A recent study analyzing 670,000 patients found a higher frequency of advanced disease among non-white men and differences in access to modern therapies. The study also revealed significant racial inequalities in treatment costs, with white patients receiving 16.2% more funding.
A review of nearly 50,000 patients found significantly higher mortality rates for community-acquired pneumonia in intensive care units of middle-income countries compared to high-income countries. The study highlights major inequalities in outcomes and underscores the need for improved healthcare access and quality.
A national survey of over 47,000 healthcare professionals found that engaging care teams remains the biggest challenge for concrete improvements in quality of care. The study highlights the importance of valuing teams and promoting a good experience for both patients and healthcare workers.
Hospital accreditation in Brazil has a positive impact on patient safety culture, with accredited hospitals showing stronger openness to communication and incident reporting. However, non-punitive responses to errors and underreporting of incidents remain significant challenges.
A new AI-based tool proves effective in assessing individual risk in severe cases of community-acquired pneumonia in Intensive Care Units (ICUs), enabling ICU performance evaluation adjusted for patient severity. The Standardized Length of Stay Ratio (SLOSR) shows strong explanatory power with low prediction errors.
Researchers identified miR-21 as a key regulator of bladder cancer growth and spread, highlighting its potential as a therapeutic target and diagnostic biomarker. By inhibiting miR-21, tumor cells lose their ability to multiply and invade tissues, slowing down tumor growth.
A recent study investigated problematic pornography use (PPU) among men and found that increased time spent on pornography was closely associated with other intensity indicators. Binge sessions, tab-jumping, and edging were strongly linked to PPU, suggesting that digital novelty plays a central role in usage patterns.
The article advocates for a global scoring system to measure ICU patient severity, addressing local limitations and data gaps in low-income countries. A simplified international score based on common ICU variables could provide a shared language for comparison between countries.
A study led by Brazilian researchers has reconstructed the brain environment in the lab, revealing live interactions between cancer and healthy tissue. The 3D model allows real-time observation of brain metastases and has potential to reshape future therapies against metastatic melanoma.
A study published in The Lancet highlights disparities and obstacles faced by low- and middle-income countries in gaining recognition for their scientific contributions. Researchers propose increasing visibility of journals from low- and middle-income countries, reducing publication fees, and ensuring a fairer peer-review process to fo...
A recent study reveals genes that may help predict prostate cancer outcomes, including androgen receptor AR-V7 and p160 gene family. The research suggests these genes could serve as potential prognostic biomarkers for prostate cancer, highlighting the importance of androgen signaling in disease progression.
A recent study explores the connection between chronic inflammation and arrhythmia development, identifying potential therapeutic targets for preventing and treating AF. The research team discovered that interleukin-1 beta (IL-1β) triggers atrial fibrillation by activating its receptors on macrophages.
A recent study by D'Or Institute for Research and Education highlights the importance of cultural adaptation in behavioral interventions aimed at the population. Community engagement throughout the entire adaptation cycle is key to success, according to researchers.
A new study using next-generation molecular sequencing and DNA methylation profile analysis identified a rare type of pediatric brain tumor with specific genetic alterations. The tumors were found to be clinically aggressive but some responded well to chemotherapy, highlighting the need for personalized treatment strategies.
A phase III study found that selpercatinib significantly improves cancer progression-free survival in patients with NSCLC and RET gene translocations. The therapy also demonstrated efficacy in treating intracranial lesions, a common challenge in advanced NSCLC.
Clinical quality registries collect and store health information to optimize healthcare and management in ICUs, providing valuable data for scientific research and epidemiological maps. The review highlights the role of CQRs in benchmarking strategies between hospitals and improving resource management.
A recent study published in CHEST Science Journal reveals that high-performance ICUs exhibited lower mortality rates during the COVID-19 pandemic, with a range of 3.6% to 63.2%. The research also found that these ICUs had better patient outcomes before and after the pandemic, regardless of disease severity or comorbidities.
A new AI tool developed by Brazilian researchers can detect potentially cancerous lung nodules in CT reports, missing a crucial early diagnosis. The NLP tool achieved an accuracy rate of 97% in identifying suspicious nodules.
Research reveals increased sympathetic nerve activity and reduced exercise capacity in patients with heart failure resulting from anthracycline chemotherapy. Sympathetic neural overdrive is associated with skeletal myopathy and decreased cardiac function.
A Brazilian study evaluated the impact of quick and accessible SEL Kernels on children aged 3-6. The program showed significant reductions in conduct problems and improvements in prosocial behavior, indicating improved sociability and reduced hyperactivity.
Researchers found that severe COVID-19 survivors exhibit elevated muscle sympathetic nerve activity in response to mental stress, which accelerates heartbeat and increases blood pressure. This exaggerated reaction, combined with impaired vasodilation, poses a significant risk for cardiovascular complications.
Researchers found immune markers associated with myocardial injury in hypertensive patients with Covid-19, including altered cytokine levels and immune cell activation. These findings suggest a key role for immune dysregulation in the development of cardiac muscle injury.
A Brazilian study analyzed data from over 40,000 patients admitted to ICUs and found lower mortality rates during the Omicron outbreak compared to previous strains of Covid-19. Vaccination coverage contributed to the lower mortality observed in the Omicron period, but vulnerable patients remain at risk.
A Brazilian study found that pediatric ICU workers experienced high levels of burnout, anxiety, depression, and post-traumatic stress disorder during the COVID-19 pandemic. Despite high job satisfaction, organizational support can help mitigate psychological distress.
Researchers used transcranial stimulation to regulate Autonomic Nervous System responses and increase oxygen saturation in hospitalized patients with Covid-19. The treatment improved ANS regulation and reduced symptoms without adverse effects.
