Articles tagged with Collagen
Researchers at NIH have discovered a gene responsible for a previously unexplained, fatal form of Osteogenesis Imperfecta. The CRTAP gene plays a crucial role in collagen production and is found to be nonfunctional in patients with this rare disorder, leading to deformed brittle bones.
A new mathematical model explains the distinctive structure of collagen, a material key to healthy human bone, muscles, and tissues. The model shows collagen's structure from the atomic to the tissue scale, providing insights into its high extensibility and strength.
A team of researchers has identified a new genetic mutation responsible for osteogenesis imperfecta (OI), a condition that makes bones more likely to break. The study found that mutations in the CRTAP gene reduce the ability of a protein involved in collagen formation, leading to weaker bone and increased risk of fracture.
A newly identified gene mutation in the CRTAP gene helps explain a subset of osteogenesis imperfecta (OI) cases, where bones break easily due to abnormal collagen protein modification. The finding may also offer clues to as-yet-undescribed connective tissue diseases and provide insight into collagen formation.
Injectable fillers can combat aging around the lips and mouth, but not all are created equal, with some carrying a higher risk of complication depending on targeted area. Hyaluronic acid fillers are considered superior for inner lip augmentation due to their short-term results.
Researchers in Germany have developed a new, non-invasive technique to measure skin aging using a laser-based method. The technique measures collagen and elastin levels by a single factor, providing a quantitative assessment of skin health.
A genetic variant in the SERPINH1 gene has been identified as a potential cause of premature delivery in African-American women. The variant reduces collagen production, making membranes more prone to rupture. This discovery may help physicians identify high-risk patients and prevent serious pregnancy complications.
In the absence of MT1-MMP, preadipocytes fail to break through extracellular matrix, disrupting fat cell development. However, MT1-MMP is essential for remodeling the surrounding matrix to facilitate normal fat formation. The enzyme may also regulate collagen in white adipose tissue and act as a protein-degrading rheostat.
Researchers at U-M's Life Sciences Institute discovered that the MT1-MMP gene regulates fat cell size and metabolic gene expression. In three-dimensional environments, the gene plays a critical role in adipocyte development, potentially leading to novel therapeutics for obesity prevention.
Researchers found that lampreys, long thought to be evolutionary outliers, use the same essential protein to build cartilage as all other vertebrates, including humans. The discovery sheds light on the early origins of vertebrate skeletal development and challenges traditional views on vertebrate evolution.
A team of scientists from the University of Wisconsin-Madison reports a breakthrough in making human collagen in the lab, opening doors for medical applications and nanotechnology. The new discovery enables the creation of synthetic collagen that can be tailored for specific uses, including wound healing and implantable sensors.
A study found that chemical modification of Type II Collagen creates a self-antigen, leading to immune system activation in rheumatoid arthritis patients. The modification of this protein contributes significantly to the disease's progression.
Researchers have developed diamond-like carbon coatings for medical implants, reducing friction and corrosion while providing biocompatibility. The new method of coating plastics, metals, and collagen enables the production of harder-wearing implants and enhances patient outcomes.
Researchers have developed a method to modify collagen, allowing it to be used in new medical treatments such as preventing blood clots and scar tissue. The modified collagen can also be used to deliver drugs and control the shape of engineered tissue.
Research reveals that nitrite is a potent inhibitor of ischemia/reperfusion injury in the liver and heart, limiting cell death and preserving organ function. Additionally, adipocyte-derived collagen VI promotes early tumor growth in breast cancer, while EBV proteins drive immune responses in multiple sclerosis.
Researchers found that collagen VI from adipocytes stimulates the proliferation and survival of malignant cells in breast tumors. The study suggests a potential link between increased adiposity and breast cancer risk, highlighting the role of extracellular matrix proteins in tumor behavior.
Researchers found that mice lacking type VI collagen developed osteoarthritis at a rate five times greater than those with a functioning gene. The study provides new insights into the role of type VI collagen in cartilage health and its impact on osteoarthritis development.
