Articles tagged with Amino Acid Sequences
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Johns Hopkins Medicine found that the location of rhomboid proteases within membranes enables them to recognize and cut unstable proteins. This discovery has profound implications for understanding diseases like Alzheimer's and developing treatments.
Researchers developed a new method called HHblits that surpasses PSI-BLAST in performance by increasing sensitivity and precision. By analyzing similar sequences, scientists can infer the structure and functions of proteins more accurately and frequently than before.
Studies using single-molecule fluorescence reveal that neighboring protein domains with similar amino acid sequences are more prone to misfold, potentially leading to neurodegenerative diseases. This finding suggests that proteins have evolved to limit similarity between domains to prevent misfolding and maintain functionality.
Researchers at UCLA have made a breakthrough in controlled engineering of nanocatalysts by using surfactants and biomolecules to produce predictable shapes. This innovation has the potential to improve catalytic properties and lead to more efficient energy production and reduced pollution.
Researchers isolated an enzyme from Arabidopsis thaliana that catalyzes glucosinolate formation and found it resembles an enzyme involved in leucine synthesis. This structural similarity enabled the plant to produce toxic compounds as a defense mechanism, highlighting the importance of small genetic changes in evolutionary adaptations.
Researchers at Arizona State University have developed synthetic antibodies that can be used for diagnostic tools. By optimizing binding affinity using random peptide sequences, these synbodies show promise in detecting diseases early on.
Researchers use temperature jump and fast chemical reaction to capture protein folding process, providing detail needed for accurate predictions. The new method offers hope for improving protein structure predictions, which are crucial for medicine and biotechnology.
Researchers create genetic sequences never seen in nature and produce substances sustaining life in cells almost as readily as natural proteins. The team's work represents a significant advance in synthetic biology, suggesting the construction of artificial genomes capable of sustaining cell life may be within reach.
Scientists have developed a bioinformatics strategy to predict membrane protein structures, which are underrepresented in existing databases. Using this approach, researchers successfully determined the tertiary structure of a bacterial membrane protein and predicted the structure of a plant membrane protein.
Researchers at Arizona State University have developed a method to create synthetic antibodies that can bind with human proteins with high affinity and specificity. This technique, called synbody construction, involves combining random amino acid sequences to form a binding molecule that can target specific proteins.
Researchers discovered that adding proline and phenylalanine amino acids improves binding rates of synthetic fibrin knobs to holes, leading to a novel peptide mimic with 10-fold higher affinity. The study also identified structural properties contributing to functional knob-hole interactions.
A new study by researchers at the University of Michigan found that echolocating bats and whales share a similar molecular mechanism for this ability, overturning conventional thinking on convergence. The research focused on the prestin gene, which plays a crucial role in hearing and amplifying sounds.
Researchers discover unique structure in viral protein Rev, allowing it to penetrate nucleus and nucleoli. This finding opens new avenues for studying the relationship between protein localization and host cell impact.
A team of Penn biochemists designed a simple and robust oxygen-transporting protein using design principles inspired by nature. They successfully created the protein, which can transport oxygen, using a set of simple design principles.
Researchers Johannes Soeding and Andreas Biegert have developed a new method called CS-BLAST that takes into account the sequence context to improve similarity searches. This approach can identify twice as many distant relatives of proteins compared to traditional BLAST, leading to better insights into gene and protein functions.
Researchers have developed a new method to reconstruct the evolutionary history of the HIV-1 V3 loop, revealing biologically dependent amino acids that form 'co-evolving' ties across the protein. This study advances understanding of HIV-1 evolution and identifies potential targets for future research.
Researchers discovered that abnormal glutamine repeats interfere with key transcription factor TBP, leading to neurodegeneration in PolyQ diseases. The study provides insight into the molecular mechanisms underlying these inherited disorders.
Scientists have developed a novel approach to probing protein folding energy, revealing the slope and height of the energy barrier proteins must overcome. This method has the potential to shed light on how amino acid sequences affect protein function and how diseases arise from misfolding.
A team of researchers has developed a computational approach to accurately predict the function of proteins with unknown structures and functions. By comparing amino acid sequences to known proteins, they can identify potential substrates and understand the protein's biological role.
Researchers at Arizona State University have evolved new proteins in a fraction of the time it took nature, providing new lessons on how to optimize proteins. The team used 'synthetic evolution' to improve protein stability and binding efficiency, discovering that subtle amino acid changes can significantly enhance function.
