Adenine Nucleotides | Topics

Characterizing antibodies targeting antisense oligonucleotide modifications

Researchers validated panels of antibodies targeting clinically relevant nucleic acid modifications to visualize antisense oligonucleotides in both in vitro and in vivo studies. The tools enable detection of modified nucleic acids irrespective of sequence, facilitating multiple clinical and pre-clinical workflows.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalNucleic Acid Therapeutics·TypeExperimental study·DateJul 31, 2025

A better understanding of how gene editing tools work

Researchers discovered that a ligase called Lig3 inhibits base editing, while the mismatch repair pathway helps cytosine base editing. The study sheds light on the complex mechanisms behind base editing and its potential applications in treating genetic diseases.

SourceUniversity of California - San Diego·JournalNature Communications·TypeExperimental study·DateJun 4, 2025

Energy crisis in kidney cells

A new study published in Nature Communications reveals that energy imbalances in podocytes contribute to kidney damage and proteinuria after ischemia-reperfusion injury. The researchers found that interventions targeting mitochondrial dynamics held promise in alleviating foot process effacement and improving podocyte outcomes.

SourceInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University·JournalNature Communications·TypeExperimental study·DateDec 3, 2024