Articles tagged with Collagen
Defective ACLP protein causes cellular stress and induces fibrosis in multiple organs, including lungs, livers, and adipose tissues. The study identifies a novel variant of EDS-causing mutations and reveals the protein's role in maintaining connective tissue integrity.
A study published in PNAS reveals that collagen maturation controls the availability of PEDF, a secreted protein involved in multiple biological functions. Researchers found that PEDF selectively destroys developing vessels by binding to newly synthesized collagen.
A study published in Developmental Cell reveals the CMG2 protein interacts with collagen VI, regulating its concentration inside cells. In Hyaline Fibromatosis Syndrome, a mutation prevents CMG2 protein function, leading to collagen VI accumulation.
Scientists discovered that collagen produces harmful radicals when stretched, but these are quickly scavenged by nearby aromatic residues. The study suggests that collagen has evolved as a radical sponge to combat damage and may hold promise for improving tissue repair and transplantation in sports medicine.
A new study published in Journal of Functional Foods finds that daily BioCell Collagen ingestion reduces wrinkles, increases skin elasticity, and maintains hyaluronic acid content in humans. The supplement's unique matrix of hydrolyzed collagen type II peptides, chondroitin sulfate, and hyaluronic acid helps combat UVB-induced photoaging.
A study from Kumamoto University predicts Alport syndrome severity by examining the causative protein genotype, providing a new tool for precision medicine. The researchers developed a system to analyze type IV collagen trimer formation and secretion, which helps identify pathogenic mutations and predict disease severity.
A team of scientists has identified a triple-helix structure in calcium acetate hemihydrate, a compound formed on an ancient artwork through corrosion. The structure is similar to that found in collagen proteins and may have potential applications for bioinorganic chemistry.
A new two-step technique repairs herniated discs by re-inflating the disc with hyaluronic acid gel and sealing the hole with collagen gel. This method maintains mechanical function and prevents collapse or deterioration, offering a promising alternative to existing treatments.
Researchers found that a body clock mechanism boosts collagen production when we're most active, replenishing sacrificial fibrils at night. This discovery sheds light on the extracellular matrix and its role in maintaining body structure, with implications for understanding aging and wound healing.
Researchers identified a rare genetic syndrome, CATIFA, caused by mutation of the RIC1 gene, characterized by cleft palate, intellectual disability, facial dysmorphism, and ADHD. The study combined zebrafish models, pediatric genetic diseases, and electronic health records to define the underlying mechanism.
A team of researchers has developed a technique for fabricating tiny strands of collagen called fibrils to facilitate further research on the eye's repair process. The study, funded in part by a $1.8 million NIH grant, aims to improve our understanding of how corneal keratocytes respond to injury and leave scar tissue.
Researchers at UConn have discovered that transplanting healthy donor bone marrow cells into mice with OI can improve bone strength and structure. The study found that these cells can replace mutant collagen and increase bone mass, offering potential for new therapies to correct the disorder.
Researchers found that the nervous system controls a worm's skin-like barrier against bacterial infections, challenging traditional views on innate defense. The discovery may have implications for human health and longevity by regulating collagen production, a key protein in maintaining tissue structure.
A study using ancient bone protein analysis identified green turtles as a primary target for human consumption in Florida and the Caribbean thousands of years ago. The technique, collagen fingerprinting, allowed scientists to visualize distinct chemical signatures in collagen that are species-specific.
Arapaima's scales are made of tough yet flexible layers bound by collagen, adapting to prevent piranha bites. The thick collagen layers may be the secret to its defense.
Researchers at Imperial College London aim to re-engineer stump skin using the tough properties of foot sole skin to reduce rubbing and pain from prosthetics. They found that thicker collagen fibers and different types of keratin are key factors in protecting sole skin from ulcers and blisters.
Researchers at Washington University in St. Louis found that collagen fiber length can affect how cells move collectively, with longer fibers supporting streaming out of colonies and elongating cells. The study suggests that a balance between aggressiveness and cooperation is crucial for cell movement.
A team of researchers has developed a method to screen bone samples for collagen using near-infrared spectrometry, reducing the need to destroy valuable remains. This breakthrough could enable scientists to analyze ancient DNA and gain insights into human history.
Researchers from North Carolina State University have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments. The nanometer-sized exosomes can be delivered to the target cells via needle-free injections.
A 12-week clinical trial found BioCell Collagen increased skin collagen content by 12% and improved signs of aging in women. The study showed significant reductions in facial lines and wrinkles, crow's feet width, and improved skin elasticity compared to placebo.
