A new analysis linked short-acting calcium channel blockers to a twice increased risk of breast cancer in postmenopausal women. However, longer-acting varieties were not found to have the same association.
A meta-analysis of 98 studies found that sustained-release and extended-release formulations of nifedipine are safe when used in combination with diuretics or beta blockers. However, patients taking short-acting nifedipine were more likely to experience adverse side effects.
High blood pressure can lead to enlargement of heart cells and a silent defect in the heart's pumping mechanism. The researchers found that this defect reduces contraction in each heart cell, contributing to heart failure. Developing novel treatments may be possible with improved understanding of the molecular defects.