Articles tagged with Targeted Drug Delivery
Researchers developed a prodrug delivery method using a commensal Lactobacillus strain that binds specifically to cancer cells, releasing the chemotherapy drug SN-38 directly at the tumour site. This approach reduces tumour growth by 67% and increases chemotherapy drug effectiveness by 54% in preclinical models of nasopharyngeal cancer.
A new alpha-ray therapeutic agent ([At-211] PSMA-5) has been developed to target prostate-specific membrane antigen (PSMA) in refractory prostate cancer patients. The therapy has shown efficacy in animal models and is now being tested in a first-in-human clinical trial.
Scientists have discovered the transporters responsible for delivering essential nutrients choline and ethanolamine to human cells. The study sheds light on the atomic structure of these transporters and their role in distributing micronutrients throughout the body, providing a foundation for new therapeutic approaches.
A new study published in Nature Biomedical Engineering shows that targeted cancer treatment using antibody-displaying extracellular vesicles reduces tumour growth and improves survival in mice. The treatment has the potential to be used against other diseases and cancer types, offering a more effective and fewer side effects compared t...
Researchers from Osaka University have discovered a way to deliver antisense oligonucleotides to their targets inside cancer cells by opening specific calcium permeable channels. The new compound, L687, promotes efficient uptake of ASO into cancer cells, suppressing target gene activity and enhancing ASO efficacy.
A large observational study of 148,000 individuals with ADHD found that initial dispensation of ADHD medication was associated with lower all-cause and unnatural-cause mortality. The association with natural-cause mortality was not significant in this study.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have invented a new way to synthesize key components of lipid nanoparticles, simplifying their manufacture while boosting efficacy. The new method involves combining three chemicals to create branched lipidoids that promote mRNA delivery to target c...
A novel chemotherapy approach uses patient's own cells as Trojan horses to deliver targeted cancer-killing drugs to lung cancer cells. The method has shown promise in reducing tumor size and improving treatment efficacy with minimal collateral damage to healthy tissues.
A new study aims to enhance and prolong vaccine effectiveness by delivering adjuvants to white blood cells using lipid nanoparticles. The research, led by WVU professor Sharan Bobbala, has the potential to provide broader protection against evolving viruses and multiple diseases.
Researchers at São Paulo State University developed a novel technique using lipid nanoparticles to administer lupeol, killing Leishmania protozoan parasites. The therapy eliminated parasites from organs in animal tests, reducing spleen and liver parasite numbers by 99.9% with minimal side effects.
Researchers develop nanovector nanogels that selectively target glial cells involved in spinal cord injury inflammation, reducing damage and improving recovery. The treatment demonstrates potential for modulating glial cells in neurodegenerative diseases like Alzheimer's.
Researchers have developed a needle-free ultrasound vaccine delivery technique that produces a higher immune response than traditional methods. By harnessing acoustic energy to clear passages and drive drug molecules into cells, the approach shows promise in reducing costs and increasing efficacy while minimizing risks.
Temperature-sensitive emulsions offer a new method to control when droplets dissolve, enabling precise targeting of medicines to specific areas in the body. The discovery could revolutionize methods of delivering medication in higher concentrations to diseased areas.
Scientists have developed a drug-eluting hydrogel that provides sustained, pH-dependent drug co-delivery and promotes anti-tumor immune responses, reducing tumor cell proliferation and growth. The treatment shows promise in treating hepatocellular carcinoma, with enhanced efficacy compared to traditional methods.
Researchers developed a flexible new platform that solves part of the daunting delivery problem in cell and gene therapies. The workhorses behind this platform are extracellular vesicles, which bind to target cells and effectively transfer drugs inside.
Researchers at the University of California San Diego have created modular nanoparticles that can be tailored for various applications, including targeted drug delivery and neutralizing biological agents. By leveraging a plug-and-play approach, scientists can rapidly modify functional biological nanoparticles with ease.
Researchers developed a nanotechnology method to deliver medication through the blood-brain barrier, overcoming its selectivity and expanding therapeutic options for glioblastoma treatment. The technique demonstrated improved tumor shrinkage and survival rates in mice, paving the way for further preclinical studies.