A team of scientists led by Dr. Mary Schweitzer confirmed the presence of original protein fragments in soft tissue from a 68 million-year-old Tyrannosaurus Rex fossil. The discovery uses mass spectrometry to analyze ancient proteins, providing new insights into fossil preservation and potential medical applications.
Researchers have successfully sequenced tiny pieces of collagen protein from a 68 million-year-old Tyrannosaurus rex fossil, closely matching amino acid sequences found in present-day chickens. The findings support the long-debated proposal that birds and dinosaurs are evolutionarily related.
Recent breakthroughs have enabled researchers to construct an atom-by-atom model of the ribosome, a complex molecular machine responsible for synthesizing proteins. The high-resolution images reveal detailed interactions between the ribosome, messenger RNA, and transfer RNAs, providing new insights into protein synthesis.
Researchers found that a slight difference in protein shape allows dioxin to bind more easily, triggering harmful effects. A test using molecular analysis could help assess dioxin sensitivity in wild animal populations.
A new study by researchers at Case Western Reserve University has found that an abnormal form of the prion protein from one mammal species can infect another species, bypassing natural barriers. This discovery sheds light on the mechanisms behind prion diseases like mad cow disease and Creutzfeldt-Jakob disease.
Scientists have identified amino acid sequences that allow prions to aggregate and replicate, leading to the creation of an artificial yeast prion. This breakthrough sheds light on the mechanisms behind diseases like mad cow disease and Alzheimer's, potentially paving the way for new treatments.
Scientists successfully designed and built an artificial protein using a novel computational approach, opening up new possibilities for medicine and industrial applications. The achievement represents a significant breakthrough in understanding protein folding and design.
Researchers at UCSD have identified two peptide sequences that bind to abnormal beta-amyloid plaques in Alzheimer's disease. The peptides may be used for diagnostic tests or coupled with molecules to inhibit plaque toxicity, making them a promising new approach to the disease.
Researchers use high-speed imaging to track movement of calcium waves in cell signaling, identifying a sequence of amino acids (LTL) that controls the pathway. The findings have implications for treating autoimmune diseases such as arthritis and uveitis.
Researchers will use computational biolinguistics to analyze protein sequences and understand their structure, dynamics, and function. This project aims to extract information from gene sequences that may lead to developing drugs to fight degenerative diseases.
Researchers at JCI Journals have made significant strides in understanding the biological function and clinical relevance of copolymers. The study's findings hold promise for developing new treatments for various human diseases.
Scientists have identified a protein segment responsible for fibrous tissue growth leading to liver cirrhosis. They've developed a mutated version of the protein that blocks this process in mice, offering potential new hope for treating liver diseases.
Researchers at Brown University have developed a new way to sequence DNA that is faster and more efficient than current methods. By inserting gaps into DNA probes, they can extract substantially more information about the DNA, allowing for the sequencing of tens of thousands of bases.
Scientists create first bi-directional molecular motor by changing a single amino acid, disrupting the sense of direction in another. The discovery opens up new possibilities for understanding diseases caused by incorrect chromosome distribution during cell division.
Scientists from Max Planck Institute report correlation between impaired RNA editing and epilepsy. Genetic manipulation in mice reveals that correcting the defect can lead to improved brain function and reduced seizures. The study suggests a potential link between human genome sequence and neurological disorders.
Researchers have identified a structural anomaly in the Taq DNA polymerase enzyme that hampers its performance in DNA sequencing. By modifying this anomaly, scientists created an improved version of the enzyme, which increases sequencing speed and reduces errors.
Researchers at University of Wisconsin-Madison found that amino acids must attach to transfer RNA (tRNA) in the nucleus for efficient delivery out of the nucleus. This quality-control process, known as proofreading, ensures genetic instructions are complete and ready to function.
Researchers have developed molecular sensors that can detect specific proteins in blood plasma or other biological fluids with high accuracy. The sensors could also be used to construct an environmental detector, giving new insights into cell functioning and promoting medical diagnostics.
A new software developed by Ohio University researchers reduces amino acid sequence misidentification rates by at least twice, combining human intelligence with automated systems. The software aims to minimize time spent on identifying protein sequences, improving accuracy and efficiency in biochemistry research.