Researchers identified structural changes in the thalamus and strengthened connections with the temporal cortex, enabling visual cortex activation through non-visual stimuli.
Researchers found positive correlations between lipoxin A4 and cognitive brain functions, as well as its potential to potentiate the endocannabinoid system. The study suggests that reducing levels of this substance may weaken the body's defenses against neurodegeneration.
Researchers found that alpha-synuclein aggregates cause skin thinning by triggering inflammation and reducing cell multiplication. This protein accumulation is linked to decreased skin sensoriality, impacting quality of life.
A new study by D'Or Institute for Research and Education found that storytelling can decrease cortisol levels and increase oxytocin production in ICU children. The results showed that the narrative activity was more effective than riddles, improving the quality of life for hospitalized kids.
Researchers found unique fingerprints of hypoplasia and agenesis in corpus callosum dysgenesis, using distinct plastic mechanisms to compensate for partial or complete lack of the corpus callosum. This discovery sheds light on brain plasticity and its relation to symptoms in patients with this condition.
A Brazilian study found that consuming contaminated water with saxitoxin worsens Zika neurotoxicity, tripling cell mortality and causing microcephaly-like malformations. This research highlights the public health problem of low water quality in the Northeast region, exacerbating the effects of arbovirus diseases.
A new study by Brazilian researchers sheds light on astrogliosis, a common inflammatory process in brain tissue linked to Alzheimer's and Parkinson's diseases. Human astrocytes created in the lab were found to exhibit impaired function and morphological changes after exposure to an inflammatory protein.
A recent study published in Scientific Reports reveals that Zika virus infection causes damage to astrocytes, leading to oxidative stress, DNA breakage, and permanent mutations. This damage can contribute to brain malformations like microcephaly and potentially other neurological disorders.
A multi-institutional study found that neurofeedback training can alter guilt-related brain connections in patients with Major Depression Disorder, increasing self-esteem. After a single session, participants showed strengthened connectivity between specific brain areas and reported improved self-esteem.
A new study reveals that neurofeedback can strengthen neural connections and communication among brain areas in under 1 hour, paving the way for optimizing therapeutic approaches against stroke and Parkinson's. The technique showed increased integrity of the corpus callosum and strengthened neural networks controlling body movements.
Researchers at D'Or Institute improve human brain organoid cultivation protocol to display regionalized brain structures and retinal pigmented cells. The team's advancements aim to mimic later stages of brain development, enabling studies on neurological diseases and drug effects.
A new study published in Scientific Reports found that brain areas responsible for movement and sensation alter their functional communication after a limb amputation. Researchers discovered that sensitive and motor areas of the brain exhibited abnormal patterns of communication among hemispheres, even in patients without phantom pain.
Researchers from D'Or Institute and L'Oréal R&I successfully generated functional human sensory neurons that respond to painful stimuli. The breakthrough discovery has significant implications for the study of chronic pain, analgesic drugs, and the development of reconstructed human skin with enhanced neuro-inflammation predictivity.
Research elucidates the neural basis of complex altruistic behavior, discovering two brain circuits that govern moral decisions in war veterans. The study used CT scans and an altruistic decision task to map brain damage and behavior, finding correlations between specific brain areas and punishment or donation behaviors.
Researchers found that neural cells from schizophrenic patients produce less pro-angiogenic molecules and more anti-angiogenic proteins, impairing blood vessel formation. The study provides new insights into the causes of schizophrenia and potential therapeutic solutions.
A new study at D'Or Institute for Research and Education uses Magnetic Resonance machine to read participants' minds and identify the song they're listening to. The computer achieves 85% accuracy in identifying the correct song, paving the way for future research on brain decoding and communication.
Researchers used functional magnetic resonance imaging to investigate the neural basis of team-related altruism in soccer fans. The study found that brain areas involved in decision-making and values, such as the medial orbitofrontal cortex, showed increased activity when donations were targeted to fans of the same soccer club.
Researchers have identified changes in molecular signaling related to neural plasticity, inflammation and neurodegeneration triggered by the psychedelic substance 5-MeO-DMT. This study suggests that classic psychedelics may induce neuroplasticity and exert antidepressant effects.
Researchers found that combining CDKs' inhibitors with conventional anti-cancer drugs like cisplatin increases tumor cell death. However, treating cells with 5-FU can lead to decreased death rates and resistance. This study suggests a promising approach for developing new anti-cancer treatments.
A new study uses X-ray synchrotron radiation to analyze human minibrains, revealing the distribution of essential micronutrients such as phosphorus and zinc. The results show that these nutrients play a crucial role in brain formation and are related to memory deficits and psychiatric disorders like schizophrenia.
Researchers have found that Zika virus alters the expression of hundreds of genes responsible for guiding brain cell formation, leading to microcephaly. The study reveals new therapeutic targets by analyzing molecular interactions in infected brain cells.
Researchers found that harmine increases proliferation of human neural progenitor cells by inhibiting DYRK1A, leading to a 70% increase in new neural cell generation. This effect may lead to potential therapeutic applications for depression and neurodegenerative diseases.
Researchers found that diabetes causes a specific inflammation leading to heart arrhythmias. Two promising drugs inhibit this inflammatory process, reversing cardiac alterations in diabetic mice.
Researchers found that Zika virus congenital infection causes a range of brain malformations, including cortical malformations and ventriculomegaly. The study used CT, MRI, and ultrasound to assess pregnant women, fetuses, and newborns infected with the virus.
Researchers found daily meetings between physicians and intensivists, care protocols, and pharmacist presence are associated with increased survival rates among cancer patients in ICUs. These simple processes can reduce mortality by up to 70% and promote cost reduction.