surface plasmons, achieving a seven-fold enhancement and one million counts per second with an oil lens. This low-cost method allows precise manipulation of distance and improves efficiency of spin control.
A team of scientists has identified 7 prehistoric flutes in Eynan-Mallaha, Israel, dated to 12,000 years ago. The flutes were made from the bones of small waterfowl and produced a sound similar to certain birds of prey.
Researchers develop artificial photosynthesis devices to convert sunlight into oxygen, potentially supplementing space travel with sustainable energy. These devices mimic plants' natural process, recycling carbon dioxide and producing oxygen using only sunlight.
A study by the University of Exeter found that people who experience sexual harassment prioritize needs for safety, personal control, and social support over formal actions like reporting to police. This gap between expected and actual responses may explain why many victims don't come forward immediately or at all.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
Current vector control strategies are ineffective, increasing the disease burden of arboviruses. Wolbachia-based biocontrol is a promising alternative to prevent mosquito-borne diseases like dengue in Bangladesh and other developing countries.
A University of Bath study found that women are less willing to take risks due to their increased sensitivity to potential losses, while men are more optimistic and confident in their abilities. The research suggests this difference in risk-taking behavior could explain sex-specific outcomes in employment and financial markets.
Researchers achieve 3D printing within mini-organs growing in hydrogels, allowing for precise control over shape, activity, and tissue growth. This breakthrough enables the creation of realistic models of organs and disease, with potential applications in cancer research and treatment.
The study found that taking home methadone doses increased deaths of black and hispanic men but had little effect on the other demographic groups. Relaxing methadone restrictions may help certain at-risk groups, addressing the heterogeneity in treatment.
Scientists investigate how salt uptake affects polyester microdroplets' surface potential, turbidity, size, and internal water distribution. The results suggest that microdroplets can selectively partition salt cations, leading to differential coalescence.
Researchers developed Eye2Gene, an AI system that accurately identifies genetic causes of inherited retinal diseases from retinal scans. The system achieved higher accuracy than human experts in identifying causative genes, with a ranking score above 70% in over 70% of cases.