Research identifies DDR2 as critical signaling molecule in osteoarthritis progression, leading to increased MMP-13 expression and cartilage degradation. The study suggests that DDR2 inhibitors may slow down osteoarthritis progression, offering a potential new approach for treatment.
A new study suggests that resveratrol in red wine can prevent the excessive production of collagen in heart cells, leading to a stiffening of the heart muscle and reduced blood pumping efficiency. Drinking moderate amounts of red wine may offer protective effects against hypertension and heart failure.
A multi-disciplinary team at SUNY Buffalo designed fibrin gel matrix-based vessel ready for test transplantation after only two weeks in culture, exhibiting remarkable remodeling and physiological levels of blood flow. The study holds significant promise for treatment of vascular disease and as a model system to address questions with ...
Researchers discovered that MMP-1 operates as an extracellular molecular motor converting chemical energy into motion by breaking collagen bonds. This process contributes to tissue growth, development, and repair, and may even aid in cancerous invasion.
A study found that women with pelvic floor disorders have lower collagen levels in their cervix, regardless of other factors. This intrinsic factor may contribute to these problems, and further studies aim to develop predictive measures.
A new study found that Actonel maintained the size of calcium-based mineral crystals and the integrity of collagen structure over five years, preserving bone quality. This is significant because osteoporosis therapies should aim to reduce fracture risk, not just treat symptoms.
Researchers used second-harmonic generation to image tumors in mice, revealing that collagen levels correlate with tumor permeability. The study suggests that a hormone called relaxin could selectively break down tumor-matrix collagen, improving drug delivery to cancer cells.
A Texas Agricultural Experiment Station scientist has developed a method of producing collagen and other health-related proteins from plants, replacing human or animal sources. The process involves introducing collagen proteins into sugarcane callus, transforming the cane to produce both sugar and collagen protein in cane stems.
A study by Mirjam Smeets reveals that haptoglobin inhibits collagen breakdown and improves cell migration in damaged blood vessels. This discovery may lead to the development of drugs to prevent rehospitalization for patients after percutaneous angioplasty.
USC researchers have successfully used gene therapy to prompt mouse cells to produce human collagen, a crucial step towards treating patients with dystrophic epidermolysis bullosa. This breakthrough could lead to the development of new treatments for this debilitating skin condition, which causes blisters and permanent scars.
Researchers found that collagen in bone contains sacrificial bonds that rupture when stretched and reform when healed, allowing bones to recover quickly. The study suggests these bonds may contribute to the toughness of bone and could have implications for human health and technology.
Researchers found that a specific mutation in collagen II affects the interaction with another collagen, leading to cartilage damage and osteoarthritis progression. The study's results provide insight into how mutations in collagen genes contribute to the disease.
Research has identified DDR2 as a key player in the development of hepatic fibrosis, a liver disease characterized by excessive scar tissue buildup. High levels of DDR2 expression have been linked to advanced fibrosis and poor patient outcomes.
A novel drug ALT-711 snips vascular collagen bonds, improving flexibility and reducing systolic blood pressure in older non-human primates. The treatment also increased blood flow through the heart, with effects persisting for over a year after administration.
Jefferson scientists discover that blocking a protein affects collagen gene expression in both normal and scleroderma cells, offering new hope for treating the disease. The findings suggest that therapeutic compounds may be developed to inhibit this pathway and reduce collagen production.
Researchers discover byssal threads in marine mussels, which feature a mix of collagenous and elastin-like properties. The unique structure of these threads may inspire the development of biomimetic materials with improved stretchiness and toughness.
Researchers discovered a genetic mutation in people with Alport syndrome prevents normal transformation process in collagen proteins, leading to gradual loss of membrane integrity. The mutation affects production of alpha-5 collagen, resulting in breakdown of critical glomerular basement membrane.