Articles tagged with Collagen
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Researchers discovered that cathepsins, involved in various diseases, may attack each other, reducing degradation of critical proteins like collagen. This phenomenon could explain the failure of current drugs to inhibit cathepsin activity.
Researchers used bovine collagen to enhance gum healing around exposed roots, resulting in thicker margins and complete coverage of roots in over half the cases. The study found that the collagen acted as a scaffold for the body's own cells to repair damage, making it a possible solution for patients with limited donor tissue.
A new device, designed to mimic the periosteum, has shown promising results in healing critical-sized bone defects in sheep. The device delivers stem cells, growth factors, and natural components of the periosteum to promote bone growth, and can be used for a range of applications beyond bone healing.
Collagen crosslinking treatment using riboflavin (vitamin B) has improved vision in nearly 70% of patients with keratoconus, according to a recent three-year clinical trial. The treatment addresses the underlying causes of the disease and provides a permanent solution.
Researchers at UC Berkeley have developed a self-templating material assembly process using a harmless virus to mimic the formation of complex structures from helical macromolecules like collagen. The technique allows for control over the type of pattern formed, enabling the creation of materials with diverse functions.
Researchers at Rice University have developed a new method to create synthetic collagen, which forms from a liquid in just an hour and has properties similar to native collagen. The material may be used as a scaffold for regenerating tissues and organs using stem cells.
Research reveals age-related degradation of bone's intrinsic and extrinsic toughness. Biological aging increases collagen cross-linking, osteonal density, and micro cracking, compromising fracture resistance.
Researchers have successfully produced synthetic collagen in maize with similar levels of proline hydroxylation to human collagen. This breakthrough enables the production of a protein with human-like modifications, making it suitable for various applications in reconstructive and cosmetic surgery, as well as the food industry.
Researchers at Ames Laboratory discovered citrate plays a crucial role in the nanostructure of bones, providing stiffness and preventing crack propagation. Higher citrate concentrations result in thinner apatite nanocrystals, which are more resistant to brittleness.
A study presented at The Endocrine Society's annual meeting found that women with worse facial wrinkles during early menopause tend to have lower bone density. This association was independent of age and body composition, suggesting a potential link between skin health and bone quality.
Dr. Mala S. Mahendroo will investigate biological mechanisms and causes of premature birth with a new $600,000 Burroughs Wellcome Fund grant. She aims to develop an imaging tool to assess collagen changes that precede preterm birth.
Researchers from the University of York and Manchester have extracted protein from a 600,000 year old mammoth fossil, providing a near complete collagen sequence. This breakthrough enables the identification of ancient fossils and opens up new possibilities for studying extinct animals.
Researchers at Case Western Reserve University have discovered the weakest link in tendons, a crucial connection between bones and muscles. The discovery focuses on collagen fibrils, which are five times stronger than tendons but may hold the key to increasing flexibility and healing damage.
A 2-year clinical study demonstrated that biosynthetic corneas formulated with recombinant human type III collagen restored vision and promoted nerve regeneration in patients with corneal damage. The results provide proof-of-concept for a viable replacement for human donor tissue or animal-sourced collagens.
Researchers at the University of Louisville have developed a new technology that prevents scar tissue from forming around implanted devices, allowing them to function longer. The technology uses tiny blood vessel fragments suspended in collagen gel to create an environment that resists scarring.
Researchers at Hebrew University successfully produced human type I pro-collagen in transgenic tobacco plants, solving a major issue with scarce and pathogen-ridden human cadaver sources. This breakthrough has significant commercial potential, valued at multi-million dollars.
Research reveals that high-strain tendons, like the Achilles tendon, repair themselves less frequently due to increased mechanical damage. This study sheds light on the increased susceptibility of certain tendons to injury during aging.
Researchers identified a new gene, Cyclophilin B, linked to osteogenesis imperfecta's recessive form. The protein plays a crucial role in modifying collagen, which forms the molecular scaffolding of bone tissue.
Researchers created super-strong collagen with improved stability, which could treat conditions like arthritis by mimicking natural collagen. The new collagen holds together at high temperatures and has a similar three-dimensional structure to natural collagen.
Researchers have discovered changes in the collagen component of bone that directly relate to bone health. The study uses atomic force microscopy to measure key features of collagen fibrils and found that normal bone contains a distribution of collagen fibril spacings, whereas diseased bone has a different spacing distribution.
Researchers found that chicken type II collagen (CCII) capsules improved joint function in RA patients with fewer side effects compared to the established antirheumatic drug methotrexate. Oral tolerance induction via dietary exposure is believed to contribute to this finding.
