Articles tagged with Targeted Drug Delivery
A new drug capsule developed at MIT may be able to replace injections for biologic drugs by tunneling through the mucus barrier in the small intestine. The capsule's robotic cap spins and displaces mucus, allowing drugs to pass into cells lining the intestine.
Researchers at the University of California San Diego developed microscopic robots called microrobots that can swim around in the lungs and deliver medication. The microrobots safely eliminated pneumonia-causing bacteria in mice, resulting in 100% survival rates, whereas untreated mice died within three days.
Scientists have successfully delivered a common blood pressure medication directly to the inner membrane of mitochondria, targeting energy-producing parts of cells. The new method uses the body's natural transport system to deliver drugs more precisely, potentially improving therapy efficacy and reducing negative side effects.
Researchers developed artificial microtubules to transport microscopic cargo along magnetic stepping stones, overcoming fluid flow obstacles. The technology could facilitate targeted drug delivery and treat blocked vessels or cancerous tumors.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers at Georgia Institute of Technology have developed a new screening technique called DNA barcoding, which accelerates the discovery of effective lipid nanoparticle carriers. The technique allows for simultaneous testing of many experiments and has improved nanoparticle pre-clinical screening.
Researchers from Osaka University have developed a system to coat nematodes with hydrogel sheaths that can carry functional cargo. The study found that the sheaths protect the worms from UV light and hydrogen peroxide while allowing them to deliver anti-cancer agents to kill cancer cells in vitro.
Researchers at Karolinska Institutet have successfully repurposed a cancer drug to target neuroinflammatory diseases like multiple sclerosis. A novel drug carrier was developed to deliver the treatment specifically to microglia, reducing inflammation and disease progression.
Researchers have developed biodegradable nanovesicles that efficiently encapsulate and deliver PARP1 siRNA to breast cancer tumors in mice, inhibiting oncogene expression and extending survival. The polymersomes, assembled from three biodegradable block copolymers, have strong potential for precision-targeted therapeutic carriers.
Researchers at Penn Medicine have developed an imaging agent that detects cancer cells in real-time during biopsies, offering promise for earlier and more accurate diagnoses. The technology, known as NIR-nCLE, uses a combination of near-infrared tracers and confocal laser endomicroscopy to identify microscopic cancer cells.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.
The new center aims to advance a groundbreaking combination of focused ultrasound and cancer immunotherapy, potentially revolutionizing cancer treatment. The partnership will focus on overcoming existing limitations of immunotherapy and expanding treatment options for various types of cancer.
Researchers at the University of Missouri are applying AI to analyze protein dynamics, identifying potential target sites for new drug therapies. The approach can simulate protein changes related to conditions like cancer, enhancing the chances of successful therapies.
A new nanofiber-based biodegradable millirobot called Fibot can move in the intestines and release different drugs at anchored positions. Fibot's degradation capability is pH-responsive, allowing for controlled drug release.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Researchers at NTU Singapore have developed a novel drug delivery system using protein-based microdroplets that can bypass the cell membrane and deliver biomacromolecules effectively. This breakthrough enables faster, safer, and more effective treatments for diseases such as cancer and metabolic disorders.
Researchers at the University of Bologna have developed a new targeted cancer therapy based on a genetically modified phage that selectively eliminates tumour cells. The virus is engineered to transport a drug activated by light to target tumour cells, reducing side effects.
A UC Riverside-led team developed a theory and performed simulations to understand how viruses package their genetic material. The research reveals that capsid proteins are inclined to form shells around viral RNAs due to lower stress distribution, which can aid in designing nanocontainers for drug delivery.
Researchers at the University of South Australia have developed a new way to deliver chemotherapy drugs, using liposomal formulations that target tumors more effectively. This breakthrough could improve treatment outcomes for thousands of cancer patients, reducing side effects and improving quality of life.
A new form of drug delivery microparticle mimics the properties of a red blood cell, enabling controlled release of drugs and targeting specific destinations. The goal is to bypass the body's filtration systems, allowing for improved efficacy and reduced negative side effects.
Scientists create a hybrid technology called heteroduplex oligonucleotide (HDO) that can safely and effectively silence disease-causing genes in certain immune cells. The HDO delivery method has shown promise in improving symptoms of autoimmune disorders and cancers by regulating the function of T and B lymphocytes.
Researchers have developed a low-cost, easy-to-use focused ultrasound device that can precisely target the mouse brain. The $80 device, created using a 3D printer, has been shown to achieve sub-millimeter targeting accuracy and improve drug delivery outcome.