Researchers create paper-based structures that mimic aortic valves, allowing them to study how calcifying diseases slow or stop hearts from functioning. The device helps understand the chemical transactions in heart disease and may eventually lead to non-invasive medication.
Carnegie Mellon researchers create functional heart components using FRESH technology, which enables bioprinting of complex tissues and organs. The breakthrough overcomes a major printing obstacle, allowing for high-fidelity structures and dynamic biological materials.
Researchers have developed a new 3D bioprinting technique using rapid changes in pH to create complex collagen-based cardiac structures. The method, called FRESH v2.0, can print tissue architectures up to 10 micrometers resolution and accurately reproduce patient-specific anatomical structures.
A team of researchers from Carnegie Mellon University has developed a new technique to 3D bioprint tissue scaffolds out of collagen, allowing them to overcome challenges associated with existing methods and achieve unprecedented resolution and fidelity. The technique, known as Freeform Reversible Embedding of Suspended Hydrogels (FRESH...
A team from Kyoto University found that collagen in the skin is organized in a mesh-like structure, with elastic fibers following the same orientation. This discovery has significant implications for understanding skin pliability and could lead to breakthroughs in skin grafts and transplantation.
A recent study published in PLOS Neglected Tropical Diseases investigated the expression levels of two immune proteins, interleukin-17 and matrix metalloprotein-9, in mycetoma grains. The researchers found that these molecules are present in specific zones of the grains and correspond with disease duration and lesion size.
A GW pilot study found topical collagen powder to be as effective as primary closure for punch biopsy wound treatment and possibly superior in early cosmetic outcomes. The study showed that wounds treated with collagen healed at least as well as those treated with primary closure.
Researchers develop a technique to confine cytokine treatments to tumors by attaching a collagen-binding protein called lumican. The treatment improves survival rates in mice when combined with immunotherapies, while eliminating toxicity associated with cytokines alone.
Researchers created a pliable, 3D-printed mesh material that can be tailored to support soft tissues like muscles and tendons. The mesh was successfully tested on human ankles, increasing stiffness during inversion while leaving it unaffected in other directions.
A recent study published in the FASEB Journal has found that inhibiting various stages of mitochondrial dysfunction can suppress muscle atrophy. Researchers used Caenorhabditis elegans worms to model human muscle diseases and showed that experimental drugs could prevent muscle decline caused by dysfunctional mitochondria.
New molecular evidence contradicts long-held views on sloth relationships, suggesting that tree sloths and extinct kin are more closely related than previously thought. The research uses both mitochondrial genome and protein collagen data to support convergent origins of adaptations in the six living tree sloth species.
Researchers at Universite Paris-sud studied how collagen fibrils form complex tissues. They found that the fibers grow in a unique, parabolic profile, with a constant diameter throughout growth, similar to a sunflower's florets.
Researchers found that hydrogen peroxide in whitening strips damages dentin tissue beneath the enamel. The active ingredient converts collagen into smaller fragments, potentially causing permanent tooth damage.
Researchers at Binghamton University developed a new device that can ascertain the orientation of skin tension lines, crucial for wound-healing post-surgery. The device directly measures skin tension direction with high accuracy, making it more reliable than existing methods.
Researchers re-dated giant ground sloth remains, challenging popular hypothesis that megamammals survived into the Holocene. Their findings suggest humans hunted and butchered the animal near a swamp during the end of the Pleistocene.
A new study by Prof. Sarah-Maria Fendt and her PhD student Ilaria Elia found that breast cancer cells require pyruvate to reshape the lung environment and create a pro-tumor niche. In contrast, normal bone cells rely on glutamine for this process.
Researchers at Imperial College London have developed a new molecule called TrAPs that interact with the body's natural repair systems to drive healing. The technique mimics nature and can be tailored to release specific therapeutic proteins based on cell type, offering new hope for patients with difficult-to-heal wounds.
Researchers found that collagen fibrils in mammalian tissues become stronger and tougher when repeatedly stretched and relaxed. This discovery has significant implications for understanding tissue mechanics and designing better biocompatible materials for wound healing and tissue growth.
Studies in mice with psoriasis-like conditions found that stiff blood vessel walls trapped cholesterol, promoting plaques and increasing cardiovascular risk. Neutralizing a specific immune cell type reduced collagen density and cholesterol deposits, suggesting a preventable link between autoimmune diseases and heart disease.
A new study from McMaster University reveals that whey protein is the most effective protein source for seniors to rebuild lost muscle, with minimal impact on lean muscle loss. In contrast, collagen peptides showed no benefits in mitigating muscle loss.