A study published in World Journal of Gastroenterology found that green tea extract inhibited proliferation, reduced collagen content, and downregulated collagen type 1 expression in liver fibrosis models.
Researchers found that aggressive microdermabrasion using a coarse diamond-studded instrument induced molecular changes in the skin of older adults, similar to those seen during wound healing. This procedure mimicked natural skin remodeling processes and increased collagen production.
Researchers at Duke University Medical Center found that mice deficient in Type IX collagen develop osteoarthritis and degenerative disc disease, leading to impaired physical abilities and increased pain sensitivity. The study provides valuable insights into the effects of collagen deficiency on musculoskeletal disorders.
Researchers have discovered a potential therapeutic agent for treating hepatic fibrosis, a scarring condition that impairs liver function and can lead to organ failure. The CCN2 hammerhead ribozyme shows promise in reducing collagen production and cell proliferation, offering new hope for millions affected by liver fibrosis.
A genetic mutation in a single amino acid causes defective collagen molecules to repel each other, leading to brittle bones and tissue failure. This study uses molecular-based multi-scale analysis to understand the impact of material properties on human disease.
A new study re-examining Tyrannosaurus rex remains has confirmed the presence of proteins from blood and bone, tendons, or cartilage, resolving a long-standing controversy over detectable biochemical remnants. The analysis also found evidence of substances typical of bird-like bones, which were previously disputed.
A study published in Archives of Ophthalmology found that collagen copolymer lens implantation is effective in correcting moderate to high myopia over four years. The procedure has been shown to provide stable correction with minimal complications, but longer-term follow-up is necessary to assess potential late-onset issues.
Researchers develop nanotechnology process to prevent bonding failure in composite resin fillings. By feeding minerals back into the collagen network, they aim to create a delivery system that can repair cavities on their own.
Scientists have discovered that p90RSK plays a critical role in activating hepatic stellate cells, which produce excessive collagen leading to liver fibrosis. Downregulating p90RSK inhibits HSC proliferation and collagen expression, providing a new therapeutic target for treating liver fibrosis.
Scientists at Beth Israel Deaconess Medical Center and North Carolina State University have confirmed that collagen protein is preserved in the bone fragments of a 80-million-year-old hadrosaur, supporting earlier results from a Tyrannosaurus rex study. The discovery provides robust evidence for bird-dinosaur evolution.
Researchers found evidence of preserved collagen, fibrous matrix, and microstructures in an 80 million-year-old hadrosaur fossil, similar to previous findings in a Tyrannosaurus Rex sample. The discovery supports the theory that molecules can be preserved over time in fossilized remains.
Researchers found that collagen injections can improve symptoms of stress urinary incontinence (SUI) in some patients, even after surgical treatment fails. The procedure involves injecting collagen into the tissue surrounding the urethra to tighten the sphincter and prevent leakage.
Researchers at Cardiff University are making discoveries about the eye using X-ray scattering techniques at Diamond Light Source, shedding light on keratoconus and its effects. The study aims to advance laser surgeries like LASIK and develop artificial corneas to improve the quality of life for those affected by serious eye diseases.
Researchers at UT Southwestern Medical Center found that mice lacking collagen VI developed 'healthy' obesity when fed a high-fat diet, without inflammation or insulin resistance. The study highlights the role of collagen VI in modulating fat-cell physiology and its potential as a target for intervention.
Research found that inflammation weakens collagen caps in atherosclerotic plaques, making them more prone to rupture. The study identifies lysyl-oxidase as a potential target for preventing plaque rupture and thrombosis.
Researchers at the Gladstone Institute of Neurological Disease discovered that collagen VI protects brain cells against amyloid-beta proteins, which are widely thought to cause Alzheimer's disease. The study found that increased collagen VI expression can effectively protect neurons against Aβ toxicity.
A study found that interleukin-6, a biochemical marker in the blood, is significantly higher in patients with age-related macular degeneration (AMD) and correlates with oxidative stress. Additionally, collagen crosslinking treatment has shown promising results in stabilizing keratoconus patients' vision.
A study published in Archives of Dermatology found that light-activated therapy increased levels of Ki67, a protein involved in new skin cell growth, and collagen production. Skin thickness also increased after treatment, suggesting improved appearance.
Research from Michigan Medicine found that estrogen treatments stimulate collagen production in non-sun damaged skin, but have no effect on sun-damaged skin. The study suggests it's difficult to repair photoaged skin due to altered skin response to topical estrogen treatment.
Topical estradiol application stimulates collagen production in sun-protected skin of older men and women, but not in sun-exposed areas like the face or arms. This study found that natural aging and photo-aging share biochemical features, including a reduction in collagen, which is essential for maintaining skin's inner layer structure.