Codiak BioSciences' exoASO-STAT6 demonstrates potent anti-tumor efficacy by reprogramming tumor-associated macrophages to an M1 phenotype, showing promise as a monotherapy candidate for hepatocellular carcinomas and other cancers. The company plans to initiate Phase 1 clinical trials in the first half of 2022.
Scientists at Tufts University create nanoparticles that carry genetic instructions to specifically target the lungs, reducing tumors in a preclinical model of a rare genetic lung disease. The breakthrough could lead to improved treatment options for patients with lymphangioleiomyomatosis.
Researchers have designed a nanoparticle system that can deliver fluorescent dyes to diagnose and treat pancreatic cancer tumors. The system overcomes the challenge of reaching cells deep within dense tumor masses, enabling detailed images of tumor structures and potentially targeted therapies.
Researchers successfully engineered mesenchymal stromal cells to carry and deliver therapeutics specifically to targeted tissues, offering a precise and reliable approach for treating diseases. This novel cargo-carrier, dubbed 'Cargocytes,' retains most of its cellular functionality while greatly enhancing therapeutic capacity.
Scientists develop hairy cellulose nanocrystals to capture and remove excess chemotherapy drugs from the blood. The nanocrystals effectively removed over 6,000 milligrams of doxorubicin per gram, increasing DOX capture by two to three orders of magnitude compared to existing methods.
The new method can boost the potency of drugs reaching their target, increasing the effectiveness of treatments and reducing side effects. With the potential to personalize treatment and optimize doses, this technology may eventually change the current dosage needed for patients.
Scientists at UC San Diego create nanoparticles that mimic the flu virus's ability to escape endosomes, enabling efficient delivery of mRNA into cells. This breakthrough could lead to improved delivery of mRNA vaccines and therapies.
Researchers have developed fish-shaped microrobots that can guide themselves to cancer cells using magnets, where a pH change opens their mouths to release chemotherapy. The microrobots demonstrate promising capabilities for targeted cancer treatment, but need further improvements in size and tracking methods.
A gene-silencing therapy harnessing nanoparticles called small extracellular vesicles (sEVs) for drug delivery has protected against Zika virus transmission in pregnant mice to the mouse fetuses. The treatment reduced fetal neurological damage, including virus-induced brain shrinkage.
Researchers have identified a new method for clearing senescent cells using an antibody treatment, which could transform treatments for ageing and related conditions. The treatment targets specific membrane markers on senescent cells, effectively eliminating them and slowing age-related degeneration.
Researchers at Cornell University have developed micro-robotic swimmers powered by high-frequency sound waves, which can propel tiny robots forward. The technology has potential for targeted drug delivery and could be used to navigate the human body.
Researchers at SpheroFill are developing a unique oral drug delivery platform using microsphere technology, protecting drugs from degradation and enabling targeted release. This technology has the potential to improve medication compliance and delivery of sensitive biological drugs.
A CRISPR screening tool identified ZMYND8, an epigenetic regulatory protein, as a potential new therapeutic target for acute myeloid leukemia. Inhibiting ZMYND8 has been shown to leave cancer cells with smaller tumors and better survival in mouse models.
This issue of Acta Pharmaceutica Sinica B features innovative research on pharmacologically targeting molecular motor for anti-cancer, novel PGAM5 inhibitor LFHP-1c protecting blood-brain barrier integrity in ischemic stroke, and a versatile tool for anchor pharmacophore steered drug discovery. Additionally, the journal publishes revie...
Researchers develop tiny tumbling robots called MANiACs that can climb slopes and move against fluid flow in the body, delivering substances to neural tissue. The study finds these robots have potential for controlled local delivery in neural diseases, offering targeted treatment with improved efficacy and reduced side effects.
Computational modeling reveals that smaller drug particles can reach the distal region of airways, improving treatment efficacy. The study aims to enhance inhaler design and reduce drug loss, benefiting patients with respiratory illnesses.
Researchers at Hokkaido University created a lipid polymer that can carry genetic code into lung cells, potentially treating diseases such as acute respiratory distress syndrome and lung cancers. The delivery method bypasses the liver and targets specific lung cells without targeting ligands.
Researchers developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where needed. The study showed complete treatment of inflammation in mice, at a drug concentration where standard delivery methods were ineffective.
A new study from the University of Technology Sydney models how coronavirus aerosols travel through our lungs, revealing that more than 65% of particles reach the deepest region where damage can occur. The research also shows that the right lung is more affected by virus deposition due to its asymmetrical anatomy.