Researchers developed a new method called pneumatospinning to produce collagen microfibres, which have significantly higher tensile strength than traditional methods. The technique has potential applications in medical devices, clinical treatments, and combination therapies.
A recent study found no correlation between circulating bone turnover markers and hip fracture risk among postmenopausal women. The research adds to the existing evidence that these markers are not useful for predicting hip fracture risk.
Researchers at Tokyo Institute of Technology identified USP8 as a key enzyme controlling large collagen carrier formation. The enzyme inhibits collagen secretion when active, promoting its transport instead.
The study reveals that bone's mineral crystals have a hierarchical structure integrated into the larger-scale skeleton, with 12 levels of hierarchy. The combination of mineral and protein forms continuous networks to provide strength essential for functional bones. This breakthrough builds on previous studies and sheds light on the uni...
A team of engineers at Washington University in St. Louis studied the formation of new bone and teeth, discovering that miniscule gaps in collagen's fiber structure facilitate the nucleation of calcium phosphate. The findings provide a new view into the current theory of calcium phosphate nucleation in confined spaces.
A team of researchers has identified a previously unknown feature of human anatomy, revealing layers of the body as interconnected, fluid-filled compartments. This discovery has significant implications for understanding organ function, disease progression, and the development of new diagnostic tools.
Researchers studying a rare skin disorder called DEB found that loss of collagen VII affected the cellular microenvironment, leading to abnormal mRNA and protein turnover. Meanwhile, another study used novel proteomics to characterize changes in O-GlcNAc modification sites on proteins involved in T cell activation.
Researchers from Kumamoto University have established a highly sensitive system to assess Col4 functionality, enabling the screening of therapeutic drug candidates. The detection system reduces labor and time costs compared to conventional methods, making it possible to analyze multiple compounds simultaneously.
Researchers created a new type of microfluidic device using collagen-based membranes to mimic the growth of human intestinal cells. The results showed that colon cells grown on the collagen membrane were more viable and differentiated compared to those in other devices.
The new microscope developed by SFU researchers allows for the study of molecular interactions under high forces and fast spinning speeds, revealing new insights into collagen stability. This breakthrough has significant implications for developing better treatments to prevent collagen degradation.
Scientists at ICN2 have found that bone's mineral component exhibits flexoelectricity, which triggers the bone repair process. This effect is localized to the tip of microfractures and signals to osteoblasts where damage needs repair.
A team of biomedical engineers has developed a photocrosslinkable, thermoreversible type-I collagen bioink for 3D printing of scaffolds. The bioink allows for spatially controlled cross-linking and can be used to print scaffolds with macroscale features, facilitating tissue engineering and regenerative medicine applications.
Researchers at Nanyang Technological University developed a gel patch enriched with Angiopoietin-like 4, which speeds up wound healing while reducing scarring. The patch shows promise for treating hard-to-heal skin lesions in diabetic patients and post-surgical patients.
Collagen in cartilage exhibits reversible changes in crystallinity in response to physical forces, affecting its resilience to compression. The findings may help explain why cartilage breaks down with aging or osteoarthritis, a leading cause of joint pain and immobility.
A University of Guelph professor has identified a protein that enables fish to adjust the size of their hearts in response to changing temperatures. This finding may lead to new insights into preventing or treating cardiac fibrosis, a condition where the heart builds up scar tissue after injury.
A new study led by Princeton University researchers finds that cells must move around and change shape to gain a meaningful understanding of their environment. The typical cell's environment is highly varied in stiffness or flexibility, making it difficult for the cell to determine its surroundings through mechanosensing.
Scientists discovered that changes in mechanical behavior and gene signaling play a crucial role in the development of heart defects, with LOX-deficient mice exhibiting protection against aneurysms. The research provides new insights into the chemo-mechanics of heart defects and its potential applications for disease prevention.
A team from Ireland developed a collagen scaffold loaded with an antibiotic to prevent bacterial biofilm formation, successfully targeting Escherichia coli and Staphylococcus epidermidis. The discovery marks a significant step forward in combating implant infections, which can cause long hospitalization periods and additional surgeries.
Researchers identified that the CMG2 protein binds and controls collagen VI levels, leading to its accumulation in tissues causing painful deformities. The study provides new insights into the physiological function of CMG2 and demonstrates its interaction with collagen VI.
Researchers from Kyoto University have made a breakthrough in understanding the role of unfolded protein response (UPR) transducers in coping with ER stress. They found that different UPR transducers are activated selectively, depending on the developmental stage of the cell and type of stress, to orchestrate various biological processes.