A novel biomaterial developed at the Federal University of São Paulo can deliver medication directly to the gastrointestinal tract of fish, enhancing the efficacy of conventional drugs. The material is administered orally in powder form and has shown high penetration into epithelial cells without cytotoxic effects.
The team created a proof-of-concept nanocapsule capable of delivering specific payloads to targeted locations, with potential applications in drug delivery, nutrient transport, and other fields. By using calcium metal ions as building blocks, they can generate identical reservoirs for different substances.
Researchers at the University of California San Diego have developed nanoparticles that can deliver pesticide molecules to soil depths previously unreachable, targeting root-damaging nematodes. The technology holds promise for enhancing treatment effectiveness while minimizing costs and environmental toxicity.
A Brown University team developed a hydrogel-based delivery system that balances tumor acidity and increases doxorubicin's effectiveness against cancer cells. Initial lab tests show promising results, paving the way for pre-clinical trials.
Researchers at UniSA develop nanocarriers to deliver the antibiotic Narasin to acne-prone areas, demonstrating a 100-fold increase in absorption compared to traditional treatments. The findings have significant implications for treating drug-resistant acne and improving treatment outcomes.
A randomized trial published in The Lancet Oncology found that condensing prostate beam scanning proton therapy for breast cancer patients can result in similar control of the cancer while sparing surrounding normal tissue. The study demonstrated excellent outcomes, with reduced skin side effects and comparable complication rates.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers developed a liver-targeting drug that reversed obesity and lowered cholesterol in obese mice by delivering the drug via nanogel. The treatment, which was administered intraperitoneally, effectively normalized weight and reduced cholesterol levels despite continued high-fat diet consumption.
Researchers at Binghamton University have developed genetically engineered nanovesicles that can target cancer cells more effectively than traditional chemotherapy. These nanocarriers can deliver therapeutic agents directly to the interior of cancer cells, reducing harm to healthy cells and increasing treatment efficacy.
Scientists create optically controllable liposomes called LiDLs, which can selectively release contents inside cells upon exposure to acidic pH induced by green light. The researchers demonstrated that LiDLs efficiently deliver substances without causing side effects, showcasing exceptional extracellular stability.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
A team of researchers at Johannes Gutenberg University Mainz studied the collective behavior of small robots and found that they can solve tasks that a single machine cannot. The study uses statistical physics to analyze how the robots interact and move, revealing potential applications in medical and pharmaceutical applications.
Researchers create patch that uses ultrasound to deliver drugs directly to the site of need, reducing systemic toxicity and improving local drug delivery. The device shows promise for treating a range of skin conditions and could also be adapted for hormone delivery and cancer treatment.
Researchers at Tokyo Medical and Dental University have found that a specific lipid, alpha-tocopherol, increases the uptake of antisense oligonucleotides in the stroke-lesioned brain. This delivery method has potential for targeted protein expression after a stroke.
Researchers from the University of Cambridge have built a super-sized nanocage that could deliver larger drug cargoes, outperforming existing nanocages in terms of internal volume and stability.
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
Researchers have developed a novel 3D covalent organic framework, TUS-64, with the largest pore size and lowest density ever recorded. The material shows promise as a drug nanocarrier vehicle, with high capacity to hold drugs and sustained release rate.
A research team from HKUMed developed thyroid hormone (TH)-encapsulated nanoparticles that selectively target adipose tissues, reducing obesity-related metabolic complications and atherosclerosis. The treatment converts 'bad' white fat to 'good' brown fat, burning calories and alleviating hypercholesterolemia.
Researchers found that adding immunotherapy before surgical removal of stage III-IV melanoma significantly improved event-free survival compared to standard-of-care treatment. The study showed that neoadjuvant therapy is superior to the same therapy given in the adjuvant setting.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
Scientists at the University of Illinois Chicago have found a way to selectively degrade disease-causing proteins in specific parts of cells. By studying the movement of enzymes inside cells, they discovered that attaching or detaching a fat molecule can direct where these enzymes go.
Patent thickets and evergreening strategies hinder generic competition, leading to higher brand name drug prices. Generic entry can drop prices by 90%, affecting patient welfare. Patent expert Sean Tu advocates for a balanced patent system that promotes innovation while preventing monopolies.