Researchers at NUS have created a new class of intelligent materials that can adapt their properties depending on changes in their surroundings. These smart materials show promise for targeted drug delivery and could also be used in artificial muscles and energy storage applications.
Researchers have discovered that nanoparticles containing chemotherapy drug Capecitabine can attach to diseased cells, bypassing healthy ones and reducing toxic side effects. This targeted delivery system has shown promising results in animal experiments, improving cancer treatment outcomes.
Scientists have developed novel multi-stimuli-responsive drug delivery systems using hydrogels that can release drugs in response to temperature, pH, and reducing conditions. The hydrogels can control the amount of drug loaded onto them, ensuring effective delivery to target tumor sites.
Researchers from MIPT and ITMO University have created a system for controlled formation of melamine cyanurate crystals, which can be used to deliver drugs directly to specific tissues in the human body. The discovery opens up new possibilities for targeted drug delivery technology.
Researchers developed a metal organic framework (ZIF) that improves the delivery and sustained release of cancer immunotherapy drugs like nivolumab, targeting leukemia cells with minimal toxicity. Coating ZIF with a cancer cell membrane enhances accurate delivery to solid tumors.
Researchers developed more efficient magnets to control magnetic nanoparticles for targeted drug delivery. Non-symmetrical magnet combinations showed almost ten times stronger magnetic force than regular cylindrical magnets, which could potentially apply to humans too.
A new treatment approach and delivery vehicle has been developed to reverse botulism paralysis in mice, showing promise for treating other neurological disorders. The therapy uses a detoxified botulinum toxin as a delivery vehicle for a mini-antibody derived from camels.
Researchers at Kanazawa University demonstrate the ability to reversibly control the emission of blue-green light from water-soluble tetraphenylethene molecules on artificial cell membrane surfaces. This controlled emission has potential applications in new biological sensors and smart drug delivery platforms.
A new molecular concept dubbed 'range selectivity' allows for targeted drug delivery to diseased cells with high specificity, reducing side effects. By identifying specific receptor densities, researchers can develop nano-sized drug carriers that attach only to diseased cells.
Researchers have developed a reagent for selective and safe coating of the liver sinusoidal walls to control clearance of gene therapy drugs. The coating agent improved gene transfer efficacy by 2-4 times to the myocardium and skeletal muscles, and 10 times to colorectal cancer, reducing medical costs and adverse effects.
Advances in nanoparticles as anticancer drug delivery vectors offer improved targeting efficiency and non-toxicity. The use of external and internal stimulating factors enhances the efficacy of nanopolymer-based platforms, making them ideal for personalized medicine.
Scientists at Peter the Great Saint-Petersburg Polytechnic University create a method of targeted drug delivery to cancer cells using microcapsules made of polymeric compounds and gold nanorods. The technology allows for precise treatment of tumors without harming healthy tissues.
Researchers at Cornell University have developed a technique using fluorescent probes to study the performance of molecules inside living cells. The probes can accurately measure the rate at which linkers release drugs in cells, enabling pharmaceutical companies to make informed decisions about drug delivery systems.
Researchers use deflating beach balls to model microscopic hollow spheres, revealing properties that could aid in targeted drug delivery. This understanding may help control directed motion and improve cancer treatment.
Researchers at UT Austin have developed multifunctional nanogels that can deliver drugs to treat cancer in a precise manner. The nanogels can be chemically modified with bioactive molecules, allowing them to target malignant cells and degrade into nontoxic components.
A WSU researcher has created a new technology that harnesses the immune system to target diseased tissues, improving drug delivery and reducing side effects. The technology uses neutrophils to deliver drugs directly to inflammatory sites, showing promise in treating acute lung injury and potentially other diseases.
Researchers developed a novel technique using transcranial ultrasound and microbubbles to open the blood-brain barrier, enabling drugs to penetrate the brain and restore dopaminergic pathways. The method has been approved by FDA for clinical trials in Alzheimer's patients and shows promise for treating Parkinson's disease at early stages.
Researchers analyzed methods of targeted drug delivery to malignant tumors, exploring passive targeting, active targeting, and cell-mediated targeting. By understanding tumor structure and metabolism, scientists can develop personalized treatment approaches to increase efficiency and reduce side effects.
Researchers at UNIST developed a novel targeted drug delivery system using protein corona shield, achieving 10 times greater therapeutic efficacy in preventing unwanted protein adsorption. The system demonstrated lower toxicity and excellent tumor-targeting ability in mouse models of cancer.