Researchers found that a natural lipid, phosphatidylserine, can prevent collagen reduction and increase MMPs in both natural and UV-induced aging. Topical application of the molecule may be a simple way to slow down skin wrinkling.
Researchers found that topical retinoic acid, carbon dioxide laser resurfacing, and injections of cross-linked hyaluronic acid improve skin's appearance and resistance to bruising by stimulating new collagen production. Collagen collapse is a key factor in skin aging, but fibroblast cells can recover and make more collagen.
Researchers found that serum type IV collagen is a predictive factor of esophageal varices in patients with severe alcoholic disease. The combination of abdominal ultrasound scan and type IV collagen correctly identified patients with esophageal varices at a high rate.
Cpd 861 regulates collagen synthesis and degradation-related genes in human hepatic stellate cells, demonstrating an antifibrotic effect. The study found that Cpd 861 inhibits collagen synthesis and enhances collagen degradation, offering a new mechanism for antifibrogenic drug development.
A study published in Science confirms that Tyrannosaurus rex shares common ancestry with modern-day birds, including chickens and ostriches, based on molecular analysis of ancient protein sequences. This finding provides the first molecular evidence for the evolutionary relationships of a non-avian dinosaur.
Scientists at Argonne's Advanced Photon Source have mapped the molecular structure of collagen fibrils, revealing how they bind to enzymes that regulate growth and development. This breakthrough could lead to the creation of inhibitors to prevent cancerous tumors or rheumatoid arthritis.
The American Chemical Society presents groundbreaking research on the biotechnology of health and wellness, including a study that reveals 'good' cholesterol can be bad for the heart. Additionally, scientists uncover new information about HDL cholesterol's protein composition, which could lead to more accurate lab tests and life-saving...
A study published in The Lancet found that injecting autologous myoblasts and fibroblasts into the urethra improved continence rates for women with stress urinary incontinence. After 12 months, 38 out of 42 women treated with autologous cells were completely continent, compared to only two out of 21 women treated with collagen.
Researchers tested retinol-containing lotions on elderly patients, finding significant reductions in wrinkles, roughness, and overall aging severity. The study also showed increased collagen production, making the skin more resistant to injury and ulcer formation.
A new study by researchers from the Agricultural University of Poznan in Poland found that collagen injections can help retain important nutrients like iodine and thiamine in meatballs. Thiamine is essential for energy conversion, while iodine deficiency can lead to severe health issues such as goiter and impaired mental development.
A team of scientists led by Dr. Mary Schweitzer confirmed the presence of original protein fragments in soft tissue from a 68 million-year-old Tyrannosaurus Rex fossil. The discovery uses mass spectrometry to analyze ancient proteins, providing new insights into fossil preservation and potential medical applications.
Researchers have successfully sequenced tiny pieces of collagen protein from a 68 million-year-old Tyrannosaurus rex fossil, closely matching amino acid sequences found in present-day chickens. The findings support the long-debated proposal that birds and dinosaurs are evolutionarily related.
Researchers at the University of Michigan have discovered that Restylane works by stretching fibroblasts, causing them to create new collagen. This natural collagen then contributes to reducing wrinkle appearance. The study also found that Restylane inhibits the breakdown of existing collagen.
Researchers found that hyaluronic acid injections induce type 1 collagen production in photo-damaged skin, suggesting potential benefits for facial skin as well. This mechanism may involve mechanical stretching of fibroblasts, stimulating growth factors and inhibiting collagen breakdown.
Researchers at NIH have found a second genetic defect causing previously unexplained forms of osteogenesis imperfecta (OI), a disorder weakening bones and resulting in frequent fractures. The affected gene contains information for P3H1 protein, crucial for refining collagen to its final form.
Researchers at NIH have discovered a gene responsible for a previously unexplained, fatal form of Osteogenesis Imperfecta. The CRTAP gene plays a crucial role in collagen production and is found to be nonfunctional in patients with this rare disorder, leading to deformed brittle bones.
A new mathematical model explains the distinctive structure of collagen, a material key to healthy human bone, muscles, and tissues. The model shows collagen's structure from the atomic to the tissue scale, providing insights into its high extensibility and strength.
A team of researchers has identified a new genetic mutation responsible for osteogenesis imperfecta (OI), a condition that makes bones more likely to break. The study found that mutations in the CRTAP gene reduce the ability of a protein involved in collagen formation, leading to weaker bone and increased risk of fracture.
A newly identified gene mutation in the CRTAP gene helps explain a subset of osteogenesis imperfecta (OI) cases, where bones break easily due to abnormal collagen protein modification. The finding may also offer clues to as-yet-undescribed connective tissue diseases and provide insight into collagen formation.