Researchers have engineered a family of adeno-associated viral vectors that can deliver cargo to the primate brain, offering a safer and more efficient way to treat genetic diseases. The PAL family of AAVs has been shown to be three times better at delivering their cargo into the brain than current leading AAV delivery vehicle AAV9.
Researchers from SMU and ARA demonstrate that chemical coatings alter microparticle propulsion in biological fluids. The study offers new approaches to drug delivery strategies by designing specialized surface coatings for precise navigation.
Kevin McHugh, a Rice bioengineer, has received the Distinguished Scientist Award from The Sontag Foundation for his work on gene editing to defeat glioblastoma multiforme. His approach involves delivering gene therapy agents directly to tumor cells, aiming to improve survival and reduce side effects.
A novel radiopharmaceutical treatment targeting prostate-specific membrane antigen effectively shrinks prostate tumors in mice, with minimal impact on major organs. Researchers plan to launch a clinical trial for refractory prostate cancer patients in two years.
The platform enhances neurosurgical procedures by delivering precise treatment and diagnosis in deep brain tissue. Researchers successfully implanted the catheter in live sheep without damage or infection, paving the way for potential human trials within four years.
A new approach combines an immunotherapy agent with a molecular delivery system that targets tumor acidity, successfully eradicating colorectal tumors in mice. The researchers believe this method may increase the effectiveness of STING agonist therapy for cancer patients.
Researchers develop autonomous navigation strategies for microswimmers, allowing them to navigate optimally in complex environments. These strategies utilize external stimuli, such as light, to guide the microswimmers and improve their performance.
Rescue Biomedical's technology detects opioid overdoses and delivers naloxone to reverse them. The NIH grant will help the company complete milestones, including regulatory approval and scaling up manufacturing.
A new drug capsule developed at MIT may be able to replace injections for biologic drugs by tunneling through the mucus barrier in the small intestine. The capsule's robotic cap spins and displaces mucus, allowing drugs to pass into cells lining the intestine.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers at the University of California San Diego developed microscopic robots called microrobots that can swim around in the lungs and deliver medication. The microrobots safely eliminated pneumonia-causing bacteria in mice, resulting in 100% survival rates, whereas untreated mice died within three days.
Scientists have successfully delivered a common blood pressure medication directly to the inner membrane of mitochondria, targeting energy-producing parts of cells. The new method uses the body's natural transport system to deliver drugs more precisely, potentially improving therapy efficacy and reducing negative side effects.
Researchers developed artificial microtubules to transport microscopic cargo along magnetic stepping stones, overcoming fluid flow obstacles. The technology could facilitate targeted drug delivery and treat blocked vessels or cancerous tumors.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers at Georgia Institute of Technology have developed a new screening technique called DNA barcoding, which accelerates the discovery of effective lipid nanoparticle carriers. The technique allows for simultaneous testing of many experiments and has improved nanoparticle pre-clinical screening.
Researchers from Osaka University have developed a system to coat nematodes with hydrogel sheaths that can carry functional cargo. The study found that the sheaths protect the worms from UV light and hydrogen peroxide while allowing them to deliver anti-cancer agents to kill cancer cells in vitro.
Researchers at Karolinska Institutet have successfully repurposed a cancer drug to target neuroinflammatory diseases like multiple sclerosis. A novel drug carrier was developed to deliver the treatment specifically to microglia, reducing inflammation and disease progression.
Researchers have developed biodegradable nanovesicles that efficiently encapsulate and deliver PARP1 siRNA to breast cancer tumors in mice, inhibiting oncogene expression and extending survival. The polymersomes, assembled from three biodegradable block copolymers, have strong potential for precision-targeted therapeutic carriers.
Researchers at Penn Medicine have developed an imaging agent that detects cancer cells in real-time during biopsies, offering promise for earlier and more accurate diagnoses. The technology, known as NIR-nCLE, uses a combination of near-infrared tracers and confocal laser endomicroscopy to identify microscopic cancer cells.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.
The new center aims to advance a groundbreaking combination of focused ultrasound and cancer immunotherapy, potentially revolutionizing cancer treatment. The partnership will focus on overcoming existing limitations of immunotherapy and expanding treatment options for various types of cancer.